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Topic: Multifactorial

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	Human Genetics - Multifactorial Inheritance
		Multifactorial inheritance was first studied by Galton, a close relative of Darwin and a contemporary of Mendel.
		As the number of multifactorial genes for the trait increases, the liability for the disease increases.
		In summary, the hallmarks for multifactorial inheritance are:
	www.uic.edu /classes/bms/bms655/lesson11.html (2713 words)

	Southeast Missouri Hospital - Multifactorial Inheritance
		Multifactorial inheritance means that many factors (multifactorial) are involved in causing a health problem.
		Multifactorial traits do recur in families, because they are partly caused by genes and shared environmental factors.
		The chance for a multifactorial trait or condition to happen to you depends upon how closely the family member with the trait is related to you.
	www.southeastmissourihospital.com /cancerresource/mfi.htm (259 words)

	MULTIFACTORIAL INHERITANCE
		Multifactorial conditions tend to run in families, but the pattern of inheritance is not as predictable as with single gene disorders.
		The degree of risk of a multifactorial disorder occurring in relatives is related to the number of genes they share in common with the affected individual.
		Although multifactorial conditions run in families, the risk is generally less than the 25% or 50% seen in Mendelian conditions.
	www.usd.edu /med/som/genetics/curriculum/1GMULTI5.htm (556 words)

	Multifactorial Inheritance - Children's Hospital of Philadelphia
		Multifactorial inheritance means that "many factors" are involved in causing a birth defect.
		Multifactorial traits do recur in families, because they are partly caused by genes.
		The chance for a multifactorial trait or condition to happen again depends upon how closely the family member with the trait is related to you.
	www.chop.edu /consumer/your_child/condition_section_index.jsp?root_id=0&id=-8563 (1218 words)

	Multifactorial Disorders (Site not responding. Last check: 2007-10-17)
		Among the diseases with known multifactorial inheritance are heart disease, hypertension, diabetes, obesity, cancer, and congenital defects such as cleft palate.
		Multifactorial inheritance is also involved in other, non-clinical traits such as height and skin color.
		Multifactorial disorders also emphasize the role of the environment, a key piece in the development of most genetic diseases.
	www.uic.edu /nursing/genetics/Lecture/Types/Multifactorial/multifact.htm (770 words)

	[No title] (Site not responding. Last check: 2007-10-17)
		Now not everything is this simple, but the main point is the genetic components of a multifactorial disorder have a dosage effect, meaning the greater number of mutant genes inherited the more severe the expression of the disorder.
		Some known multifactorial disorders are cleft lip or palate, congenital heart disease, coronary heart disease, hypertension, gout, clubbed foot, diabetes mellitus, and pyloric stenosis.
		Multifactorial disorders are established from monozygotic and dizygotic twin studies.
	www.muhealth.org /~md2004/update5/8-27multifactorial.doc (587 words)

	Reports - Multifactorial Inheritance of Autoimmune Rheumatic Diseases (Site not responding. Last check: 2007-10-17)
		The second important feature of multifactorial inheritance for lupus nephritis is that multiple genes are required for the development of the disease, but no gene is individually necessary or sufficient for the development of autoimmunity.
		Disease susceptibilities that are inherited as a multifactorial threshold liability would be postulated to have several interesting genetic features.
		Given this degree of complexity, it is not surprising that linkage analysis of multifactorial traits and diseases in human populations requires extremely large sample populations to obtain significant results.
	www.niams.nih.gov /ne/reports/sci_wrk/1997/wakeland.htm (1173 words)

	Multifactorial Traits
		Multifactorial traits are determined by interactions between a gene or genes and the environment, and do not exhibit Mendelian ratios.
		Fingerprint pattern is a multifactorial trait and environmental differences during gestation results in dermatoglyphic differences between identical twins.
		Heritability estimates the proportion of variation in a population for a multifactorial trait that is due to genotype.
	highered.mcgraw-hill.com /sites/007246268x/student_view0/chapter7 (751 words)

	ILLEGAL COPY of PRINCIPLES of GENETICS!!! (Site not responding. Last check: 2007-10-17)
		Multifactorial inheritance disorders are caused by a combination of genetic factors (multiple loci and alleles) and often affected by environmental factors.
		Multifactorial traits more frequent in one sex than in the other increase the risk for relatives (of affected patients) if the proband is the opposite (less susceptible sex)!
		Pyloric stenosis is (probably) a multifactorial trait, with a different threshold for the two sexes.
	www.synapses.co.uk /genetics/medmulti.html (2210 words)

	THE MERCK MANUAL, Sec. 21, Ch. 286, General Principles Of Medical Genetics
		Similarly, a parent with a multifactorial NTD has a 3 to 4% chance of having an affected child.
		Other examples of multifactorial inheritance, with similar risks for siblings and offspring of affected persons, are congenital anomalies of the heart (see in Ch.
		Attention is being focused on common adult disorders with multifactorial causes (eg, hypertension, arteriosclerotic heart disease, diabetes mellitus, cancer, arthritis).
	www.merck.com /pubs/mmanual/section21/chapter286/286c.htm (544 words)

	Medical Dictionary: Multifactorial inheritance - WrongDiagnosis.com
		Introduction: The term multifactorial inheritance typically refers to inheritance patterns of polygenic diseases, where no single gene is responsible.
		A multifactorial inheritance pattern is affected by multiple genes, not just a single gene as in Mendelian inheritance, and in many cases the inheritance pattern is extremely unclear.
		Typically for polygenic diseases, having a parent or other family relative with the disease is a risk factor that increases your risk of getting the disease, but there is no definite pattern over generations.
	www.wrongdiagnosis.com /medical/multifactorial_inheritance.htm (206 words)

	Child Health Library - Medical Genetics - Multifactorial Inheritance
		Multifactorial inheritance means that many factors (multifactorial) are involved in causing a birth defect.
		The factors are usually both genetic and environmental, where a combination of genes from both parents, in addition to unknown environmental factors, produce the trait or condition.
		Examples of multifactorial traits and diseases include: height, neural tube defects, and hip dysplasia.
	www.chp.edu /greystone/genetics/multi.php (1154 words)

	[No title] (Site not responding. Last check: 2007-10-17)
		Multifactorial Inheritance (non-Mendelian) is more common than simple gene defects.
		Multifactorial Inheritance traits follow a curve of normal distribution (bell-shape).
		Most inherited diseases are transmitted via multifactorial inheritance, which means: a.
	www.muhealth.org /~md2003/pbldraft/08-04hil2.doc (682 words)

	Multifactorial Conditions - Prenatal Diagnosis and Medical Genetics - Mount Sinai Hospital, Toronto
		Conditions such as cleft lip, cleft palate, congenital heart disease and spina bifida (among others) are caused by the interaction of several genes which are not working well and environmental issues.
		Researchers will look at the number of children with a specific birth defect born to a parent with the same defect or, to parents who had a child or other family members with the same defect.
		Most multifactorial birth defects happen "out of the blue" to just one person in a family.
	www.mtsinai.on.ca /pdmg/Genetics/multi.htm (325 words)

	The Multifactorial Nature of Employee Errors (Site not responding. Last check: 2007-10-17)
		A model for causes (either events or conditions) culminating in an accident is displayed in Figure 3; The Multifactorial Nature of Employee Error.
		The multifactorial nature of employee error is corroborated by actuarial data.
		If accidents are analyzed using a multifactorial model, not only will direct causes be identified, but root and contributing causes will also emerge.
	www.eh.doe.gov /analysis/trac/1000/cairs_1.html (1475 words)

	MULTIFACTORIAL INHERITANCE (Site not responding. Last check: 2007-10-17)
		The most common cause of genetic disorders is multifactorial or polygenic inheritance.
		Identical twins who are exactly alike genetically, do not always have the same condition when inheritance is multifactorial.
		Some of the most common chronic diseases are multifactorial genetic disorders.
	med.usd.edu /som/genetics/curriculum/1GMULTI5.htm (556 words)

	Multifactorial Inheritance (Site not responding. Last check: 2007-10-17)
		In terms of disease, multifactorial inheritance implies a genetic predisposition or susceptibility and an environmental trigger.
		Cleft lip is usually considered a multifactorial disorder when it is the only anomaly but it is often one of several anomalies when cytogenetic abnormalities occur.
		Because multifactorial disorders require a genetic predisposition and an environmental trigger, the recurrence risk is lower than for disorders with single gene inheritance.
	skyway.usask.ca /~schmutz/Multifactorial.html (750 words)

	Successful multifactorial strategies (Site not responding. Last check: 2007-10-17)
		This section presents a non-exhaustive review of some multifactorial fall prevention strategies that have been implemented in countries around the world.
		A prospective study of an intervention area, matched to a control area, the Stay on Your Feet (SOYF) Programme, showed that health promotion reduced the rate of fall-related hospitalization and increased awareness (123,130).
		A strategy with deadlines for implementation of fall injury reduction services has been presented as part of a framework of practice covering medical procedures for all older adults (133; www.doh.gov.uk/nsf/olderpeople.htm), the National Service Framework for Older People (Standard 6: Falls).
	www.euro.who.int /HEN/Syntheses/Fallsrisk/20040322_4 (734 words)

	University of Miami School of Medicine - Glossary - Multifactorial inheritance
		Type 2 diabetes, the most common type of diabetes, is multifactorial.
		It is due to the inheritance of susceptibility genes (genes that make one susceptible to developing diabetes) plus environmental factors such as obesity.
		Obesity, in turn, clearly is multifactorial in causation.
	www.med.miami.edu /glossary/art.asp?articlekey=4453 (111 words)

	[No title] (Site not responding. Last check: 2007-10-17)
		This can be done, and designs of this type are known as multifactorial or multivariate, but obviously as more independent and dependent variables are introduced, so the complexity of the study increases.
		Also it is worth noting that as complexity increases in this way, so the required number of participants will also increase very quickly and the researcher may also find that the interactions become increasingly difficult to make sense of.
		The primary aim of multifactorial studies is to untangle this web of interconnections between the independent and dependent variables, and by using sophisticated statistical analyses, this is often possible.
	www.chssc.salford.ac.uk /healthSci/resmeth2000/resmeth/multfac.htm (457 words)

	A multifactorial intervention after a fall did not prevent falls in elderly patients with cognitive impairment and ...
		A multifactorial intervention after a fall did not prevent falls in elderly patients with cognitive impairment and dementia
		Multifactorial intervention after a fall in older people with cognitive impairment and dementia presenting to the accident and emergency department: randomised controlled trial.
		In elderly patients with cognitive impairment and dementia, is multifactorial assessment and intervention as effective as conventional care for preventing falls?
	ebn.bmjjournals.com /cgi/content/full/6/4/114 (952 words)

	Multifactorial intervention after a fall in older people with cognitive impairment and dementia presenting to the ...
		Multifactorial intervention after a fall in older people with cognitive impairment and dementia presenting to the accident and emergency department: randomised controlled trial -- Shaw et al.
		Multifactorial intervention prevents falls in cognitively normal older people living in the community and in those who present to the accident and emergency department after a fall
		No benefit was shown from multifactorial assessment and intervention after a fall in patients with cognitive impairment and dementia presenting to the accident and emergency department
	bmj.com /cgi/content/abstract/326/7380/73 (499 words)

	Effects of a programme of multifactorial home visits on falls and mobility impairments in elderly people at risk: ...
		Multifactorial home visits by community nurses did not reduce falls and impairments in mobility among a group of elderly people
		A programme of multifactorial home visits aimed at reducing falls and impairments in mobility in elderly people at risk living in the community is not effective in the Dutch healthcare setting
		A multifactorial intervention to reduce the risk of falling among elderly people living in the community.
	bmj.bmjjournals.com /cgi/content/full/321/7267/994 (2543 words)

	multifactorial polygenic (Site not responding. Last check: 2007-10-17)
		The presence of such environmental factors provides evidence that migraine is also multifactorial.
		Taken as a whole, the evidence shows that migraine should be considered a multifactorial, polygenic trait.
		As research continues, it may be found that migraine is a symptom of a larger disorder with multiple factors involved and different degrees of expressivity.
	www.bol.ucla.edu /~crclark/mult.poly.dis.html (215 words)

	Running head: MULTIFACTORIAL ANALYSIS (Site not responding. Last check: 2007-10-17)
		Schizophrenia is a term used to define what may indeed prove eventually to be a diverse set of disorders.
		Efforts shall be directed toward the goal of reconciling discrepancies within the framework of a multifactorial understanding of the pathogenesis of schizophrenia.
		The wealth of differing brain structure abnormalities discussed in only a few examples of the relevant literature surely provides a wealth of evidence for the multifactorial explanation of schizophrenia.
	www.augustana.edu /users/psjohnson/abnsamplepaper1.htm (1974 words)

	Focus on Multifactorial Genetics (Site not responding. Last check: 2007-10-17)
		The challenge posed by multifactorial genetics is to understand the genetic contribution to any phenotype that results from the action of multiple genes and the environment.
		The phenotypes are as diverse as common human disease and crop yield, and they have become the focus of attention for scientists with a broad range of backgrounds.
		The intense interest in multifactorial genetics reflects the huge potential for rewards: benefits for human health and productivity; a better understanding of evolutionary processes; and fuller knowledge of the connections between genotype and phenotype.
	www.nature.com /nrg/focus/multigen/index_mf.html (159 words)

	MSN Encarta - Search Results - multifactorial
		Multifactorial disorders are caused by several genes as well as the influence of a person’s environment, such as diet or lifestyle.
		Genetic Disorders : Types of Genetic Disorders : Multifactorial Disorders
		Exclusively for MSN Encarta Premium Subscribers--quickly search thousands of articles from magazines such as Time, Newsweek, The Atlantic Monthly, and Smithsonian.
	encarta.msn.com /multifactorial.html (81 words)

	Genetic Disease Information
		A genetic disorder is a disease caused by abnormalities in an individual’s genetic material (genome).
		There are four different types of genetic disorders: (1) single-gene, (2) multifactorial, (3) chromosomal, and (4) mitochondrial.
		Multifactorial inheritance also is associated with heritable traits such as fingerprint patterns, height, eye color, and skin color.
	www.ornl.gov /TechResources/Human_Genome/medicine/assist.html (2023 words)

	Multifactorial inheritance disorders (from genetic disorder) -- Britannica Student Encyclopedia (Site not responding. Last check: 2007-10-17)
		Multifactorial inheritance disorders (from genetic disorder) -- Britannica Student Encyclopedia
		More results on "Multifactorial inheritance disorders (from genetic disorder)" when you join.
		More from Britannica on "Multifactorial inheritance disorders (from genetic disorder)"...
	www.britannica.com /ebi/article?tocId=201414&ct=eb (846 words)

	BioMed Central \| Full text \| Multifactorial experimental design and the transitivity of ratios with spotted DNA ...
		Multifactorial experimental design and the transitivity of ratios with spotted DNA microarrays
		Multifactorial experimental designs using DNA microarrays are becoming increasingly common, but the extent of the transitivity of cDNA microarray expression measurements across multiple samples has yet to be explored.
		A strong correlation between direct and transitive inference for significantly differentially expressed genes is demonstrated, using subsets of a dye-swap loop design.
	www.biomedcentral.com /1471-2164/4/41 (3707 words)

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