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Topic: Mucin

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Mucous membrane

Mucus

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Aphrodite Pandemos

Sayed Abul Ala Mawdudi

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	Mucin - Wikipedia, the free encyclopedia
		Mucins are a family of large, heavily glycosylated proteins.
		Although some mucins are membrane-bound due to the presence of a hydrophobic membrane-spanning domain that favors retention in the plasma membrane, the concentration here is on those mucins that are secreted on mucosal surfaces and saliva.
		Mucin genes encode mucin monomers that are synthesized as rod-shape apomucin cores that are post-translationally modified by exceptionally abundant glycosylation.
	en.wikipedia.org /wiki/Mucin (349 words)

	RedOrbit - Science - The DHE Cell Line As a Model for Studying Rat Gastro-Intestinal Mucin Expression: Effects of ...
		Mucins are high molecular weight glycoproteins with wide biological functions, including physicochemical protection from acids, enzymes, toxins and mutagens, adhesion modulation, signal transduction, and regulation of cell growth (Moniaux et al., 2001; Porchet et al., 1999).
		The protein backbone of human mucins is encoded by a family of MUC genes, and it has been demonstrated that each mucin has a characteristic tissue distribution (Audie et al., 1993; Ho et al., 1995; Reis et al., 1997).
		This gastric mucin is expressed in human colorectal adenocarcinomas (Sylvester et al., 2001) and in rat colon during dimethyhydrazine or methyl-N'-nitroso-guanidine (MNNG)- induced carcinogenesis (Bara et al., 2003; Decaens et al., 1988).
	www.redorbit.com /news/display?id=102753 (7557 words)

	RedOrbit - Science - Modulation of mucin synthesis by [gamma]-interferon in human colon adenocarcinoma cells
		These studies together with evidence that intracellular mucin, such as that in signet ring cells, may be present to a variable extent in non-mucinous colonic adenocarcinomas [16], point to the need for further correlating the qualitative and quantitative mucin changes in colon cancer cells in the context of tumorigenicity and other biological properties.
		Mucin separation and measurement: Mucin synthesis was estimated by measuring the amount of [^sup 3^H]glucosamine-labeled glycoprotein in the medium and cytosolic fractions excluded on Sepharose CL-4B column (method I), or by measuring the length of the void volume of the column and extrapolating the result to the concentration curve of standard mucins (method II).
		Mucin concentrations were expressed as dpm/4 x 10^sup 6^ cells according to the first method or as mg/10^sup 7^ cells according to the second method.
	www.redorbit.com /news/display?id=3415 (3175 words)

	MUCIN BIOLOGY-RESEARCH
		Mucin or PTS domains are found also in other extracellular proteins, but are dominating in molecules that are usually called mucins.
		Mucin domains are rich in the amino acids threonine, serine and proline, where the oligosaccharides are linked via N-acetylgalactosamine to the hydroxy amino acids.
		An understanding of mucins and the alteration of their properties will be very important for several types of diseases in the gastrointestinal and respiratory tracts.
	www.medkem.gu.se /mucinbiology/research.html (561 words)

	MAUB Is a New Mucin Antigen Associated with Bladder Cancer -- Bergeron et al. 271 (12): 6933 -- Journal of Biological ...
		Although mucins are natural components of normal epithelial tissues, their abnormal expression in cancers may be due either to aberrant regulation of mucin gene expression or aberrant glycosylation of the gene products.
		Mucin genes may be up- or down-regulated in cancers originating from tissues where they are constitutively expressed, or they may be ectopically expressed in cancers derived from tissues that do not normally express them.
		The identification of MAUB as a new mucin antigen associated with bladder cancer may have important implications for the treatment of superficial bladder tumors, since cancer mucins appear to have immunomodulatory properties and thus are good candidates for the design of specific cancer vaccines(72, 73).
	www.jbc.org /cgi/content/full/271/12/6933 (7409 words)

	MUCIN BIOLOGY-PUBLICATIONS
		G.C., (1994) Purification and characterization of sialyl-Lea-carrying mucins of human bile; evidence for the presence of MUC1 and MUC3 apoproteins.
		Karlsson, N.G., and Hansson, G.C., (1995) Analysis of monosaccharide composition of mucin oligosaccharide alditols by high-performance anion-exchange chromatography.
		Sikut, R., Zhang, K., Baeckström, D., and Hansson, G.C. (1996) Distinct sub-populations of carcinoma-associated MUC1 mucins as detected by the monoclonal antibody 9H8 and antibodies against the sialyl-Lewis a and sialyl-Lewis x epitopes in the circulation of breast-cancer patients.
	www.medkem.gu.se /mucinbiology/publications.html (1955 words)

	Regulation of mucin secretion from human bronchial epithelial cells grown in murine hosted xenografts -- Conway et al. ...
		Mucins secreted by SPOC1 cells were detected in microtiter plates by an SBA ELLA as described previously (3).
		Mucin secretion for this and most such studies with HBE xenografts was normalized to the mean of the 30-min baseline values.
		Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase.
	ajplung.physiology.org /cgi/content/full/284/6/L945 (6836 words)

	Selective secretion and replenishment of discrete mucin glycoforms from intestinal goblet cells -- Stanley and Phillips ...
		Extracellular mucin and background signal outside the thecal stores of mucous secretory granules are removed using the "paint" function in the image analysis software.
		Total mucin stores (solid bars) and mucin stained by the carbohydrate-specific monoclonal antibody (gray bars) were measured and expressed as a percentage of their levels in mock-stimulated control monolayers.
		Gastric M1 mucin, an early oncofetal marker of colon carcinogenesis, is encoded by the MUC5AC gene.
	ajpgi.physiology.org /cgi/content/full/277/1/G191 (5368 words)

	Targeted disruption of the murine mucin gene 1 decreases susceptibility to cholesterol gallstone formation -- Wang et ...
		mucin that is abundant in the secretory epithelia of the gallbladder
		The mRNA expression of mucin gene 1 (Muc1), Muc3, Muc4, Muc5ac, and Muc5b in the gallbladders of wild-type (A) and Muc1 knockout (Muc1
		absence of Muc1 mucin and Muc1 mRNA in the gallbladders of Muc1
	www.jlr.org /cgi/content/full/45/3/438 (5088 words)

	Airway Mucus Obstruction: Mucin Glycoproteins, MUC Gene Regulation and Goblet Cell Hyperplasia -- Rose et al. 25 (5): ...
		Mucin overproduction is maintained by increased expression of MUC genes and of glycosyltransferase genes.
		Characterization of human mucin 5B gene expression in airway epithelium and the genomic clones of the amino-terminal and 5'-flanking region.
		Regulation of mucous differentiation and mucin gene expression in the tracheobronchial epithelium.
	ajrcmb.atsjournals.org /cgi/content/full/25/5/533 (3311 words)

	Pfam 20.0 : Mucin (Site not responding. Last check: 2007-10-23)
		Indirect evidence suggested that these genes might encode the core protein of parasite mucins, glycoproteins that were proposed to be involved in the interaction with, and invasion of, mammalian host cells.
		The N and C terminii are conserved between all members of the family, whereas the central region is not well conserved and contains a large number of threonine residues which can be glycosylated PUBMED:7592617.
		The Trypanosoma cruzi mucin family is transcribed from hundreds of genes having hypervariable regions.
	pfam.wustl.edu /cgi-bin/getdesc?name=Mucin (203 words)

	Characterization of Binding of Candida albicans to Small Intestinal Mucin and Its Role in Adherence to Mucosal ...
		degradation of mucins by bacterial proteinases or glycosidases
		Mucin (5% [wt/vol]) was treated with 50 mM sodium periodate in 0.1 M sodium acetate (pH 5.5) for 20 min at 22°C in the dark,
		backbone of the 118-kDa C-terminal glycopeptide of mucin.
	iai.asm.org /cgi/content/full/68/6/3172 (6242 words)

	Mucin (EMA, sialomucin) related antibodies from RDI Divison of Fitzgerald Industries Intl
		Background: MUc-2 glycoprotein also known as intestinal mucin related protein antigen is an intestinal apomucin.Muc-2 glycoprotein is expressed in mucinous tumors but not in serous tumors.
		Antibody to gastric mucin M1 reacts with the gastric epithelium of normal gastrointestinal tract as well as with the precancerous and cancerous colon but not with normal adult colon.
		Resurgence of gastric mucin reactivity during colonic carcinogenesis is due to reexpression of the peptide core of gastric (or fetal colonic) mucin.
	www.researchd.com /tumorabs/mucinab.htm (1983 words)

	Developmental expression of mucin genes in the human gastrointestinal system -- Reid and Harris 42 (2): 220 -- Gut
		Mucin genes are expressed from the early mid-trimester of gestation in the developing human fetal gastrointestinal
		Mucin gene expression was analysed at 13 weeks, 17/18 weeks, and 23 weeks of gestation and in adult colon and small intestine.
		The developmental expression of mucin genes is of importance in the context of neonatal diseases of the digestive system.
	gut.bmjjournals.com /cgi/content/full/42/2/220 (3269 words)

	Group A Streptococci Bind to Mucin and Human Pharyngeal Cells through Sialic Acid-Containing Receptors -- Ryan et al. ...
		A modified solid-phase mucin binding assay was performed with bovine mucin as described previously (54).
		acid is a constituent of the receptor on mucin for the M protein.
		Evidence for mucins and sialic acid as receptors for Pseudomonas aeruginosa in the lower respiratory tract.
	iai.asm.org /cgi/content/full/69/12/7402 (7496 words)

	Differential Regulation of Airway Mucin Gene Expression and Mucin Secretion by Extracellular Nucleotide Triphosphates ...
		and synthesis of mucin in airway is poorly understood.
		Secreted CM was collected from each culture chamber as described and the mucin content in the secreted medium was quantified by a double-sandwich mucin ELISA method, as described elsewhere (23).
		Nucleotide-induced mucin release from primary hamster tracheal surface epithelial cells involves the P2u purinoceptor.
	ajrcmb.atsjournals.org /cgi/content/full/25/4/409 (5346 words)

	Two Novel Mucin Genes Down-Regulated in Colorectal Cancer Identified by Differential Display -- Williams et al. 59 ... (Site not responding. Last check: 2007-10-23)
		of a mucin gene cluster at this locus.
		presence of a new cluster of mucin genes at this locus.
		Mucins are encoded by large genes that have proved difficult
	cancerres.aacrjournals.org /cgi/content/full/59/16/4083 (5845 words)

	A Novel Mechanism for Desulfation of Mucin: Identification and Cloning of a Mucin-Desulfating Glycosidase ...
		A Novel Mechanism for Desulfation of Mucin: Identification and Cloning of a Mucin-Desulfating Glycosidase (Sulfoglycosidase) from Prevotella Strain RS2 -- Rho et al.
		A Novel Mechanism for Desulfation of Mucin: Identification and Cloning of a Mucin-Desulfating Glycosidase (Sulfoglycosidase) from Prevotella Strain RS2
		mucin desulfation was thought to take place by the action of
	jb.asm.org /cgi/content/abstract/187/5/1543 (274 words)

	GeneCard for MUC5B
		Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon.
		Oppenheim F.G. The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharidesthat is large and diverse.
		Thomsson K.A....Hansson G.C. Human mucin gene MUC5B, the 10.7 kb large central exon encodes various alternate subdomains resulting in a super-repeat.
	www.genecards.org /cgi-bin/carddisp.pl?gene=MUC5B (684 words)

	Initiation of Mucin-type O-Glycosylation in Dictyostelium Is Homologous to the Corresponding Step in Animals and Is ... (Site not responding. Last check: 2007-10-23)
		Extracellular mucin proteins are employed throughout the eukaryotic
		that mucin O-glycosylation is a critical virulence factor for
		mucin peptide-1 (Table I), was not an acceptor in this assay
	www.jbc.org /cgi/content/full/278/51/51395 (6902 words)

	UniProtKB/Swiss-Prot entry P98088 [MUC5A_HUMAN] Mucin-5AC
		Escande F. Aubert J.-P. Porchet N. Buisine M.P. "Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region.";
		Meerzaman D. Charles P. Daskal E. Polymeropoulos M.H. Martin B.M. Rose M.C. "Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).";
		Buisine M.P. Desseyn J.L. Porchet N. Degand P. Laine A. Aubert J.-P. "Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family.";
	www.expasy.org /uniprot/P98088 (371 words)

	Biotechnology Encyclopedia (Site not responding. Last check: 2007-10-23)
		Its ophthalmic products and product candidates are concentrated in the allergic conjunctivitis, dry eye disease and retinal disease indications
		The lead product diquafosol tetrasodium (INS365 Ophthalmic) for the treatment of dry eye disease Diquafosol tetrasodium is a P2Y2 receptor agonist that activates receptors on the ocular surface and inner lining of the eyelid to stimulate the release of water, salt, mucin and lipids - the key components of natural tears.
		Diquafosol tetrasodium (INS365 Ophthalmic) for the treatment of dry eye disease
	www.biotech100.com /drugs/inspire.htm (123 words)

	Mucin like glycoprotein antibodies from RDI Divison of Fitzgerald Industries Intl
		Mucin like glycoprotein antibodies from RDI Divison of Fitzgerald Industries Intl
		Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
		FOR IN VITRO RESEARCH USE ONLY-NOT FOR USE IN DIAGNOSTICS
	www.researchd.com /tumorabs/trk4m40.htm (914 words)

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