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	Mirtazapine - Wikipedia, the free encyclopedia
		Mirtazapine is an antidepressant introduced by Organon International in 1996 used for the treatment of mild to severe depression.
		Mirtazapine is marketed under the tradenames Remeron® in the U.S. and Finland, Avanza® and Axit® in Australia, Zispin® in the UK and Ireland, Norset® in France, Remergon® in Belgium, Remergil® in Germany, Mirtabene® in Austria and Rexer® in Spain.
		Mirtazapine is primarily used to treat the symptoms of mild to severe depression.
	en.wikipedia.org /wiki/Mirtazapine (964 words)

	Mirtazapine
		Remeron® is the tradename of Organon's new antidepressant mirtazapine.
		Mirtazapine is a potent antagonist of 5-HT2 and 5-HT3 receptors.
		Mirtazapine is a moderate peripheral a1 adrenergic antagonist, a property that may explain the occasional orthostatic hypotension reported in association with its use.
	www.angelfire.com /journal2/sadhelp/mirtazapine.htm (2258 words)

	Mirtazapine - Definition, Purpose, Description, Recommended dosage, Precautions, Side effects, Interactions
		Mirtazapine is broken down by the liver and eliminated from the body mostly by the kidneys.
		Mirtazapine may cause weight gain and may increase cholesterol levels and should be used carefully in overweight individuals and those with high cholesterol levels.
		Use of mirtazapine with antidepressants referred to as monoamine oxidase inhibitors (MAOIs) such as Parnate (tranylcypromine) and Nardil (phenelzine), is strongly prohibited due to the potential for high fever, muscle stiffness, sudden muscle spasms, rapid changes in heart rate and blood pressure, and the possibility of death.
	www.minddisorders.com /Kau-Nu/Mirtazapine.html (711 words)

	ACS :: Cancer Drug Guide: mirtazapine
		Mirtazapine increases the amount of serotonin and norepinephrine in the brain so that the feeling of depression is prevented or relieved.
		Mirtazapine is a pill given by mouth once a day at bedtime, or in 2 divided doses morning and evening, with or without food.
		Mirtazapine affects the central nervous system (CNS), so it is important not to take other drugs or substances that are known to suppress the CNS such as alcohol, sedatives, and hypnotics.
	www.cancer.org /docroot/CDG/content/CDG_mirtazapine.asp (623 words)

	Mirtazapine ( Remeron , Zispin , Avanza, Norset, Remergil )
		Mirtazapine is well absorbed from the gastrointestinal tract following oral administration, and it is extensively metabolized in the liver to four metabolites via demethylation and hydroxylation, followed by glucuronide conjugation.
		Mirtazapine was consistently superior to placebo, and equivalent in efficacy to the tricyclic antidepressants amitriptyline, doxepin and clomipramine, but with an improved tolerability profile.
		Mirtazapine is a unique addition to the antidepressant armamentarium as first-line therapy in patients with major depression and symptoms of anxiety/agitation or anxiety/somatization or complaints of insomnia and as a useful alternative in depressed patients who do not adequately respond to or are intolerant of tricyclic antidepressants or serotonin-specific reuptake inhibitors.
	www.biopsychiatry.com /mirtazapine.html (436 words)

	Remeron
		Mirtazapine was begun at 15 mg at bedtime, with possible titration to 30 mg at bedtime per physician's discretion after week 1.
		Mirtazapine 15-30 mg QHS was added to initial anti-depressant that was not adequately effective in the 24 patients (SSRIs, venlafaxine, desipramine or bupropion).
		Paroxetine, Fluvoxamine Increase Mirtazapine Levels: Paroxetine inhibits the metabolism of mirtazapine, as shown by increases of approximately 17% and 25% of the 24 h AUC's of mirtazapine and its demethyl metabolite, respectively.
	www.modern-psychiatry.com /mirtazapine.htm (1636 words)

	Mirtazapine (Site not responding. Last check: 2007-11-07)
		If your child’s doctor has prescribed mirtazapine for your child, you should watch his or her behavior very carefully, especially at the beginning of treatment and any time his or her dose is increased or decreased.
		Mirtazapine, an antidepressant or mood elevator, is used to treat depression.
		Mirtazapine is in a class of medications called antidepressants It works by increasing certain types of activity in the brain.
	www.safemedication.com /displaydrug.cfm?id=697009 (980 words)

	Where Does Mirtazapine Fit in Current Antidepressant Therapy?
		The average daily dose of mirtazapine was 18 mg and that of amitriptyline was 111 mg.
		Mirtazapine is a substrate of cytochrome P450 isoenzymes 2D6, 1A2, and 3A4; however, it does not appear to inhibit these isoenzymes.
		Mirtazapine in combination with benzodiazepines or ethanol may result in additive effects with respect to sedation and psychomotor impairment.
	www.uspharmacist.com /oldformat.asp?url=newlook/files/Drug/ACF2F1B.cfm&pub_id=8&article_id=51 (978 words)

	Mirtazapine is used in the treatment of major depressive disorder
		Mirtazapine is used in the treatment of major depressive disorder.
		Results of these studies indicate that the antidepressant effect of mirtazapine (5–35 mg daily) is greater than placebo and comparable to that of tricyclic antidepressants (e.g., amitriptyline [40–280 mg daily]).
		Since hypomanic or manic attacks have been reported rarely in patients receiving mirtazapine, the drug should be used with caution in patients with a history of hypomanic or manic attacks.
	home.gci.net /~blessing/pages/mirtazapine.htm (539 words)

	Mirtazapine 45mg Tablets x 28 , SPC from the eMC
		Mirtazapine should not be administered concomitantly with MAO inhibitors or within two weeks after discontinuation of MAO (monoamine oxidase) inhibitor therapy.
		Mirtazapine induced no effects of clinical relevance in chronic safety studies in rats and dogs or in reproductive toxicity studies in rats and rabbits.
		Mirtazapine was not genotoxic in a series of tests for gene mutation and chromosomal and DNA damage.
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?DocumentID=16441 (2054 words)

	mirtazapine Consumer Drug Information
		While you are taking mirtazapine you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed.
		Mirtazapine is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide.
		Mirtazapine is in the FDA pregnancy category C. This means that it is not known whether mirtazapine will harm an unborn baby.
	www.drugs.com /MTM/mirtazapine.html (1609 words)

	RemedyFind: patient ratings of Remeron etc. (Mirtazapine) for Premenstrual Syndrome (PMS; PMDD)
		Mirtazapine works by increasing levels of norepinephrine and serotonin, two of the neurotransmitter chemicals that carry messages between brain nerve cells.
		Mirtazapine shows a significantly earlier onset of action than SSRI antidepressants and appears to be at least as effective as Effexor (Venlafaxin), and the older tricyclic antidepressants.
		Mirtazapine also appears to be associated with a low rate of sexual adverse effects.
	www.remedyfind.com /rem.asp?ID=9997 (605 words)

	MedlinePlus Drug Information: Mirtazapine (Systemic) (Site not responding. Last check: 2007-11-07)
		Mirtazapine must be used with caution in children with depression.
		Mirtazapine may be taken with or without food, on a full or empty stomach.
		Mirtazapine may cause some people to be agitated, irritable or display other abnormal behaviors.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/203490.html (1567 words)

	Tissue Distribution of Mirtazapine (Remeron¨) in Postmortem Cases (Site not responding. Last check: 2007-11-07)
		Mirtazapine (Remeron) is a member of the relatively new class of tetracyclic antidepressants.
		This report documents the tissue distribution of mirtazapine in eight postmortem cases in which it was identified but did not contribute to the cause or manner of death.
		In each case, the mirtazapine concentration in heart blood was approximately equal to that of peripheral blood, indicating that postmortem redistribution was not a factor in evaluating postmortem blood concentrations in these cases.
	www.jatox.com /abstracts/1999/october/541-moore.htm (210 words)

	Distribution of Mirtazapine (Remeron¨) in Thirteen Postmortem Cases* (Site not responding. Last check: 2007-11-07)
		Mirtazapine is a new antidepressant agent that entered the United States market in April 1996.
		The analysis of mirtazapine from postmortem specimens (2-mL sample size) consisted of an n-butylchloride basic extraction procedure with identification and quantitation on a gas chromatograph–nitrogen-phosphorus detector.
		Mirtazapine was not implicated in the cause of death in any of the 13 cases studied.
	www.jatox.com /abstracts/1999/october/544-anderson.htm (206 words)

	Mirtrazapine, Remeron, antidepressant, drug therapy for depression, Depression, Alternative therapies, mind-body ...
		Mirtazapine may be effective for both mildly depressed patients and for more severely depressed patients.
		Mirtazapine is not likely to cause stomach upset, insomnia, nervousness, and sexual problems commonly seen with the SSRIs.
		Mirtazapine must not be combined with the MAOI antidepressants because of the risk of the serotonin syndrome (hyperpyrexic crisis).
	www.holisticonline.com /Remedies/Depression/dep_antidepressant_mirtrazapine.htm (223 words)

	Column - Imipramine, Mirtazapine, and Nefazodone: Multiple Targets
		Thus, mirtazapine most likely causes sedation at low doses (i.e., concentrations) by preferentially blocking the histamine-1 receptor, while at higher doses (i.e., concentrations), mirtazapine blocks the alpha-2 adrenergic receptor, which theoretically could reduce its sedating effects to some degree.
		Imipramine, mirtazapine, and nefazodone are at the opposite end of the spectrum from the SSRIs (e.g., sertraline) or the NSRIs (e.g., desipramine or reboxetine) in terms of number of mechanisms of action that are affected at concentrations achieved in the usual patient taking these drugs at their respective antidepressant doses.
		In contrast, the pharmacology of imipramine, mirtazapine, and nefazodone is richer or more varied or more complicated (i.e., pick the spin you prefer) than that of the SSRIs as a result of their effects on multiple mechanisms of action.
	www.preskorn.com /columns/0003.html (3864 words)

	mirtazapine (Remeron) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
		Mirtazapine was approved by the FDA in 1996.
		Fluvoxamine (Luvox) may increase the levels of mirtazapine in the blood which may lead to increased side effects from mirtazapine.
		Because of the possibility of developing an increased body temperature (hyperpyrexia), high blood pressure, or seizures, use of mirtazapine is not recommended together with monoamine oxidase inhibitors (MAO's), such as furazolidone (Furoxone), phenelzine (Nardil), procarbazine (Matulane), selegiline (Carbex), or tranylcypromine (Parnate).
	www.medicinenet.com /mirtazapine/article.htm (579 words)

	Newly Approved Drug Therapies (663): Remeron SolTab (mirtazapine), Organon
		Mirtazapine was also shown to be superior to placebo for certain factors of the HDRS, such as anxiety/somatization and sleep disturbance.
		The mean mirtazapine dose for subjects who completed these four studies ranged from 21 to 32 mg per day.
		These studies have shown that mirtazapine acts as an antagonist at central presynaptic a2 adrenergic inhibitory autoreceptors and heteroreceptors, which may contribute to the increase in central noradrenergic and serotonergic activity.
	www.centerwatch.com /patient/drugs/dru663.html (556 words)

	News - Mirtazapine Attenuates Hypothalamic-pituitary-adrenocortical Axis Hyperactivity in Depressed Patients
		Previous studies demonstrated that mirtazapine acts as an antagonist at presynaptic beta 2 receptors and at post-synaptic 5-hydroxytryptamine (5-HT) and histamine H1 receptors.
		Schüle and colleagues investigated whether mirtazapine might reduce HPA axis hyperactivity in patients with depression, and whether this is related to treatment outcome.
		The clinicians found that mirtazapine effectively reduced the overshoot of cortisol and adrenocorticotropin in the DEX/CRH test in the first week among patients who either responded or did not respond to treatment.
	www.docguide.com /news/content.nsf/news/8525697700573E1885256CFD004B4129 (430 words)

	Mirtazapine - Biocrawler (Site not responding. Last check: 2007-11-07)
		It is thought to work by blocking presynaptic alpha-2 adrenergic receptors that normally inhibit the release of the neurotransmitters norepinephrine and serotonin, thereby increasing active levels in the synapse.
		The side effects that do occur are thought to be primarily related to the blockage of histamine receptors, which decreases with higher dosages.
		You can find it there under the keyword Mirtazapine (http://en.wikipedia.org/wiki/Mirtazapine)The list of previous authors is available here: version history (http://en.wikipedia.org/w/index.php?title=Mirtazapineandaction=history).
	www.biocrawler.com /encyclopedia/Mirtazapine (239 words)

	DSRU - Lay Summary - Mirtazapine
		It is the first of a new type of antidepressant that works by altering levels of chemicals in the brain, known as noradrenaline and serotonin.
		We monitored the safety of mirtazapine during its introduction into use in general practice in England.
		Patients prescribed mirtazapine were identified from dispensed prescriptions issued between September 1997 and February 1999.
	www.dsru.org /pat_guide_mirtazapine.html (290 words)

	Mirtazapine's Pharmacologic Profile
		Mirtazapine (Org 3770) is a new AntiDepressant with prominent alpha 2-Adrenergic Auto- and Heteroreceptor Antagonistic properties and no effect on Monoamine Reuptake.
		Mirtazapine increases NorAdrenergic and Serotonergic transmission, as measured by on-line microdialysis and by enhancement of NorAdrenergic Locus Ceruleus and Serotonergic Raphe Nucleus Cell firing.
		Mirtazapine is a new AntiDepressant that falls into the general class of Receptor-Blocking drugs rather than being an Uptake or Enzyme Inhibitor.
	members.tripod.com /~ThJuland/mirtazapine.html (491 words)

	Remeron SolTab Online, Description, Chemistry, Ingredients - Mirtazapine - RxList Monographs
		(mirtazapine) Orally Disintegrating Tablets or any other antidepressant in a child or adolescent must balance this risk with the clinical need.
		The average risk of such events in patients receiving antidepressants was 4%, twice the placebo risk of 2%.
		Mirtazapine has a tetracyclic chemical structure and belongs to the piperazino-azepine group of compounds.
	www.rxlist.com /cgi/generic4/remeron_soltab.htm (289 words)

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