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Topic: Midbrain


In the News (Wed 25 Nov 09)

  
  2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Zebrafish Embryo: Local Circulation Failure in the Dorsal Midbrain ...
60 hpf in the dorsal midbrain of the embryo.
and apoptosis in the dorsal midbrain of the zebrafish embryo
in the dorsal midbrain at 60 hpf in zebrafish embryos exposed
toxsci.oxfordjournals.org /cgi/content/full/69/1/191   (6825 words)

  
 Mesencephalon - Wikipedia, the free encyclopedia
In biological anatomy, the mesencephalon (or midbrain) is the middle of three vesicles that arise from the neural tube that forms the brain of developing animals.
On the anterior surface the cerebral peduncles are prominent.
The cerebral aqueduct runs through the midbrain, and is the communication between the third and fourth ventricle.
en.wikipedia.org /wiki/Mesencephalon   (351 words)

  
 Role of Aryl Hydrocarbon Receptor in Mesencephalic Circulation Failure and Apoptosis in Zebrafish Embryos Exposed to ...
of apoptosis in the forebrain and dorsal midbrain of zebrafish
of zfAHR2 in dorsal midbrain endpoints of TCDD developmental
The increased bovine serum albumin (BSA) immunostaining in the
toxsci.oxfordjournals.org /cgi/content/full/77/1/109   (4876 words)

  
 FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals -- ...   (Site not responding. Last check: 2007-11-07)
inferior colliculi in the posterior midbrain and vermis of the
Morphology of the midbrain and cerebellum of the midbrain–hindbrain-specific and hypomorphic Fgfr1 mutants.
Morphology of the midbrain and cerebellum of the midbrain-specific Fgfr1 mutants.
embojournal.npgjournals.com /cgi/content/full/22/8/1811   (6071 words)

  
 Cooperation of Pax2 and Pax5 in midbrain and cerebellumĀ development -- Urbánek et al. 94 (11): 5703 -- ...
Cooperation of Pax2 and Pax5 in midbrain and cerebellumĀ development -- Urbánek et al.
Absence of the cerebellum and posterior midbrain in Pax5 (
plexus was fused to the remnants of the anterior midbrain.
www.pnas.org /cgi/content/full/94/11/5703   (5359 words)

  
 midbrain (mesencephalon)   (Site not responding. Last check: 2007-11-07)
Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons.
Cell death in the midbrain of the murine mutation weaver.
Sprouting by tracts descending from the midbrain to the spinal cord: the result of thoracic funiculotomy in the newborn, 21-day-old, and adult rat.
www.arclab.org /node_pages/54.html   (1939 words)

  
 Arcuate Plan of Chick Midbrain Development -- Sanders et al. 22 (24): 10742 -- Journal of Neuroscience
The ventral midbrain and adjoining hindbrain have been dissected away from the forebrain and the other head tissues of stage 26 (E5) chick embryos and flattened on a glass slide with a coverslip.
Expression throughout the midbrain tectum of DELTA1 and the HX gene PAX3 is indicated by arrows, the base of which identifies the lateral edge of the tegmentum.
Arcs of the embryonic midbrain tegmentum have gross morphological correlates.
www.jneurosci.org /cgi/content/full/22/24/10742   (6576 words)

  
 AANS.org | Education and Meetings | AANS Scientific Journals | Neurosurgical Focus
The anatomical deformation has completely resolved, the midbrain hyperintensity has disappeared, and the CSF flow artifact is visible through the floor of the third ventricle.
Mild deformation of the midbrain is visible with abnormal hyperintensity.
Schematic representation of the anatomical structures of the midbrain and the upper pons.
www.aans.org /education/journal/neurosurgical/dec98/5-6-p2.asp   (4784 words)

  
 Vim thalamotomy for Holmes' tremor secondary to midbrain tumour -- Kim et al. 73 (4): 453 -- Journal of Neurology, ...
Vim thalamotomy for Holmes' tremor secondary to midbrain tumour -- Kim et al.
Vim thalamotomy for Holmes' tremor secondary to midbrain tumour
lesions in the vicinity of the red nucleus in the midbrain.
jnnp.bmjjournals.com /cgi/content/full/73/4/453   (1473 words)

  
 Vertical Gaze Palsies From Medial Thalamic Infarctions Without Midbrain Involvement -- Clark and Albers 26 (8): 1467 -- ...   (Site not responding. Last check: 2007-11-07)
of the rostral midbrain or the midbrain/thalamic junction as
Illustrations show sagittal view of arterial supply to the midbrain and thalamus (A); paramedian thalamic and paramedian peduncular artery arising from a single vessel from the top of the basilar artery (B); and paramedian thalamic and paramedian peduncular artery arising separately from the basilar artery (C) (B and C modified from Castaigne et al
Palsy of upward and downward saccadic, pursuit, and vestibular movements with a unilateral midbrain lesion: pathophysiologic correlations.
stroke.ahajournals.org /cgi/content/full/26/8/1467   (1911 words)

  
 Midbrain infarction: associations and aetiologies in the New England Medical Center Posterior Circulation Registry -- ...
Midbrain infarction: associations and aetiologies in the New England Medical Center Posterior Circulation Registry
isolated midbrain infarction occurred in 8% of posterior circulation strokes (22 of 281 patients)
Dissociated vertical nystagmus and internuclear ophthalmoplegia from a midbrain infarction.
jnnp.bmjjournals.com /cgi/content/full/64/3/392   (2085 words)

  
 Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain -- Puelles et al. ...
the ventral midbrain in the absence of Otx2.
The sections are focussed on the ventral midbrain area approximately corresponding to the area included in the dotted square in B. The arrows in A,D,E indicate the anterior border of the Fgf8 domain and the arrows in B indicate the ventral posterior border of the functional Otx2 expression domain.
Abnormal differentiation is maintained at later stages in the ventral midbrain of conditional mutants.
dev.biologists.org /cgi/content/full/131/9/2037   (5970 words)

  
 Regulation of Otx2 expression and its functions in mouse forebrain and midbrain -- Kurokawa et al. 131 (14): 3319 -- ...
Arrowheads in a and e indicate faint ectopic expression in DRG and residual expression in dorsal midbrain, respectively.
Expression in midbrain is lost in b; furthermore, only residual expression exists in midbrain (arrowhead).
midbrain and the hindbrain or the isthmus is established.
dev.biologists.org /cgi/content/full/131/14/3319   (6753 words)

  
 Effect of Prenatal Fluoxetine (Prozac) Exposure on Brain Serotonin Neurons in Prepubescent and Adult Male Rat Offspring ...
midbrain of adult progeny prenatally exposed to fluoxetine.
and midbrain), regardless of the age of the animal.
hippocampus, striatum or midbrain of prepubescent male progeny.
jpet.aspetjournals.org /cgi/content/full/280/1/138   (5421 words)

  
 Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: Evidence from ...
the midbrain, the hindbrain, and the spinal cord.
En-2 are markers for the midbrain and/or cerebellum (10, 19,
and midbrain, with a sharp caudal boundary at the isthmic constriction
www.pnas.org /cgi/content/full/94/26/14518   (4317 words)

  
 University of Chicago Hospitals: Sonic Hedgehog shapes the brain
The midbrain was an attractive model for studying the formation of the organization of brain, or morphogenesis, because it is very simply organized during development into a set of cell columns, called arcs, each with distinct molecular identities.
The group found that Sonic Hedgehog is normally expressed along the midline during midbrain development, suggesting that Sonic Hedgehog might be the morphogen setting up the midbrain pattern.
This signal is called a morphogen because it is a "form-producing substance." Though the idea of morphogens has been around since 1952 when the British mathematician Alan Turing coined the term, it is only in the last ten years that true morphogens used in animal development have been molecularly identified.
www.uchospitals.edu /news/2001/20010309-sonic.html   (754 words)

  
 Brain Stem Glioma   (Site not responding. Last check: 2007-11-07)
The brain stem consists of the midbrain, pons and medulla located deep in the posterior part of the brain.
Long-term survival ranges from 65 to 90 percent for brain stem tumors that arise from the midbrain or medulla.
To improve the outcome of pontine gliomas, researchers are studying drugs that may enhance the effect of radiation therapy.
www.stjude.org /disease-summaries/0,2557,449_2160_5033,00.html   (554 words)

  
 Alexandra L. Joyner
Our long-standing interest has been development of the midbrain, which receives visual and auditory input, and the cerebellum of the anterior hindbrain, which regulates motor control.
This suggested that anterior/posterior patterning of the midbrain and anterior hindbrain is controlled by a centrally located isthmus organizer that instructs the cells on one side to become the midbrain cell types and on the other side to become the cerebellum.
A set of transcription factors, including the Engrailed (EN) proteins, are expressed across most of the midbrain and cerebellum, and the secreted factors FGF8 and WNT1 are expressed in the organizer (Figure 1).
www.hhmi.org /research/investigators/joyner.html   (1441 words)

  
 Long-term Effects of Amphetamine Neurotoxicity on Tyrosine Hydroxylase mRNA and Protein in Aged Rats -- Bowyer et al. ...
Total cellular RNA isolated from either midbrain (5-10 µg) or striatum (20-30 µg) was used in the RNase protection assay.
Midbrain TH protein was measured using Western blot analysis and normalized to the micrograms of total cellular protein subjected to electrophoresis.
TH protein was measured in the midbrain of saline-treated (lanes 1-3) and amphetamine-treated (lanes 4-6) rats.
jpet.aspetjournals.org /cgi/content/full/286/2/1074   (8606 words)

  
 Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain -- Hirata et al. 20 ...   (Site not responding. Last check: 2007-11-07)
neurons were differentiated in the ventral side of the midbrain and hindbrain but not in the isthmic region.
The lack of the midbrain and anterior hindbrain structures of the double mutants is not caused by neural tube defects
Crossley,P.H. and Martin,G.R. (1995) The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo.
embojournal.npgjournals.com /cgi/content/full/20/16/4454   (6416 words)

  
 MR Imaging of the Superior Profile of the Midbrain: Differential Diagnosis between Progressive Supranuclear Palsy and ...
MR Imaging of the Superior Profile of the Midbrain: Differential Diagnosis between Progressive Supranuclear Palsy and Parkinson Disease -- Righini et al.
MR Imaging of the Superior Profile of the Midbrain: Differential Diagnosis between Progressive Supranuclear Palsy and Parkinson Disease
midbrain on axial T2-weighted sections at the level of the superior
www.ajnr.org /cgi/content/abstract/25/6/927   (312 words)

  
 MSN Encarta - Search Results - midbrain
anatomy of midbrain, diseases and disorders of midbrain, evolution of brain, functions of midbrain, structure of the brain stem
The topmost structure of the brain stem is the midbrain.
Brain : Anatomy : Brain Stem : Midbrain
encarta.msn.com /midbrain.html   (102 words)

  
 Activation of Midbrain Structures by Associative Novelty and the Formation of Explicit Memory in Humans -- Schott et ...
Activation of Midbrain Structures by Associative Novelty and the Formation of Explicit Memory in Humans -- Schott et al.
Activation in the midbrain dopaminergic area also shows a preference for associative novelty but not for spatial relationship.
Superimposition of the midbrain activations onto the average MT image.
www.learnmem.org /cgi/content/full/11/4/383   (2632 words)

  
 Electrophysiological Properties of Midbrain Dopamine Neurons
Although identification of neurons on the basis of location or morphology may suffice when the investigator is studying the postsynaptic actions of these neurohumors, meaningful data cannot be collected from the cells that synthesize and release a given neurotransmitter unless this identification is definitive.
In order to reliably separate the fluorescence of the intracellular stain from that of the tyrosine hydroxylase immunolocalization within the same brain section, the putative DA neuron was injected intracellularly with the highly fluorescent dye Lucifer yellow, which could be readily separated from the rhodamine-labeled secondary antibody employed in the immunocytochemical localization of tyrosine hydroxylase.
Unlike that reported in vivo, in both cases the DA-containing cells were identified as the non-burst-firing cell class, with the cells showing prominent rebound burst firing shown to be the nondopaminergic zona reticulata neurons.
www.acnp.org /G4/GN401000015/CH015.html   (6513 words)

  
 The Combined Graduate Program in Developmental Genetics   (Site not responding. Last check: 2007-11-07)
We have focused on early specification of the midbrain and rhombomere 1 (r1), the anterior most region of the hindbrain that forms the cerebellum.
Mouse mutants in these genes, or in the secreted factors Fgf8 and Wnt1, have deletions of the midbrain and cerebellum, indicating that the earliest function of these gene families involves specification of a broad midbrain/r1 domain.
Transplantation studies in chick have shown that the junction between the midbrain and r1 (isthmus) is a source of secreted factors that can transform regions of the brain into midbrain or cerebellum structures, indicating that patterning of the midbrain and cerebellum is controlled by a centrally located organizer.
www.med.nyu.edu /Sackler/dgp/faculty/joyner.html   (1005 words)

  
 Effects of midbrain and spinal cord transections on sympathetic nerve responses to heating -- Kenney et al. 278 (5): ...
Effects of midbrain and spinal cord transections on sympathetic nerve responses to heating -- Kenney et al.
Effects of midbrain and spinal cord transections on sympathetic nerve responses to heating
(midbrain or spinal cord) or sham transections (midbrain or spinal
ajpregu.physiology.org /cgi/content/full/278/5/R1329   (4890 words)

  
 Nervous System - James Eunson 11K: Midbrain   (Site not responding. Last check: 2007-11-07)
The midbrain is located between the hindbrain and the forebrain and co-ordinates responses involving both sensory and motor stimuli (eg.
The midbrain also seems to be involved in speed of movement.
The only area of this brain segment susceptible to disease is the stantia nigra - this structure is the area affected by Parkinson's Disease and results in loss of sensory-motor co-ordination (thus reinforcing the importance of the midbrain.)
www.bigsix.net /psych/?id=14   (85 words)

  
 Dopamine-Mediated Volume Transmission in Midbrain Is Regulated by Distinct Extracellular Geometry and Uptake -- Cragg ...
of midbrain regions, the corresponding tortuosity factors were similar to that of cortex.
Extrasynaptic vesicular transmitter release from the somata of substantia nigra neurons in rat midbrain slices.
Pothos EN, Davila V, and Sulzer D. Presynaptic recording of quanta from midbrain dopamine neurons and modulation of the quantal size.
jn.physiology.org /cgi/content/full/85/4/1761   (6731 words)

  
 Hypothalamic and Midbrain Circuitry That Distinguishes Between Escapable and Inescapable Pain -- Lumb 19 (1): 22 -- ...
Midbrain circuitry that distinguishes between escapable and inescapable pain
midbrain, and the opposing cardiovascular effects evoked from
Activation of hypothalamic and midbrain circuits by escapable and inescapable pain.
physiologyonline.physiology.org /cgi/content/full/19/1/22   (3293 words)

  
 midbrain signs - General Practice Notebook
Ocular abnormalities are a prominent feature of space- occupying lesions in the midbrain.
lesions of the upper midbrain - weakness of conjugate deviation upwards and ptosis
lesions of the lower midbrain - weakness of conjugate deviation downwards - often accompanied by ptosis and weakness of convergence
gpnotebook.co.uk /simplepage.cfm?ID=-1207566313&linkID=22571&cook=yes   (854 words)

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