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Topic: Molecular genetics

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In the News (Thu 25 Apr 19)

  Molecular genetics - Wikipedia, the free encyclopedia
It is so-called to differentiate it from other sub fields of genetics such as ecological genetics and population genetics.
An important area within molecular genetics is the use of molecular information to determine the patterns of descent, and therefore the correct scientific classification of organisms: this is called molecular systematics.
One of the first tools available to molecular geneticists is the forward genetic screen.
en.wikipedia.org /wiki/Molecular_genetics   (254 words)

 Howard University - National Human Genome Center   (Site not responding. Last check: 2007-10-07)
The molecular genetics research interests are in human population genetics, anthropological genetics, immunogenetics, and the genetics of complex diseases.
The research goals of the molecular genetics component are predicated upon the two broad hypotheses of population variation in DNA polymorphic markers used to map genes and the correlation of population-based variation in DNA polymorphic markers with disease.
The Molecular Genetics Laboratory in the National Human Genome Center is newly renovated and is located on the 6th floor of the Howard University Cancer Center.
www.genomecenter.howard.edu /units/molecular_gen   (2843 words)

 Molecular Genetics
Molecular genetics is the study of the agents that pass information from generation to generation.
The methods used by molecular geneticists to obtain and study DNA have been developed through keen observation and adaptation of the chemical reactions and biological processes that occur naturally in all cells.
Genetic susceptibilities have been implicated in many major disabling and fatal diseases including heart disease, stroke, diabetes, and several kinds of cancer.
www.ncbi.nlm.nih.gov /About/primer/genetics_molecular.html   (6301 words)

 Welcome to Working Retriever Central! The World Wide Website for Working Retrievers!
With the recent availability of molecular markers for the canine genome, and the ongoing work to develop a comprehensive canine genetic map, we are at the beginnings of a revolution in canine health care.
Genetic tests are not all sophisticated polymerase chain reaction (PCR) based assays.7 While some genetic tests identify the animals genotype (affected, carrier, or normal), others indicate the phenotype of the disorder.
Genetic diversity concerns are also compounded with the widespread use of frozen and fresh shipped semen, where individual males can have a profound input on a breed’s gene pool.
www.working-retriever.com /library/ana.html   (3351 words)

 [No title]
The Department of Molecular Genetics was established in 1987 with the mission to build the programmatic and methodological infrastructure of molecular biology within the Research Institute and to stimulate research on the structure, regulation and mechanisms of activity of viral and cellular genes.
Richard Padgett primarily focuses his studies on the molecular mechanisms of RNA splicing, including the chemistry of this process, identification of cellular factors involved in control of RNA splicing and evolution of splicing machinery.
The Department of Molecular Genetics Section on Virology is comprised of investigators who specialize in and recognize the paramount importance of investigating the molecular and immunological bases of the infectious processes of human viruses.
www.lerner.ccf.org /molecbio   (1094 words)

 Genetics and Molecular Genetics of the MHC
The purpose of this review is to highlight current trends in the genetics and molecular genetics of the MHC region in particular and its relevance to study of the human genome in general.
Landmark molecular studies, first by positional cloning of a candidate gene, followed by functional analysis, have clearly elucidated the molecular basis of the iron storage disease hereditary haemochromatosis, and the key role the Hfe molecule plays in the regulation of body iron status in humans.
The underlying molecular pathology is different in that common functional variants of particular genes (polymorphisms or "aetiological mutations" (117) which are neither necessary nor sufficient in themselves to account for disease, are present at increased frequency in patients.
www-immuno.path.cam.ac.uk /~immuno/mhc/mhc.html   (4648 words)

 David Ginsburg
Genetic deficiency of factor V results in a rare bleeding disorder called parahemophilia.
Factor V Leiden is remarkably common, (present in ~5 percent of the population) and may contribute to up to 50 percent of hospital admissions for blood clot–related illnesses.
We are studying genetically engineered mice deficient in LMAN1 in an effort to identify other proteins that, along with factors V and VIII, also depend on this unique intracellular pathway for their production.
www.hhmi.org /science/genetics/ginsburg.htm   (1291 words)

 Category:Molecular genetics - Wikipedia, the free encyclopedia
Molecular genetics is the field of biology which studies the structure and function of genes at a molecular level.
Molecular genetics employs the methods of genetics and molecular biology.
For more information, see the article about Molecular genetics.
en.wikipedia.org /wiki/Category:Molecular_genetics   (74 words)

 Plagiarized Errors and Molecular Genetics
In fact, the answer to this question appears to be "yes," since recent molecular genetics investigations have uncovered some examples of the same "errors" present in the genetic material of humans and apes.
When molecular geneticists examine the DNA of patients with such well-characterized diseases, they can almost always find the defective gene and identify the mutation that inactivated it, since it is rare for such genetic disease to be caused by a deletion that removes an entire gene.
Molecular geneticists who examine DNA sequences from an evolutionary perspective know that large gene deletions are rare, so scientists expected that non-functional mutant GLO gene copies--known as "pseudogenes"--might still be present in primates and guinea pigs as relics of the functional ancestral gene.
www.talkorigins.org /faqs/molgen   (16141 words)

 Eccles Institute of Human Genetics
Dedicated in 1990, the George and Dolores Eccles Institute of Human Genetics is the focal point for genetic research at the University of Utah.
Genetic Science Learning Center -- an outreach education program for high school and undergraduate students and teachers.
Human Molecular Biology and Genetics Program -- an interdepartmental effort to strengthen the interface between clinical application and basic genetic research.
www-genetics.med.utah.edu   (201 words)

 Human Molecular Genetics -- Instructions to Authors
Areas of interest include the molecular basis of human genetic disease, developmental genetics, neurogenetics, chromosome structure and function, molecular aspects of cancer genetics, gene therapy, biochemical genetics and advances in gene mapping and understanding of genome organization.
The molecular analysis of other organisms such as yeast, Drosophila, C.elegans or mouse is also of interest where such studies are relevant to the understanding of the function of human genes.
It is understood that by publishing a paper in Human Molecular Genetics, the authors agree to make available to colleagues in academic (non-profit) research any of the cells, nucleic acids, antibodies, etc. that are not available from commercial suppliers and are required to substantiate the scientific conclusions of the paper.
hmg.oxfordjournals.org /misc/ifora.dtl   (3000 words)

 Institute of Molecular Evolutionary Genetics
Molecular Evolutionary Biology is one of the options for specialization that are offered in the Biological Doctoral Program.
Molecular Evolutionary Biology option is concerned with the study of evolution at the molecular level to understand the mechanisms of evolution and to clarify the evolutionary history of genes or species at the molecular level.
It is a multidisciplinary science that integrates molecular biology, developmental biology, and population biology.
imeg.psu.edu   (389 words)

 Molecular Genetics Services
The Molecular Genetics Laboratory offers analysis of 14 CFTR mutations, identifying approximately 84% of the mutations associated with cystic fibrosis in the Caucasian population.
Molecular diagnostic testing for Gaucher disease complements the glucocerebrosidase activity assay and may be used, for example, to clarify the finding of intermediate GC activity or to guide the choice of therapeutic regimen.
Molecular diagnostic testing also is used for prenatal diagnosis and to detect carrier status.
path.upmc.edu /divisions/diagnostics/services/molgen.html   (862 words)

 The Daily Princetonian - Mapping the path of genetics
In addition to creating techniques for genetic mapping, he helped sequence the yeast genome and pioneered microarray technology, which allows scientists to assess the behavior of many genes at once.
It was only when he left college that he became interested in the burgeoning field of molecular genetics.
After pursuing a doctorate in human genetics at the University of Michigan, Botstein returned to the East Coast, where he rose through the ranks at MIT from lecturer to professor.
www.dailyprincetonian.com /archives/2005/10/18/news/13503.shtml   (1100 words)

 Oxford Journals | Life Sciences | Human Molecular Genetics | About the Journal
Human Molecular Genetics concentrates on full-length research papers covering a wide range of topics in all aspects of human molecular genetics.
With the enthusiastic support of the executive editors and editorial board, we intend to ensure that the journal's reputation for quality is reinforced in the years to come.
Human Molecular Genetics was launched in 1992 and so acquired its first impact factor in 1993.
www.oxfordjournals.org /hmg/about.html   (222 words)

 Molecular genetics of Alzheimer's disease
Genetic linkage of AD with marker D1S479 and a missense mutation causing substitution of asparagine by isoleucine at codon 141 (Asn141Ile) were identified in chromosome 1 of the Volga German families (Levy-Lahad et al., 1995b,c).
At the molecular level, changes in ChE and particularly in AChE in the AD brain are mainly due to loss of the predominant membrane-associated G4 molecular form (Atack et al., 1986; Fishman et al., 1986; Younkin et al., 1986).
Population genetics of apolipoprotein polymorphism in Papua New Guinea.
www.uku.fi /neuro/44the.htm   (18824 words)

 Welcome to the Human Genetics Di   (Site not responding. Last check: 2007-10-07)
The strengths of the Division lie in the diversity of expertise and ongoing research combined with well equipped laboratories, all of which permit comprehensive, integrated research in human genetics and molecular cell biology.
There is a wide diversity of interests in complex trait genetics and a substantial grouping in developmental genetics.
Interests in complex traits cover cardiovascular genetics, immunogenetics, asthma genetics, ophthalmic genetics, neurogenetics and genetics of ageing, theoretical epidemiology and bioinformatics, and developments in genotyping and mutation detection.
www.som.soton.ac.uk /research/geneticsdiv   (341 words)

 Molecular Genetics Program
olecular genetic research is fundamentally important to the field of medicine and to the elucidation of the basic mechanisms of biological systems.
The identification of the genetic basis of diseases has accelerated rapidly as a result of dramatic advances in molecular genetics and new discoveries will lead to innovative, effective treatments for many human genetic diseases.
The Molecular Genetics Program includes a broad range of molecular biologists from the faculty in each of the basic science departments and several of the clinical departments of the medical school.
www.wfubmc.edu /molecular_genetics   (225 words)

 Botany online: Molecular Genetics - Breakage and Fusion Bridges - Control Elements - Unstable Genes
The actual conformation of a DNA crossover was speculated to be a four-way-junction with separate DNA helices, or with stacked helices in either a parallel or an antiparallel orientation of the helices.
These genetic data fitted neatly with molecular biological models (B. NEVERS and H. DÖRING and P. Mrs BARBARA McCLINTOCK was awarded the Nobel prize for medicine and physiology for her pioneer achievements.
STARLINGER and his collaborators (Genetic Institute of the University of Cologne) isolated an insertion of more than 30,000 base pairs flanked by Ds elements on both ends out of mutants with a defect sucrose synthethase gene [the Sh- (shrunken) locus].
www.biologie.uni-hamburg.de /b-online/e21/21f.htm   (1864 words)

 Peninsula Medical School - Molecular Genetics
Close collaboration with the NHS diagnostic lab in the Royal Devon & Exeter laboratory and has led to the introduction of new diagnostic molecular genetic tests which are available worldwide.
Research has also looked at the interpretation of genetic information by patients and has led international thinking on how to develop genetic counselling and diagnostic genetic testing in monogenic diabetes.
Studying subjects with mutations is a crucial way of defining the function of the specific gene in man. We have shown the key role of glucokinase in fetal growth and the sensing of hypoglycaemia.
www.pms.ac.uk /pms/research/molecular_gene.php   (670 words)

 Amazon.com: Books: Genetics: A Molecular Perspective   (Site not responding. Last check: 2007-10-07)
He has taught the genetics course as well as the senior capstone seminar course in human and molecular genetics to undergraduate Biology majors for each of the last 33 years.
Michael R. Cummings is currently Associate Professor in the Department of Biological Sciences and in the Department of Molecular Genetics at the University of Illinois at Chicago.
Genetics: A Molecular Perspective is simply a rearrangement of the chapters in Essentials of Genetics to introduce the student to the concepts surrounding DNA replication and protein synthesis before venturing into the territory of Mendelian genetics and more traditional genetic studies.
www.amazon.com /exec/obidos/tg/detail/-/0130085308?v=glance   (1058 words)

 HMGC Homepage
As the Human and Molecular Genetics Center (HMGC) completes its fifth year of operation, it has met its initial goals for faculty recruitment, creation of technology platforms and recognized leadership in the field of molecular genetics.
The premier rat genetics and genomics meeting, Rat Genomics and Models, will be held at Cold Spring Harbor Laboratory December 8-11 and will feature a special session on Neuroscience.
RGD is the premier source of rat genetics and genomics data for the international research community as evidenced by the nearly 4.4 million
hmgc.mcw.edu   (234 words)

 Molecular Genetics Laboratory
Increased public awareness of the relationship between genetics and personal health has increased the demand for molecular genetic testing.
The utility of molecular genetic testing is apparent in many settings, such as prenatal and pre-implantation diagnosis, risk assessment for familial cancer and the diagnosis of many neurologic disorders.
The Molecular Genetics laboratory at Mayo provides expertise in DNA/molecular genetic testing for both congenital and inherited cancer syndromes.
www.mayoclinic.org /laboratorygenetics-rst/molecular.html   (151 words)

 An Introduction to the Genetics and Molecular Biology of the   (Site not responding. Last check: 2007-10-07)
An Introduction to the Genetics and Molecular Biology of the
The "awesome power of yeast genetics" has become legendary and is the envy of those who work with higher eukaryotes.
Furthermore, the ease of genetic manipulation of yeast allows its use for conveniently analyzing and functionally dissecting gene products from other eukaryotes.
dbb.urmc.rochester.edu /labs/sherman_f/yeast/index.html   (125 words)

 Molecular Genetics   (Site not responding. Last check: 2007-10-07)
Genetic dissection of complex behaviors in mice; Functional genomics.
These traits are being used to increase resolution of human genetics studies; at the same time, efforts are underway to identify single gene mutations affecting corresponding traits in the mouse.
We are currently identifying and characterizing behavioral mutations induced by ENU mutagenesis in the mouse.
www.uphs.upenn.edu /cnb/bucan.htm   (749 words)

 Amazon.com: Books: Human Molecular Genetics   (Site not responding. Last check: 2007-10-07)
Molecular genetics is primarily concerned with the interrelationship between the information macromolecules DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) and how these molecules are used to synthesize polypeptides, the basic component of all proteins.
Genetics: From Genes to Genomes by Leland Hartwell
Being a graduate student in human genetics I was looking long and hard for a comprehensive text on how and why experiment are done in the lab, and the scientific basis for these experiments.
www.amazon.com /exec/obidos/tg/detail/-/0471330612?v=glance   (1581 words)

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