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U.S. Patent: 5049664 - Trehalose derivatives - September 17, 1991 |
 | | Zinc (352.7 mg, 5.40 millimole) was suspended in a mixed solvent (9 ml) of dry benzene and dry tetrahydrofuran (5:1) under argon atmosphere. |
 | | Anhydrous.alpha.,.alpha.-trehalose (1)(10 g, 27.7 millimole) and zinc chloride (50 g, 36.7 millimole) were suspended in benzaldehyde (90 ml) as described in the literature, and the suspension was stirred vigorously at room temperature for 20 hours. |
 | | Anhydrous.alpha.,.alpha.-trehalose (1) (2.15g, 6.3 millimole) was suspended in dry pyridine (90 ml), and 1,3-dichloro-1,1,3,3,-tetraisopropyldisiloxane (5.0 g, 15.8 millimole) in dry pyridine (30 ml) was added dropwise to the suspension and the mixture was allowed to react at room temperature for 24 hours. |
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