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Topic: Monoamine oxidase

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	Monoamine Oxidase
		Monoamine oxidase A is located in the outer membrane of the mitochondria of neurons and initiates degradation of neurotransmitters of the catecholamine family - dopamine, adrenalin (= epinephrine) and noradrenalin (= norepinephrine).
		Monoamine oxidase A degrades the neurotransmitters norepinephrine and dopamine by converting the amine group into aldehyde group.
		The gene for monoamine oxidase A (MAO-A) is located on the X chromosome and individuals with deletions and point mutations are known.
	www.science.siu.edu /microbiology/micr302/MAO.html (403 words)

	monoamine oxidase inhibitor â“ Dictionary Definition of monoamine oxidase inhibitor \| Encyclopedia.com: FREE Online ...
		Any of a group of antidepressant drugs that inhibit the action of the intracellular enzyme monoamine oxidase in neurons of the central nervous system, thereby slowing the metabolism of neurotransmitters such as adrenalin (epinephrine), noradrenalin (norepinephrine), and dopamine and allowing their concentrations to increase at the synapses (1).
		Monoamine oxidase inhibitors (MAOIs) are the granddaddy of antidepressants...
		O-methylperlatolic acid, monoamine oxidase B inhibitors in a Brazilian plant...
	www.encyclopedia.com /doc/1O87-monoamineoxidaseinhibitor.html (1378 words)

	Monoamine oxidase inhibitor - Wikipedia, the free encyclopedia
		Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression.
		Monoamine oxidase inhibitors can be used to potentiate the effect of a number of hallucinogenic drugs, notably phenethylamines, tryptamines and several others.
		There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates serotonin, melatonin, adrenaline and noradrenaline.
	en.wikipedia.org /wiki/Monoamine_oxidase_inhibitor (1114 words)

	eMedicine - Toxicity, Monoamine Oxidase Inhibitor : Article by Soumya Ganapathy
		Monoamine oxidase is a mitochondrial enzyme that functions to deaminate primary and secondary aromatic amines.
		Monoamine oxidase inhibitors (MAOIs) are not typically prescribed to children; they are prescribed to adults in a household.
		Patients with monoamine oxidase inhibitor (MAOI) overdoses should be admitted to the hospital primarily because of the prolonged latent stage.
	www.emedicine.com /ped/topic2785.htm (2813 words)

	Drugs and the Brain: Antidepressants
		Subsequent studies demonstrated the ability of this drug to block the activity of monoamine oxidase, the enzyme that destroys the monoamine neurotransmitters (norepinephrine, serotonin and dopamine).
		The monoamine oxidase inhibitors and tricyclic antidpressants, although having different modes of action, have as their primary effect an increase in the activity of monoamines in the brain.
		Since antidepressant drugs increase the activity of monoamines, this hypothesis suggests that depression is primarily the result of a monoamine deficit.
	www.csusm.edu /DandB/AD.html (2007 words)

	Low Tyramine Diet for Use with Monoamine Oxidase Inhibitors
		Monoamine oxidase inhibitors are a class of drugs used to treat depression and, when ingested along with a high dietary intake of tyramine-containing foods, can cause constriction of blood vessels and elevation of blood pressure as a result of inhibited tyramine metabolism.
		Tyramine is normally deaminated by mono- and diamine oxidases in the liver and forms harmless metabolites.
		Monoamine oxidase inhibitors are most often prescribed for depression.
	gcrc.med.unc.edu /investigators/diet/diet_maoi.html (750 words)

	MAOIs - Monoamine oxidase inhibitors (MAOI)
		MAOI is an acronym for Monoamine Oxidase Inhibitor.
		Once the brain's three neurotransmitters, known as monoamines (serotonin, norepinephrine, and dopamine), have played their part in sending messages in the brain, they get burned up by a protein in the brain called monoamine oxidase, a liver and brain enzyme.
		Monoamine oxidase inhibitors, or MAOIs, are the oldest class of antidepressant medications.
	www.depression-guide.com /maoi.htm (682 words)

	Tyramine-Containing Foods
		Abstract: The concentration of p-tyramine in the rat striatum was increased significantly by intraperitoneal injection of phenelzine (5 or 100 mg/kg).
		Effect of moclobemide, a new reversible monoamine oxidase inhibitor, on absorption and pressor effect of tyramine.
		Abstract: Monoamine oxidase inhibitors (MAOIs) are attracting renewed attention as effective antidepressants for refractory depressions, particularly among the elderly.
	home.caregroup.org /clinical/altmed/interactions/Nutrients/Tyramine-Contai.htm (3014 words)

	MAO
		In the following study monoamine oxidase (type B) and diamine oxidase were found to be low in psoriasis patients while histamine was found to be high.
		Monoamine- and diamine oxidase activities were measured by a sensitive photometric assay in 25 psoriasis vulgaris patients.
		Serotonin metabolism and platelet monoamine oxidase activity in patients with medullary carcinoma of the thyroid and pheochromocytoma.
	www.ithyroid.com /mao_and_maoi.htm (3093 words)

	CNS Spectrums: Transdermal Selegiline: The New Generation of Monoamine Oxidase Inhibitors
		Monoamine oxidase inhibitors (MAOIs) are an important class of antidepressants that have been used for over 40 years.
		Iproniazid, an inhibitor of the enzyme monoamine oxidase (MAO), was originally synthesized as an antituberculosis agent and ushered in the era of antidepressant development.
		Monoamine oxidase activity and monoamine metabolism in braines of parkinsonian patients treated with l-deprenyl.
	www.cnsspectrums.com /aspx/articledetail.aspx?articleid=400 (5629 words)

	Monoamine oxidase inhibitors
		Monoamine oxidase inhibitors (MAOIs) are one of the oldest classes of antidepressants and are typically used when other antidepressants have not been effective.
		Monoamines are broken down by a chemical (enzyme), called monoamine oxidase.
		The reversible inhibitor of monoamine oxidase type A, moclobemide, is more likely to be used than these older MAOIs, because it is believed to cause fewer food and drug interaction problems.
	www.netdoctor.co.uk /diseases/depression/monoamineoxidaseinhibitors_000101.htm (951 words)

	Fast and Easy Luminescent Assay to Measuring Monoamine Oxidase
		The Mao-Glo™ Assay is a homogenous, luminescent assay that measures MAO A and MAO B activity from native and recombinant sources.
		Monoamine oxidase catalyze the oxidative deamination of biogenic and xenobiotic amines.
		Monoamine oxidase acts on the luminogenic MAO Substrate to produce methyl ester Luciferin, which is then converted into light by the esterase and luciferase in the reconstituted Luciferin Detection reagent.
	www.promega.com /uk/adme1/mao.htm (288 words)

	MAO Inhibitors General Statement (28:16.04.12) - 382904
		Because monoamine oxidase is widely distributed throughout the body, MAO inhibitor therapy can be expected to cause diverse pharmacologic effects.
		Monoamine oxidase, an enzyme found mainly in nerve tissue and in the liver and lungs, catalyzes the oxidative deamination of various amines, including epinephrine, norepinephrine, dopamine, and serotonin (5-HT).
		Attempts have been made to correlate inhibition of platelet monoamine oxidase (a possible index of a drug’s effect on brain monoamine oxidase) with therapeutic effect; preliminary evidence suggests that a dose-related effect of phenelzine on platelet monoamine oxidase correlates with a beneficial effect on mood in depressed patients.
	www.ashp.org /mngrphs/ahfs/a382904.htm (8201 words)

	Antidepressant Update
		Monoamine oxidase inhibitors (MAOIs) nonspecifically inhibit type A and type B monoamine oxidases to block the degradation of norepinephrine, serotonin, and dopamine.
		(1, 5) Monoamine oxidase is an intracellular enzyme located in the mitochondria that catalyzes the conversion of biogenic amines (ie, norepinephrine and serotonin) to their deaminated products.
		However, monoamine oxidase is also responsible for metabolizing compounds, such as tyramine, which are present in certain aged cheeses and other food substances.
	www.dr-bob.org /tips/antidepressants.html (5961 words)

	Monoamine oxidase inhibitor Summary
		Monoamine oxidase inhibitors (MAO inhibitors) are a type of antidepressant used to treat mental depression.
		Due to potentially serious dietary and drug interactions they are used less frequently than other classes of antidepressant drugs (for example tricyclic antidepressants and selective serotonin reuptake inhibitors).
		Reversible Inhibitor of Monoamine oxidase A (RIMA): {Brofaromine} {Moclobemide}
	www.bookrags.com /Monoamine_oxidase_inhibitor (1594 words)

	Mapping the Cerebral Monoamine Oxidase Type A: Positron Emission Tomography Characterization of the Reversible ...
		H]harman binding and monoamine oxidase subtypes A and B activity in Marmoset and rat.
		Westlund KN, Denney RM, Kochersperger LM, Rose RM and Abell CW (1985) Distinct monoamine oxidase A and B population in primate brain.
		Westlund KN, Denney RM, Rose RM and Abell CW (1988) Localization of distinct monoamine oxidase A and monoamine oxidase B cell population in human brainstem.
	jpet.aspetjournals.org /cgi/content/full/305/2/467 (4364 words)

	Scientists determine the structure of human Monoamine Oxidase B (MAO B)
		Scientists determine the structure of human Monoamine Oxidase B (MAO B) Scientists from Emory University School of Medicine and the University of Pavia, Italy, have determined for the first time the three-dimensional structure of monoamine oxidase B (MAO B) — an enzyme important in several major disease processes; particularly age-related neurological disorders.
		Monoamine oxidases (MAO B and MAO A) are well-known targets for antidepressant drugs and for drugs used to treat neurological disorders and diseases of aging, such as Parkinson’s disease and Alzheimers disease.
		MAO A and MAO B are attached to the outer membrane of the mitochondria — the energy powerhouses of cells and function to oxidize amine neurotransmitters such as dopamine and serotonin.
	www.eurekalert.org /pub_releases/2001-11/euhs-sdt_1112101.php (639 words)

	Virtual Hospital: Clinical Psychopharmacology Seminar : Monoamine Oxidase Inhibitors: Adverse Effects
		The therapeutic combination of monoamine oxidase inhibitors and tricyclic antidepressants is widely considered to be potentially lethal.
		Monoamine oxidase inhibitor hypertensive crisis headache and orthostatic hypotension [letter].
		Acute cardiovascular response to monoamine oxidase inhibitors: a prospective assessment.
	www.tu.edu /user_files/10/19.html (4628 words)

	Immunohistochemical Localization of Monoamine Oxidase Type B in Pancreatic Islets of the Rat -- Huang et al. 53 (9): ...
		Monoamine oxidase (MAO) is regarded as a mitochondrial enzyme.
		Immunohistochemical examination of monoamine oxidase type B (MAOB) localization in A cells and B cells of the rat pancreatic islet.
		Stenstrom A, Lundquist I (1990) Monoamine oxidase (MAO) A and B in pancreatic islets from the mouse.
	www.jhc.org /cgi/content/full/53/9/1149 (4107 words)

	Monoamine oxidase inhibitors (MAOIs) for depression - Information and Resources
		These medications balance certain brain chemicals called neurotransmitters by reducing the amount of monoamine oxidase, the substance that breaks down the neurotransmitters.
		Monoamine oxidase inhibitors (MAOIs) are usually given to people with depression who:
		Current research suggests that monoamine oxidase inhibitors may be less effective than other antidepressants (such as tricyclics) in treating severe depression but may be more effective than other antidepressants in those who have depression with uncommon symptoms such as sleeping and eating too much and being overly sensitive to rejection.
	www.kaiserpermanente.org /kpweb/healthency.do?hwid=hw29535 (508 words)

	Membrane Proteins of Known Structure
		Monoamine Oxidase B with bound Isatin: Human mitochondrial outer membrane (expressed in Pichia pastoris), 1.70 Å
		Monoamine Oxidase A with bound Clorglycine: Human mitochondrial outer membrane (expressed in Pichia pastoris), 3.00 Å
		Monoamine Oxidase B with bound Deprenyl, 2.20 Å: 2BYB
	blanco.biomol.uci.edu /Membrane_Proteins_xtal.html (939 words)

	Monoamine oxidase-B inhibition in the treatment of...[Pharmacotherapy. 2007] - PubMed Result
		Inhibitors of monoamine oxidase (MAO) with selectivity and specificity for MAO type B prolong the activity of both endogenously and exogenously derived dopamine, making them an option either as monotherapy in early Parkinson's disease or as adjunctive therapy in patients treated with levodopa who are experiencing motor complications.
		Recent advances in Parkinson's disease therapy: use of monoamine oxidase inhibitors.
		Community and long-term care management of Parkinson's disease in the elderly: focus on monoamine oxidase type B inhibitors.
	www.ncbi.nlm.nih.gov /pubmed/18041937?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum (399 words)

	Medical Dictionary: Monoamine oxidase inhibitor - WrongDiagnosis.com
		Monoamine oxidase inhibitor: any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate
		Monoamine oxidase inhibitor: A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines.
		The following list attempts to classify Monoamine oxidase inhibitor into categories where each line is subset of the next.
	www.wrongdiagnosis.com /medical/monoamine_oxidase_inhibitor.htm (257 words)

	Schizophrenia, Monoamine Oxidase Activity, and Cigarette Smoking
		Lower levels of monoamine oxidase activity were found in the smokers and this is the likely explanation for the low levels hypothesized as a marker for schizophrenia.
		Reduced monoamine oxidase activity (MAO) was reported in 1972 (Murphy and Wyatt 1972) in the blood platelets of schizophrenic patients and they later suggested that reduced MAO activity might be a genetic marker for vulnerability to schizophrenia (Wyatt et al.
		Recent studies have demonstrated that smoking is associated with reduced monoamine oxidase A and B activity (Oreland et al.
	www.nature.com /cgi-taf/dynapage.taf?file=/npp/journal/v20/n4/full/1395302a.html (1466 words)

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