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Topic: Motor neurone disease

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	BioTrax Motor Neurone Disease Clinical and Medical Research
		Motor Neurone Disease (MND) is a very rare neurological condition which robs sufferers of the ability to walk, speak, move their limbs, and eventually breathe.
		The underlying cause of the disease is damage and death of the motor neurones.
		Where MND is familial it is normally autosomal dominant; this means that as with Huntington's Disease, the child of a Familial MND patient has a 50/50 chance of developing the disease in the future.
	www.biotrax.com /motorneuron.php (1566 words)

	Motor neurone disease Health Guide - Health Guides Online
		Motor neurone diseases are now regarded as multisystem diseases in which the motor neurones tend to be affected earliest and most severely, however other parts of the nervous system may also be affected.
		The disease causes progressive injury and cell death of lower motor neurone groups in the spinal cord and usually of upper motor neurones in the motor cortex of the brain as well.
		Another example of damage to cell bodies of motor neurones is syringomyelia where cavities form in the brainstem and spinal cord, lying near to the center of the cord.
	www.healthguidesonline.com /Motor_neurone_disease.html (2087 words)

	NHS Direct - Health encyclopaedia -Motor neurone disease
		Motor Neurone Disease (MND) is the name given to a group of relatively rare disorders that affect the motor neurones in the brain and spinal cord.
		Motor neurones are the nerves cells that send instructions to your brain, in the form of electrical impulses.
		MND is a condition that usually affects adults and it is most common among people aged 50 to 70.
	www.nhsdirect.nhs.uk /articles/article.aspx?articleId=251 (147 words)

	Motor Neurone Disease - A Family Affair By Dr David Oliver
		Motor Neurone Disease: A Family Affair shows how much can he done to help people with this condition live their lives to the full.
		Motor neurone disease affects everyone differently, but often you, and your family, feel rather helpless when you first find out that this is the diagnosis.
		The disease will vary in its effect, the time taken for changes to occur and the help needed, but there is always something more that can be done to help — whether this takes the form of drugs, the provision of helping aids or support and comfort.
	www.mypharmacy.co.uk /health_books/books/m/motor_neurone_disease.htm (1061 words)

	Motor neurone disease awareness campaign launched
		Booklets on Motor Neurone Disease are now regularly given to people when they are first diagnosed with the disease and clinical guidelines have been the development that help ensure the better treatment and care of people with MND.
		Motor Neurone Disease is the name given to a group of diseases in which damage to motor neurones occurs.
		Motor Neurones are nerve cells that control the movement of muscles, including all the muscles of the trunk and limbs, and speech and swallowing.
	www.health.gov.au /internet/wcms/Publishing.nsf/Content/health-mediarel-yr1999-mw-mw99030.htm (510 words)

	Motor Neurone Disease - Patient UK
		Motor neurone disease causes a progressive weakness of many of the muscles in the body.
		Nerves (neurones) are like wires that carry tiny electrical impulses ('messages') between the brain, spinal cord, and the rest of the body.
		In these cases there is no family history of the disease, and you do not pass it on to your children (it is not hereditary).
	www.patient.co.uk /showdoc/23069193 (1724 words)

	BBC - Health - Conditions - Motor neurone disease
		MND tends to affect people over 40 and is most common between the ages of 55 and 65.
		MND can run in families and for this reason one of the presumed causes is believed to be genetic.
		For many of those suffering with MND the fact that they are aware of what is happening to their body is often described as the worst part of the disease.
	www.bbc.co.uk /health/conditions/mnd1.shtml (809 words)

	Motor neurone disease British Medical Journal - Find Articles
		The incidence of the disease is one to two per 100 000, and a general practice with 10 000 patients is likely to encounter a case of motor neurone disease every two to three years.
		The disease causes progressive injury and cell death of lower motor neurone groups in the spinal cord and brain stem and usually also of upper-motor neurones in the motor cortex.
		It is a ubiquitous enzyme, expressed in cells throughout the body, and why motor neurones should be especially vulnerable to injury in the presence of mutations in the enzyme is not clear.
	www.findarticles.com /p/articles/mi_m0999/is_7191_318/ai_54654553 (717 words)

	MND Victoria Home Page
		MND is an abbreviation for Motor Neurone Disease (MND).
		MND is a neurological disease that affects over 350,000 of the world's population, and kills over 100,000 every year.
		Living with MND is a booklet providing practical advice on the many issues that arise from the impact of MND.
	www.mnd.asn.au (551 words)

	Motor Neurone Disease
		Motor neurone disease (MND) is the name for a group of related diseases characterised by progressive degeneration of specialised nerve cells (motor neurones) in the brain and spinal cord.
		Motor neurone disease in adults generally starts between the age of 50 and 60.
		This rare disease is hereditary and tends to have a higher incidence and severity in males.
	www.southerncross.co.nz /?6AA343B6-FAD0-48E4-8C9F-F4EA803A0FD7 (1005 words)

	GENETICS OF MOTOR NEURONE DISEASE
		Motor neurone disease (MND) or amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of unknown cause pathologically characterised by progressive degeneration of motor neurones in the cortex, brain stem and spinal cord.
		There is an absolute association of the larger polyglutamine stretch with the disease phenotype and, furthermore, the number of the repeats correlates with the severity of the disease.
		Functional studies of the receptor carrying the expanded polyglutamine stretch have now shown that the mutated protein exhibits reduced transcriptional competence, The molecular mechanisms by which this may impair motor neuron-specific survival remain to be clarified.
	sabryabdelfattah.tripod.com /docs/GEN_MND.htm (845 words)

	ALS (motor neurone disease) (Site not responding. Last check: 2007-11-02)
		Motor neurone disease and senile dementia could result from the calcium being deposited in the central nervous system.
		Iwami O et al: Motor neuron disease on the Kii Peninsula of Japan: excess manganese intake from food coupled with low magnesium in drinking water as a risk factor.
		30 of 53 patients with neurological disease (ataxia, peripheral neuropathy, nononeuritis multiplex, myopathy, motor neuropathy) of unknown cause were found to have antibodies to the substance gliaden found in gluten.
	www.health-diets.net /research/ALS.htm (283 words)

	Statements of Principles — Motor Neurone Disease — balance of probability
		“motor neurone disease” means a progressive neurodegenerative disease with clinical signs of lower and upper motor neurone damage in the absence of electrophysiological and neuroimaging evidence of other disease processes that explain the clinical signs.
		death from motor neurone disease is inability to obtain appropriate clinical management for motor neurone disease.
		“death from motor neurone disease” in relation to a person includes death from a terminal event or condition that was contributed to by the person’s motor neurone disease;
	www.dva.gov.au /pensions/SOPs/f035bp_motor_neurone_disease.htm (350 words)

	MOTOR NEURONE DISEASE
		Motor neurone disease (MND) is a tragic but fortunately rare disease which usually strikes people in middle and later life.
		Neurones are the cells in the nervous system responsible for the transmission of nerve messages (impulses) to and from all parts of the body.
		Motor neurones are involved in nerve messages to muscles, which ‘make things happen’ such as, for example, moving your arm or leg or opening your mouth.
	www.mydr.com.au /?article=2287 (480 words)

	MOTOR NEURONE DISEASE : Contact a Family - for families with disabled children: information on rare syndromes and ...
		The description of motor neurone disease (MND) is given to a group of closely related conditions where degeneration of the motor neurones (nerve cells which control muscles) in the brain and spinal cords causes progressive muscular wasting and weakness.
		Involving both upper and lower motor neurones (upper motor neurones descend from the brain to the brain stem and the spinal cord; lower motor neurones extend from the brain stem and the spinal cord to the muscles);
		Lower motor neurone damage causing nasal speech, regurgitation of fluid via the nose, tongue atrophy (wasting away) and fasciculation (muscle twitching) and pharyngeal (tube between mouth and stomach) weakness.
	www.cafamily.org.uk /Direct/m39.html (1368 words)

	BBC NEWS \| Health \| Medical notes \| Motor neurone disease
		Motor neurone disease is a progressive fatal condition that causes muscle wastage.
		Motor Neurone Disease (MND) is a group of related diseases affecting the motor neurones in the brain and spinal cord.
		Motor neurones are the nerve cells along which the brain sends instructions, in the form of electrical impulses, to the muscles.
	news.bbc.co.uk /go/rss/-/2/hi/health/medical_notes/1500231.stm (441 words)

	Motor neurone disease - symptoms, causes and prognosis of MND
		Motor neurone disease - symptoms, causes and prognosis of MND
		Motor neurone disease (MND) is a rare condition caused by the breakdown of the nerve cells in the brain that control the muscles.
		As the disease progresses, the muscles of your chest wall may be affected, leading to breathing difficulties.
	hcd2.bupa.co.uk /fact_sheets/html/motor_neurone_disease.html (1259 words)

	mnd
		Motor neurone disease (MND) is a progressive fatal disorder of the central nervous system characterised by degeneration of motor nerve cells in the brain (upper motor neurones) and spinal cord (lower motor neurones).
		In MND, motor nerve cells in the cerebral cortex, the base of the brain (brain stem) and in the spinal cord degenerate, resulting in muscular wasting and weakness, with death due to involvement of the muscles controlling breathing.
		We have suggested that this could be due to loss of intrinsic inhibitory mechanisms, a hypothesis in keeping with the notion that glutamate could be causing abnormal excitation of motor neurone nerves leading to their degeneration.
	www.iop.kcl.ac.uk /iop/prt/mnd.htm (2106 words)

	OTdirect Occupational Therapy Revision Notes: Motor Neurone Disease
		Motor Neurone Disease is an umbrella term covering three main sub-types of the condition: Amyotrophic Lateral Sclerosis (ALS) Progressive Bulbar Palsy (PBP) and Progressive Muscular Atrophy (PMA).
		MND is sometimes known as Lou Gehrig's Disease in the US, where a famous baseball player died of the disease in 1941.
		People with MND and their carers should be kept well informed of the availability of support services such as home care, home respite, institutional respite, palliative care services and hospice care.
	www.aopx83.dsl.pipex.com /otdirect/mnd.html (2491 words)

	Motor Neurone Disease: Patient guide
		Motor neurone disease causes a progressive weakness of many of the muscles in the body.
		Nerves (neurones) are like wires that carry tiny electrical impulses ('messages') between the brain, spinal cord, and the rest of the body.
		Most people with MND are cared for by a professional team which include neurologists, specialist nurses, physiotherapists, occupational therapists, dieticians, counsellors, etc. Each problem that arises needs to be assessed, and dealt with as far as possible by the relevant members of the team.
	www.privatehealth.co.uk /diseases/brain-nerves-neurology/motor-neurone-disease (1364 words)

	Motor neurone disease
		Motor neurone disease (MND) is the name given to a group of related diseases in which there is progressive degeneration of the motor neurones in the brain and spinal cord.
		Motor neurones are the nerve cells that control muscles, and their degeneration therefore leads to weakness and wasting of the muscles.
		MND can present itself in a number of ways, depending on the particular group of muscles which are initially affected.
	www.irishhealth.com /index.html?level=4&con=523 (801 words)

	Brain Foundation - Motor Neurone Disease
		Motor Neurone Disease (MND) is the name given to a group of diseases in which the nerve cells (neurons) that control the muscles degenerate and die.
		MND causes increasing disability due to muscular weakness, generally without mental impairment or incontinence.
		There are a range of treatments for MND aimed at reducing the symptoms and improving the quality of life for people with the condition.
	www.brainaustralia.org.au /AZ_of_Brain_Disorders/motor_neurone_disease (393 words)

	Family Health Articles - Pregnant Parent Articles and News
		My Father in Law was diagnosed with Motor neurone disease earlier this year which came as a huge shock to our family as the disease is incurable and one which isn’t really ever talked about or brought to anyones attention.
		Motor Neurone Disease is a progressive neuro-degenerative disease that attacks the upper and lower motor neurones.
		Unfortunately this disease (also known as Sudden Death Syndrome) is on the increase and it is estimated that 4 fit and healthy people die from it every week.
	www.madmums.com /GH_FrontPage.asp?catid=4 (666 words)

	Motor neurone disease explained - Better Health Channel.
		Motor neurone disease often begins with weakness of the muscles of the hands or feet.
		People with motor neurone disease need help with daily activities and have a life expectancy of three to five years after their diagnosis.
		In the majority of cases the intellect and memory are not affected, nor are the senses of eyesight, hearing, taste, smell and touch.
	www.betterhealth.vic.gov.au /bhcv2/bhcarticles.nsf/pages/Motor_neurone_disease_explained?open (530 words)

	Motor neurone disease
		Motor neurones are the nerves cells that control muscles.
		Amyotrophic lateral sclerosis (ALS) is the most common form of the disease and in the USA it is commonly known as Lou Gehrig’s disease.
		Motor neurone disease is a disease of adulthood and it is most common among people aged 50 to 70 and is slightly more common in men than women.
	www.tripdatabase.com /spider.html?itemid=260024 (167 words)

	Molecular Mechanisms in Motor Neurone Disease
		MND is normally a disorder of middle age, and is characterized by the degeneration and death of large motor neurones in the brain and spinal cord.
		Upper motor neurones in the brain normally send signals to lower motor neurones in the spinal cord, which send signals to muscles.
		In the mouse, alsin is expressed primarily in neurones of the central nervous system, with particularly high levels in the granular layer of the cerebellum and the alpha motor neurons of the spinal cord.
	www.genetics.med.ed.ac.uk /alsin (633 words)

	Motor neurone disease
		Neurones are cells that transmit data from the brain to the muscles, allowing us to move our limbs and breathe etc. MND is a disorder where these neurones degenerate to the point where the muscles weaken and movement is impaired.
		MND varies greatly between one person and the next – it is, in fact, a collection of diseases and does not exist in the singular.
		Anyone can get the disease, but men have a higher chance of developing it than women, and most carriers are over the age of 40.
	health.ninemsn.com.au /article.aspx?id=19149 (342 words)

	Genetic hit for motor neurone disease
		MND causes motor neurones, the nerve cells which the brain uses to send signals to the muscles, to degenerate leading to weakness and muscle wastage.
		According to the Motor Neurone Disease Association, three people die from MND in the UK every day and the disease affects more than 5000 people at any one time.
		MND is still incurable, generally resulting in paralysis and death three to five years after onset.
	www.rsc.org /chemistryworld/Issues/2004/July/disease.asp (448 words)

	Motor Neurone Disease
		in patients with motor neurone disease (ALS) because of clumping and condensation of chromatin in the dying anterior horn cells in ALS patients.
		Nicholson GA, "Motor neurone disease and the life of motor neurones." Med J Aust 1996; 165:80-181.
		Nicholson GA, "Motor neurone disease and the life of motor neurones." Med J Aust 1997; 166:109-110.
	www.acnem.org /journal/16-1_december_1997/motor_neurone_disease.htm (842 words)

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