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Topic: Microsome

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	Y-Point BioAnalytical - Bioanalytical Support that is Quick and Effective (Site not responding. Last check: 2007-10-13)
		Microsomes are sub-cellular liver structures that contain a variety of enzymes responsible for phase I metabolism.
		Liver microsome and S9 incubations are used to determine the potential metabolic stability of test compounds.
		Compounds are incubated at pre-determined concentrations with liver microsomes and NADPH.
	www.ypointbio.com /services/microsome_stability.htm (222 words)

	Microsome - Wikipedia, the free encyclopedia
		In cell biology, a microsome is a small vesicle that is derived from fragmented endoplasmic reticulum produced when cells are homogenized.
		These microsomes can be concentrated and separated from the other cellular organelles by means of differential centrifugation.
		In this way, P450s in microsomes are concentrated and isolated.
	en.wikipedia.org /wiki/Microsome (206 words)

	BD Biosciences : Use and Storage of Microsome Products
		Microsome preparations may be frozen and thawed a few times without substantial loss of activity.
		Formany cytochrome P450 assays, a 30 minute incubation with 0.5 mg microsomal protein (humanlymphoblast-derived microsomes) or 50 pmole P450 BD Supersomes in 1 ml is sufficient toproduce readily detectable quantities of metabolites.
		Microsomal protein can adhere to glass and exhibit lowercatalytic activity, particularly, at low protein concentrations.
	www.bdbiosciences.com /discovery_labware/gentest/tech_resources/use_stor.shtml (735 words)

	Amazon.com: microsome (Site not responding. Last check: 2007-10-13)
		Microsomes, Drug Oxidation and Chemical Carcinogenesis by 4th, Ann Arbor, 1979.
		Microsomes and Drug Oxidations by James R. Gillette and Allan H. Conney and George J. Cosmides and Ronald W. Estabrook and James R. Fouts and Gilbert J. Mannering (Hardcover - 1969)
		Effects of methotrexate on calcium flux in rat liver mitochondria, microsomes and plasma membrane vesicles by C.L.S. Pagadigorria, F. Marcon, A.M. Kelmer-Bracht, and A. Bracht (Jul 2006)
	www.amazon.com /s?ie=UTF8&keywords=microsome&tag=lexico&index=blended&link_code=qs&page=1 (317 words)

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