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| | RAIS: 1,1-Dichloroethylene (75-35-4) |
 | | The main biotransformation pathway in the rat most likely involves conjugation with glutathione (GHS), either with the epoxide or following rearrangement of the epoxide to chloroacetylchloride, with subsequent hydrolysis to monochloroacetic acid (ATSDR, 1993). |
 | | Major urinary metabolites of 1,1-dichloroethylene identified in rats are thiodihydroxyacetic acid and N-acetyl-S-cysteinylacetyl derivatives. |
 | | Additional metabolites identified are chloroacetic acid, dithiohydroxyacetic acid (dithioglycolic acid), thiohydroxyacetic acid (thioglycolic acid), and methylthioacetylamino-ethanol. |
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