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Topic: Monocyte

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In the News (Mon 19 Aug 19)

  Expression of the monocyte chemoattractant protein-1 receptor CCR2 is increased in hypercholesterolemia: differential ...
Expression of the monocyte chemoattractant protein-1 receptor CCR2 is increased in hypercholesterolemia: differential effects of plasma lipoproteins on monocyte function -- Han et al.
Monocyte CCR2 expression was determined by semi-quantitative RT-PCR as described in Figure 1 and the expression levels before (before) and after (after) estrogen replacement therapy were compared.
THP-1 monocytes were treated with HDL as described in Figure 5 and the effect on the expression of functional CCR2 protein on the cell surface was analyzed by ligand binding assay as described under Materials and Methods.
www.jlr.org /cgi/content/full/40/6/1053   (6607 words)

  MedFriendly.com: Monocyte
A monocyte is a relatively large type of white blood cell with one nucleus.
Monocytes contain delicate chromatin material with a lacy or stringy pattern that appears more condensed where the strands are in contact with each other.
Monocytes are normally found in loose connective tissue, the spleen, lymph nodes, and bone marrow.
www.medfriendly.com /monocyte.html   (475 words)

 Platelet-Monocyte Complexes Support Monocyte Adhesion to Endothelium by Enhancing Secondary Tethering and Cluster ...
to PMC-rich or PMC-poor monocyte suspensions at a shear of 0.8
in the perfusate an increase in monocyte adhesion and clustering
on monocyte adhesion or clustering by antibody-mediated blockade
atvb.ahajournals.org /cgi/content/full/24/1/193   (3807 words)

 Thrombosis Journal | Full text | Soluble fibrin inhibits monocyte adherence and cytotoxicity against tumor cells: ...
The efferent tubing was also connected to the same tube, and Di-I [30] labelled monocytes were recirculated across the tumor cells for 1 h, after which, the tubing was set up to the initial configuration and the cells were again washed with RPMI for 10 min to remove unbound monocytes.
In the absence of sFn, monocytes adherence was 32.9 ± 1.3%.
Monocyte cytotoxicity against A375 melanoma cells was measured in a static microplate assay (Figure 3).
www.thrombosisjournal.com /content/4/1/12   (6925 words)

 MOnocyte   (Site not responding. Last check: )
LAB 6 Blood and Myeloid Tissue: 1) Introduction 2) Erythrocytes and Platelets 3) Neutrophils 4) Basophils 5) Monocytes 6) Eosinophils 7) Bone Marrow Smear 8)Practical
The blue arrow is pointing to a Monocyte.
When the monocyte leaves the blood, it becomes a macrophage.
www3.umdnj.edu /histsweb/lab5/lab5monocyte.html   (60 words)

 Distinct scavenger receptor expression and function in the human CD14+/CD16+ monocyte subset -- Draude et al. 276 (4): ...
Monocyte infiltration is crucially involved in chronic inflammatory reactions and in the pathogenesis of atherosclerosis,
Monocyte infiltration is crucially involved in atherogenesis (21, 38), and in atherosclerotic plaques, lipid accumulation
Monocytic cell adhesion to endothelial cells stimulated by oxidized low density lipoprotein is mediated by distinct endothelial ligands.
ajpheart.physiology.org /cgi/content/full/276/4/H1144   (3089 words)

 Monocyte definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms
Monocyte: A white blood cell that has a single nucleus and can ingest (take in) foreign material.
(In other words, a monocyte is thus a mononuclear phagocyte that circulates in the blood.)
Monocytes later emigrate from blood into the tissues of the body and there differentiate (evolve into) into cells called macrophages which play an important role in killing of some bacteria, protozoa, and tumor cells, release substances that stimulate other cells of the immune system, and are involved in antigen presentation.
www.medterms.com /script/main/art.asp?articlekey=4426   (156 words)

 Advanced glycation end-products increase monocyte adhesion to retinal endothelial cells through vascular endothelial ...
Monocyte adhesion to BRECs was measured by the MPO assay as described in Materials and Methods.
Monocyte adhesion to BRECs was determined by the MPO assay as described in Materials and Methods.
Monocyte adhesion to BRECs (A) and endothelial cell-surface expression of ICAM-1 (B) were measured by the MPO assay and the cellular ELISA method, respectively.
www.jleukbio.org /cgi/content/full/75/6/1062   (4263 words)

 RedOrbit - Science - Integrin Engagement Regulates Monocyte Differentiation Through the Forkhead Transcription Factor ...
Neutrophil and monocyte recruitment in acute inflammation is mediated in part by the [beta]2-integrin family of receptors, LFA-1 ([alpha]^sub L^[beta]^sub 2^, CD11a/CD18), Mac-1 ([alpha]^sub M^[beta]^sub 2^, CD11b/CD18), and p150,95 ([alpha]^sub X^[beta]^sub 2^, CD11c/CD18).
Monocyte maturation is accompanied by a shift from ER- MP12^sup high^/ER-MP20^sup low^ to ER-MP12^sup +^/ER-MP20^sup +^ and ERMP12^sup low^/ER-MP20^sup high^ populations of cells.
LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice.
www.redorbit.com /news/display?id=80059   (7729 words)

 Lipids Online Slides: monocytes, macrophage, atherogenesis, inflammation
One candidate for stimulating this directed migration of the adherent leukocytes is monocyte chemoattractant protein 1 (MCP-1), for the reasons shown on this slide.
Monocytes interact with the endothelial layer, attach firmly to the endothelium, and migrate into the subendothelial space, where the monocytes differentiate into macrophages.
Modified LDL activates endothelial cells to express monocyte chemotactic protein 1 (MCP-1), which attracts monocytes from the vessel lumen and into the subendothelial space, in what is one of the very early stages in the inflammatory process leading to the development of atherosclerosis.
www.lipidsonline.org /slides/slide01.cfm?q=monocytes   (668 words)

 The Individualist: Monocyte
Monocytes are produced by the bone marrow from haematopoietic stem cell precursors, circulate in the blood stream for about one to three days and then typically move into tissues throughout the body.
Monocytes can perform phagocytosis using intermediary (opsonising) proteins such as antibodies or complement that coat the pathogen, as well as by binding to the microbe directly via pattern-recognition receptors that recognize pathogens.
A monocyte count is part of a complete blood count and is expressed either as a ratio of monocytes to the total number of white blood cells counted, or by absolute numbers.
www.dadamo.com /wiki/wiki.pl/Monocyte   (402 words)

 Yersinia, monocytes, macrophages, autism
All in all, knowing the monocyte- pathogen status of an autism-spectrum child seems to be an important addition to his or her medical profile.
The increased binding to previously nonstimulated endothelial cells was mediated by P-selectin, whose translocation to the endothelial cell surface was induced by monocytes with intracellular Yersinia bacteria.
However, as differentiation of monocytes to monocyte-derived macrophages results in increased permissiveness to infection with HCMV in vitro, we examined whether such differentiation could result in reactivation of endogenous viral gene expression.
members.jorsm.com /~binstock/yersin.htm   (7564 words)

 Monocyte Survival Factors Induce Akt Activation and Suppress Caspase-3 -- Goyal et al. 26 (2): 224 -- American Journal ...
Monocytes (66 + 2.1% CD14+) were isolated from the heparinized blood of normal volunteers as described previously (22, 23).
Monocyte survival factors suppress caspase-3 and caspase-9 activation, which is reversed by the PI 3-kinase inhibitors LY294002 and wortmannin.
Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway that is blocked by endotoxin and is independent of caspase-1.
ajrcmb.atsjournals.org /cgi/content/full/26/2/224   (3856 words)

 Monocyte Disorders: White Blood Cell Disorders: Merck Manual Home Edition
Monocytes are produced in the bone marrow and then enter the bloodstream, where they account for about 1 to 10% of the circulating leukocytes (200 to 600 monocytes per microliter of blood).
An increased number of monocytes in the blood (monocytosis) occurs in response to chronic infections, in autoimmune disorders, in blood disorders, and in cancers.
A low number of monocytes in the blood (monocytopenia) can occur in response to the release of toxins into the blood by certain types of bacteria (endotoxemia), as well as in people receiving chemotherapy or corticosteroids.
www.merck.com /pubs/mmanual_home2/sec14/ch174/ch174f.htm   (234 words)

A type of leukocyte (white blood cell) that patrols the bloodstream in search of antigens.
In time, monocytes migrate into the tissues and develop into macrophages.
Monocytes are comparatively large (12 to 20 microns in diameter) and, when stained, have abundant blue-gray or sometimes pale pink cytoplasm with small, generally indistinct, granules.
www.daviddarling.info /encyclopedia/M/monocyte.html   (135 words)

 Lipoprotein Lipase Can Function as a Monocyte Adhesion Protein -- Obunike et al. 17 (7): 1414 -- Arteriosclerosis, ...
A, For monocyte binding to LPL-plastic, 24-well plates were incubated with indicated concentrations of LPL in albumin-containing buffer, and monocyte binding was assessed.
A, For monocyte binding to LPL-coated plastic, labeled monocytes were incubated with 1 U/mL each of heparinase and heparitinase for 1 hour at 37°C, after which the cells were added to 24-well plates coated with albumin (with or without LPL [10 µg/mL]) and then incubated at either 4°C or 37°C for 1 hour.
Labeled monocytes were incubated in medium with or without H/H (1 U/mL each) for 1 hour at 37°C. Control and H/H-treated cells were then cooled, incubated in medium containing no or 50 µmol/L RGD peptides, and incubated further at 4°C for 30 minutes.
atvb.ahajournals.org /cgi/content/full/17/7/1414   (5043 words)

 Arthritis Research & Therapy | Full text | Identification of a human peripheral blood monocyte subset that ...
Monocytes are therefore involved not only in synovial inflammation, but also in bone remodeling as potential precursors for synovial macrophages and osteoclasts.
RA synovial macrophages are derived from peripheral blood monocytes, and their recruitment into the synovium is facilitated by various adhesion molecules and chemokines [24].
monocytes, we examined the expression of molecules known to be involved in osteoclastogenesis.
arthritis-research.com /content/8/5/R152   (6218 words)

 Expression of Monocyte Chemoattractant Protein-1 and Distribution of Immune Cell Populations in the Bovine Corpus ...
Expression of Monocyte Chemoattractant Protein-1 and Distribution of Immune Cell Populations in the Bovine Corpus Luteum Throughout the Estrous Cycle -- Townson et al.
Expression of Monocyte Chemoattractant Protein-1 and Distribution of Immune Cell Populations in the Bovine Corpus Luteum Throughout the Estrous Cycle
Prolactin-induced regression of the rat corpus luteum: expression of monocyte chemoattractant protein-1 and invasion of macrophages.
www.biolreprod.org /cgi/content/full/66/2/361   (4140 words)

 Role of Monocyte Chemoattractant Protein-1 in Cardiovascular Remodeling Induced by Chronic Blockade of Nitric Oxide ...
confined to the endothelium and infiltrating monocytes in the L-NAME
increase in ED1-positive monocytes was inhibited in a dose-dependent
Intradermal injection of monocyte chemoattractant protein-1 induces emigration and differentiation of blood monocytes in rat skin.
circ.ahajournals.org /cgi/content/full/102/18/2243   (4352 words)

 Increased Endothelial Monocyte Chemoattractant Protein-1 and Interleukin-8 in Preeclampsia -- Kauma et al. 100 (4): 706 ...
Human umbilical vein endothelial cells were incubated in 5% plasma from patients with severe preeclampsia with or without the addition of 50 µmol/L of vitamin E for 48 or 72 hours and the conditioned media measured for monocyte chemoattractant protein-1 (48 hours) and interleukin-8 (72 hours) by enzyme-linked immunosorbent assay.
Monocyte chemoattractant protein-1 and interleukin-8 levels in urine and serum of patients with hemolytic uremic syndrome.
Monocyte chemoattractant protein-1 is excreted in excessive amounts in the urine of patients with lupus nephritis.
www.greenjournal.org /cgi/content/full/100/4/706   (3715 words)

 Monocyte Adhesion to Activated Aortic Endothelium: Role of L-Selectin and Heparan Sulfate Proteoglycans -- ...
Monocyte Adhesion to Activated Aortic Endothelium: Role of L-Selectin and Heparan Sulfate Proteoglycans
Monocyte attachment to arterial endothelium is considered to be a key event of the early phase of atherosclerosis.
Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions.
www.jcb.org /cgi/content/full/136/4/945   (7579 words)

 Dynal’s Negative Monocyte Isolation Kit - Biocompare Product Review
The principle of the monocyte isolation kit is the use of uniform superparamagnetic polystyrene beads (Dynabeads).
The manufacturers state that the average monocyte purity is around 80%, however surprisingly after routinely isolating monocytes daily we achieved greater than 90% purity.
In summary the monocyte negative isolation kit from Dynal, is effective at isolating relatively high yields of resting pure monocyte populations from whole blood.
www.biocompare.com /prorev.asp?id=173   (567 words)

 Essential role of ICAM-1 in mediating monocyte adhesion to aortic endothelial cells -- Kevil et al. 281 (5): C1442 -- ...
monocyte adhesion in response to oxLDL and was not significantly
Differential monocyte adhesion and adhesion molecule expression in venous and arterial endothelial cells.
Seitz, CS, Kleindienst R, Xu Q, and Wick G. Coexpression of heat-shock protein 60 and intercellular-adhesion molecule 1 is related to increased adhesion of monocytes and T cells to aortic endothelium of rats in response to endotoxin.
ajpcell.physiology.org /cgi/content/full/281/5/C1442   (3583 words)

 The Effects of Alpha Tocopherol Supplementation on Monocyte Function . Decreased Lipid Oxidation, Interleukin 1beta ...
monocytes was found to be 94% by Trypan blue exclusion (20).
Monocyte oxidation of the artificial lipoprotein emulsion was assessed at 0, 8, and 14 wk as depicted in Fig.
Calphostin C was preincubated with the mixed mononuclear cell preparation for the 2 h and to the monocyte preparation for
www.jci.org /cgi/content/full/98/3/756   (5890 words)

 Hypertension Online Slides - monocyte, VSMC, vascular smooth muscle cells
Among them are: vascular smooth muscle cell (VSMC) relaxation; modulation of renal medullary blood flow; inhibition of VSMC growth; inhibition of platelet aggregation; inhibition of polymorphonuclear (PMN) leukocyte and monocyte (MF) adhesion molecule expression and immigration into the vascular wall and interstitium; and augmentation of apoptosis or programmed cell death.
An additional consequence of glomerular hypertension and resultant reduction in glomerular filtration rate (GFR) activates growth factors and cytokines that promote an influx of monocytes and macrophages into the vessel wall and into the renal interstitium, and also causes the differentiation of renal cells into fibroblasts.
Monocytes, macrophages and fibroblasts are capable of producing those growth factors and cytokines that activate pathways leading to expansion of extracellular matrix, fibrosis and loss of both tubular and glomerular structures.
www.hypertensiononline.org /slides2/slide01.cfm?q=monocyte   (479 words)

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