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Topic: Midazolam


  
  BBC NEWS | Health | Medical notes | Midazolam: the sedative drug
Midazolam is a sedative drug commonly used in medicine, but which can be dangerous in the wrong hands.
Midazolam is a benzodiazepine which is used as a sedative and to treat people who have gone into convulsions.
People who take midazolam are recommended not to drive or to operate a machine for 24 hours after administration.
news.bbc.co.uk /1/hi/health/medical_notes/j-m/750437.stm   (198 words)

  
  Midazolam - Wikipedia, the free encyclopedia
Midazolam is frequently used (usually in combination with other agents, such as morphine) by anesthesiologists for sedating patients prior to surgery or other invasive medical procedures, such as endoscopy.
An exception is buccal midazolam, used for the rapid treatment of prolonged seizures.
Midazolam is a Schedule IV drug under the Convention on Psychotropic Substances[2].
en.wikipedia.org /wiki/Midazolam   (631 words)

  
 Buccal midazolam - Family factsheets - GOSH and ICH
Midazolam belongs to a group of medicines called benzodiazepines, which are used to treat a number of different conditions.
Midazolam is chemically related to diazepam, which is another medicine used to treat seizures.
Midazolam is also available as an injection (10mg in 2ml) in a glass ampoule.
www.gosh.nhs.uk /factsheets/families/F060390/index.html   (917 words)

  
 MedlinePlus Drug Information: Midazolam (Systemic)   (Site not responding. Last check: 2007-10-11)
Midazolam (MID-ay-zoe-lam) is used to produce sleepiness or drowsiness and to relieve anxiety before surgery or certain procedures.
Midazolam is used sometimes in patients in intensive care units in hospitals to cause unconsciousness.
Midazolam is given only by or under the immediate supervision of a doctor trained to use this medicine.
www.nlm.nih.gov /medlineplus/druginfo/uspdi/202372.html   (998 words)

  
 Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit   (Site not responding. Last check: 2007-10-11)
The third study (Anand 1999) comparing midazolam to morphine and placebo found no statistically significant difference in sedation level among the three groups, but a statistically significantly higher level of sedation was found in the midazolam group compared with the placebo group during the treatment infusion.
Midazolam was administered at 200 mcg/kg loading dose followed by an infusion of 20, 40, or 60 mcg/kg/hr for infants of gestational ages 24-26, 27-20, or 30-33 weeks, respectively.
Midazolam was given as 200 mcg/kg loading dose followed by infusion of 20, 40, or 60 mcg/kg/hr for those whose gestational age were 24-26, 27-29, or 30-33 weeks, respectively.
www.nichd.nih.gov /cochrane/ng2/ng.htm   (6716 words)

  
 Intramuscular midazolam vs Intravenous diazepam for acute seizures Shah Ira, Deshmukh CT - Indian J Pediatr
Midazolam in the dose of 0.1 mg/kg to 0.3 mg/kg is readily available for intramuscular dose due to its water-soluble nature.
In the present study, intramuscular midazolam is effective for controlling seizures in all age groups that was statistically significant which again signifies that it may be effective in all children irrespective of age.
Thus it may be concluded, that intramuscular midazolam is safe and effective in control of acute seizures irrespective of the type of convulsions and age of the child.
www.ijppediatricsindia.org /article.asp?issn=0019-5456;year=2005;volume=72;issue=8;spage=667;epage=670;aulast=Shah   (1907 words)

  
 Midazolam
Midazolam does not reduce pain or cause loss of consciousness.
Midazolam is for injection into a muscle or slow injection into a vein.
Midazolam syrup is given by a health-care professional in a hospital or clinic setting.
www.stjohn.org /HealthInfoLib/swArticle.aspx?26,403   (1129 words)

  
 Buccal Midazolam - Family factsheets - GOSH and ICH   (Site not responding. Last check: 2007-10-11)
Midazolam belongs to a family of medicines known as benzodiazepines and it has a number of different medicinal uses.
Midazolam is available as an injection (10mg in 2ml) in a glass ampoule.
Hold the base of the midazolam ampoule in one hand and, with the other hand using a finger and thumb, place pressure on the weak spot of the ampoule.
www.ich.ucl.ac.uk /factsheets/families/F040014   (877 words)

  
 Benzodiazepine withdrawal reaction in two children following discontinuation of sedation with midazolam -- van Engelen ...   (Site not responding. Last check: 2007-10-11)
Midazolam infusion was restarted, and the signs and symptoms disappeared for the second time.
Within 12 hours after discontinuation of midazolam he became restless, developed a bulging stomach secondary to aerophagia, and was vomiting.
Midazolam therapy was reinstituted and continued for another 2 months by constant infusion.
www.theannals.com /cgi/content/abstract/27/5/579   (398 words)

  
 Versed Online, Description, Chemistry, Ingredients - Midazolam - RxList Monographs
Midazolam, a white to light yellow crystalline compound, is insoluble in water, but can be solubilized in aqueous solutions by formation of the hydrochloride salt in situ under acidic conditions.
Each mL of the syrup contains midazolam hydrochloride equivalent to 2 mg midazolam compounded with sorbitol, glycerin, citric acid anhydrous, sodium citrate, sodium benzoate, sodium saccharin, edetate disodium, FDandC Red #33, artificial cough syrup flavor, artificial bitterness modifier and water; the pH is adjusted to approximately 3 with hydrochloric acid.
Under the acidic conditions required to solubilize midazolam in the syrup, midazolam is present as an equilibrium mixture (shown below) of the closed ring form shown above and an open-ring structure formed by the acid-catalyzed ring opening of the 4,5-double bond of the diazepine ring.
www.rxlist.com /cgi/generic2/versedsyr.htm   (391 words)

  
 CHEST: Midazolam as intravenous sedative for electrocardioversion   (Site not responding. Last check: 2007-10-11)
The intravenous dose of midazolam for the 17 procedures ranged from 2.5 to 16 mg (average 6.6 mg).
Unlike diazepam, parenteral formulation of midazolam excludes propylene glycol which renders it less irritant and therefore less liable to cause pain at the site of injection [6,8] and lasser chance of subsequent venous sequelae compared to diazepam.
Although significant respiratory depression was not encountered in healthy volunteers given intravenous midazolam for conscious sedation, clinically significant respiratory depression may occur in patients with COPD, [12,13] in those receiving concomitant CNS depressant medication, and those who are older and debitated.
www.findarticles.com /p/articles/mi_m0984/is_n5_v95/ai_7832707   (1311 words)

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