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Topic: Monocytosis

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	Cecil Textbook of Medicine : />
		Accordingly, monocytosis is often seen in patients with tuberculosis, syphilis, fungal infections, ulcerative and granulomatous colitis, and sarcoidosis (Table 163-6).
		Mild monocytosis is common in patients with Hodgkin's disease and a variety of cancers.
		High levels of monocytes in the blood are most often seen in patients with hematopoietic malignancies, including acute and chronic myelomonocytic leukemia, acute monocytic leukemia, and chronic myelogenous leukemia of the juvenile type.
	www.merckmedicus.com /ppdocs/us/common/cecils/chapters/163_018.htm (232 words)

	eMedicine - Leukocytosis : Article by Susumu Inoue, MD (Site not responding. Last check: 2007-10-12)
		From a practical point of view, leukocytosis traditionally is classified according to the component of white cells that is contributing to an increase in the total number of WBCs.
		Therefore, leukocytosis may be caused by an increase in (1) neutrophil count (ie, neutrophilia), (2) lymphocyte count (ie, lymphocytosis), (3) monocyte count (ie, monocytosis), (4) eosinophilic granulocyte count (ie, eosinophilia), (5) basophilic granulocyte count (ie, basophilia), or (6) immature cells (eg, blasts).
		Monocytosis: This is defined as a monocyte count exceeding the upper limit of the reference range of 0.95 X 19
	www.emedicine.com /ped/topic1303.htm (2634 words)

	Diagnostic Edge&##151;February 2005 Case Studies
		There was a leukocytosis with a neutrophilia and left shift, a lymphopenia and a monocytosis.
		At the time of presentation, the leukogram (Table 3, Day 1) was characterized as a leukocytosis with a neutrophilia, a left shift, a lymphopenia and a monocytosis.
		This leukogram was interpreted as indicative of active inflammation with superimposed stress (high circulating glucocorticoids) and potential tissue demand for macrophages (monocytosis) as might be seen with tissue necrosis.
	www.idexx.com /animalhealth/education/diagnosticedge/de200501_case.jsp (1159 words)

	Hyponatremia in a Foal \| Study Case (Site not responding. Last check: 2007-10-12)
		The foal had a sepsis score of 17, characterized by a thickened umbilicus, petechia of the ears, injected mucus membranes, 3+ scleral injection and reddened coronary bands.
		Leukocytosis consisting of a mature neutrophilia with a left shift, monocytosis and increased fibrinogen.
		The source of the inflammation was thought to be an in utero infection such as placentitis, which may also have been an inciting factor for the foals premature birth.
	www.vet.uga.edu /vpp/clerk/barber/index.htm (888 words)

	Study Case: Pulmonary Infiltrates with Eosinophils (PIE)
		Other causes for eosinophilia, such as adrenocortical insufficiency and neoplasia, are not likely since values on the biochemistry panel were within reference intervals, and abdominal and thoracic radiographs were not suggestive of a mass.
		Monocytosis may occur with acute and chronic inflammatory disease; this finding is nonspecific.
		The mature neutrophilia and a lymphocyte count at the lower end of the reference interval are most likely secondary to previous use of corticosteroids.
	www.vet.uga.edu /vpp/clerk/jboggs (956 words)

	Glossary: M - R
		Monocytes are the most commonly misidentified leukocyte in blood smears, often being placed into the lymphocyte category.
		Increased numbers of circulating monocytes (monocytosis) occur in chronic suppurative, pyogranulomatous, necrotic, malignant, hemolytic, hemorrhagic or immune-mediated diseases.
		Monocytosis also occurs in dogs as a corticosteroid-induced response from stress, adrenal hyperfunction or exogenous corticosteroids.
	www.anjotech.co.za /glossary2.htm (1477 words)

	Myelodysplastic Syndrome
		It resembles the other members of MDS in that it consists of anemia, neutropenia, and thrombocytopenia, but it also resembles members of the myeloproliferative disorders with monocytosis, circulating blasts, and splenomegaly.
		The differentiation from CML by the monocytosis and lack of the Philadelphia chromosome.
		MDS is usually seen in people greater than 60 and is slightly more common in men.
	home.uchicago.edu /~adamcifu/MDS.htm (767 words)

	Clinical Study: 04-H-0090, A Pilot Study of the Safety and Efficacy of Imatinib in Reducing Monocytosis or Leukocytosis ... (Site not responding. Last check: 2007-10-12)
		Clinical Study: 04-H-0090, A Pilot Study of the Safety and Efficacy of Imatinib in Reducing Monocytosis or Leukocytosis in Patients with Chronic Myelomonocytic Leukemia and Atypical Chronic Myelogenous Leukemia, Respectively
		A Pilot Study of the Safety and Efficacy of Imatinib in Reducing Monocytosis or Leukocytosis in Patients with Chronic Myelomonocytic Leukemia and Atypical Chronic Myelogenous Leukemia, Respectively
		If dysplasia is absent the diagnosis of CMML can still be made if the other requirements are met and a cytogenetic abnormality is present in the marrow cells or if monocytosis has been persistent for at least 3 months and all other causes of monocytosis have been excluded.
	clinicalstudies.info.nih.gov /cgi/detail.cgi?A_2004-H-0090.html (912 words)

	Nonmyeloablative Bone Marrow Transplantation of BXSB Lupus Mice Using Fully Matched Allogeneic Donor Cells from Green ...
		The monocytosis characteristic of BXSB mice was significantly
		Monocytosis in the BXSB model for systemic lupus erythematosus.
		Expanded macrophage precursor populations in BXSB mice: possible reason for the increasing monocytosis in male mice.
	www.jimmunol.org /cgi/content/full/172/9/5415 (3171 words)

	Untitled Document (Site not responding. Last check: 2007-10-12)
		The absence of a frank lymphopenia or eosinopenia
		In the dog, monocytosis must accompany one or more of the other 4 criteria or the absolute monocyte count must be greater than twice normal.
		Occurs from a neoplastic change in hematopoietic stem cells.
	www.vet.purdue.edu /bms/nour/bms520/content/blood/leukocytes7.htm (245 words)

	Monocyte Disorders: White Blood Cell Disorders: Merck Manual Home Edition
		Genetic abnormalities that affect the function of monocytes and macrophages and cause buildup of debris within the cells result in the lipid storage diseases (such as Gaucher's disease and Niemann-Pick disease (see Hereditary Metabolic Disorders: Gaucher's Disease).
		An increased number of monocytes in the blood (monocytosis) occurs in response to chronic infections, in autoimmune disorders, in blood disorders, and in cancers.
		A proliferation of macrophages in tissues can occur in response to infections, sarcoidosis (see Infiltrative Lung Diseases: Sarcoidosis), and Langerhans' cell granulomatosis (see Infiltrative Lung Diseases: Langerhans' Cell Granulomatosis).
	www.merck.com /pubs/mmanual_home2/sec14/ch174/ch174f.htm (234 words)

	kind of stuck
		My liver enzymes remain fairly normal, a biopsy showed "slight changes consistent with hepatitis c".
		My differential shows pretty consistent monocytosis; is this common in hep c?
		My doctor says it's not likely that either the monocytosis or my symptoms are related to hep c, since "no one gets symptoms 'til end stage cirrhosis."
	www.medhelp.org /forums/Hepatitis/messages/30911.html (100 words)

	AccessMedicine - Harrison's Internal Medicine: Mononuclear Phagocytes
		Monocytosis is associated with tuberculosis, brucellosis, subacute bacterial endocarditis, Rocky Mountain spotted fever, malaria, and visceral leishmaniasis (kala azar).
		Monocytosis also occurs with malignancies, leukemias, myeloproliferative syndromes, hemolytic anemias, chronic idiopathic neutropenias, and granulomatous diseases such as sarcoidosis, regional..."
		For full access subscribe today or log into an existing user account below.
	www.accessmedicine.com /content.aspx?aID=58714 (264 words)

	What is Kostmann's syndrome? - Health and Medical Information produced by doctors - MedicineNet.com
		They do, however, have an increased risk of developing acute myelogenous leukemia or myelodysplasia, a bone marrow disorder.
		Aside from agranulocytosis, the bone marrow and blood show a number of other abnormalities (including maturational arrest of neutrophil precursors at the promyelocyte stage, absolute monocytosis, eosinophilia and thrombocytosis).
		The gamma globulin level (antibodies) in blood is low, further increasing the risk for infection.
	www.medicinenet.com /script/main/art.asp?articlekey=8781 (375 words)

	Clinical Trials (PDQ®) - National Cancer Institute
		Determine the efficacy of imatinib mesylate, in terms of reducing peripheral blood monocytosis or leukocytosis, in patients with chronic myelomonocytic leukemia or atypical chronic myeloid leukemia.
		Patients who do not respond to treatment are followed monthly for 6 months.
		Note: The purpose of most clinical trials listed in this database is to test new cancer treatments, or new methods of diagnosing, screening, or preventing cancer.
	www.cancer.gov /clinicaltrials/NHLBI-04-H-0090 (484 words)

	Clinical Trial: Imatinib Mesylate in Treating Patients With Chronic Myelomonocytic Leukemia or Atypical Chronic Myeloid ...
		Official Title: A Pilot Study of the Safety and Efficacy of Imatinib in Reducing Monocytosis or Leukocytosis in Patients With Chronic Myelomonocytic Leukemia or Atypical Chronic Myelogenous Leukemia, Respectively
		Further study details as provided by National Cancer Institute (NCI):
		Dysplasia in one or more myeloid lineages* NOTE: In the absence of dysplasia, CMML can be diagnosed if a cytogenetic abnormality is present in the marrow cells OR if monocytosis* is persistent for at least 3 months (and all other causes of monocytosis have been excluded)
	clinicaltrials.gov /ct/show/NCT00076297 (557 words)

	The association of impaired myocardial perfusion and monocytosis with late recovery of left ventricular function ...
		The association of impaired myocardial perfusion and monocytosis with late recovery of left ventricular function following primary percutaneous coronary intervention -- Gibson and Gibson 27 (21): 2487 -- European Heart Journal
		European Heart Journal Advance Access originally published online on September 25, 2006
		The association of impaired myocardial perfusion and monocytosis with late recovery of left ventricular function following primary percutaneous coronary intervention
	eurheartj.oxfordjournals.org /cgi/content/short/27/21/2487?rss=1 (257 words)

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