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Topic: Monoamine transporter

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	Serotonin - Wikipedia, the free encyclopedia
		NCCC1=CNC2=C1C=C(O)C=C2 Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesised in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract.
		This is through the specific monoamine transporter for 5-HT, 5-HT reuptake transporter, on the presynaptic neuron.
		The effects of MDMA, which may in fact be the effects of the 5-HT which floods synapses during an MDMA "roll," include feelings of well-being, comfort, tactile sensitivity, and, at very high doses, feelings of emotional empathy or entactogenesis.
	en.wikipedia.org /wiki/Serotonin (804 words)

	Monoamine transporter -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-19)
		There are several different (A molecule containing one amine group (especially one that is a neurotransmitter)) monoamine transporters.
		The (A monoamine neurotransmitter found in the brain and essential for the normal functioning of the central nervous system; as a drug (trade names Dopastat and Intropin) it is used to treat shock and hypotension) dopamine transporter, (An audiotape recording of sound) DAT.
		Modern antidepressants typically work by enhancing serotonergic or noradrenergic (Click link for more info and facts about neurotransmission) neurotransmission by binding to the SERT or NET, and thereby inhibiting reuptake of serotonin and/or norepinephrine and raising active levels in the (The junction between two neurons (axon-to-dendrite) or between a neuron and a muscle) synapse.
	www.absoluteastronomy.com /encyclopedia/m/mo/monoamine_transporter.htm (284 words)

	MUSC Neurosciences (Site not responding. Last check: 2007-10-19)
		Thus, the monoamine transporters are the primary high affinity targets for cocaine in the brain and drug-induced changes in transporter kinetics and number will strongly influence the effects of subsequent drug administration.
		While changes in monoamine transporter mRNAs, and binding sites have been implicated in chronic cocaine administration, there are no studies investigating relevant alterations in transporter function, regulation and cell surface expression in presynaptic terminals that are associated with cocaine self-administration, extinction and reinstatement.
		To accomplish this a number of dependent variables related to transporter function will be quantified, including 1) expression, transport activity, surface distribution, 2) phosphorylation state of transporters, transporter protein-protein association and 3) the degree to which the monoamine transporters are regulated by presynaptic auto- and hetero-receptors.
	neuroscience.musc.edu /research/narc/projects/ramamoorthy_project.html (290 words)

	Identified neurons in C. elegans coexpress vesicular transporters for acetylcholine and monoamines -- Duerr et al. 280 ...
		Identified neurons in C. elegans coexpress vesicular transporters for acetylcholine and monoamines -- Duerr et al.
		elegans coexpress vesicular transporters for acetylcholine and monoamines
		The distributions of the vesicular acetylcholine transporter and
	ajpcell.physiology.org /cgi/content/abstract/280/6/C1616 (223 words)

	Identified neurons in C. elegans coexpress vesicular transporters for acetylcholine and monoamines -- Duerr et al. 280 ...
		Erickson, JD, Eiden LE, Schafer MK, and Weihe E. Reserpine- and tetrabenazine-sensitive transport of (3)H-histamine by the neuronal isoform of the vesicular monoamine transporter.
		Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus.
		The vesicular monoamine transporter 2 is present in small synaptic vesicles and preferentially localizes to large dense core vesicles in rat solitary tract nuclei.
	ajpcell.physiology.org /cgi/content/full/280/6/C1616 (3635 words)

	Untitled Document
		The biogenic monoamine transporters are the primary mechanism for clearance of their respective neurotransmitter from the extracellular space and serve as important regulators of signal amplitude and duration at synapses.
		These drugs either block transport of substrates as is the case for SSRIs and cocaine, or are carrier substrates, such as amphetamines, which both inhibit uptake and stimulate efflux of intracellular neurotransmitter.
		One mechanism for acute presynaptic regulation of dopamine transport is modulation of transporter number through the trafficking of carriers to and from the cell surface.
	www.neurobio.pitt.edu /faculty/mortensen.htm (587 words)

	REHAVI, MOSHE, Ph (Site not responding. Last check: 2007-10-19)
		The role of the presynaptic dopamine transporter in the pathophysiology and pharmacotherapy of schizophrenia and Parkinson’s Disease is unclear.
		The pharmacodynamic properties of the vesicular monoamine transporter studied in synaptic vesicles isolated from rat brain using binding and uptake techniques.
		The mRNA levels of the brain vesicular monoamine transporter in discrete brain regions are studied by in situ hybridization.
	www.tau.ac.il /medicine/Med_school/Physiology/ResearchDir/Rehavi.htm (502 words)

	Expression of the Two Isoforms of the Vesicular Monoamine Transporter (VMAT1 and VMAT2) in the Endocrine Pancreas and ...
		Monoamine storage mediated by VMAT1 in EC cells is apparently maintained in EC cell tumors.
		Eiden LE, Schutz B, Anlauf M, Depboylu C, Schafer MKH, Weihe E (2002) The vesicular monoamine transporters (VMATs): role in the chemical coding of neuronal transmission and monoamine storage in amine-handling immune and inflammatory cells.
		Weihe E, Schäfer MKH, Erickson JD, Eiden LE (1994) Localization of vesicular monoamine transporter isoforms (VMAT1 and VMAT2) to endocrine cells and neurons in rat.
	www.jhc.org /cgi/content/full/51/8/1027 (4494 words)

	VMAT, AChT, NET, Proline, SERT, Tau transporters
		Vesicular monoamine transporters (VMATs) catalyze transport and storage of monoamines, serotonin, dopamine, norepinephrine, epinephrine, and histamine.
		In contrast to the plasma membrane transporters for dopamine, norepinephrine, and 5-HT which show relative substrate specificity, the monoamine transporter recognizes various monoamine with similar affinity.
		It was therefore speculated that either similar or identical transporters mediate the monoamine transport in all the tissues.
	www.4adi.com /flr/vmat.html (502 words)

	Center Stage for the Serotonin Transporter: A Gain-of-Function Polymorphism in Persons with Obsessive-Compulsive ...
		Gainetdinov RR and Caron MG (2003) Monoamine transporters: from genes to behavior.
		Hastrup H, Karlin A, and Javitch JA (2001) Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment.
		Kilic F and Rudnick G (2000) Oligomerization of serotonin transporter and its functional consequences.
	molpharm.aspetjournals.org /cgi/content/full/64/2/196 (1571 words)

	NEUROSCIENCE : R.Edwards complete publications (Site not responding. Last check: 2007-10-19)
		Merickel, A. and Edwards, R.H. Transport of histamine by vesicular monoamine transporter-2.
		Sievert, M.K., Thiriot, D.S., Edwards, R.H., Ruoho, A.E. High-efficiency expression and characterization of the synaptic-vesicle monoamine transporter from baculovirus-infected insect cells.
		Liu, Y. and Edwards, R.H. The role of vesicular transport proteins in synaptic transmission and neural degeneration.
	www.ucsf.edu /neurosc/faculty/neuro_edwards_pub.html (2060 words)

	Phosphorylation of a Vesicular Monoamine Transporter by Casein Kinase II -- Krantz et al. 272 (10): 6752 -- Journal of ...
		Phosphorylation of a Vesicular Monoamine Transporter by Casein Kinase II -- Krantz et al.
		Phosphorylation of a Vesicular Monoamine Transporter by Casein Kinase II
		Transport assays were performed essentially as described (13) with minor modifications.
	www.jbc.org /cgi/content/full/272/10/6752 (5838 words)

	cars.ca - Auto Transporters (Site not responding. Last check: 2007-10-19)
		A Economy Auto Transporters, Inc is the name to trust when it comes to auto transport.
		We are fully licensed to transport vehicles to and from anywhere in the United States.
		Even as the ban on the burning of stubble in the fields has come into effect, Agricultural Department officials, who are given the responsibility of checking the practice, are still unaware of the powers under which they...
	www.cars.ca /Auto-Transporters/reference/search (278 words)

	The Antidepressant-Sensitive Dopamine Transporter in Drosophila melanogaster: A Primordial Carrier for Catecholamines ...
		transport of 5-HT, indicating that 5-HT is not a substrate for
		The vertebrate catecholamine transporters (NET, DAT and fET) and the serotonin transporters (including dSERT) were grouped in two separate branches of the phylogenetic tree.
		Ritz MC, Lamb RJ, Goldberg SR and Kuhar MJ (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine.
	molpharm.aspetjournals.org /cgi/content/full/59/1/83 (7864 words)

	Mice with Very Low Expression of the Vesicular Monoamine Transporter 2 Gene Survive into Adulthood: Potential Mouse ...
		Dopamine, noradrenaline, and serotonin, as well as their main metabolites, DOPAC, HVA, and 5-HIAA, were measured in perchloric acid extracts prepared from brain areas of 13 wild-type, 17 heterozygous, and 6 homozygous mice using HPLC with electrochemical detection (12).
		Murine vesicular monoamine transporter 2: molecular cloning and genomic structure.
		Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine.
	mcb.asm.org /cgi/content/full/21/16/5321 (5826 words)

	British Journal of Pharmacology - Abstract of article: Activation of the extraneuronal monoamine transporter (EMT) from ...
		The extraneuronal monoamine transporter from rat (EMTr) was heterologously expressed by stable transfection in human embryonic kidney 293 cells and characterized in radiotracer experiments.
		Since the extent of activation depends markedly on the chemical structure of the monitored substrate, involvement of a receptor-mediated signalling pathway or recruitment of transporter reserve are implausible.
		We speculate that activation may serve to keep the transporter working for specific substrates in the face of inhibitors.
	www.nature.com /bjp/journal/v137/n6/abs/0704926a.html (313 words)

	The Vesicular Monoamine Transporter 2 (VMAT2) Is Expressed by Normal and Tumor Cutaneous Mast Cells and Langerhans ...
		Eiden LE, Schütz B, Anlauf M, Depboylu C, Schafer MKH, Weihe E (2002) The vesicular monoamine transporters (VMATs): role in the chemical coding of neuronal transmission and monoamine storage in amine-handling immune and inflammatory cells.
		Eissele R, Anlauf M, Schafer MK, Eiden LE, Arnold R, Weihe E (1999) Expression of vesicular monoamine transporters in endocrine hyperplasia and endocrine tumors of the oxyntic stomach.
		Weihe E, Schäfer MKH, Erickson JD, Eiden LE (1994) Localization of vesicular monoamine transporter isoforms (VMAT1 and VMAT2) to neuroendocrine cells and neurons in rat.
	www.jhc.org /cgi/content/full/52/6/779 (4455 words)

	Gastrin Induces Expression and Promoter Activity of the Vesicular Monoamine Transporter Subtype 2 -- Gerhard et al. 142 ...
		1994 Biochemistry and molecular biology of the vesicular monoamine transporter from chromaffin granules.
		Nirenberg MJ, Liu Y, Peter D, Edwards RH, Pickel VM 1995 The vesicular monoamine transporter 2 is present in small synaptic vesicles and preferentially localizes to large dense core vesicles in rat solitary tract nuclei.
		H-histamine by the neuronal isoform of the vesicular monoamine transporter.
	endo.endojournals.org /cgi/content/full/142/8/3663 (4825 words)

	Toward a Rapidly Acting Antidepressant: The Normetanephrine and Extraneuronal Monoamine Transporter (Uptake 2) ...
		Toward a Rapidly Acting Antidepressant: The Normetanephrine and Extraneuronal Monoamine Transporter (Uptake 2) Hypothesis -- Schildkraut and Mooney 161 (5): 909 -- American Journal of Psychiatry
		Toward a Rapidly Acting Antidepressant: The Normetanephrine and Extraneuronal Monoamine Transporter (Uptake 2) Hypothesis
		inhibit the extraneuronal monoamine transporter, uptake 2, in
	ajp.psychiatryonline.org /cgi/content/abstract/161/5/909 (190 words)

	In vivo imaging of the vesicular acetylcholine transporter and the vesicular monoamine transporter -- EFANGE 14 (15): ...
		In vivo imaging of the vesicular acetylcholine transporter and the vesicular monoamine transporter -- EFANGE 14 (15): 2401 -- The FASEB Journal
		In vivo imaging of the vesicular acetylcholine transporter and the vesicular monoamine transporter
		and the neuronal vesicular monoamine transporter (VMAT2) as
	www.fasebj.org /cgi/content/abstract/14/15/2401 (310 words)

	The Vesicular Monoamine Transporter 2 (VMAT2) Is Expressed by Normal and Tumor Cutaneous Mast Cells and Langerhans ...
		The Vesicular Monoamine Transporter 2 (VMAT2) Is Expressed by Normal and Tumor Cutaneous Mast Cells and Langerhans Cells of the Skin but Is Absent from Langerhans Cell Histiocytosis -- Anlauf et al.
		The Vesicular Monoamine Transporter 2 (VMAT2) Is Expressed by Normal and Tumor Cutaneous Mast Cells and Langerhans Cells of the Skin but Is Absent from Langerhans Cell Histiocytosis
		Monoamine storage in secretory granules is mediated by the vesicular
	www.jhc.org /cgi/content/abstract/52/6/779 (268 words)

	The heterotrimeric G protein Go2 regulates catecholamine uptake by secretory vesicles -- Ahnert-Hilger et al. 17 (2): ... (Site not responding. Last check: 2007-10-19)
		In the present study, we have demonstrated that the monoamine transporter of secretory granules is regulated by the
		monoamines in the cytoplasm and rapidly to refill secretory vesicles
		and regulation of the bovine vesicular monoamine transporter gene.
	embojournal.npgjournals.com /cgi/content/full/17/2/406 (4349 words)

	Pharmacological and Physiological Functions of the Polyspecific Organic Cation Transporters: OCT1, 2, and 3 (SLC22A1-3) ...
		Eisenhofer G (2001) The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines.
		Gründemann D, Hahne C, Berkels R, and Schömig E (2003) Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).
		Mooslehner KA and Allen ND (1999) Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from an enhancer-trap transgene integration locus.
	www.jpet.org /cgi/content/full/308/1/2 (5182 words)

	Synaptic Vesicle Transporter Expression Regulates Vesicle Phenotype and Quantal Size -- Pothos et al. 20 (19): 7297 -- ...
		Krantz DE, Peter D, Liu Y, Edwards RH (1997) Phosphorylation of a vesicular monoamine transporter by casein kinase II.
		Travis ER, Wang YM, Michael DJ, Caron MG, Wightman RM (2000) Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice.
		Wang YM, Gainetdinov RR, Fumagalli F, Xu F, Jones SR, Bock CB, Miller GW, Wightman RM, Caron MG (1997) Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine.
	www.jneurosci.org /cgi/content/full/20/19/7297 (7815 words)

	Loss of Striatal Vesicular Monoamine Transporter Protein (VMAT2) in Human Cocaine Users -- Little et al. 160 (1): 47 -- ...
		Wilson JM, Kish SJ: The vesicular monoamine transporter, in contrast to the dopamine transporter, is not altered by chronic cocaine self-administration in the rat.
		Beskow K, Gottfries CG, Roos BE, Winblad B: Determination of monoamine and monoamine metabolites in the human brain: postmortem studies in a group of suicides and in a control group.
		Kilbourn MR, Kuszpit K, Sherman P: Rapid and differential losses of in vivo dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) radioligand binding in MPTP-treated mice.
	ajp.psychiatryonline.org /cgi/content/full/160/1/47 (3896 words)

	In vivo imaging of the vesicular acetylcholine transporter and the vesicular monoamine transporter -- EFANGE 14 (15): ...
		Henry, J.-P., Scherman, D. (1989) Radioligands of the vesicular monoamine transporter and their use as markers of monoamine storage vesicles.
		H]dihydrotetrabenazine to the vesicular monoamine transporter of rat brain: bolus vs equilibrium studies.
		Wilson, J. M., Kish, S. (1996) The vesicular monoamine transporter, in contrast to the dopamine transporter is not altered by chronic cocaine self-administration in the rat.
	www.fasebj.org /cgi/content/full/14/15/2401 (6885 words)

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