| | Molecular Biology and Biochemistry Department Faculty Profile |
 | | Our research is aimed at understanding the molecular mechanisms of microfilament reorganization associated with the alterations of cell morphology seen during oncogenic transformation and during cell division. |
 | | Because caldesmon stimulates the actin binding activity of tropomyosin, and because tropomyosin stabilizes the structure of the microfilament, we hypothesized that the decrease in caldesmon expression in transformed cells, as well as the dissociation of caldesmon from microfilaments in mitotic cells, would destabilize microfilaments. |
 | | The functions of fascin in microfilament organization contrast with those of caldesmon: While caldesmon localizes mainly in stress fibers, fascin is present in filopodia, membrane ruffles and stress fibers. |
| www.rci.rutgers.edu /~molbio/faculty/yamashiro.html (587 words) |