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| | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other ... |
 | | mixing a second moiety with the first moiety, wherein the second moiety is selected from the group of proteins, peptides, lipoproteins, haptens, and carbohydrates, whereby the first moiety and the second moiety react to form the conjugate vaccine. |
 | | A method according to claim 1, wherein the first moiety is a polysaccharide, the method further including the step of carboxylating the polysaccharide before mixing in the uronium salt reagent and before mixing in the second moiety. |
 | | Also, in the method of the invention, a second moiety (e.g., a protein, a peptide, a hapten, a lipoprotein, a carbohydrate, an organic molecule, a spacer molecule, a solid phase material, a homobifunctional reagent, a heterobifunctional reagent, etc.) is mixed with the first moiety. |
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