| | New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis -- Inoue et al. 8 (7): 1201 -- ... |
 | | To test whether Morc is also expressed in somatic cells of the testis, we examined mice that lacked germ cells due to either the recessive atrichosis (at) mutation (16) or the XX,Sxr sex-reversal mutation (17). |
 | | The relatively low overall identity between human and mouse MORC proteins (66%) is attributable to the less conserved C-terminal region, but MORC conservation is nevertheless comparable with that of some other nuclear proteins, such as the orphan nuclear receptor DAX1 (65%) (18,19) or the meiosis-specific synaptonemal complex protein 1 (72%) (20,21). |
 | | The punctate staining pattern of transfected MORC suggests that the protein may be part of a large nuclear complex such as the DNA `repairosome' (25). |
| hmg.oupjournals.org /cgi/content/full/8/7/1201 (5213 words) |