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Topic: Microtubule

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  Microtubule Structures
A microtubule is a polymer of globular tubulin subunits, which are arranged in a cylindrical tube measuring 24 nm in diameter
A microtubule is a polar structure, its polarity arising from the head-to-tail arrangement of the
For example, during mitosis, the cytosolic microtubule network characteristic of interphase cells disappears, and the tubulin from it is used to form the spindle-shaped apparatus that partitions chromosomes equally to the daughter cells (Figure 19-4a).
www.ncbi.nlm.nih.gov /books/bv.fcgi?rid=mcb.section.5406   (1668 words)

 Microtubule Structure   (Site not responding. Last check: 2007-10-13)
The hydrolysis of GTP of course is facilitated at a temperature of 37 C and stopped at temperatures of 4 C. This figure shows that, as the oligomers assemble, they form a series of rings, 25 nm in diameter.
In the cell itself, microtubules are formed in an area near the nucleus called the "aster".
Taxol stabilizes microtubules by binding to a polymer.
cellbio.utmb.edu /CELLBIO/microtubule_structure.htm   (1072 words)

 Microtubule Dynamics
During mitosis, microtubule plus-ends are embedded in the kinetochore and movement of a kinetochore towards and away from its attached spindle pole is coordinated with the shrinkage and growth of its bound microtubules.
The polymerization phase is thought to be stabilized by a thin cap of tubulin dimers at the microtubule plus-end that have a GTP molecule associated with the beta-tubulin subunit.
Contours of the microtubule boundary were manually traced in green on slices taken along the microtubule axis (i.e., orthogonal to the slice in c).
www.wadsworth.org /BMS/SCBlinks/mcewen/microtubule_dynamics.html   (1014 words)

 Microtubule - Wikipedia, the free encyclopedia
Microtubules serve as structural components within cells and are involved in many cellular processes including mitosis, cytokinesis, and vesicular transport.
Microtubules are nucleated and organized by the microtubule organizing centers (MTOCs), such as centrosomes and basal bodies.
Microtubules are also part of the cilia and flagella of eukaryotic cells (prokaryote flagella are entirely different).
en.wikipedia.org /wiki/Microtubule   (726 words)

 Exploring News & Features - Paraplegia-microtubule link   (Site not responding. Last check: 2007-10-13)
Microtubules are dynamic structures, continually growing and shrinking, and their stability is closely regulated by a number of associated proteins.
In nerve cells, microtubules carry cellular components to distant regions of the cell, regulate the growth of cellular branches and provide a substrate for important protein interactions.
Moreover, the researchers found that specific drugs that alter microtubule stability remedy the defects that occur in synaptic function as a result of changes in spastin levels.
exploration.vanderbilt.edu /news/news_hsp.htm   (956 words)

 Microtubules   (Site not responding. Last check: 2007-10-13)
A protofilament is a linear row of tubulin beads.
Microtubules may work alone, or join with other proteins to form more complex structures called cilia, flagella or centrioles.
With respect to microtubules, what is dynamic instability and why is it important to the cell?
cellbio.utmb.edu /cellbio/microtub.htm   (441 words)

 Cornell News: microtubule imaging
In developing nerve cells, microtubules are the pioneering extensions from the cell body that grow to form two kinds of processes: the dendrites (branches that collect and conduct impulses inward to the cell body) and the axon (the single, longer process that conducts impulses away from the neuron cell body).
Microtubules, made of tiny polymers, are a major part of the cellular cytoskeleton and are responsible for mechanical support.
The researchers predict that their system to image microtubule polarity deep within living brain tissue could expedite the study of neuronal development and repair, the dynamics of migrating cells and neurodegenerative disease.
www.news.cornell.edu /releases/June03/microtubule.hrs.html   (667 words)

the wall of one microtubule partly consists of the wall of an attached microtubule.
Microtubules may grow steadily, and then shrink rapidly by loss of tubulin dimers at the plus end.
of the cell, contributing to treadmilling (flow of microtubule subunits toward the poles) and shortening of kinetochore-linked microtubules during anaphase of mitosis.
www.rpi.edu /dept/bcbp/molbiochem/MBWeb/mb2/part1/microtub.htm   (1324 words)

 The Drosophila Toucan protein is a new mitotic microtubule-associated protein required for spindle microtubule ...
In contrast, astral microtubules are not disturbed by Toc depletion.
in the absence of Toc, the depolymerization of microtubule minus-ends
Brust-Mascher, I. and Scholey, J.M. (2002) Microtubule flux and sliding in mitotic spindles of Drosophila embryos.
www.genestocellsonline.org /cgi/content/full/10/1/37   (4628 words)

 The Microtubule Plus-End Proteins EB1 and Dynactin Have Differential Effects on Microtubule Polymerization -- Ligon et ...
on microtubule polymerization in the absence and in the presence
microtubule polymerization, thus increasing the extent of polymerization.
Waterman-Storer, C.M., and Salmon, E.D. Actomyosin-based retrograde flow of microtubules in the lamella of migrating epithelial cells influences microtubule dynamic instability and turnover and is associated with microtubule breakage and treadmilling.
www.molbiolcell.org /cgi/content/full/14/4/1405   (6038 words)

 CAMB: Faculty: Phong T. Tran
For example, our previous studies in fission yeast have shown that bundles of microtubules can set up a spatial map for the cell to know where to grow and where to position its nucleus.
Microtubule architecture and dynamics are influenced by both plus- and minus-end microtubule-associated-proteins.
Measure the flexural rigidity and magnitude of pushing forces of microtubules in living cells.
www.med.upenn.edu /camb/faculty/cbp/tran.html   (286 words)

 AMF-R Tubules Concentrate in a Pericentriolar Microtubule Domain After MSV Transformation of Epithelial MDCK Cells -- ...
in parallel with the reorganization of the microtubule cytoskeleton.
a subpopulation of microtubules in the motile, invasive MSV-MDCK
Kreis TE (1990) Role of microtubules in the organisation of the Golgi apparatus.
www.jhc.org /cgi/content/full/45/10/1351   (5047 words)

 Biology4Kids.com: Cell Structure: Microtubule
While microfilaments are thin, microtubules are thick, strong spirals of thousands of subunits.
All of the microfilaments and microtubules combine to form the cytoskeleton of the cell.
Beyond the role they play in internal cell movement, microtubules work together to form larger structures that work on the outside of the cells.
www.biology4kids.com /files/cell_microtubule.html   (304 words)

 Microtubule-associated protein - Wikipedia, the free encyclopedia
This detachment is usually associated with a destabilization of the microtubule causing it to fall apart.
MAP2 and tau stabilize microtubules, and thus shift the reaction kinetics in favor of addition of new subunits, accelerating microtubule growth.
This increase in microtubule instability may be one of the main causes of the symptoms of Alzheimer's Disease.
en.wikipedia.org /wiki/Microtubule-associated_protein   (880 words)

 ch-TOGp Is Required for Microtubule Aster Formation in a Mammalian Mitotic Extract -- Dionne et al. 275 (16): 12346 -- ...   (Site not responding. Last check: 2007-10-13)
Microtubules induced to polymerize with taxol in a mammalian mitotic extract organize into aster-like arrays in a centrosome-independent
Lane 2, microtubule asters were assembled in the actin-diminished extract and collected by sedimentation through 20% (w/v) sucrose.
Lack of microtubule polymerization in the absence of ch-TOGp depends on ATP.
intl.jbc.org /cgi/content/full/275/16/12346   (4438 words)

A protofilament is a linear row of tubulin dimers.
Why is the temperature important during assembly of a microtubule and what ingredients would you need to make a microtubule?
For the lecture on microtubules, we will discuss the following paper: Bloom, GS and Goldstein, LSB 1998 Cruising along Microtubule Highways: How Membranes Move Through the Secretory Pathway.
www.cytochemistry.net /Cell-biology/microtub.htm   (483 words)

 Rapid Microtubule-dependent Induction of Neurite-like Extensions in NIH 3T3 Fibroblasts by Inhibition of ROCK and Cbl ...
Microtubule bundles formed by ROCK inhibition are enriched in detyrosinated tubulin.
Glu-tubulin–rich nocodazole-resistant microtubule bundles are indicated by the arrowheads.
Omelchenko, T., Vasiliev, J.M., Gelfand, I.M., Feder, H.H., and E. (2002) Mechanisms of polarization of the shape of fibroblasts and epitheliocytes: separation of the roles of microtubules and Rho-dependent actin-myosin contractility.
www.molbiolcell.org /cgi/content/full/14/11/4605   (6146 words)

 The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast -- Pardo and ...
A role for Amo1 in microtubule organisation and polarity.
Arrowheads in B indicate polymerising microtubules (white) and depolymerising microtubules (yellow) in the same bundle.
White arrowheads in C indicate polymerising microtubules and yellow arrowheads depolymerising microtubules in bundles with more than one microtubule touching the cell tip at the same time.
jcs.biologists.org /cgi/content/full/118/8/1705   (5493 words)

 Microtubule Stabilization in Pressure Overload Cardiac Hypertrophy -- Sato et al. 139 (4): 963 -- The Journal of Cell ...
The rate of microtubule depolymerization at 0°C was used as the second additional measure of microtubule stability.
Generation of a stable, posttranslationally modified microtubule array is an early event in myogenic differentiaiton.
Microtubule dynamics in vitro are regulated by the tubulin isotype composition.
www.jcb.org /cgi/content/full/139/4/963   (6890 words)

 Synergistic Suppression of Microtubule Dynamics by Discodermolide and Paclitaxel in Non-Small Cell Lung Carcinoma Cells ...
In the presence of paclitaxel (I), the ends of microtubules "chattered" or underwent many small changes in length (arrows), whereas in the presence of discodermolide (H), the ends were more stable to minor changes in length.
Honore S, Kamath K, Braguer D, et al Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation.
Carre M, Carles G, Andre N, et al Involvement of microtubule and mitochondria in the antagonism of arsenic trioxide on paclitaxel-induced apoptosis.
cancerres.aacrjournals.org /cgi/content/full/64/14/4957   (5139 words)

 {beta}III-Tubulin Induces Paclitaxel Resistance in Association with Reduced Effects on Microtubule Dynamic Instability ...
were calculated per microtubule as described previously (12).
affects microtubule dynamics in the presence or absence of paclitaxel.
III-tubulin (green) that colocalized with endogenous tubulin (red) in induced cells (E, G) were overlaid producing yellow microtubules, whereas HA-tubulin expression was negligible in uninduced cells (F, H) and overlaid images resulted in red microtubules.
www.jbc.org /cgi/content/full/280/13/12902   (3018 words)

 The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends : Nature
Chromosomes interact through their kinetochores with microtubule plus ends and they are segregated to the spindle poles as the kinetochore microtubules shorten during anaphase A of mitosis.
This out-of-register arrangement with respect to the 13-fold microtubule symmetry is consistent with a sliding mechanism based on an electrostatically coupled ring–microtubule interface.
The Dam1 ring complex is a molecular device that can translate the force generated by microtubule depolymerization into movement along the lattice to facilitate chromosome segregation.
www.nature.com /nature/journal/v440/n7083/abs/nature04409.html   (293 words)

 Dynamics of microtubule asters in microfabricated chambers: The role of catastrophes -- Faivre-Moskalenko and Dogterom ...
Dynamics of microtubule asters in microfabricated chambers: The role of catastrophes -- Faivre-Moskalenko and Dogterom 99 (26): 16788 -- Proceedings of the National Academy of Sciences
Dynamics of microtubule asters in microfabricated chambers: The role of catastrophes
that microtubule pushing alone is sufficient to position a microtubule-organizing
www.pnas.org /cgi/content/full/99/26/16788   (4379 words)

 Biology & Medicine : Microtubule-Stabilizing Agent   (Site not responding. Last check: 2007-10-13)
Non-transformed cells treated with the agent exhibited interphase arrest and extensive microtubule bundling.
Many of the microtubule bundles were located in the cell periphery, apparently nucleated independent of the microtubule-organizing center.
It represents only the sixth class of compounds that has been found (after extensive searching by many academic and industrial groups) that possesses microtubule-stabilizing activity, the first microtubule-stabilizing agent to be discovered in higher plants since Taxol®, and the first natural steroid to exhibit these microtubule effects.
www.mic.hawaii.edu /dev_tech/biology/taccalonolide.html   (306 words)

 Dynamic Localization of CLIP-170 to Microtubule Plus Ends Is Coupled to Microtubule Assembly -- Diamantopoulos et al. ...
Dynamic Localization of CLIP-170 to Microtubule Plus Ends Is Coupled to Microtubule Assembly -- Diamantopoulos et al.
CLIP-170 is a cytoplasmic linker protein that localizes to plus ends of microtubules in vivo.
Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3{beta} in migrating epithelial cells
www.jcb.org /cgi/content/abstract/144/1/99   (1159 words)

 Anti-MAP-2 (2a & 2b) Microtubule Associated Protein 2 Monoclonal Antibody, Fluorescein Conjugated, Clone AP20 from ...
Anti-MAP-2 (2a & 2b) Microtubule Associated Protein 2 Monoclonal Antibody, Fluorescein Conjugated, Clone AP20 from Leinco Technologies, Inc. - Biocompare Buyer's Guide
Home » Antibodies » Antibodies » Anti-MAP-2 (2a & 2b) Microtubule Associated Protei...
Anti-MAP-2 (2a & 2b) Microtubule Associated Protein 2 Monoclonal Antibody, Fluorescein Conjugated, Clone AP20 from Leinco Technologies, Inc.
www.biocompare.com /itemdetails.asp?itemid=181191   (122 words)

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