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Topic: Moricizine

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	Moricizine: a novel antiarrhythmic agent -- Carnes and Coyle 24 (7): 745 -- The Annals of Pharmacotherapy
		Moricizine is a phenothiazine derivative with Vaughan Williams class 1 antiarrhythmic properties.
		Moricizine is extensively metabolized and may have pharmacologically active metabolites.
		Further studies are needed comparing moricizine with other class 1 agents in the treatment of life-threatening arrhythmias; available data suggest that moricizine is comparable with these agents in the treatment of ventricular tachycardias and fibrillation.
	www.theannals.com /cgi/content/abstract/24/7/745 (211 words)

	[No title] (Site not responding. Last check: 2007-10-26)
		I suspect the moricizine of causing the increase in pressure to ca.
		I went on moricizine to get away from the crushing effect of a beta blocker (sotolol) taken orally.
		Now the moricizine may be forcing me back into the same situation.
	www.druginfonet.com /faq/new/DRUG_FAQ/Ethmozine.htm (319 words)

	Carilion - Moricizine(Systemic) - [Medication]
		Moricizine mor-IH-siz-een belongs to the group of medicines known as antiarrhythmics.
		Since other antiarrhythmic medicines have been shown to cause severe problems in some patients, moricizine is only used to treat serious heart rhythm problems.
		Moricizine may cause some people to become dizzy or lightheaded.
	www.carilion.com /kbase/htm/mdx-/drde/2023/81/mdx-drde202381.htm (1044 words)

	MedlinePlus Drug Information: Moricizine
		Moricizine is used to treat irregular heartbeats (arrhythmias) and to maintain a normal heart rate.
		Moricizine comes as a tablet to take by mouth.
		Moricizine controls irregular heartbeats, but does not cure them.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601080.html (693 words)

	MedlinePlus Drug Information: Moricizine (Systemic) (Site not responding. Last check: 2007-10-26)
		There is a chance that moricizine may cause new or make worse existing heart rhythm problems when it is used.
		Before taking moricizine, make sure your doctor knows if you are pregnant or if you may become pregnant.
		There is no specific information comparing use of moricizine in the elderly with use in other age groups, although the risk of some unwanted effects may be increased.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202381.html (1078 words)

	Moricizine Hydrochloride Drug Information, Professional
		Moricizine has been reported to be present in human breast milk and is distributed into the milk of laboratory animals.
		Coronary artery disease (incidence of moricizine-induced arrhythmias is increased
		Prevalence and characteristics of proarrhythmia from moricizine (Ethmozine).
	www.drugs.com /MMX/Moricizine_Hydrochloride.html (2842 words)

	Moricizine concentration to guide arrhythmia treatment: with attention to elderly patients -- Giardina et al. 34 (7): ...
		Moricizine concentration to guide arrhythmia treatment: with attention to elderly patients -- Giardina et al.
		To test the relationship between plasma moricizine concentration and the electrocardiogram (ECG) and arrhythmia suppression, 17 symptomatic cardiac patients with 30 or more ventricular premature complexes per hour were studied.
		The mean moricizine dose was 215 +/- 29 mg every 8 hours; mean maximal moricizine concentration was 1.4 +/- 0.84 micrograms/ml; and mean t1/2 beta was 1.5 +/- 0.7 hours.
	jcp.sagepub.com /cgi/content/abstract/34/7/725 (190 words)

	Moricizine (Site not responding. Last check: 2007-10-26)
		Moricizine is used to treat irregular heartbeats (arrhythmias), maintain a normal heart rate or slow an overactive heart.
		Moricizine comes in tablets and is usually taken three times a day (every 8 hours).
		Before moricizine is prescribed, tell your health care provider about any other medicines you may be taking, including vitamins, herbals, dietary supplements, and other prescription and nonprescription (over-the-counter) medications and especially if you are taking:
	clevelandclinic.org /health/health-info/docs/0700/0713.asp?...&src=news (724 words)

	moricizine Consumer Drug Information
		You may not be able to take moricizine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.
		Moricizine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby.
		You may not be able to take moricizine or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.
	www.drugs.com /MTM/moricizine.html (1012 words)

	Moricizine (Systemic)
		Moricizine has not been studied in pregnant women.
		Moricizine passes into the milk of some animals and may also pass into the milk of humans.
		Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of moricizine in children with use in other age groups.
	healthqa.stbernards.info /html_healthgate/html/0_268/26837.php (955 words)

	moricizine - Hartford, Connecticut CT
		Moricizine may cause dizziness, drowsiness, or blurred vision.
		Moricizine is used to treat seriously irregular heartbeat patterns.
		Symptoms of a moricizine overdose include vomiting, tiredness, dizziness, an irregular heartbeat, severe chest pain, a heart attack, difficulty breathing, and coma.
	www.saintfranciscare.com /110704.cfm (916 words)

	Ethmozine - Drugs & Vitamins - Drug Library - DrugDigest
		Moricizine can help your heart to return to and maintain a normal rhythm.
		Because your condition and the use of moricizine carry some risk, it is a good idea to carry an identification card, necklace or bracelet with details of your condition, medications and prescriber or health care professional.
		Ask your prescriber or health care professional what your heart rate and blood pressure should be, and when you should contact him or her.
	www.drugdigest.org /DD/DVH/Storage/0,3920,464\|Ethmozine,00.html (627 words)

	Moricizine Hydrochloride, chemical structure, molecular formula, Reference Standards (Site not responding. Last check: 2007-10-26)
		Standard solution— Prepare a solution ofUSP Moricizine Hydrochloride RSinDiluenthaving a known concentration of about 0.10mg per mL.Transfer 10.0mLof this solution to a 500-mLvolumetric flask,add 25.0mLofInternal standard solution,dilute withDiluentto volume,and mix to obtain a solution containing about 0.0020mg ofUSP Moricizine Hydrochloride RSper mL.
		Test solution— Transfer about 1g of Moricizine Hydrochloride,accurately weighed,to a 50-mLglass-stoppered centrifuge tube,add 19.0mLof water,and sonicate to dissolve.Transfer 1.0mLof 3Nammonium hydroxide to the tube,insert the stopper,and shake the tube by mechanical means for 30minutes.Centrifuge,draw off a portion of the clear supernatant and filter through a filter having a porosity of 0.5µm or finer.
		in which Cis the concentration,in mg per mL,ofUSP Moricizine Hydrochloride RSin theStandard preparation;and RUand RSare the ratios of the peak area responses of moricizine and butamben obtained from theAssay preparationand theStandard preparation,respectively.
	www.newdruginfo.com /pharmacopeia/usp28/v28230/usp28nf23s0_m54790.htm (767 words)

	The CAST RR Interval Sub-Study Database: Introduction
		Those subjects enrolled within 90 days of the index MI were required to have left ventricular ejection fractions less than or equal to 55%, while those enrolled after this 90 day window were required to have an ejection fraction less than or equal to 40%.
		In April of 1989, the Data and Safety Monitoring Board recommended that the encainide and flecainide arms of the study be discontinued because of excessive mortality in the drug arms of the trial primarily due to arrhythmia, acute MI with shock, or chronic congestive heart failure.
		CAST-II was stopped early because long-term treatment with moricizine after an MI was associated with a trend to excess mortality as compared with no treatment or placebo.
	www.physionet.org /physiobank/database/crisdb/introduction.shtml (961 words)

	Clinical Trial: Cardiac Arrhythmia Suppression Trial (CAST)
		Prior to actual randomization, there was an open-label titration period to identify patients who responded to treatment.
		A total of 1,727 patients who responded were randomized: 1,455 to encainide, flecainide, or placebo, and 272 to moricizine or placebo.
		CAST continued to compare moricizine to placebo in 1,300 patients for 18 months until August 1991 when the moricizine portion of the trial was stopped early because of excess deaths.
	clinicaltrials.gov /ct/show/NCT00000526 (2219 words)

	NEJM -- Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. The Cardiac Arrhythmia ...
		The Cardiac Arrhythmia Suppression Trial (CAST) tested the hypothesis that the suppression of asymptomatic or mildly symptomatic ventricular premature depolarizations in survivors of myocardial infarction would decrease the number of deaths from ventricular arrhythmias and improve overall survival.
		At the completion of the long-term phase, there were 49 deaths or cardiac arrests due to arrhythmias in patients assigned to moricizine, and 42 in patients assigned to placebo (adjusted P = 0.40).
		As with the antiarrhythmic agents used in CAST-I (flecainide and encainide), the use of moricizine in CAST-II to suppress asymptomatic or mildly symptomatic ventricular premature depolarizations to try to reduce mortality after myocardial infarction is not only ineffective but also harmful.
	content.nejm.org /cgi/content/short/327/4/227 (1647 words)

	Cardiac Arrhythmia Suppression Trial (CAST) - Article
		Circadian pattern of arrhythmic death in patients receiving encainide, flecainide or moricizine in the Cardiac Arrhythmia Suppression Trial (CAST).
		Interaction of baseline characteristics with the hazard of encainide, flecainide, and moricizine therapy in patients with myocardial infarction.
		Moricizine and quality of life in the Cardiac Arrhythmia Suppression Trial II (CAST II).
	goldbamboo.com /topic-t5565-a111047.html (2278 words)

	Unbound MEDLINE \| Moricizine journal articles
		Analysis of moricizine block of sodium current in isolated guinea-pig atrial myocytes.
		Moricizine, an antiarrhythmic agent, as a potent inhibitor of hepatic microsomal CYP1A.
		Efficacy and safety of moricizine in the maintenance of sinus rhythm in patients with recurrent atrial fibrillation.
	www.unboundmedicine.com /medline/ebm/research/Moricizine (256 words)

	Moricizine (Systemic) (Site not responding. Last check: 2007-10-26)
		• Liver disease-Effects may be increased because of slower removal of moricizine from the body
		Children-Use and dose must be determined by your doctor.
		Use of any information is solely at the user's own risk.
	allnutritionals.com /drugs/m/moricizine-systemic.shtml (1055 words)

	moricizine - SJMMC, Ann Arbor, Michigan MI
		What is the most important information I should know about moricizine?
		What are the possible side effects of moricizine?
		Moricizine is available with a prescription under the brand name Ethmozine.
	www.sjmercyhealth.org /116500.cfm (1050 words)

	Moricizine bioavailability via simultaneous, dual, stable isotope administration: bioequivalence implications -- ...
		Moricizine bioavailability via simultaneous, dual, stable isotope administration: bioequivalence implications -- Pieniaszek HJ et al.
		Moricizine bioavailability via simultaneous, dual, stable isotope administration: bioequivalence implications
		CONTACT US Copyright © 1999 by American College of Clinical Pharmacology
	jcp.sagepub.com /cgi/content/abstract/39/8/817 (140 words)

	Moricizine Effects, Dosage, and Side Effects
		Moricizine is used to treat a blood disorder (high platelet count)...
		Every day, thousands of users find businesses like yours in the GoldBamboo directory.
		Your Integrative Health and Wellness Resource for Moricizine.
	goldbamboo.com /topic-t5565.html (170 words)

	Government and academic resources on MORICIZINE HYDROCHLORIDE (Site not responding. Last check: 2007-10-26)
		Block of Na+ channel by moricizine hydrochloride in isolated...
		: The effect of moricizine hydrochloride, a potent class I antiarrhythmic agent,
		:...agents that include quinidine, procainamide hydrochloride, disopyramide, mexiletine hydrochloride, encainide hydrochloride, flecainide acetate, and moricizine.
	names.mongabay.com /drugs/ingredients/MORICIZINE_HYDROCHLORIDE.html (154 words)

	Healthopedia.com Drugs Information - Moricizine : Before Using (Ethmozine)
		Healthopedia.com Drugs Information - Moricizine : Before Using (Ethmozine)
		You are here : Healthopedia.com > Drugs and Medications > Detailed Drug Information (USP DI) > Moricizine : Before Using
		In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do.
	www.healthopedia.com /drugs/detailed/moricizine/before-using.html (534 words)

	MORICIZINE - ORAL (Ethmozine) side effects, medical uses, and drug interactions.
		MORICIZINE - ORAL (Ethmozine) side effects, medical uses, and drug interactions.
		MedicineNet Home > Medications A-Z List > moricizine-oral
		MedicineNet does not provide medical advice, diagnosis or treatment.
	www.medicinenet.com /moricizine-oral/index.htm (72 words)

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