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| | Versed Online, Description, Chemistry, Ingredients - Midazolam - RxList Monographs |
 | | Midazolam, a white to light yellow crystalline compound, is insoluble in water, but can be solubilized in aqueous solutions by formation of the hydrochloride salt in situ under acidic conditions. |
 | | Each mL of the syrup contains midazolam hydrochloride equivalent to 2 mg midazolam compounded with sorbitol, glycerin, citric acid anhydrous, sodium citrate, sodium benzoate, sodium saccharin, edetate disodium, FDandC Red #33, artificial cough syrup flavor, artificial bitterness modifier and water; the pH is adjusted to approximately 3 with hydrochloric acid. |
 | | Under the acidic conditions required to solubilize midazolam in the syrup, midazolam is present as an equilibrium mixture (shown below) of the closed ring form shown above and an open-ring structure formed by the acid-catalyzed ring opening of the 4,5-double bond of the diazepine ring. |
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