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Topic: Microtubule-associated protein

    Note: these results are not from the primary (high quality) database.

Microtubule-associated protein - Wikipedia, the free encyclopedia In cell biology, microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton. This detachment is usually associated with a destabilization of the microtubule causing it to fall apart. This increase in microtubule instability may be one of the main causes of the symptoms of Alzheimer's Disease. en.wikipedia.org /wiki/Microtubule-associated_protein   (895 words)

Mapt - microtubule-associated protein tau Mapt is a homologue of MAPT (microtubule-associated protein tau) from Homo sapiens. This protein is highly homologous to the sequence of the mouse microtubule-associated protein tau and thus constitutes the human equivalent of mouse tau. Apolipoprotein E (apoE)-deficient mice have memory deficits that are associated with synaptic loss of basal forebrain cholinergic projections and with hyperphosphorylation of distinct epitopes of the microtubule-associated protein tau. www.ihop-net.org /UniPub/iHOP/gg/122953.html   (1674 words)

GeneCard for MAPT Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy. bioinfo.cnio.es /cgi-bin/genecards/carddisp?MAPT   (1187 words)

Pfam 19.0 : MAP1_LC3 Light chain 3 is proposed to function primarily as a subunit of microtubule associated proteins 1A and 1B and that its expression may regulate microtubule binding activity [1]. Light chain 3 (LC3) may function primarily as a MAP1A and MAP1B subunit and its expression may regulate the microtubule binding activity of of the neuronal microtubule-associated proteins (MAPs), MAP1A and MAP1B PUBMED:7908909. Related proteins that belong to this group include the human ganglioside expression factor and a symbiosis-related fungal protein. pfam.wustl.edu /cgi-bin/getdesc?name=MAP1_LC3   (87 words)

MAPRE1 - microtubule-associated protein, RP/EB family, member 1 EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle. We further confirm that the adenomatous polyposis coli (APC) tumour suppressor protein is recruited to adherens junctions, and demonstrate that both APC and microtubule- associated EB1 homologues are required for the symmetric epithelial division along the planar axis. The interaction between the adenomatous polyposis coli (APC) tumour suppressor and the microtubule- associated protein EB1 was examined. www.ihop-net.org /UniPub/iHOP/gg/96420.html   (2268 words)

Re: how similar are tau and microtubule-associated protein 2? Tau and MAP2 are both microtubule associated proteins that are expressed primarily in neurons. However, the N-terminal regions (called "projection domains" as they are thought to project out from the surface of the microtubule) differ greatly between the two proteins and probably serve different functions in each protein. The association of both MAP2 and tau with microtubules is regulated in part by phosphorylation. www.madsci.org /posts/archives/2004-11/1099512168.Mb.r.html   (209 words)

The Drosophila Gene abnormal spindle Encodes a Novel Microtubule-associated Protein That Associates with the Polar Regions of the Mitotic Spindle -- Saunders et al. 137 (4): 881 -- The Journal of Cell Biology Microtubule-stabilizing activity of microtubuleassociated proteins (MAPs) is due to increase in frequency of rescue in dynamic instability: shortening length decreases with binding of MAPs onto microtubules. The Drosophila Gene abnormal spindle Encodes a Novel Microtubule-associated Protein That Associates with the Polar Regions of the Mitotic Spindle are positioned by the centrosome and its associated microtubules. www.jcb.org /cgi/content/full/137/4/881   (6263 words)

ScienceDirect - Brain Research: Hippocampal microtubule-associated protein-2 alterations with contextual memory C.G. Dotti, G.A. Banker and L.I. Binder, The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. R.J. Montoro, J. Diaz-Nido, J. Avila and J. Lopez-Barneo, N-methyl-D-aspartate stimulates the dephosphorylation of the microtubule-associated protein 2 and potentiates excitatory synaptic pathways in the rat hippocampus. Fifty micrograms of protein was run on each lane of a 7% SDS polyacrilamide gel and probed with AP-18 (1:4000). nwoolf.bol.ucla.edu /woolfetal1999.htm   (5116 words)

Microtubule Associated Protein Fraction (MAPF) MAPF protein is isolated from MAP-rich tubulin by ionic exchange chromatography over phosphocellulose matrix, similar to the protocols of Vallee and of Kuznetsov et al. One unit of MAPF protein is defined as 100 µg of protein (as determined by the Precision Red Advanced Protein Assay, Cat. When MAPF (final concentration 0.1 mg/ml) was added to purified tubulin protein (final concentration 1.0 mg/ml) in G - PEM buffer, in vitro tubulin polymerization (at 35°C, over 30 min) was stimulated by a factor of approximately 25-fold when compared to polymerization of tubulin protein alone (see Fig.1). www.cytoskeleton.com /mapf.htm   (157 words)

Microtubule-associated protein elongation factor-1-alpha Evidence indicates that elongation factor-1a (EF-1a), a ubiquitous and abundant protein factor involved in the first step of peptide elongation, is also associated with the cytoskeleton in a variety of organisms. In carrot protoplasts fixed after detergent lysis, at least a fraction of pp50 appears to be associated with microtubules. Furthermore, what is likely to be a fluorescence resonance energy transfer (FRET) between fluorochromes associated with anti-pp50 and anti-tubulin reporters was observed, indicating that some pp50 is intimately associated with microtubules. www.geocities.com /ndurso/pr_abs.htm   (406 words)

The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8 -- Sugawara et al. 9 (7): 611 -- Genes to Cells The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8 -- Sugawara et al. www.genestocellsonline.org /cgi/reprint/9/7/611   (20 words)

The Drosophila Toucan protein is a new mitotic microtubule-associated protein required for spindle microtubule stability -- Mirouse et al. 10 (1): 37 -- Genes to Cells The Drosophila Toucan protein is a new mitotic microtubule-associated protein required for spindle microtubule stability -- Mirouse et al. Articles by Mirouse, V. Articles by Couderc, J.-L. The Drosophila Toucan protein is a new mitotic microtubule-associated protein required for spindle microtubule stability In contrast, astral microtubules are not disturbed by Toc depletion. www.genestocellsonline.org /cgi/content/abstract/10/1/37   (217 words)

[Frontiers in Bioscience 1, d118-130, August 1, 1996] Vallee: Distribution of microtubule-associated protein 2 in the nervous system of the rat studied by immunofluorescence. Brandt and G. Lee: Orientation, assembly, and stability of microtubule bundles induced by a fragment of tau protein. Burton and J. Paige: Polarity of axoplasmic microtubules in the olfactory nerve of the frog. www.bioscience.org /1996/v1/d/brandt1/htmls/6.htm   (2255 words)

Structure and elasticity of microtubule-associated protein tau Tau is one of the diverse group of microtubule-associated proteins that bind to microtubules and may thereby influence their structure and function. They show distinct transverse banding and polarity, indicating that the protein subunits are aligned with the same orientations. In contrast to other paracrystals, those of tau protein can stretch or contract continuously by more than three-fold; the axial repeats range from 22 to 68 nm. www.nature.com /nature/journal/v334/n6180/abs/334359a0.html   (263 words)

Proteolysis of microtubule associated protein 2 and sensitivity of pancreatic tumours to docetaxel Proteolysis of microtubule associated protein 2 and sensitivity of pancreatic tumours to docetaxel We have studied the state of microtubule associated protein 2 (MAP2) in the pancreatic ductal adenocarcinomas P03 and P02 (sensitive and refractory to docetaxel respectively) since they express the corresponding mRNA and MAP2-related peptides. Proteolysis was found to increase the tendency of tubulin to assemble into macromolecular structures (microtubules and aggregates) in the presence of docetaxel. www.nature.com /bjc/journal/v83/n4/abs/6691294a.html   (283 words)

MAP2 [Microtubule Associated Protein; MAP2A and 2B] , clone AP20 : MAB3418 MAP-2 (microtubule associated protein-2) is one of several high molecular weight proteins that play an important role in brain neuron microtubule assembly. In addition to its association with microtubules, MAP-2 associates with neurofilaments and actin filaments suggesting that it may guide interaction among microtubules, other cytoskeletal elements, and cytoplasmic organelles (Binder, 1984). In SDS-PAGE, MAP-2 from adult rat migrates as a closely associated doublet having a molecular weight of approximately 280-300 kD representing the MAP-2A and -2B isoforms but not the 70 kDa MAP-2C isoform. www.chemicon.com /Product/ProductDataSheet.asp?ProductItem=MAB3418   (369 words)

Microtubule-Associated Protein 2: Monoclonal Antibodies Demonstrate the Selective Incorporation of Certain Epitopes into Alzheimer Neurofibrillary Tangles -- Kosik et al. 81 (24): 7941 -- Proceedings of the National Academy of Sciences Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau Staging of Cytoskeletal and {beta}-Amyloid Changes in Human Isocortex Reveals Biphasic Synaptic Protein Response during Progression of Alzheimer's Disease Neurofibrillary tangles (NFT) are the principal structural alteration of neuronal cell bodies in Alzheimer disease as well as in normal aging of the human brain. www.pnas.org /cgi/content/abstract/81/24/7941   (532 words)

E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis -- Komada et al. 14 (11): 1332 -- Genes and Development E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis -- Komada et al. Cell type-specific microtubules, such as the Sertoli cell microtubules and the manchette and flagellum microtubules of the a possible role for E-MAP-115 in stabilizing microtubules, microtubule www.genesdev.org /cgi/content/abstract/14/11/1332   (470 words)

2004 Alzheimer Award to Lester I Binder, PhD By marking the brain tissues of deceased AD patients with two antibodies specific to different folded states of the protein, the authors show that the tau protein undergoes a stepwise folding and truncation. The formation of neurofibrillary tangles (NFTs) of proteins in the brains of Alzheimer's disease (AD) patients may play an important role in the progression of the disease. The Associate Editors of the Journal of Alzheimer's Disease select the award recipient from among articles published the previous year's volume. www.medicalnewstoday.com /medicalnews.php?newsid=11724   (620 words)

The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development -- Lu et al. 101 (42): 15201 -- Proceedings of the National Academy of Sciences Scores between 0 and 1 indicate negligible disruption of microtubule with majority of microtubule polymers remain intact. Considering the critical roles of microtubule dynamics in the of MAP1B and microtubule dynamics within the individual dendrite www.pnas.org /cgi/content/full/101/42/15201   (4010 words)

Neuronal Damage and Plasticity Identified by Microtubule-Associated Protein 2, Growth-Associated Protein 43, and Cyclin D1 Immunoreactivity After Focal Cerebral Ischemia in Rats • Editorial Comment -- Li et al. 29 (9): 1972 -- Stroke Microtubule-associated protein 2 as an early indicator of ischemia-induced neurodegeneration in the gerbil forebrain. A protein associated with axon growth, GAP43 is widely distributed and developmentally regulated in rat CNS. A 43-kDa growth-associated protein (GAP-43) is a nervous tissue–specific protein. stroke.ahajournals.org /cgi/content/full/29/9/1972   (6493 words)

Human protein: Q8NDS5 - Microtubule-associated protein (Fragment). EMBL Bioinformatic Harvester The protein encoded by this gene is a major non-neuronal microtubule-associated protein. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. harvester.embl.de /harvester/Q8ND/Q8NDS5.htm   (760 words)

Microtubule-associated Protein 1 Light Chain 3 Is a Fibronectin mRNA-binding Protein Linked to mRNA Translation in Lamb Vascular Smooth Muscle Cells -- Zhou et al. 100 (12): 3070 -- Journal of Clinical Investigation whereas this was not associated with a significant increase in Proteins were separated by 15% SDS-PAGE and transferred onto a PVDF membrane. Hong (1991) A redox switch and phosphorylation are involved in the post-translational up-regulation of the adenosine-uridine binding factor by phorbol ester and ionophore. www.jci.org /cgi/content/full/100/12/3070   (7878 words)

A muscle-specific variant of microtubule-associated protein 4 (MAP4) is required in myogenesis -- Mangan and Olmsted 122 (3): 771 -- Development A muscle-specific variant of microtubule-associated protein 4 (MAP4) is required in myogenesis Microtubule-associated protein 4 (MAP4) regulates assembly, protomer-polymer partitioning and synthesis of tubulin in cultured cells A muscle-specific variant of microtubule-associated protein 4 (MAP4) is required in myogenesis -- Mangan and Olmsted 122 (3): 771 -- Development dev.biologists.org /cgi/content/abstract/122/3/771   (695 words)

MPB2C, a Microtubule-Associated Plant Protein Binds to and Interferes with Cell-to-Cell Transport of Tobacco Mosaic Virus Movement Protein -- Kragler et al. 132 (4): 1870 -- PLANT PHYSIOLOGY MPB2C, a Microtubule-Associated Plant Protein Binds to and Interferes with Cell-to-Cell Transport of Tobacco Mosaic Virus Movement Protein -- Kragler et al. www.plantphysiol.org /cgi/reprint/132/4/1870   (22 words)

Human tau becomes phosphorylated and forms filamentous deposits when overexpressed in lamprey central neurons in situ -- Hall et al. 94 (9): 4733 -- Proceedings of the National Academy of Sciences The microtubule-associated protein tau is thought to be important for the development and maintenance of axonal identity and protein is transported to both the axon and dendrites of expressing Full-Length htau Protein Is Found Throughout the Cell and Is Most Heavily Phosphorylated in ABC Dendrites. www.pnas.org /cgi/content/full/94/9/4733   (4511 words)

Plant-Specific Microtubule-Associated Protein SPIRAL2 Is Required for Anisotropic Growth in Arabidopsis -- Shoji et al. 136 (4): 3933 -- PLANT PHYSIOLOGY Plant-Specific Microtubule-Associated Protein SPIRAL2 Is Required for Anisotropic Growth in Arabidopsis -- Shoji et al. microtubule-associated protein and is required for proper microtubule The SPR2 gene encodes a plant-specific 94-kD protein www.plantphysiol.org /cgi/content/abstract/136/4/3933   (369 words)

Identification and Characterization of Human VCY2-Interacting Protein: VCY2IP-1, a Microtubule-Associated Protein-Like Protein -- Wong et al. 70 (3): 775 -- Biology of Reproduction Identification and Characterization of Human VCY2-Interacting Protein: VCY2IP-1, a Microtubule-Associated Protein-Like Protein -- Wong et al. Identification and Characterization of Human VCY2-Interacting Protein: VCY2IP-1, a Microtubule-Associated Protein-Like Protein VCY2 is a testis-specific protein that locates in a frequently www.biolreprod.org /cgi/content/abstract/70/3/775   (340 words)

The Scientist : Natural selection in humans The inversion appears at chromosome 17q21.31, a region scrutinized in detail because it contains the gene for microtubule-associated protein tau (MAPT), variants of which are linked with Parkinson disease as well as corticotropin releasing hormone (CRH) receptor 1 (CRHR1). CRH, which is normally released by the mother and embryo soon after the embryo implants in the uterus, appears to protect the embryo from immunologic rejection by the mother. It's difficult to imagine this can be an artifact." www.biomedcentral.com /news/20050117/01   (700 words)

Q15555.blastp Southeast Collaboratory of Structural Genomics (327 letters) Database: pdb 24,766 sequences; 5,738,144 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Q15691 unk Southeast Collaboratory of Structural Genomics 290 2e-79 1wyo_A mol:protein length:159 Microtubule-associated protein RP... 266 4e-72 hss001000902.1 unk RSGI 262 9e-71 1vka_A mol:protein length:153 Microtubule-associated protein RP... 178 1e-45 mmt007009322.1 unk RSGI 176 5e-45 1yig_A mol:protein length:76 Microtubule-associated protein RP/... www.secsg.org /BLAST/Q15555.blastp   (143 words)

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