| | The Combined Graduate Program in Developmental Genetics (Site not responding. Last check: 2007-11-07) |
 | | We have focused on early specification of the midbrain and rhombomere 1 (r1), the anterior most region of the hindbrain that forms the cerebellum. |
 | | Mouse mutants in these genes, or in the secreted factors Fgf8 and Wnt1, have deletions of the midbrain and cerebellum, indicating that the earliest function of these gene families involves specification of a broad midbrain/r1 domain. |
 | | Transplantation studies in chick have shown that the junction between the midbrain and r1 (isthmus) is a source of secreted factors that can transform regions of the brain into midbrain or cerebellum structures, indicating that patterning of the midbrain and cerebellum is controlled by a centrally located organizer. |
| www.med.nyu.edu /Sackler/dgp/faculty/joyner.html (1005 words) |