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Topic: Monoclonal

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	Monoclonal Antibody
		Monoclonal antibodies are excellent as the primary antibody in an assay due to their great specificity.
		Monoclonals recognize only one epitope of the antigen and are highly specific to that particular antigen, and thus will usually give substantially less background staining than polyclonal antibodies.
		Monoclonal antibodies (mAb) are a single type of antibody that are identical and are directed against a specific epitope (antigen, antigenic determinant) and are produced by B-cell clones of a single parent or a single hybridoma cell line.
	www.antibodystation.com /monoclonal-antibody (423 words)

	Monoclonal Antibody Technology - The Basics
		Monoclonal antibody technology allows us to produce large amounts of pure antibodies in the following way: We can obtain cells that produce antibodies naturally; we also have available a class of cells that can grow continually in cell culture.
		These antibodies are called monoclonal because they come from only one type of cell, the hybridoma cell; antibodies produced by conventional methods, on the other hand, are derived from preparations containing many kinds of cells, and hence are called polyclonal.
		Monoclonal antibodies attack the target molecule and only the target molecule, with no or greatly diminished side effects.
	www.accessexcellence.org /AB/IE/Monoclonal_Antibody.html (586 words)

	Monoclonal Antibodies
		Monoclonal antibodies are widely used as diagnostic and research reagents.
		This is a monoclonal antibody against the CD20 molecule on B cells (and lymphomas) conjugated to either
		a monoclonal antibody that binds CD33, a cell-surface molecule expressed by the cancerous cells in acute myelogenous leukemia (AML) but not found on the normal stem cells needed to repopulate the bone marrow.
	users.rcn.com /jkimball.ma.ultranet/BiologyPages/M/Monoclonals.html (1628 words)

	Korean J Parasitol
		The aim of this study was to analyze C. sinensis antigens recognized by monoclonal antibodies, and to set up ELISA-inhibition test using C. sinensis specific monoclonal antibodies for improved specificity of immunodiagnostic tests.
		The antigenic determinant recognized by CsHyb 0714-20 monoclonal antibody was revealed to be located at the surface and parenchyme of a parasite by indirect immunofluorescent antibody technique, and those reacted with CsHyb 0605-10, CsHyb 0714-25 monoclonal antibodies were found at the parenchyme and intestine.
		Four antigenic determinants recognized by specific monoclonal antibodies were all found to be present in the early eluted fractions of C. sinensis antigens separated by Sephadex G-200 gel filtration.
	www.parasitol.or.kr /kjp/1991/abstracts/293.html (382 words)

	Conjugation of monoclonal antibodies
		In this series of web pages, protocols, notes, and various illustrations are given to aid in the conjugation of proteins--principally monoclonal antibodies--to fluorescent dyes.
		These conjugation procedures are commonly performed in our laboratory--we have conjugated several hundred different monoclonals using almost all of the various dyes listed.
		The procedures are relatively straightforward and require only minimal familiarity with standard laboratory techniques (gel filtration and spectrophotometry are the most difficult!).
	rd.business.com /index.asp?epm=s.1&bdcq=monoclonal&bdcr=2&bdcu=http://www.drmr.com/abcon/&bdcp=&partner=2662601&bdcs=nwuuid-2662601-BE3F28AA-CFA0-0E09-2A98-329FC3D0BEDD-ym (633 words)

	Clinical Trial: Radiolabeled Monoclonal Antibody, Cyclophosphamide, and Total Body Irradiation Followed By Donor Stem ...
		Donor stem cell transplantation may be able to replace immune cells that were destroyed by radiolabeled monoclonal antibody therapy, chemotherapy and radiation therapy.
		PURPOSE: Phase II trial to study the effectiveness of combining radiolabeled monoclonal antibody with cyclophosphamide and total-body irradiation followed by donor stem cell transplantation in treating patients who have advanced acute myeloid leukemia.
		Determine the efficacy, in terms of overall survival and disease-free survival, and toxicity of cyclophosphamide and total body irradiation in patients with acute myeloid leukemia beyond first remission receiving HLA-matched related or unrelated hematopoietic stem cell transplantation.
	www.clinicaltrials.gov /ct/show/NCT00003868 (670 words)

	Treatment and monoclonal gammopathy research at Mayo Clinic
		Monoclonal gammopathy of undetermined significance is often identified as a result of routine blood tests, or medical care related to another problem.
		A monoclonal gammopathy indicates the presence of abnormal levels of a protein in the blood.
		Monoclonal gammopathy can occur in both sexes and in people of all backgrounds and occupations.
	www.mayoclinic.org /monoclonal-gammopathy (414 words)

	Antibody
		Antibody Station provides you with vendor information, sources of custom antibody synthesis services, contract antibody information, antibody protocols, monoclonal and polyclonal antibody suppliers, information on antibodies and B-Cells, news on antibody research, recently published research, and antibody techniques forum.
		Antibody microarrays permit the analysis of the expression of thousands of proteins at a time.
		We provide the information you need to learn about these antibodies, and find custom monoclonal antibody services.
	www.antibodystation.com (80 words)

	Datamonitor - Monoclonal Antibodies in Asthma: The choice between life and breath? - Market Analysis Report (Site not responding. Last check: )
		Xolair is set to dominate the respiratory monoclonal antibody market through to 2010, and data from the TENOR study may help Genentech and Novartis to further increase market penetration if a role for IgE in non-atopic asthma is identified.
		Th2 mediators are the target of most respiratory monoclonal antibody programs, of which IL-13 is generating the greatest interest, with one third of programs targeting this mediator.
		Although there is a significant unmet need among severe asthma patients who are non-responsive to corticosteroids, the price point of respiratory monoclonal antibodies will limit penetration in cost-conscious Europe, transforming the US into the dominant revenue-creation market.
	www.datamonitor.com /~43e2d1aa906c4ab59502625d927202a1~/industries/research/?pid=BFHC0719 (310 words)

	Clinical Trial: Monoclonal Antibody Therapy in Treating Patients With T-Cell Large Granular Lymphocyte Leukemia
		PURPOSE: This phase I trial is studying the side effects and best dose of a monoclonal antibody in treating patients with T-cell large granular lymphocyte leukemia.
		Determine the adverse effects, dose-limiting toxicity, and maximum tolerated dose of humanized monoclonal antibody MiK-beta-1 in patients with T-cell large granular lymphocyte leukemia.
		Cohorts of 3-6 patients receive escalating doses of humanized monoclonal antibody MiK-beta-1 until the maximum tolerated dose (MTD) is determined.
	www.clinicaltrials.gov /ct/show/NCT00079196?order=17 (729 words)

	Lymphoma Information Network - Monoclonal Antibodies
		Monoclonal antibodies (MABs or MOABs) work on cancer cells in the same way natural antibodies work, by identifying and binding to the target cells.
		In this case, the monoclonal antibodies contain a radioactive substance such as radioactive iodine that targets and destroys the cancer cells.
		They may help destroy any cancer cells in a patient's bone marrow before an autologous bone marrow transplant - a procedure in which bone marrow is removed from a patient, stored, and later given back to the patient after high-dose chemotherapy and/or radiation therapy.
	www.lymphomainfo.net /therapy/immunotherapy/mab.html (733 words)

	Clinical Trial: Iodine I 131 Monoclonal Antibody BC8, Fludarabine, Total-Body Irradiation, and Donor Stem Cell ...
		Giving a radiolabeled monoclonal antibody together with donor stem cell transplant, cyclosporine, and mycophenolate mofetil may be an effective treatment for advanced acute myeloid leukemia or myelodysplastic syndromes.
		Determine the maximum tolerated dose and toxicity of iodine I 131 monoclonal antibody BC8 (^131I MOAB BC8) when administered with fludarabine and low-dose total body irradiation followed by allogeneic peripheral blood stem cell transplantation and immunosuppression comprising cyclosporine and mycophenolate mofetil in patients with advanced acute myeloid leukemia or high-risk myelodysplastic syndromes.
		OUTLINE: This is a dose-escalation study of therapeutic dose iodine I 131 monoclonal antibody BC8 (^131I MOAB BC8).
	www.clinicaltrials.gov /ct/show/NCT00119366?order=1 (1008 words)

	Clinical Trial: Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With ...
		Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
		It is not yet known if chemotherapy is more effective with or without monoclonal antibody therapy for acute myelogenous leukemia.
		PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without monoclonal antibody therapy in treating patients who have refractory or relapsed acute myelogenous leukemia.
	www.clinicaltrials.gov /ct/show/NCT00006045?order=9 (1204 words)

	Monoclonal antibody production
		We also offer customized monoclonal antibody production and purification services, at up to Gram scale.
		Besides polyclonal antibodies it also provides (not limited to) monoclonal antibodies, customized monoclonal antibody production, custom peptide synthesis, various anti-chicken immunoglobulins and custom antibody affinity purification.
		Its chicken antibody purification kit is cheaper than other kits on the market, while obtaining a higher yield per egg yolk.
	www.gallusimmunotech.com /monoclonals/monoclonal-antibody-production.htm (335 words)

	Google Search
		BIOSCOT Blood typing monoclonal antibodies Millipore (formerly Celliance) offers its BIOSCOT® monoclonal antibodies in various forms from standarized...
		BIOSCOT Blood typing monoclonal antibodies Millipore offers a wide range of BIOSCOT finished reagents compliant with the requirements of the European Directive...
		Title: Fluorescent EIA Screening of Monoclonal Antibodies to Cell Surface Antigens.
	www.millipore.com /search.nsf/results?open&filter=0&access=p&getfields=*&output=xml_no_dtd&sort=date%3AD%3AL%3Ad1&sort=date%3AD%3AS%3Ad1&ie=UTF-8&oe=utf-8&client=default_frontend&q=monoclonal+antibodies&ip=192.168.233.30&requiredfields=Content-Language%3Aen&queryLang=en&start=500 (193 words)

	Anogen Monoclonal Antibodies
		Monoclonal Antibody Products to Cytokines and Growth Factors A-H
		Monoclonal Antibody Products to Cancer Antigens and H
		Monoclonal Antibody Products to Infectious Diseases and Agents
	www.anogen.ca /antibodies_mono.htm (98 words)

	Google Search
		capacity can be determined using either partially purified monoclonal antibody (MAb...
		Capacity chromatography media with v Protein A is ideally suited as the capture step in the purification of monoclonal, polyclonal and engineered antibodies.
		With the mouse antibody no longer available, the mouse monoclonal IgG1 capacity...
	www.millipore.com /search.nsf/results?open&filter=0&access=p&getfields=*&output=xml_no_dtd&sort=date%3AD%3AL%3Ad1&sort=date%3AD%3AS%3Ad1&ie=UTF-8&oe=utf-8&client=default_frontend&q=monoclonal+antibodies&ip=192.168.233.30&requiredfields=Content-Language%3Aen&queryLang=en&start=30 (205 words)

	Millipore - Applications Bibliography - A simple method of cDNA cloning for variable regions of monoclonal antibody
		A simple method of cDNA cloning for variable regions of monoclonal antibody
		cDNA cloning was evaluated for variable regions of monoclonal antibodies.
		Amino acid micro-sequencing with PVDF membrane (Immobilon-P) and reverse transcriptase-PCR were employed.
	www.millipore.com /bibliography.nsf/docs/imm96 (112 words)

	Sloan-Kettering - Neuroblastoma: 3F8 Monoclonal Antibody Therapy Q & A
		3F8 is the name of a substance called a monoclonal antibody.
		It attaches to GD2, which is a marker on the surface of neuroblastoma cells.
		This means that 3F8 looks different from a human antibody, and a human will form antibodies (HAMA) against 3F8.
	www.mskcc.org /mskcc/html/3215.cfm (1215 words)

	Clinical Trial: Treatment of the Human Anti-TNF Monoclonal Antibody Adalimumab in Moderate to Severe Crohn's Disease ...
		Treatment of the Human Anti-TNF Monoclonal Antibody Adalimumab in Moderate to Severe Crohn's Disease With Previous Exposure to Infliximab (CHOICE)
		The primary objective of this study is to make adalimumab available to patients suffering from moderately to severely active Crohn’s Disease who have failed to respond to, lost response to, or are intolerant to infliximab, and to evaluate safety
		Official Title: A Multi-Center, Open-Label Treatment Protocol of the Human Anti-TNF Monoclonal Antibody Adalimumab in Patients With Moderate to Severe Crohn's Disease With Previous Exposure to Infliximab
	www.clinicaltrials.gov /show/NCT00338650 (226 words)

	Clinical Trial: Isotretinoin With or Without Monoclonal Antibody, Interleukin-2, and Sargramostim Following Stem Cell ...
		It is not yet known if chemotherapy is more effective with or without monoclonal antibody therapy, interleukin-2, and sargramostim following stem cell transplantation in treating neuroblastoma.
		PURPOSE: Randomized phase III trial to compare the effectiveness of chemotherapy with or without monoclonal antibody, interleukin-2, and sargramostim following stem cell transplantation in treating patients who have neuroblastoma.
		Compare the event-free survival of patients with neuroblastoma who have completed myeloablative therapy and autologous stem cell transplantation (ASCT) when treated with adjuvant isotretinoin with or without monoclonal antibody Ch14.18, interleukin-2, and sargramostim (GM-CSF).
	www.clinicaltrials.gov /ct/show/NCT00026312?order=40 (3234 words)

	Clinical Trial: Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Older Patients With ...
		Monoclonal antibodies such as rituximab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
		It is not yet known if combination chemotherapy is more effective with or without rituximab for non-Hodgkin's lymphoma.
		Official Title: Phase III Trial of CHOP Versus CHOP and Chimeric Anti-CD20 Monoclonal Antibody (IDEC-C2B8) in Older Patients With Diffuse Mixed, Diffuse Large Cell and Immunoblastic Large Cell Histology Non-Hodgkin's Lymphoma
	www.clinicaltrials.gov /ct/show/NCT00003150?order=4 (1730 words)

	Chemie.DE News-Center: Cambridge Antibody Technology and AMRAD Corporation Ltd. Form Alliance for Human Monoclonal ...
		Chemie.DE News-Center: Cambridge Antibody Technology and AMRAD Corporation Ltd. Form Alliance for Human Monoclonal Antibody Co-Development
		Cambridge Antibody Technology and AMRAD Corporation Ltd. Form Alliance for Human Monoclonal Antibody Co-Development
		Dr. Sandra Webb, Managing Director and Chief Executive Officer of AMRAD, added, ``The number of antibodies which have been identified and are presently in development using CAT technology provides AMRAD with great confidence that the collaboration we have initiated with CAT will deliver vitally important new medicines and great commercial results.''
	www.chemie.de /news/e/6795/?pw=a&defop=and&wild=yes&sdate=01/01/1995&edate=02/22/2006 (383 words)

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