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Topic: Modafinil

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	Modafinil ( Provigil ) (via CobWeb/3.1 planetlab2.isi.jhu.edu) (Site not responding. Last check: 2007-09-09)
		Modafinil inhibits the reuptake of noradrenaline by the noradrenergic terminals on sleep-promoting neurons of ventrolateral preoptic nucleus (VLPO).
		Modafinil is proving clinically useful in the treatment of narcolepsy, a neurological disorder marked by uncontrollable attacks of daytime sleepiness.
		Experimentally, modafinil is also used in the treatment of Alzheimer's disease, depression, attention-deficit disorder (ADHD), myotonic dystrophy, multiple sclerosis-induced fatigue, post-anaesthesia grogginess, cognitive impairment in schizophrenia, spasticity associated with cerebral palsy, age-related memory decline, idiopathic hypersomnia, jet-lag, and everyday cat-napping.
	www.modafinil.com.cob-web.org:8888 (704 words)

	Modafinil - Wikipedia, the free encyclopedia
		Modafinil blocks the reuptake of norepinephrine by the noradrenergic terminals on sleep-promoting neurons from the ventrolateral preoptic nucleus (VLPO).
		Modafinil is currently classified as a Schedule IV controlled substance under United States federal law.
		"Modafinil increases histamine release in the anterior hypothalamus of rats.".
	en.wikipedia.org /wiki/Modafinil (1605 words)

	Modafinil - Provigil
		Modafinil is only available by prescription, do not use with either sedatives or other stimulants.
		Cautions: Modafinil may not be a suitable treatment for all individuals, and others may require precautions to ensure safe and effective treatment.
		Modafinil may be an unsuitable or dangerous treatment for you.
	www.accessmednet.com /prescription-drug-information/modafinil-.html (1352 words)

	Sleep-Disordered Breathing and Modafinil - American Sleep Apnea Association - ASAA
		Modafinil was originally approved by the Food and Drug Administration to improve wakefulness in patients with excessive daytime sleepiness associated with narcolepsy.
		In addition, in cases of extreme sleepiness thought to be from untreated sleep apnea, modafinil may have a short-term role to minimize the direct risk of sleepiness until definitive treatment is initiated and found to be effective.
		Yet modafinil must not be seen as a panacea; the drug must not hinder appropriate diagnosis and treatment of the underlying cause for the sleepiness.
	www.sleepapnea.org /about/archive/modafinil.html (1248 words)

	Buy Modafinil (Alertec / ProVigil / Modiodal) Information on Modafinil
		Experimentally, Modafinil is also used in the treatment of Alzheimer's disease, depression, attention-deficit disorder, myotonic dystrophy, multiple sclerosis-induced fatigue, post-anaesthesia grogginess, cognitive impairment in schizophrenia, spasticity associated with cerebral palsy, age-related memory decline, idiopathic hypersomnia, jet-lag and everyday cat-napping.
		Modafinil is effective in reducing excessive diurnal drowsiness associated with this condition.
		Modafinil and excipients- Lactose, corn starch, monosilicate of dehydrated magnesium, sodium croscarmellose polyvidone, talc, magnesium sterate.
	www.antiaging-systems.com /a2z/modafinil.htm (1758 words)

	Erowid Modafinil Vault : Provigil Prescription Information
		Modafinil is reinforcing, as evidenced by its self-administration in monkeys previously trained to self-administer cocaine; modafinil was also partially discriminated as stimulant-like.
		Modafinil is a racemic compound, whose enantiomers have different pharmacokinetics (e.g., the half-life of the l-isomer is approximately three times that of the d-isomer in humans).
		Modafinil has not been evaluated or used to any appreciable extent in patients with a recent history of myocardial infarction or unstable angina, and such patients should be treated with caution.
	www.erowid.org /smarts/modafinil/modafinil_health1.shtml (5164 words)

	CBC Sports Online: Drugs and Sport: Frequently Asked Questions on modafinil
		Modafinil, also known as provigil in the U.S., is a prescription drug that helps people who suffer from narcolepsy (a sleep disorder associated with uncontrollable sleepiness and frequent daytime sleeping) to stay awake during the day.
		Modafinil is a tablet that is taken orally and should only be taken as directed by a physician.
		The dose of modafinil varies for different patients, with adults, on average, being prescribed 200 milligram a day to be taken as a single dose in the morning.
	www.cbc.ca /sports/indepth/drugs/stories/modafinil_faq.html (668 words)

	Phase III Trials Demonstrate Modafinil Efficacy in ADHD
		Swanson said that modafinil significantly improved the inattention and hyperactivity/impulsivity ADHD-RS-IV subscales, the overall clinical condition as measured by the CGI-I, and the TOVA measurements of ADHD.
		Swanson acknowledged that modafinil’s mechanism of action in ADHD is unknown, but he proposed a possible mechanism in the context of the neuroanatomical network theory of attention.
		Modafinil was given once daily, starting at 85 mg/day and increasing for a period of seven or nine days to 340 mg for patients weighing less than 30 kg or 425 mg for patients weighing more than 30 kg.
	www.neuropsychiatryreviews.com /aug05/modafinil.html (1270 words)

	Modafinil Provides Non-Addicting Option For Narcolepsy (Site not responding. Last check: 2007-09-09)
		"Modafinil represents a significant advance in the treatment of narcolepsy and offers patients an excellent alternative to current treatments," said neurologist Paul Gross, MD, the study's corresponding author and neurology chairman at Lahey Clinic in Burlington, MA, and associate professor of neurology at Tufts University in Boston.
		Those receiving modafinil reported a slight increase in headache and nausea, but when compared to patients taking placebo the increase was not significantly higher.
		Women taking modafinil should discuss this with their physicians and may need to switch to higher dose birth control pills, he said.
	www.pslgroup.com /dg/18F17A.htm (547 words)

	CERTIFICATE OF MEDICAL NECESSITY ADDENDUM FOR PROVIGIL (MODAFINIL)
		Modafinil is the first medication in a new class of medications with a unique mechanism of action, categorized as tuberomammillary activators.
		Since modafinil is the only currently available tuberomammillary activator, it must be included in every formulary, and cannot be substituted for medications in a different and unrelated class of agents.
		Several studies that evaluated the use of modafinil for the treatment of EDS and fatigue in patients with PD are presented for your consideration.
	www.mentalhealthandillness.com /forms/pbmFormsAddendum.html (3514 words)

	Modafinil In Multiple Sclerosis Fatigue Abstracts - 2g5
		To assess whether Modafinil, a wakefulness-promoting agent, is useful for Fatigue in patients with Multiple Sclerosis (MS).
		Modafinil is a unique wake-promoting agent that is chemically distinct from traditional stimulants.
		Treatment with Modafinil significantly improves Fatigue and sleepiness and is well tolerated by patients with MS.
	members.tripod.com /~ThJuland/modafinil.html (699 words)

	modafinil research on sleep, narcolepsy, depression, and cerebral palsy (via CobWeb/3.1 planetlab2.isi.jhu.edu) (Site not responding. Last check: 2007-09-09)
		Modafinil did not produce peripheric side effects, disturb night sleep and it was never responsible for drug dependence.
		The official insert for the modafinil package remains unclear as to the precise drug contraindications, but as it is an alpha-adrenergic agonist, those drugs that represent alpha-adrenergic antagonists should be avoided.
		It is true that modafinil is more potent, "average" doses of adrafinil are in the region of 600 mg to 1200 mg daily, compared to modafinil's 200 mg to 400 mg daily and this is self evident by the respective tablet sizes.
	www.modafinil.org.cob-web.org:8888 (2403 words)

	Modafinil & Adrafinil - Research and Sources
		They concluded that modafinil "does not possess amphetamine-like subjective effects in a healthy population," and speculated that it probably has low abuse potential.
		Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of residual excessive daytime sleepiness in the sleep apnea/hypopnea syndrome, Kingshott RN, Vennelle M, Coleman EL, Engleman HM, Mackay TW, Douglas NJ Ann Neurol.
		Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat.
	www.modafinil-adrafinil.com (2223 words)

	modafinil Consumer Drug Information
		Modafinil may decrease the effects of hormonal methods of birth control including birth control pills and depot and implantable formulations (e.g., Norplant, Depo-Provera).
		Modafinil is used to improve wakefulness in patients with excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea/ hypoapnea syndrome (OSAHS), and shift work sleep disorder (SWSD).
		Modafinil is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby.
	www.drugs.com /MTM/modafinil.html (1429 words)

	Modafinil - Drugs & Vitamins - Drug Library - DrugDigest (Site not responding. Last check: 2007-09-09)
		MODAFINIL (Provigil®) is a medication that helps to promote alertness during daytime hours.
		Modafinil may affect your concentration, function, or may hide signs that you are tired.
		Because alcohol may interfere with your response to modafinil or your alertness, it is recommended that you avoid alcohol-containing beverages while on this medication.
	www.drugdigest.org /DD/DVH/Uses/0,3915,550410\|Modafinil,00.html (946 words)

	Medscape Search: modafinil
		A new formulation of modafinil (film-coated tablets) improves symptoms of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents, and is well tolerated, according to a report in the January Journal of Clinical Psychiatry.
		Modafinil (Provigil), a drug first developed for the treatment of narcolepsy, alleviates some of the fatigue that patients with fibromyalgia experience, according to a presentation today at the American Psychiatric Association's 2006 annual meeting in Toronto.
		Modafinil (Provigil), a wake-promoting agent approved for use in narcolepsy, does not appear to promote wakefulness in patients with Parkinson's disease-related excessive daytime somnolence, according to results of a 4-week double-blind, placebo-controlled study.
	search.medscape.com /uslclient/searchMedscape.do?queryText=modafinil (898 words)

	The Modafinil and Fatigue Trial - National Cancer Institute
		Research suggests that the drug modafinil, a stimulant, may be effective in relieving fatigue.
		This study is testing the ability of modafinil to reduce fatigue in cancer patients who are receiving chemotherapy.
		The modafinil trial seeks to enroll 837 cancer patients age 18 and older who are currently undergoing chemotherapy.
	www.cancer.gov /clinicaltrials/ft-URCC-U2901 (255 words)

	National MS Society \| Provigil (Modafinil)
		Modafinil is a wakefulness-promoting agent approved for the treatment of narcolepsy.
		Participants reported feeling least fatigued while taking a lower dose of modafinil, and there was a statistically significant difference in fatigue scores for the lower dose versus placebo.
		Since modafinil has not been approved by the FDA for use in multiple sclerosis, there are no precautions specific to MS-related uses of the drug.
	www.nationalmssociety.org /Meds-modafinil.asp (793 words)

	MedlinePlus Drug Information: Modafinil
		Modafinil is used to treat excessive sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours in people who work at night or on rotating shifts).
		Modafinil is also used along with breathing devices or other treatments to prevent excessive sleepiness caused by obstructive sleep apnea/hypopnea syndrome (OSAHS; a sleep disorder in which the patient briefly stops breathing or breathes shallowly many times during sleep and therefore doesn't get enough restful sleep).
		Some children who took modafinil had a decrease in the number of their white blood cells (a type of blood cell that fights infection).
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a602016.html (1184 words)

	Modafinil Drug Information, Professional
		Modafinil produces alterations in mood, perception, thinking, and feelings that are typical of other CNS stimulants and is reinforcing in primate self-administration tests of abuse potential
		Modafinil may decrease the effectiveness of steroidal contraceptives during concurrent use and for 1 month after discontinuation of modafinil, making pregnancy more likely unless alternate forms of contraception are employed
		Renal function impairment (severe) (although exposure to modafinil was unaffected, exposure to modafinil acid, a metabolite of modafinil, was increased ninefold in patients with creatinine clearance £ 20 mL per minute compared with patients with normal renal function; the safety of exposure to high concentrations of modafinil acid is unknown
	www.drugs.com /MMX/Modafinil.html (2530 words)

	Modafinil (Systemic) - MayoClinic.com
		Modafinil (moe-DAF-i-nil) is used to help people who have narcolepsy, obstructive sleep apnea/hyponea, or shift work sleep disorder to stay awake during the day.
		Although there is no specific information comparing use of modafinil in the elderly with use in other age groups, this medicine has been used in a few elderly patients and was not shown to cause different side effects or problems in older people than it does in younger adults.
		Modafinil may cause some people to feel dizzy, to have changes in thinking, to have difficulty controlling movements, or to have blurred vision.
	www.mayoclinic.com /health/drug-information/DR203466 (1662 words)

	NIDA - Publications - NIDA Notes - Vol. 20, No. 3 - Research Findings
		Modafinil, a medication currently used to treat narcolepsy, enhances levels of glutamate, a chemical that influences the activity of cells throughout the brain.
		Modafinil's modulation of glutamate transmission may account for a striking effect reported by patients: "The mechanism for this isn't clear, but some patients receiving modafinil told us that if they did use cocaine it did not produce the irresistible urge to use more, which they had always felt before," Dr. Dackis says.
		The study will evaluate modafinil's efficacy in doses of 200 mg and 400 mg per day in combination with CBT, and results may be available by mid-2006, Dr. Montoya says.
	www.nida.nih.gov /NIDA_notes/NNvol20N3/Modafinil.html (668 words)

	Modafinil and Sleep Deprivation
		Marketed in more than 20 countries, modafinil was first approved in the United States in 1998 for the treatment of patients with excessive daytime sleepiness associated with narcolepsy.
		Modafinil’s most common adverse events, which occur in 5% or less of patients, are headache, infection, nausea, nervousness, anxiety, and insomnia.
		Modafinil does produce psychoactive and euphoric effects and alterations in mood, perception, and thinking.
	mason.gmu.edu /~sprice/Modafinil.html (676 words)

	Modafinil definition - Medical Dictionary definitions of popular medical terms
		Modafinil: An oral drug first approved by the FDA in 1998 for the treatment of narcolepsy, a condition in which there is an uncontrollable desire to sleep.
		Modafinil is said to be in common "off-label" use by college students, truckers, and others who want to stay awake when normally they should be sleeping.
		Modafinil is believed to act by affecting dopamine and other neurotransmitters including histamine and norepinephrine.
	www.medterms.com /script/main/art.asp?articlekey=33722 (271 words)

	modafinil - [Medication]
		Use a second, nonhormonal form of birth control while taking modafinil, and for one month after stopping modafinil, if prevention of pregnancy is desired.
		Modafinil is used to improve wakefulness in patients with excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea/hypoapnea syndrome (OSAHS), and shift work sleep disorder (SWSD).
		Modafinil may reduce the signs of sleepiness, but may not completely treat this problem.
	www.peacehealth.org /kbase/multum/d04378a1.htm (1369 words)

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