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| | RFA-DE-05-002: DEVELOPMENT OF IN VITRO MODELS OF HUMAN ORAL MUCOSA RELEVANT TO AIDS AND MUCOSAL INFECTIONS (Site not responding. Last check: ) |
 | | The oral mucosa is composed of both stratified and non-stratified epithelial cells which form a continuously renewing, protective 100 um layer in the mouth. |
 | | The surface of the mucosa is covered by salivary carbohydrates, lipids and proteins, and interacts directly with the oral environment, containing bacteria, fungi, viruses, food, tobacco products, alcohol etc. In addition, the mucosa produces or is bathed by cytokines, chemokines, antibodies and innate host factors in saliva. |
 | | Research on identifying protective or susceptibility factors in the oral mucosa in persons exposed to HIV would be greatly facilitated by the availability of high quality, standardized, and reproducible in vitro models of the mucosal tissue. |
| grants.nih.gov /grants/guide/rfa-files/RFA-DE-05-002.html (3987 words) |
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