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Topic: Montelukast


  
  Mosby's Drug Consult Top 200
The efficacy of montelukast sodium in pediatric patients 6-14 years of age was demonstrated in one 8 week double-blind, placebo-controlled trial in 336 patients (201 treated with montelukast sodium and 135 treated with placebo) using an inhaled β-agonist on an “as-needed” basis.
The efficacy of montelukast sodium for the chronic treatment of asthma in pediatric patients 2-5 years of age was explored in a 12 week placebo-controlled safety and tolerability study in 689 patients, 461 of whom were treated with montelukast sodium.
Montelukast sodium is indicated for the relief of symptoms of seasonal allergic rhinitis in adults and pediatric patients 2 years of age and older.
www.mosbysdrugconsult.com /DrugConsult/Top_200/Drugs/e3383.html   (6819 words)

  
 West Virginia Center for Drug and Health Information
Background: Montelukast is an effective therapy for the control of asthma exacerbations in adults and children with persistent asthma, which makes it a potential treatment modality for children with intermittent asthma.
Objective: The purpose of the study was to investigate the role of montelukast in the prevention of viral-induced asthma exacerbations in children aged 2 to 5 years with a history of intermittent asthma symptoms.
Montelukast reduces asthma exacerbations in 2- to 5-year-old children with intermittent asthma.
www.hsc.wvu.edu /sop/wvcdhi/literature/montelukastAsthma.htm   (911 words)

  
 Indian Pediatrics - Editorial
Montelukast has been found to be effective at oral doses of 10 mg per day in adults(9,10, 12,13,18) and 5 mg per day in children(14,26).
Montelukast is made available by the manufacturers as 10 mg tablets and 5 mg chewable tablets for children.
Montelukast is a new drug that relieves asthma by acting on chemical mediators of airway inflammation.
www.indianpediatrics.net /nov2000/nov-1201-1209.htm   (3514 words)

  
 Howstuffworks "Montelukast: A Profile of an Asthma Drug"
Montelukast is used to prevent the symptoms of asthma, such as wheezing and shortness of breath.
Montelukast can also be used for seasonal allergic rhinitis (hay fever) or other medical conditions when prescribed by your doctor.
Rifampin and phenobarbital, when either is taken concurrently with montelukast, may decrease the amount of montelukast in the body and therefore decrease its effectiveness.
health.howstuffworks.com /define-montelukast.htm   (692 words)

  
 Montelukast - Drugs & Vitamins - Drug Library - DrugDigest
Take montelukast every day at roughly the same time, even on days when you are not having asthma or allergy symptoms.
Montelukast chewable tablets are normally prescribed in children 2 years of age or older.
Montelukast is only used to help prevent asthma attacks; it is not used as a "quick-relief" medicine to treat an asthma attack.
www.drugdigest.org /DD/DVH/Uses/0,3915,725|Montelukast,00.html   (716 words)

  
 Clinical Trial: Montelukast in the Treatment of Duodenal Eosinophilia
This is a single site study of the effect of montelukast on eosinophil and mast cell counts and activation in the lining of the duodenum in 24 children with dyspepsia in association with duodenal eosinophilia in association with measuring the concentration of the medication in the lining of the duodenum.
Montelukast is a competitive antagonist of the cys LT1 receptor with an affinity that is similar, but lower than that of leukotriene D4.
The beneficial therapeutic effect of montelukast in patients with eosinophilic duodenitis is determined by the activation state and local density of eosinophils, and by attainment of sufficient systemic and local exposure.
www.clinicaltrials.gov /ct/show/NCT00148603   (2039 words)

  
 Montelukast Proves Effective In Asthmatic Children   (Site not responding. Last check: 2007-11-06)
CHICAGO, IL -- April 14, 1998 -- The orally-administered drug montelukast, taken once a day, is effective therapy for six- to 14-year-old children with chronic asthma, according to an article in the April 15th issue of The Journal of the American Medical Association.
Montelukast is one of a new class of asthma medications known as leukotriene inhibitors, which block leukotrienes that are produced and released from inflammatory cells.
"Montelukast not only demonstrated a rapid onset of action, but its treatment effects were maintained consistently over time," they write.
www.pslgroup.com /dg/6c68a.htm   (535 words)

  
 Treating moderate asthma – anti-inflammatory medication in asthma – montelukast vs fluticasone
Montelukast versus fluticasone: effects on lung function, airway responsiveness and inflammation in moderate asthma.
Both montelukast and fluticasone can improve lung function during a 4-week treatment period, but only the inhaled corticosteriod fluticasone reduced asthma symptoms and airway sensitivity, and had any anti-inflammatory effect.
Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomized, comparative trial.
www.myasthmamedicine.com /article/506130.aspx   (3283 words)

  
 RedOrbit - Health - Montelukast Reduces Asthma Exacerbations in 2- to 5-Year-Old Children With Intermittent Asthma
The PREVIA study was designed to investigate the role of montelukast, a leukotriene receptor antagonist, in the prevention of viral-induced asthma exacerbations in children aged 2 to 5 years with a history of intermittent asthma symptoms.
Montelukast effectively reduced asthma exacerbations in 2- to 5-year-old patients with intermittent asthma over 12 months of treatment and was generally well tolerated.
The purpose of this study was to investigate the effect of regular montelukast therapy on asthma exacerbations in young children 2 to 5 years old with a history of intermittent asthma associated with the common cold and minimal symptoms between episodes.
www.redorbit.com /news/display?id=129851   (4732 words)

  
 MedlinePlus Drug Information: Montelukast
Montelukast comes as a tablet and as a chewable tablet to take by mouth.
Montelukast controls asthma but does not cure it.
Montelukast will not stop an acute attack that has already started.
www.nlm.nih.gov /medlineplus/druginfo/medmaster/a600014.html   (555 words)

  
 MONTELUKAST SODIUM Drug Information MONTELUKAST SODIUM
Montelukast sodium, the active ingredient in SINGULAIR *, is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene CysLT
Renal Insufficiency: Since montelukast and its metabolites are not excreted in the urine, the pharmacokinetics of montelukast were not evaluated in patients with renal insufficiency.
Montelukast is a potent inhibitor of P450 2C8, but no in vivo drug interaction studies have been conducted between montelukast and cytochrome P450 2C8 substrates.
www.drugs.com /pdr/montelukast_sodium.html   (9545 words)

  
 Marginal utility of montelukast for persistent asthma CHEST - Find Articles   (Site not responding. Last check: 2007-11-06)
This is a report on the utility of montelukast for persistent asthma based on observations of and by a series of 110 patients.
On prescription (ie, study entry) for montelukast (10 mg daily, except doses of 5 mg daily for four patients under age 15 years), patients were instructed to continue individualized current programs of avoidances, immunotherapy, and medications.
One year after the initiation of montelukast therapy, medical records were audited by technicians for medication usage, including montelukast, and questionnaires sent to 103 patients (7 were lost to follow-up) were returned by 75 (73%) with responses relating to insurance coverage, perceived benefits, and side effects of the therapy.
www.findarticles.com /p/articles/mi_m0984/is_2_121/ai_83759040   (715 words)

  
 Steroid naive eosinophilic asthma: anti-inflammatory effects of fluticasone and montelukast -- Jayaram et al. 60 (2): ...   (Site not responding. Last check: 2007-11-06)
Effects of montelukast and budesonide on airway responses and airway inflammation in asthma.
Effect of montelukast (MK-0476); a potent cysteinyl leukotrine receptor antagonist, on bronchodilatation in asthmatic subjects treated with and without inhaled corticosteroids.
Montelukast, a leukotrine receptor antagonist, for the treatment of mild asthma and exercise induced bronchoconstriction.
www.arabmedmag.com /issue-15-04-2005/pneumology/main03.htm   (3209 words)

  
 Study Identifies Children Most Likely to Benefit from Montelukast: Presented at WAC   (Site not responding. Last check: 2007-11-06)
After 12 weeks of treatment, the number of children with EIA symptoms went from 59% to 7% in the montelukast group (a 52% reduction) and from 41% to 26% in the budesonide group (a 15% reduction).
Montelukast also has a good track record of safety and tolerability in paediatric patients, she said.
She recommended montelukast for patients in this age group with mild to persistent asthma if they have exercise-induced asthma or allergic rhinitis, or if they balk at using inhaled medication.
www.pslgroup.com /dg/24EB4A.htm   (499 words)

  
 Distribution of therapeutic response in asthma control between oral montelukast and inhaled beclomethasone -- ...
and placebo, beclomethasone and placebo, and montelukast and
and 45.3±35.1 for the placebo, montelukast and beclomethasone
Montelukast, a potent leukotriene receptor antagonist, causes dose-related improvements in chronic asthma.
erj.ersjournals.com /cgi/content/full/21/1/123   (3317 words)

  
 Montelukast (Systemic) - MayoClinic.com
Montelukast (mon-te-LOO-kast) is used in mild to moderate asthma to decrease the symptoms of asthma and the number of acute asthma attacks.
It is not known whether montelukast passes into breast milk in humans.
There is no specific information comparing use of montelukast in the elderly with its use in other age groups.
www.mayoclinic.com /health/drug-information/DR203613   (1216 words)

  
 Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in ...
Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial -- Bjermer et al.
Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial
Montelukast versus salmeterol in patients with asthma and exercise-induced bronchoconstriction.
bmj.bmjjournals.com /cgi/content/full/327/7420/891   (3948 words)

  
 montelukast - Asthma symptoms, relief therapies, treatment and medications on MedicineNet.com
Leukotrienes are a group of naturally occurring chemicals in the body that promote inflammation in asthma and seasonal allergic rhinitis and in other diseases in which inflammation is important (such as allergy).
Montelukast works in a manner similar to zafirlukast (Accolate), blocking the binding of some leukotrienes.
SIDE EFFECTS: The most common side effects with montelukast are headache, dizziness, abdominal pain, sore throat, and rhinitis (inflammation of the inner lining of the nose).
www.medicinenet.com /montelukast/article.htm   (556 words)

  
 montelukast
SINGULAIR ® (montelukast sodium) is a prescription medicine approved to help control asthma in adults and children as young as 12 months and to help relieve the symptoms of indoor and outdoor allergies.
Montelukast Sodium is a revolutionary drug for asthma prescribed as single daily dose with an added advantage for pediatric use.
Montelukast sodium is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene CysLT 1 receptor.
mywebpage.netscape.com /montelukast06   (664 words)

  
 Montelukast children Pediatric Oncall   (Site not responding. Last check: 2007-11-06)
What are the side effects of long term use of Montelukast and is there any monitoring to be done for the same?
Montelukast is indicated for the prophylaxis and chronic treatment of asthma in pediatric patients 12 months of age and older.
It is indicated for the relief of symptoms of seasonal allergic rhinitis in pediatric patients 2 years of age and older.
www.pediatriconcall.com /fordoctor/asthma/Montelukast.asp   (135 words)

  
 montelukast drug information, montelukast side effects
Montelukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma and...
Montelukast blocks the action of leukotriene D4 on...
Montelukast (mon-te-LOO-kast) is used in mild to moderate asthma to decrease the symptoms of asthma...
www.drugs.com /sch/montelukast   (473 words)

  
 Montelukast Reduces Asthma Exacerbations in 2- to 5-Year-Old Children with Intermittent Asthma -- Bisgaard et al. 171 ...
Montelukast Reduces Asthma Exacerbations in 2- to 5-Year-Old Children with Intermittent Asthma -- Bisgaard et al.
Montelukast for chronic asthma in 6- to 14-year-old children.
Montelukast, a leukotriene receptor antagonist, for the treatment of persistent asthma in children aged 2 to 5 years.
ajrccm.atsjournals.org /cgi/content/full/171/4/315   (4385 words)

  
 Montelukast - Wikipedia, the free encyclopedia
Montelukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT
Montelukast is marketed in United States and other countries by Merck and Co. with the brand name Singulair®.
en.wikipedia.org /wiki/Montelukast   (168 words)

  
 Montelukast, Compared With Fluticasone, for Control of Asthma Among 6- to 14-Year-Old Patients With Mild Asthma: The ...
Montelukast, Compared With Fluticasone, for Control of Asthma Among 6- to 14-Year-Old Patients With Mild Asthma: The MOSAIC Study -- Garcia Garcia et al.
of orally administered montelukast with that of inhaled fluticasone
Oral montelukast versus inhaled beclomethasone in 6- to 11-year-old children with asthma: results of an open-label extension study evaluating long-term safety, satisfaction, and adherence with therapy.
pediatrics.aappublications.org /cgi/content/full/116/2/360   (4969 words)

  
 Eosinophilic oesophagitis: treatment using Montelukast -- Sinharay 52 (8): 1228 -- Gut
Montelukast treatment for an young EG patient was published
Montelukast was originally licensed in the UK for use in asthma.
Montelukast reduces peripheral blood eosinophilia but not tissue eosinophilia or symptoms in a patient with eosinophilic gastroenteritis and esophageal stricture.
gut.bmjjournals.com /cgi/content/full/52/8/1228   (550 words)

  
 Randomised, placebo controlled trial of effect of a leukotriene receptor antagonist, montelukast, on tapering inhaled ...
A second, important finding of this study was that the number of failed rescues was lower with montelukast than placebo.
Montelukast was generally well tolerated in this asthmatic population taking high doses of inhaled corticosteroids.
Effects of montelukast (MK-0476), a potent cysteinyl leukotriene receptor antagonist, on bronchodilation in asthmatic patients treated with and without inhaled corticosteroids.
bmj.bmjjournals.com /cgi/content/full/319/7202/87   (3147 words)

  
 Montelukast, a Leukotriene Receptor Antagonist, for the Treatment of Persistent Asthma in Children Aged 2 to 5 Years -- ...
Montelukast, a Leukotriene Receptor Antagonist, for the Treatment of Persistent Asthma in Children Aged 2 to 5 Years -- Knorr et al.
Oral montelukast (4-mg chewable tablet) administered once daily is effective therapy for asthma in children aged 2 to 5 years
Key words: asthma, cysteinyl leukotrienes, leukotriene receptor antagonist, montelukast, preschool children.
pediatrics.aappublications.org /cgi/content/abstract/108/3/e48   (920 words)

  
 The combination of single-dose montelukast and loratadine on exercise-induced bronchospasm in children -- Peroni et al. ...
The combination of single-dose montelukast and loratadine on exercise-induced bronchospasm in children -- Peroni et al.
Montelukast, a leukotriene receptor antagonist, in combination with loratadine, a histamine receptor antagonist, in the treatment of chronic asthma.
The effect of montelukast (MK-0476), a cysteinyl leukotriene receptor antagonist, on allergen-induced airway responses and sputum cell counts in asthma.
erj.ersjournals.com /cgi/content/full/20/1/104   (1398 words)

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