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Topic: Minisatellite

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	Encyclopedia: Minisatellite
		Since the fortuitous discovery of the first human minisatellite in 1980 by Wyman and White and especially the discovery that minisatellites extreme polymorphism made them superb for DNA fingerprinting by Alec Jeffreys, this class of repeats has been an intense focus of studies that have addressed the turnover mechanisms that provoke their instability.
		Some human minisatellites (~10%) have been demonstrated to be hypermutable, with an average mutation rate in the germline higher that 0.5% up to over 20% making them the most unstable region in the human genome known to date.
		Finally, studies have shown that the evolutionary fate of minisatellites tends towards an equilibrium distribution in the size of alleles, until mutations in the flanking DNA affect the recombinational activity of a minisatellite by suppressing DNA instability.
	www.nationmaster.com /encyclopedia/Minisatellite (595 words)

	Polyandry in hawks
		In humans, minisatellite "fingerprints" are used to establish the identity of suspects in criminal trials.
		Parker used minisatellite fingerprints to establish that each of the nine islands on which hawks are found was settled only once.
		On each of the smaller islands like Pinta and Espanola, the minisatellite fingerprints of the hawks are identical, as if all the hawks on a particular island were clones of a single individual.
	www.txtwriter.com /Onscience/Articles/hawks.html (803 words)

	ARS \| Publication request: Genetic Mapping of Hypervariable Minisatellite Sequences in Rice (Oryza Sativa L.) (Site not responding. Last check: 2007-10-09)
		Minisatellites, or DNA fingerprinting sequences, have not generally been used as markers for plant genome mapping.
		The purpose of the present study was to generate DNA fingerprints, utilizing several minisatellites containing different core sequences and numbers of repeat units, followed by assessing their potential for use as genetic markers when mapped to a rice recombinant inbred line (RIL) population.
		The implications for the use of rice minisatellite core sequences as genetic markers on linkage maps in rice are discussed.
	www.ars.usda.gov /research/publications/publications.htm?SEQ_NO_115=99819 (351 words)

	Influences of array size and homogeneity on minisatellite mutation (Site not responding. Last check: 2007-10-09)
		Pedigree mutant data from minisatellite g3 suggest that the mutation rate is affected by flanking nucleotide variation and by the size of the tandem array itself, with higher mutation rates for larger alleles (Andreassen et al., 1996).
		A nucleotide transversion in the flanking vicinity of minisatellite MS32 is associated with a 110-fold suppression of mutation rate (Monckton et al., 1994).
		Minisatellite MS32 mutates by a predominantly inter-allelic gene conversion-like process and shows no trend towards higher mutation rates of longer alleles (Jeffreys et al., 1994); this is consistent with the fairly constant rate of inter-allelic transfers at CEB1 alleles of different lengths.
	www.nature.com /cgi-taf/DynaPage.taf?file=/emboj/journal/v17/n12/full/7591053a.html (4881 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		We are studying the radiation-induced increase of mutation rate in minisatellite loci in mice and humans.
		Minisatellite mutations were scored by multilocus DNA fingerprint analysis in the progeny of{gamma}-irradiated and non-irradiated mice.
		Germline mutation at human minisatellite loci was studied among children born in heavily polluted areas of the Mogilev district of Belarus after the Chernobyl accident and in a control population.
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=530834 (257 words)

	Environmental Health Perspectives 105, Supplement 4, June 1997: Article by Ramel (Site not responding. Last check: 2007-10-09)
		These properties of minisatellites provide the background for the "fingerprint analyses" (8), which have found several important applications, including as a powerful tool in forensic medicine, as markers for linkage studies in genetic analyses, and as a means for establishing kinship between individuals, including paternity determination.
		The minisatellites of the human genome are not evenly distributed but are primarily localized at the ends of the chromosomes, which implies a limitation in the use of these sequences in linkage analyses (10).
		Also, it can be foreseen that the use of minisatellites and other repeated DNA sequences will play an even more essential role in the future, both in research and for various practical applications.The reliability of the fingerprinting of minisatellites for legal purposes has been the subject of discussion and some controversy.
	ehp.niehs.nih.gov /members/1997/Suppl-4/ramel-full.html (8033 words)

	Genetic Analysis of Children of Atomic Bomb Survivors
		Minisatellites or VNTRs (variable number of tandem repeats) (15,16) are dispersed throughout the human genome and show a strong tendency to cluster in telomeric regions (17).
		Minisatellites consist of short-sequence units iterated in tandem to form arrays and show substantial allelic variation in the number of repeat units.
		We estimated the numerical requirement to demonstrate a significant difference between the mutation rates at the minisatellite loci of the exposed and the unexposed germ cells employing standard power function statistics (a type I error of 0.05 and a type II error of 0.2).
	ehp.niehs.nih.gov /members/1996/Suppl-3/511-519satoh/satoh-full.html (7151 words)

	RAD1 Controls the Meiotic Expansion of the Human HRAS1 Minisatellite in Saccharomyces cerevisiae -- Jauert et al. 22 ...
		the minisatellite tract increases and decreases in length at
		Representative whole-cell PCRs across the minisatellite tract in spore colonies (a, b, c, and d) derived from individual diploid cells are shown.
		the minisatellite tract in yeast recapitulates the phenotypes
	mcb.asm.org /cgi/content/full/22/3/953 (7406 words)

	Insulin minisatellite homepage:Department of Genetics: University of Leicester
		Minisatellites are regions of repetitive DNA with repeats units of typically 10-100 bp in length tandemly repeated 10-1000 times.
		The second objective was to characterise variation at the insulin minisatellite within a population from the UK (Stead and Jeffreys, 2000) and examine the relationship between minisatellite allele structure and susceptibility to type 1 diabetes (Stead et al., 2000).
		Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes.
	www.le.ac.uk /genetics/ajj/insulin (619 words)

	ANALYSIS OF INTERNAL VARIATION OF THE D1S8 AND D7S21 MINISATELLITE LOCI BY MVR-PCR: A DIGITAL APPROCH TO DNA TYPING (Site not responding. Last check: 2007-10-09)
		Sequence analysis of cloned minisatellites has shown that they are not composed of identical repeat units but instead contain intermingled arrays of different repeat types which differ subtly from the consensus repeat sequence.
		Minisatellite variat repeat mapping by PCR (MVR-PCR) was developed by Jeffreys et al., in 1991.
		So we have study the variability of these minisatellite loci in a sample from Galician population, and finally we have analyzed the suitabibility of using this methodology to be applied in forensic analysis with different forensic samples like that, blood, semen and saliva stains, teeth...
	www.usc.es /spubl/21bell~2.htm (256 words)

	City of Hope Graduate School of Biological Sciences (Site not responding. Last check: 2007-10-09)
		Minisatellites occur throughout the human genome, often next to genes and gene clusters.
		We are currently investigating the interaction of the HRAS1 minisatellite with other cancer-related loci in the human genome by conducting a study of sib pairs affected with breast, colon, prostate and lung cancer.
		The contributions to disease phenotypes of other minisatellites, such as those located in the proximity of the IGH, INS and RB1 loci, also are under investigation.
	www.cityofhope.org /Gradschool/faculty/tkrontiris.asp (582 words)

	Tandem repeat - Wikipedia, the free encyclopedia
		Minisatellite is another way of saying special regions of the loci.
		Polymerase chain reaction (or PCR) is performed on the minisatellite areas.
		The PCR must be performed on each organism being tested.
	en.wikipedia.org /wiki/Tandem_repeats (160 words)

	Minisatellite allele diversification: the origin of rare alleles at the HRAS1 locus. (Site not responding. Last check: 2007-10-09)
		Minisatellite allele diversification: the origin of rare alleles at the HRAS1 locus.
		Minisatellite allele diversification: the origin of rare alleles at the HRAS1 locus.Therefore, hyperallelism emanated from the four common alleles in a defined fashion, the size of a rare allele specifying its origin.
		Analysis of 17 rare alleles revealed a stratification of allele fragment size and upstream haplotype in which each rare VTR allele possessed the markers characteristic of the common allele nearest in size.
	www.ihop-net.org /UniPub/iHOP/gp/19592.html (164 words)

	Minisatellite Variants Generated in Yeast Meiosis Involve DNA Removal During Gene Conversion -- Bishop et al. 156 (1): ...
		Minisatellite Variants Generated in Yeast Meiosis Involve DNA Removal During Gene Conversion -- Bishop et al.
		The specific configuration of mating-type, minisatellite, and auxotrophic markers for each diploid used is given in Table 1.
		After pre-meiotic DNA replication one of the four chromatids suffers a double-strand break and the ends are processed by a 5' to 3' exonuclease that generates two single-strand 3' DNA tails (A).
	www.genetics.org /cgi/content/full/156/1/7 (6686 words)

	Jobim_B
		Allele diversity and germline mutation at the insulin minisatellite.
		Minisatellite mutation rate variation associated with a flanking DNA sequence polymorphism.
		Minisatellite repeat coding as a digital approach to DNA typing.Jeffreys, A.J., MacLeod, A., Tamaki, K., Neil, D.L. and Monckton, D.G. Nature, 354, 204-209 (1991).
	bioinfo.unice.fr /Jobim05/Jobim_B.html (1068 words)

	The Wild Trout Trust: Genetically Monomorphic Brown Trout Populations (Site not responding. Last check: 2007-10-09)
		minisatellites, the major histocompatibility complex) have revealed populations of various species, principally mammals, with reduced levels of' variation compared with other populations of the same or related species (e.g.
		Eight minisatellite loci were investigated using five single-locus probes derived from brown trout (pStr-A1, pStr-A3, pStr-A5, pStr-A9 and pStr-A22/2; Prodöhl et al., 1994) and three from Atlantic salmon (Salmo salar L.) (pSsa-A34, pSsa-A45/1 and pSsa-A45/2; Taggart et al., 1995).
		More convincing evidence of lack of variation is given by the single-locus minisatellite analyses, as these are not subject to the technical and interpretation limitations of multilocus fingerprints.
	www.wildtrout.org /WTT/library/papers/monomorphic.asp (3171 words)

	Birth and Evolutionary History of a Human Minisatellite -- Boán et al. 21 (2): 228 -- Molecular Biology and ...
		to amplify the minisatellite and its proximal flanking sequences.
		To facilitate allele comparisons, the alignment of the minisatellite is shown using the one letter code (see table 1 for the key code).
		Molecular characterization of a new human minisatellite that is able to form single-stranded loops in vitro and is recognized by nuclear proteins.
	mbe.oxfordjournals.org /cgi/content/full/21/2/228 (3337 words)

	Untitled Document
		What does the hypervariable refer to and why are these minisatellite loci particularly good for assessing the effects of radiation.
		Minisatellite loci are the same as VNTRs, described on page 325 of Russell.
		Each person has a unique pattern for different minisatellites in which there are different numbers of repeats.
	www.emu.edu /courses/biol312a/mutations.htm (725 words)

	Finding New Human Minisatellite Sequences in the Vicinity of Long CA-Rich Sequences -- Giraudeau et al. 9 (7): 647 -- ...
		Microsatellites and minisatellites are two classes of tandem repeat sequences differing in their size, mutation processes,
		of the procedure to minisatellite detection on a larger scale,
		F. DAVID, and G. Use of a set of highly polymorphic minisatellite probes for the identification of cryptic 1p36.3 deletions in a large collection of patients with idiopathic mental retardation
	www.genome.org /cgi/content/abstract/9/7/647 (400 words)

	Human Biology: Genetic polymorphism study at four minisatellite loci (D1S80, D17S5, D19S20, and APOB) among five Indian ... (Site not responding. Last check: 2007-10-09)
		Abstract The present study reports the genetic variation observed among five anthropologically distinct population groups of India, using four highly polymorphic minisatellite loci (D1S80, D17S5, D19S20, and APOB 3' VNTR) in order to examine the effect of geographical and linguistic affiliations on the genetic affinities among these groups.
		D19S20 minisatellite is located on the short arm of chromosome 19 (19p 13.3) and has a core sequence of 33 bp.
		In the case of D19S20 and APOB 3' minisatellites, the forward primers were labeled with fluorescent Cy5 dye amidite (Amersham Pharmacia Biotech).
	www.findarticles.com /p/articles/mi_qa3659/is_200206/ai_n9087073 (1441 words)

	Influences of array size and homogeneity on minisatellite mutation -- Buard et al. 17 (12): 3495 -- The EMBO Journal (Site not responding. Last check: 2007-10-09)
		A second criterion, which is a strong rule for all unstable minisatellites analysed, is that the transfer tends to occur in-register between donor and recipient alleles (Buard and Vergnaud, 1994
		that intra-allelic minisatellite mutation is not driven by a replication-based
		Jeffreys, A.J., Neumann, R. and Wilson, V. Repeat unit sequence variation in minisatellites: a novel source of DNA polymorphism for studying variation and mutation by single molecule analysis.
	embojournal.npgjournals.com /cgi/content/full/17/12/3495 (4525 words)

	Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes -- Stead et ...
		Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes -- Stead et al.
		for linkage of the minisatellite with disease for transmissions
		19 Stead, J.D. and Jeffreys, A.J. (2000) Allele diversity and germline mutation at the insulin minisatellite.
	hmg.oxfordjournals.org /cgi/content/full/9/20/2929 (4499 words)

	Minisatellite instability in severe combined immunodeficiency mouse cells -- Imai et al. 94 (20): 10817 -- Proceedings ...
		Minisatellite instability in severe combined immunodeficiency mouse cells -- Imai et al.
		Minisatellite instability in severe combined immunodeficiency mouse cells
		Untargeted mutation of the maternally derived mouse hypervariable minisatellite allele in F1 mice born to irradiated spermatozoa
	www.pnas.org /cgi/content/abstract/94/20/10817 (614 words)

	UoSAT-12 MINISATELLITE FOR HIGH PERFORMANCE
		This pioneering work by Surrey on advanced microsatellites and minisatellites has resulted in imaging missions that can respond rapidly to customer requirements, which are affordable to a far wider community of individual commercial or governmental organisations, and which provide emerging space nations with an independent Earth observation capability.
		Although the MSCs will first be flown on the UoSAT-12 minisatellite, all aspects of their design have been carefully considered to ensure that similar instruments can be flown on future microsatellites.
		Conversely, on a minisatellite where the payload real-estate is not so restricted, the choice may be to deploy multiple all-electronic cameras to improve the overall reliability.
	www.ee.surrey.ac.uk /SSC/CSER/UOSAT/papers/iaf96/minieis/minieis.html (6151 words)

	Evolution and population genetics of the H-ras minisatellite and cancer predisposition -- Langdon and Armour 12 (8): ...
		Allele tree of H-ras minisatellite flanking haplotypes, showing the evolution from the inferred ancestral haplotype to haplotypes observed in the Castilian and African Pygmy populations studied.
		The four commonest haplotypes (H1–H4) are shown in bold, and the lengths of associated minisatellite alleles in italics.
		Stead, J.D.H., Buard, J., Todd, J.A. and Jeffreys, A.J. (2000) Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes.
	hmg.oxfordjournals.org /cgi/content/full/12/8/891 (5559 words)

	A Minisatellite Sequence within the Propeptide Region of the Vacuolar Carboxypeptidase Y Gene of Schizosaccharomyces ...
		A Minisatellite Sequence within the Propeptide Region of the Vacuolar Carboxypeptidase Y Gene of Schizosaccharomyces pombe -- Ingavale et al.
		A Minisatellite Sequence within the Propeptide Region of the Vacuolar Carboxypeptidase Y Gene of Schizosaccharomyces pombe
		The minisatellite sequence was found to reside within the
	jb.asm.org /cgi/content/abstract/180/14/3727 (202 words)

	Nanosat Minisatellite Manually Launched Into Space (Site not responding. Last check: 2007-10-09)
		A Mission Control spokesman said that the minisatellite weighed only five kilograms, and the cosmonaut simply cast it aside with his hands, like a soccer ball.
		Minisatellites, the professor added, would be henceforth launched with the help of Kosmos-3M or Dnepr light class carrier rockets.
		Valeri Vishnyakov added that a more complicated, modified version of the Nanosat minisatellite was planned to be launched from a Progress carrier rocket on its way to the International Space Station.
	www.unexplainable.net /artman/publish/article_1816.shtml (572 words)

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