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Congenital adrenal hyperplasia due to 11β-hydroxylase deficiency - Wikipedia, the free encyclopedia The mineralocorticoid effect differs: hypertension is usually the clinical clue that a patient has 11- rather than 21-hydroxylase CAH. Mineralocorticoid manifestations of severe 11β-hydroxylase deficient CAH can be biphasic, changing from deficiency (salt-wasting) in early infancy to excess (hypertension) in childhood and adult life. DOC is a weak mineralocorticoid, but usually reaches high enough levels in this disease to cause effects of mineralocorticoid excess: salt retention, volume expansion, and hypertension. en.wikipedia.org /wiki/Congenital_adrenal_hyperplasia_due_to_11_beta-hydroxylase_deficiency   (969 words)

Multiple aspects of mineralocorticoid selectivity -- Farman and Rafestin-Oblin 280 (2): 181 -- AJP - Renal Physiology The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response. Immunolocalization of gluco- and mineralocorticoid receptors in the rabbit kidney. Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. ajprenal.physiology.org /cgi/content/full/280/2/F181   (6892 words)

Gene mutation linked to hypertension during pregnancy   (Site not responding. Last check: 2007-10-07) Researchers at the Yale School of Medicine recently uncovered a mutation in the mineralocorticoid steroid hormone receptor that causes rare cases of childhood high blood pressure and is exacerbated by progesterone—a steroid hormone that dramatically increases during pregnancy. The mineralocorticoid receptor, located in the kidney cells, regulates blood pressure by instructing the kidney to take in more or less salt and water, resulting in higher or lower blood pressure. All 11 have the mutation in the mineralocorticoid receptor. www.genomenewsnetwork.org /articles/07_00/mutation_hypertension.shtml   (852 words)

Endotext.com - Adrenal Physiology And Diseases, Aldosterone Excess The principal mineralocorticoid in man is aldosterone which is produced in the zona glomerulosa (outer zone) of the adrenal cortex and acts primarily at the renal distal convoluted tubule. As a result of ineffective glucocorticoid synthesis, excess mineralocorticoids (such as 11-deoxycorticosterone) and androgens are produced as a result of shunting of precursors into blocked and unblocked pathways, respectively. The mineralocorticoid receptor antagonist, eplerenone and spironolactone, or the sodium epithelial channel antagonist, amiloride, are also effective treatments of hypertension in GRA and are alternatives to glucocorticoid suppression. www.endotext.org /adrenal/adrenal23/adrenal23.htm   (5199 words)

Cecil Textbook of Medicine : /> The mineralocorticoid effect on the distal nephron is sodium retention at the expense of potassium and hydrogen excretion. Excess mineralocorticoid produces an expanded vascular volume in association with hypokalemia and metabolic alkalosis. In renin-angiotensin-dependent disease, the mineralocorticoid is produced in response to the renin-angiotensin trophic signal. www.merckmedicus.com /ppdocs/us/common/cecils/chapters/240_006.htm   (154 words)

Mineralocorticoid and glucocorticoid receptors inhibit UCP expression and function in brown adipocytes -- Viengchareun ... Mineralocorticoid and glucocorticoid receptors inhibit UCP expression and function in brown adipocytes -- Viengchareun et al. The mineralocorticoid receptor (MR) and/or GR inhibits the RXR/RAR activation on UCP1 expression. Implication of the mineralocorticoid receptor on UCP1 transrepression. ajpendo.physiology.org /cgi/content/full/280/4/E640   (5367 words)

Bioreagents.com: Mineralocorticoid Receptor   (Site not responding. Last check: 2007-10-07) Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. Given the function of mineralocorticoids, it is not surprising to find that the kidney is a primary target organ for mineralocorticoids and that this organ has been shown to contain MR. The corresponding gene for the mineralocorticoid receptor is NR3C2. www.bioreagents.com /index.cfm/fuseaction/products.detail/CatNbr/MA1-620   (276 words)

Golestaneh, Mol Vis 2002; 8:221-225. In this study, we investigated the presence of mineralocorticoid receptors in rat and bovine ocular tissues and during retinal development. Steroid hormones influence the development, differentiation, and homeostasis of a large number of mammalian tissues by binding to receptors that are members of a superfamily of proteins involved in the transcription regulation of cell-specific genes [1,2]. Mineralocorticoid hormones regulate the ion-water balance in many cell types of mesodermal and ectodermal origins [3,4] via appropriate modulation of ion channels and pumps in cell membranes. www.molvis.org /molvis/v8/a28   (3144 words)

eMedicine - Hyperaldosteronism : Article by George P Chrousos, MD, FAAP, MACP, MACE   (Site not responding. Last check: 2007-10-07) Mineralocorticoid receptors exhibit equal affinity for mineralocorticoids and cortisol, yet the aldosterone receptors in the distal tubule and elsewhere are protected from the activation by cortisol by 11beta-hydroxysteroid dehydrogenase type 2, which locally converts cortisol to inactive cortisone. The mineralocorticoid dependency of sodium reabsorption is increased during infancy and childhood, with its peak in the neonatal period before decreasing progressively with advancing age. Treatment is with high-dose synthetic glucocorticoids with minimal mineralocorticoid activity, such as dexamethasone (1-3 mg/d), to suppress plasma levels of ACTH and, ultimately, the secretion of adrenal steroids with androgenic and mineralocorticoid activity. www.emedicine.com /ped/topic1056.htm   (9832 words)

Pastis and hypertension--what is the molecular basis? -- Frey and Ferrari 15 (10): 1512 -- Nephrology Dialysis ... This is not the case because the mineralocorticoid receptor is protected from occupation by cortisol. Affinity of liquorice derivatives for mineralocorticoid and glucocorticoid receptors. Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. ndt.oxfordjournals.org /cgi/content/full/15/10/1512   (1520 words)

Search Results for mineralocorticoid - Encyclopædia Britannica It serves as the principal regulator of the salt and water balance of the body (a mineralocorticoid) and has a small effect on the metabolism of... The anti-inflammatory and glucocorticoid activities of cortisol are enhanced, in some cases with relative reduction of its mineralocorticoid activity, by various structural modifications (). The biologic effect of aldosterone, the principal mineralocorticoid produced by the zona glomerulosa, is to set in motion a set of reactions at the cell surface of all body tissues in order to... www.britannica.com /search?query=mineralocorticoid&submit=Find&source=MWTAB   (299 words)

Turkish pepper (extra hot) -- Woywodt et al. 76 (897): 426 -- Postgraduate Medical Journal that is incapable of binding to the mineralocorticoid receptor. to the renal mineralocorticoid receptor because of absent 11 The latter is incapable of binding the mineralocorticoid receptor. pmj.bmjjournals.com /cgi/content/full/76/897/426   (1153 words)

Inherited Forms of Mineralocorticoid Hypertension -- White 28 (6): 927 -- Hypertension Because 11-HSD is absent, cortisol inappropriately occupies mineralocorticoid receptors, leading to increased gene transcription, increased activity of sodium channels and the Na -ATPase, increased sodium resorption and potassium excretion, and hypertension. Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11ß-hydroxysteroid dehydrogenase type 2 gene. Apparent mineralocorticoid excess: genotype is correlated with biochemical phenotype. hyper.ahajournals.org /cgi/content/full/28/6/927   (5781 words)

11{beta}-Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess -- White et al. 18 (1): 135 ... As is the case with the glucocorticoid receptor, the unliganded mineralocorticoid Because 11-HSD is absent, cortisol inappropriately occupies mineralocorticoid receptors, leading to increased gene transcription, increased activity of sodium channels and the Na/K ATPase, increased resorption of sodium and excretion of potassium, and hypertension. mineralocorticoid receptors are concentrated in distal convoluted tubules edrv.endojournals.org /cgi/content/full/18/1/135   (8190 words)

MedlinePlus Medical Encyclopedia: Addison’s disease The cortex produces 3 types of hormones: sex hormones, glucocorticoid hormones, and mineralocorticoid hormones. The mineralocorticoid hormones (such as aldosterone) regulate sodium and potassium balance. Usually a combination of glucocorticoids (cortisone or hydrocortisone) and mineralocorticoids (fludrocortisone) are given. www.nlm.nih.gov /medlineplus/ency/article/000378.htm   (699 words)

eMedicine - 3-Beta-Hydroxysteroid Dehydrogenase Deficiency : Article by J Paul Frindik, MD   (Site not responding. Last check: 2007-10-07) Decreased mineralocorticoid secretion results in varying degrees of salt wasting in both males and females, and deficient androgen production results in ambiguous genitalia in 46,XY males. Aldosterone (mineralocorticoid) synthesis and secretion is regulated via the renin-angiotensin system, which is responsive to the state of electrolyte balance and the plasma volume. Mineralocorticoid replacement is achieved by the oral administration of fludrocortisone acetate (9-alpha-fluorohydrocortisone, Florinef). www.emedicine.com /ped/topic1051.htm   (3272 words)

ASN: Post Renal Transplant Hyperkalaemia and Metabolic Acidosis after Giving Cyclosporine May Be Associated with ...   (Site not responding. Last check: 2007-10-07) The level of mineralocorticoid expression in peripheral leukocytes was measured using quantitative reverse-transcriptase polychromatography specific for the mineralocorticoid receptor. In contrast, the expression level of mineralocorticoid receptors in peripheral leukocytes of renal transplant recipients treated with cyclosporine was significantly decreased versus healthy controls without renal disease (120 versus 423 RNA molecules/0.5 mg total RNA, p<.01). The level of expression of mineralocorticoid receptor in renal transplant recipients did not differ significantly between both groups with 172 molecules/0.5 mg RNA in acidotic patients versus 137 molecules/0.5 mg RNA in nonacidotic patients. www.pslgroup.com /dg/22203e.htm   (451 words)

Electrogenic Na+ transport in rat late distal colon by natural and synthetic glucocorticosteroids -- Grotjohann et al. ... Aldosterone is the most potent steroid with mineralocorticoid action, followed by the synthetic steroids dexamethasone and RU-28362; the metabolic precursors of corticosterone and cortisol together form the second group. Exclusion of corticosterone from epithelial mineralocorticoid receptors is insufficient for selectivity of aldosterone action: in vivo binding studies. Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS. ajpgi.physiology.org /cgi/content/full/276/2/G491   (4084 words)

Mineralocorticoids   (Site not responding. Last check: 2007-10-07) Another way to state this is that a small fraction of the mineralocorticoid response in the body is due to cortisol rather than aldosterone. Moreover, the same DNA sequence serves as a hormone response element for the activated (steroid-bound) forms of both mineralocorticoid and glucocorticoid receptors. Without treatment by mineralocorticoid replacement therapy, aldosterone deficiency is lethal, due to electrolyte imbalances and resulting hypotension and cardiac failure. arbl.cvmbs.colostate.edu /hbooks/pathphys/endocrine/adrenal/mineralo.html   (707 words)

Mineralocorticoid Receptor Inhibition Ameliorates the Transition to Myocardial Failure and Decreases Oxidative Stress ... Mineralocorticoid Receptor Inhibition Ameliorates the Transition to Myocardial Failure and Decreases Oxidative Stress and Inflammation in Mice With Chronic Pressure Overload -- Kuster et al. Mineralocorticoid Receptor Inhibition Ameliorates the Transition to Myocardial Failure and Decreases Oxidative Stress and Inflammation in Mice With Chronic Pressure Overload of mineralocorticoid receptors on cardiac myocytes is sufficient circ.ahajournals.org /cgi/content/full/111/4/420   (4382 words)

Mineralocorticoid - Wikipedia, the free encyclopedia Aldosterone acts on the kidneys to provide active reabsorption of sodium and an associated passive reabsorption of water, as well as, the active secretion of potassium in the principle cells of the cortical collecting tubule and active secretion of protons via proton ATPases in the lumenal membrane of the intercalated cells of the collecting tubule. If deficient in mineralocorticoids and glucocorticoids, Addison's disease occurs. This page was last modified 04:19, 16 April 2006. en.wikipedia.org /wiki/Mineralocorticoids   (190 words)

Activating Mineralocorticoid Receptor Mutation in Hypertension Exacerbated by Pregnancy -- Geller et al. 289 (5476): ... Activating Mineralocorticoid Receptor Mutation in Hypertension Exacerbated by Pregnancy -- Geller et al. A Novel Nonsense Mutation of the Mineralocorticoid Receptor Gene in a Swedish Family with Pseudohypoaldosteronism Type I (PHA1). Mineralocorticoid receptor malfunction: further insights from rare forms of hypertension. www.sciencemag.org /cgi/content/abstract/289/5476/119   (1175 words)

Mineralocorticoid receptor malfunction: further insights from rare forms of hypertension -- Mohaupt and Frey 17 (4): ... The intracellular localization of the mineralocorticoid receptor is regulated by 11ß-hydroxysteroid dehydrogenase type 2. Differential mRNA expression of the two mineralocorticoid receptor splice variants within the human brain: structure analysis of their different DNA binding domains. The human mineralocorticoid receptor gene promotor: its structure and expression. ndt.oxfordjournals.org /cgi/content/full/17/4/539   (1414 words)

Vasopressin Potentiates Mineralocorticoid Selectivity by Stimulating 11beta Hydroxysteroid Deshydrogenase in Rat ... Delahaye, H.M. Westphal, J.P. Bonvalet, and J.M. Gasc (1991) Immunolocalization of gluco and mineralocorticoid receptors in the rabbit kidney. Arriza, J.L., R.B. Simerly, L.W. Swanson, and R.M. Evans (1988) The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response. Pearce, D., and K.R. Yamamoto (1993) Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. www.jci.org /cgi/content/full/100/10/2437   (4054 words)

Mineralocorticoid Receptors and Hormones: Fishing for Answers -- Gilmour 146 (1): 44 -- Endocrinology In tetrapod vertebrates, aldosterone is the main mineralocorticoid Immunofluorescence localization of mineralocorticoid (MR) protein in the gills of rainbow trout (Oncorhynchus mykiss). A commercially available goat polyclonal antibody raised against the N-terminal region of the human MR together with an antigoat fluorescein isothiocyanate-conjugated secondary antibody were used to label trout gill sections (A). endo.endojournals.org /cgi/content/full/146/1/44   (1692 words)

[No title] RX MEDLINE=21359362; PubMed=11350956; DOI=10.1074/jbc.M100374200; RA Odermatt A., Arnold P., Frey F.J.; RT "The intracellular localization of the mineralocorticoid receptor is RT regulated by 11beta-hydroxysteroid dehydrogenase type 2."; RL J. Biol. The effect of MC is to increase ion CC and water transport and thus raise extracellular fluid volume and CC blood pressure and lower potassium levels. There are 2 forms of PHA1: CC the autosomal dominant form that is mild, and the recessive form CC which is more severe and due to defects in any of the epithelial CC sodium channel subunits. receptors.ucsf.edu /NR/seq/sw/MCR_HUMAN.SW   (1538 words)

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