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Topic: Misoprostol


In the News (Sat 22 Nov 08)

  
  Misoprostol - Wikipedia, the free encyclopedia
Although not licensed for the indication (over 60% of the drugs that American doctors prescribe are not used for a licensed indication), misoprostol is commonly prescribed to expedite the onset of labor by causing uterine contractions and the ripening (opening) of the cervix.
Misoprostol is one of the drugs used for medical (non-surgical) termination of pregnancy (see abortion).
Misoprostol alone has been shown to be highly effective (about 90%) in inducing an abortion, and it is used for this purpose in many countries where abortions are illegal.
en.wikipedia.org /wiki/Misoprostol   (409 words)

  
 Medication Abortion: Misoprostol Alone   (Site not responding. Last check: 2007-10-29)
Misoprostol is widely prescribed for the prevention and treatment of gastric ulcers and is currently available in over 80 countries worldwide.
Misoprostol is used for a wide array of conditions including the treatment and prevention of gastric ulcers.
Misoprostol is also used for a variety of obstetric and gynecological health indications, including the induction of labor, cervical ripening, and midtrimester abortion.
ec.princeton.edu /medabortion/misoprostol   (1470 words)

  
 Misoprostol (Cytotec) abortifacient-NSAIDs   (Site not responding. Last check: 2007-10-29)
Misoprostol is used for and is commonly believed to be effective for prevention of gastric and duodenal ulcers secondary to use of nonsteroidal antiinflammatory drugs (NSAIDs), although currently it is indicated only for the prevention of gastric ulcers.
While misoprostol is approved for use in preventing NSAID-induced gastric ulcers in high-risk patients and it has been shown to be superior than sucralfate for this condition, uncertainty exists regarding the role of misoprostol in patients receiving NSAIDs.
Misoprostol may increase the frequency of uterine contractions, which is responsible for its abortifacient capability.
www.rockford.uic.edu /jc/misoprostol.htm   (530 words)

  
 ..misoprostol use in obstetrics and gynecology – a bibliography..
..misoprostol use in obstetrics and gynecology – a bibliography..
Misoprostol, an E1 prostaglandin analogue, is approved in more than 85 countries since it's first marketing in 1985.
Misoprostol in Obstetrics and Gynaecology - a summary of evidence.
www.misoprostol.org   (402 words)

  
 Misoprostol
Misoprostol is a prostaglandin medication used to terminate a pregnancy by starting labor.
Misoprostol is also used to prevent stomach ulcers (labeled use) and for induction of labor for childbirth (unlabeled use).
Misoprostol used alone may terminate a pregnancy but is much more effective when used with other medications, such as mifepristone or methotrexate, in first-trimester abortions.
www.webmd.com /hw/health_guide_atoz/tw9126.asp   (384 words)

  
 Patient Education - Drugs - misoprostol
Misoprostol is a synthetic prostaglandin which enhances the ability of the stomach lining to resist the harmful effects of certain types of arthritis and pain medications called NSAIDs (non-steroidal anti-inflammatory drugs).
Misoprostol is used to prevent the development of stomach ulcers which can occur from the use of any of the NSAID drugs (see above for definition).
Misoprostol may cause dizziness so use caution when driving or operating hazardous equipment until the effect of this drug has been determined.
www.gicare.com /pated/misoprostol.htm   (884 words)

  
 Mifepristone and misoprostol for abortion
A medical abortion with mifepristone and misoprostol is effective 95% to 98% of the time among women 9 weeks pregnant or less.
Misoprostol is slightly more effective when taken vaginally than when taken orally.
This method of abortion causes symptoms similar to a miscarriage (such as cramping, nausea, diarrhea, and vaginal bleeding) as tissue and clots pass from the uterus.
www.webmd.com /hw/womens_conditions/tw1291.asp   (957 words)

  
 Misoprostol and VBAC
Misoprostol is cheaper than Prostaglandin E2, and apparently the induction to delivery interval is reduced, but uterine hyperstimulation appears more likely.
Comparison of the safety and efficacy of intravaginal misoprostol (prostaglandin E1) with those of dinoprostone (prostaglandin E2) for cervical ripening and induction of labor in a community hospital.
It is surprising that the researchers considered misoprostol to be as safe as Prostaglandin E2 gel for mothers who did not have a history of caesarean births, since one woman in their study had a ruptured uterus in these circumstances.
www.homebirth.org.uk /misoprostol.htm   (727 words)

  
 Misoprostol   (Site not responding. Last check: 2007-10-29)
Misoprostol helps prevent ulcers and enhances the stomach's natural healing ability by increasing the production of protective mucus, as well as inhibiting the secretion of stomach acid.
Misoprostol should not be used during pregnancy, because it may promote contractions and bleeding of the uterus and can cause miscarriage.
Misoprostol may pass into breast milk; avoid or discontinue use while nursing because it may cause diarrhea in nursing babies.
www.wholehealthmd.com /refshelf/drugs_view/1,1524,421,00.html   (539 words)

  
 MedlinePlus Drug Information: Misoprostol (Systemic)   (Site not responding. Last check: 2007-10-29)
Misoprostol may also be used for other conditions as determined by your doctor.
However, misoprostol is not recommended for use during breast-feeding because it may cause diarrhea in nursing babies.
Misoprostol is best taken with or after meals and at bedtime, unless otherwise directed by your doctor.
www.nlm.nih.gov /medlineplus/druginfo/uspdi/202375.html   (1026 words)

  
 Misoprostol: More on the dangers of Cytotec
I was compelled to write after reading the articles on misoprostol in the Spring 1999 issue because I was horrified that midwives are advocating the use of this drug for induction of labour when it hasn't been approved by the FDA for this purpose (according to Marsden Wagner).
Uterine rupture associated with the use of misoprostol in the gravid patient with a previous cesarean section.
Misoprostol (Cytotec) for Labor Induction: A Cautionary Tale - by Marsden Wagner
www.midwiferytoday.com /articles/misoprostol.asp   (739 words)

  
 Misoprostol in OB/Gyne - Summary of Evidence   (Site not responding. Last check: 2007-10-29)
Misoprostol is a very powerful stimulator of uterine contractions in late pregnancy and can cause fetal death and uterine rupture if used in high doses.
Misoprostol comes in tablets of 200μg (microgram) each, so 50μg is only 1/4 tablet (best cut using a razor blade).
Misoprostol is effective orally, sublingually, vaginally and rectally.
www.misoprostol.org /miso_evidence.html   (1335 words)

  
 misoprostol   (Site not responding. Last check: 2007-10-29)
The letter further stated that Searle was aware of instances where misoprostol had been used in an off-label manner for cervical ripening.
A recent analysis of vaginal misoprostol for cervical ripening and labor induction in late pregnancy was published in the Cochrane Database of Systematic Reviews.
Vaginal misoprostol for cervical ripening and labour induction in late pregnancy.
www.uic.edu /pharmacy/services/di/misopros.htm   (457 words)

  
 Non-Surgical, Chemical Abortions
Misoprostol is a commonly used prostaglandin medication for ulcers.
Published studies by other medical researchers have found that using methotrexate and misoprostol in terminating pregnancies is approximately 90% effective when it is taken up to 49 days from the first day of a woman's last menstrual period.
When misoprostol is taken in isolation, it only causes an abortion about 40% of the time.
www.religioustolerance.org /abo_nosu.htm   (1966 words)

  
 Laminaria, induced fetal demise and misoprostol in late abortion - Dr. Warren Hern
The effect of misoprostol administration on this variable is reported as well as its apparent effect, if any, on blood loss and procedure time.
Misoprostol use was begun for all patients in March, 1997.
Inclusion of misoprostol in the protocol did not increase the complication rates, but it may have enhanced patient comfort by diminishing the total length of time involved in the abortion procedure day.
www.drhern.com /laminaria.html   (3937 words)

  
 NEJM -- Use of Misoprostol during Pregnancy and Mobius' Syndrome in Infants
Use of misoprostol during pregnancy and Möbius' syndrome in infants.
of misoprostol that were ineffective for this purpose.
Misoprostol and illegal abortion in Rio de Janeiro, Brazil.
content.nejm.org /cgi/content/full/339/21/1553   (650 words)

  
 Medication Abortion: Methotrexate/Misoprostol Regimen   (Site not responding. Last check: 2007-10-29)
If the abortion has not occurred (as determined by vaginal ultrasound examination) the dose of misoprostol is repeated and the woman returns for final evaluation four weeks after the methotrexate administration (Day 28).
These include: a history of allergy or intolerance to either methotrexate or misoprostol; coagulopathy or current severe anemia; acute or chronic renal or hepatic disease; acute inflammatory bowel disease; or uncontrolled seizure disorders.
Women electing to use the methotrexate/misoprostol regimen should be informed of the possible teratogenic effects of these drugs and should be counseled on the importance of aspiration completion in the event that the medication abortion is unsuccessful.
ec.princeton.edu /medabortion/methotrexate   (1388 words)

  
 G Y N U I T Y - What We do: Medical Abortion Research (what_b.html)
Misoprostol is a prostaglandin analog that is marketed worldwide in over 60 countries for treatment and prevention of gastric ulcers.
Medical abortion regimens using mifepristone with misoprostol and misoprostol alone are quickly gaining support worldwide as safe and effective alternatives to surgical abortion.
Prominent researchers and experts on use of misoprostol for early abortion, training and advocacy organizations, and leading obstetrician-gynecologists attended this gathering.
www.gynuity.org /what_b.html   (1292 words)

  
 Cytotec Online, Description, Chemistry, Ingredients - Misoprostol - RxList Monographs
Cytotec (misoprostol) is contraindicated, because of its abortifacient property, in women who are pregnant.
has received both oral and written warnings of the hazards of misoprostol, the risk of possible contraception failure, and the danger to other women of childbearing potential should the drug be taken by mistake.
Misoprostol contains approximately equal amounts of the two diastereomers presented below with their enantiomers indicated by (±): Misoprostol is a water-soluble, viscous liquid.
www.rxlist.com /cgi/generic/misopro.htm   (280 words)

  
 diclofenac and misoprostol - Arthritis and arthritic conditions, medications, and treatment on MedicineNet.com
Misoprostol is a synthetic (man- made) prostaglandin that stimulates secretion of mucus in the gastrointestinal tract.
Misoprostol has been shown to reduce the frequency of ulcers of the stomach caused by NSAIDs.
It is recommended that Arthrotec not be taken with alcohol because of the increased risk for ulcers caused by diclofenac.
www.medicinenet.com /diclofenac_and_misoprostol/article.htm   (421 words)

  
 Misoprostol, Cytotec
Misoprostol is a type of drug called a prostaglandin E1 analog that protects the mucosal lining of the stomach and intestines.
A common side effect of misoprostol is diarrhea, which is aggravated by taking magnesium.
Taking misoprostol with food may lower the maximum concentration of the drug in the blood and delay (though not decrease) absorption up to ten hours.
www.truestarhealth.com /Notes/1159005.html   (377 words)

  
 MedlinePlus Drug Information: Misoprostol
If you are a woman of childbearing age, you may take misoprostol to prevent ulcers only if you have had a negative pregnancy test in the past 2 weeks and if you use a reliable method of birth control while taking misoprostol.
Misoprostol is also used sometimes to treat ulcers and to induce labor.
Misoprostol is used in combination with mifepristone to end an early pregnancy.
www.nlm.nih.gov /medlineplus/druginfo/medmaster/a689009.html   (640 words)

  
 A multicentre randomized controlled trial of oral misoprostol and i.m. syntometrine in the management of the third ...
Misoprostol stimulates the myometrium of the pregnant uterus
El-Refaey, H. and Templeton, A. (1994) Early induction of abortion by a combination of mifepristone and misoprostol administered by the vaginal route.
Prendiville, W., Elbourne, D. and Chalmers, I. (1989) The effects of routine oxytocic administration in the management of the third stage of labour: an overview of the evidence from controlled trials.
humrep.oxfordjournals.org /cgi/content/full/16/1/31?ijkey=99g5qHZs17kwk   (2756 words)

  
 Oral misoprostol for induction of labour (Cochrane Review)   (Site not responding. Last check: 2007-10-29)
Unlicensed use of misoprostol in pregnancy is increasingly common, because misoprostol is cheap, stable at room temperature and effective in causing uterine contractions.
Oral use of the drug misoprostol may be convenient, but high doses could cause uterine hyperstimulation and uterine rupture which may be life-threatening for both mother and fetus.
The caesarean section rate was lower in the oral misoprostol group (16.7%) compared with 21.7% in the vaginal misoprostol group (relative risk 0.77, 95% confidence intervals 0.61 to 0.97).
www.cochrane.org /cochrane/revabstr/ab001338.htm   (491 words)

  
 misoprostol - Digestion and digestive-related information on MedicineNet.com
PRESCRIBED FOR: Misoprostol (Cytotec) is prescribed for the prevention of stomach ulceration and related ulcer complications (such as ulcer bleeding, obstruction, and perforation) in patients on aspirin and other NSAIDs medications.
PREGNANCY: Misoprostol (Cytotec) is not to be used by pregnant women because misoprostol may cause miscarriage.
NURSING MOTHERS: Misoprostol (Cytotec) is avoided in nursing mothers because of concern over causing diarrhea in the baby.
www.medicinenet.com /misoprostol/article.htm   (473 words)

  
 Mifepristone and misoprostol for abortion - [Medication]   (Site not responding. Last check: 2007-10-29)
Mifepristone and misoprostol use is a two-step method.
Side effects may increase as the length of pregnancy increases and in women having their first pregnancy.
The U.S. Food and Drug Administration (FDA) has reported that a few women have died from a severe infection (sepsis) after having an abortion using mifepristone and misoprostol.
www.bcbswny.com /kbase/topic/detail/drug/tw1291/detail.htm   (999 words)

  
 Effect of sublingual misoprostol on severe postpartum haemorrhage in a primary health centre in Guinea-Bissau: ...
Effect of sublingual misoprostol on severe postpartum haemorrhage in a primary health centre in Guinea-Bissau: randomised double blind clinical trial -- Høj et al.
Misoprostol, a prostaglandin E1 analogue, is heat stable and
Rectal misoprostol in the prevention of postpartum hemorrhage: a placebo-controlled trial.
bmj.bmjjournals.com /cgi/content/full/331/7519/723?ehom   (2449 words)

  
 Methotrexate and misoprostol for abortion - [Medication] - Quest Diagnostics Patient Health Library   (Site not responding. Last check: 2007-10-29)
Methotrexate and misoprostol use is a two-step method.
Second, tablets of misoprostol are taken orally or inserted vaginally, usually 5 to 7 days later.
However, methotrexate and misoprostol can take up to 3 weeks to be effective, which is longer than other abortion methods.
www.questdiagnostics.com /kbase/topic/detail/drug/tw1277/detail.htm   (767 words)

  
 Early pregnancy termination with vaginal misoprostol before and after 42 days gestation -- Zikopoulos et al. 17 (12): ...
Blanchard, K., Winikoff, B. and Ellertson, C. (1999) Misoprostol used alone for the termination of pregnancy.
Costa, S.H. and Vessey, M.P. (1993) Misoprostol and illegal abortion in Rio de Janeiro, Brazil.
Norman, J.E., Thong, K.J. and Baird, D.T. (1991) Uterine contractility and induction of abortion in early pregnancy by misoprostol and mifepristone.
humrep.oxfordjournals.org /cgi/content/full/17/12/3079   (2472 words)

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