
	Where results make sense

Topic: Multipotency

Related Topics

Totipotent

Embryonic stem cell research

Stem cell

Transdifferentiation

Pluripotential hemopoietic stem cell

Red blood cell

Acute lymphocytic leukemia

Montreal, Quebec

Pound sterling

In the News (Sat 26 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Multipotency - Wikipedia, the free encyclopedia
		Multipotent progenitor cells can give rise to several other cell types, but those types are limited in number.
		An example of a multipotent stem cell is a hematopoietic cell — a blood stem cell that can develop into several types of blood cells, but cannot develop into brain cells or other types of cells.
		At the end of the long series of cell divisions that form the embryo are cells that are terminally differentiated, or that are considered to be permanently committed to a specific function.
	en.wikipedia.org /wiki/Multipotency (217 words)

	Stem cells: Harnessing stem cell potential - Cell Signaling Update - Signaling Gateway
		To exploit the full potential of neural stem cells, it is essential to identify not only the factors that promote their differentiation, but also the factors that preserve the stem-cell state.
		However, Sox10 also acts as a brake to delay or prevent the terminal differentiation of neurons, an activity that is reflected in its ability to repress Phox2a, a close relative of Phox2b.
		Multipotent cell lineages in early mouse development depend on SOX2 function.
	www.signaling-gateway.org /update/updates/200306/nrn1144.html (454 words)

	Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis
		Researchers in the United Kingdom and Belgium set out to investigate the characteristics of cells in the periosteum, the dense membrane at the boundary between the bone and the surrounding soft tissues.
		Their study, featured in the April 2006 issue of Arthritis and Rheumatism, is the first to identify periosteal cells as MSCs, with multipotent properties at the single cell level and the potential to regenerate cartilage, muscle, and bone in patients with inflammatory and degenerative rheumatic diseases.
		To assess their multipotency beyond the laboratory, the periosteal cells were then injected into one of three animal models: mice, with the goal of muscle regeneration; goats, with the goal of developing cartilage; and mice, with the goal of bone formation.
	www.news-medical.net /?id=17038 (530 words)

	Teaching Brief® - MedPage Today
		Cultured adult human periosteal stem cells demonstrate mesenchymal multipotency, suggesting that they may be used to repair tissue and joint damage associated with arthritis, researchers here reported.
		This is the first study to report that periosteum cells can differentiate "into skeletal muscle in vivo and are multipotent [mesenchymal stem cells] at the single-cell level," they wrote.
		But it is unclear whether the multipotency is the result of in vitro manipulation or "an intrinsic property of reserve quiescent cells that reside within the adult periosteum and undergo activation in response to signals from surrounding tissue/structures."
	www.medpagetoday.com /tbprint.cfm?tbid=2951 (575 words)

	The heart can heal itself (Site not responding. Last check: 2007-10-10)
		We have then established that atria are the heart region with the highest frequency in CSC, supporting the therapeutic strategies implying the mobilization or the isolation of the CSC from this reservoir.
		Although these cells share important SC features (immunophenotype, multipotency, clonogenicity, telomerase activity), they differ in terms of telomeric length and growth kinetics, suggesting that pathological processes can impair the resident cardiac SC reservoir.
		Because of the fact that the effect of telomerase and telomere length on stem cell behavior are intrinsic to the stem cell and do not depend on physiological niche micro-environments, the telomeric shortening of resident stem cells may represent an independent factor of the multifactorial heart failure patho-physiology.
	www.news-medical.net /?id=19887 (610 words)

	New hope for tissue regeneration and joint repair
		Study indicates therapeutic promise of adult human multipotent stem cells derived from the thick membrane covering the surface of bones
		Their study, featured in the April 2006 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis), is the first to identify periosteal cells as MSCs, with multipotent properties at the single cell level and the potential to regenerate cartilage, muscle, and bone in patients with inflammatory and degenerative rheumatic diseases.
		Article: "Mesenchymal Multipotency of Adult Human Periosteal Cells Demonstrated by Single-Cell Lineage Analysis," Cosimo De Bari, Francesco Dell'Accio, Johan Vanlauwe, Jeroen Eyckmans, Ilyas M. Khan, Charles W. Archer, Elena A. Jones, Dennis McGonagle, Thimios A. Mitsiadis, Costantino Pitzalis, and Frank P. Luyten, Arthritis & Rheumatism, April 2006, 54:4, pp.
	www.eurekalert.org /pub_releases/2006-03/jws-nhf032206.php (510 words)

	The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into ...
		Multipotency is associated with both endothelial and sub-endothelial cells of the vascular wall
		Multipotent progenitors are associated with mouse dorsal aorta
		the population of multipotent progenitors from dorsal aorta
	dev.biologists.org /cgi/content/full/129/11/2773 (7887 words)

	Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo -- Mukouyama et al. 103 (5): 1551 ... (Site not responding. Last check: 2007-10-10)
		Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo -- Mukouyama et al.
		neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo
		the multipotency and self-renewal of stem cells in the CNS have
	www.pnas.org /cgi/content/full/103/5/1551 (3123 words)

	Cell lineage analysis reveals multipotency of some avian neural crest cells
		The question of cell lineage is central to the neural crest because it gives rise to numerous and diverse derivatives including peripheral neurons, glial and Schwann cells, pigment cells, and cartilage.
		Cells as diverse as sensory neurons, presumptive pigment cells, ganglionic supportive cells, adrenomedullary cells and neural tube cells were found within individual clones.
		Our results indicate that at least some neural crest cells are multipotent before their departure from the neural tube.
	www.nature.com /nature/journal/v335/n6186/abs/335161a0.html (389 words)

	Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient ... (Site not responding. Last check: 2007-10-10)
		Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient precursor B-cell clones.
		Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient precursor B-cell clones.Here, using serial transplantations, with in vitro recloning and growth of the bone marrow-homed donor cells occurring after all transplantations, we analyzed the extent of self-renewal and hematopoietic multipotency of Pax5(-/-) precursor B-cell clones.
		Together, these data show that Pax5(-/-) precursor B-cell clones possess extensive in vivo self-renewal capacity, long-term reconstitution capacity, and hematopoietic multipotency, with their telomeres shortening at the normal rate.
	www.ihop-net.org /UniPub/iHOP/gp/9421123.html (210 words)

	Aging research; molecular concepts of aging, related diseases and cloning.
		With it goes compartmentalization of stem cells that to various degrees retain some multipotency.
		A number of factors may conspire to alter the overall multipotency of the stem cell population during aging.
		For example, as a result of damage acquired through replication or toxic metabolic products, a stem cell's repertoire of developmental programs may be restricted, until in old age it may be able to contribute to only one lineage – and perhaps even that not very well, at least in response to stress.
	www.innovitaresearch.org /news/03120801.html (2542 words)

	University Of Pittsburgh \| Stem Cell Research Center \| Groups \| Stem Cell (Site not responding. Last check: 2007-10-10)
		Muscle satellite cell populations have long been recognized as a source of stem cells that generate daughter myogenic precursor cells in adult skeletal muscle.
		Recent reports indicate that skeletal muscle also harbors multipotent stem cells (MPSCs).
		Investigate the multipotency of muscle stem cells, i.e.
	www.pitt.edu /~huardlab/stemCellGroup.htm (388 words)

	Rachel Ankeny
		As stem cell research has emerged in the public arena in recent years, visual representations of what can be learned from such research and what products may be obtained have served as simplified promissory notes about the future clinical outcomes of this research.
		Attempts to simplify concepts such as totipotency, multipotency, and even 'stemness' itself have reflected shifting understandings of not only the underlying scientific theories but of appropriate and accurate uses of language in a rapidly shifting sociopolitical environment.
		This paper explores traditional visual representations of the activity and roles of stem cells and the model systems within which research on them is occurring within the literature of developmental biology, in comparison to recent visual representations directed at both popular/lay and scientific audiences.
	www.ishpssb.org /ocs/viewabstract.php?id=305 (267 words)

	Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia ...
		Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene : Nature
		Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene
		In the adult haematopoietic system, expression of SCL/tal-1 is enriched in HSCs and multipotent progenitors, and in erythroid and megakaryocytic lineages
	www.nature.com /doifinder/10.1038/nature01345 (331 words)

	Conserved roles for Oct4 homologues in maintaining multipotency during early vertebrate development -- Morrison and ...
		Conserved roles for Oct4 homologues in maintaining multipotency during early vertebrate development -- Morrison and Brickman 133 (10): 2011 -- Development
		Articles by Morrison, G. Articles by Brickman, J. Conserved roles for Oct4 homologues in maintaining multipotency during early vertebrate development
		All vertebrate embryos have multipotent cells until gastrulation
	dev.biologists.org /cgi/content/abstract/133/10/2011 (275 words)

	Institute on Biotechnology and the Human Future (Site not responding. Last check: 2007-10-10)
		While they are the more versatile of the two categories in their ability to give rise to a wide range of cell types (a characteristic known as "multipotency"), their use in experimental studies and potentially in therapies has proven contentious.
		Around the same time that the Göttingen study was announced, a California biotech company, PrimGen, claimed that it had isolated similar "multipotent adult germ line stem cells" (maGSC) from testicular biopsies of human males.
		As maGS cells are indeed derived from the adult body, and are in this sense "adult stem cells," they are likely to escape scrutiny by those, including the U.S. government, whose opposition to the production of ES cells focuses on their source in human embryos.
	www.thehumanfuture.org /commentaries/newman_seeds_of_contention.html (564 words)

	A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by ... (Site not responding. Last check: 2007-10-10)
		A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by Myb-Ets -- Kraut et al.
		A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by Myb-Ets
		leukemia virus induces the proliferation of multipotent hematopoietic
	www.genesdev.org /cgi/content/abstract/8/1/33 (434 words)

	Cryopreservation Does Not Affect Proliferation and Multipotency of Murine Neural Precursor Cells -- Milosevic et al. 23 ...
		Cryopreservation Does Not Affect Proliferation and Multipotency of Murine Neural Precursor Cells -- Milosevic et al.
		Cryopreservation Does Not Affect Proliferation and Multipotency of Murine Neural Precursor Cells
		Multipotent Neural Stem Cells from the Adult Tegmentum with Dopaminergic Potential Develop Essential Properties of Functional Neurons
	stemcells.alphamedpress.org /cgi/content/abstract/23/5/681 (347 words)

	Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient ... (Site not responding. Last check: 2007-10-10)
		Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient precursor B-cell clones -- Schaniel et al.
		multipotency, with their telomeres shortening at the normal
		multipotency, which are the properties of long-term repopulating,
	www.bloodjournal.org /cgi/content/full/99/8/2760 (4314 words)

	Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling -- Kléber et al. 169 (2): 309 -- The ...
		Numbers (percentage of all clones per condition) are shown as the mean ± SD of three independent experiments, scoring 50–80 clones per experiment.
		Migrating neural crest cells in the trunk of the avian embryo are multipotent.
		P0 and PMP22 mark a multipotent neural crest-derived cell type that displays community effects in response to TGF-ß family factors.
	www.jcb.org /cgi/content/full/169/2/309 (6857 words)

	Patricia A. Labosky, PhD
		development of the mammalian embryo, genes that control neuronal patterning, gastrulation, neural crest specification and multipotency of stem cells.
		Transgenic mice, gene targeting (knock-outs and knock-ins), culturing of embryonic stem cells (ES cells) and trophoblast stem cells (TS cells), dissection of mouse embryos from all stages, histological techniques such as immunohistochemistry and in situ hybridizations.
		The neural crest is a multipotent lineage that gives rise to neurons, glia, smooth muscle, cartilage and other tissues.
	www.med.upenn.edu /ins/faculty/labosky.htm (420 words)

	University Of Pittsburgh \| Stem Cell Research Center \| Stem Cell Group Personnel (Site not responding. Last check: 2007-10-10)
		• Investigate the multipotency of muscle stem cells, i.e.
		This finding supports previous reports that indicate the existence of multipotent stem cells in a variety of adult tissues.
		This finding is consistent with the cells isolated from human and rat fat tissue.
	www.pitt.edu /~Huardlab/stemCellGroupPersonnel.htm (986 words)

	Biology Division - David Anderson
		Our studies of neural development focus on the control of differentiation in the vertebrate peripheral nervous system, which derives from the neural crest.
		We have isolated and characterized stem-like progenitor cells exhibiting multipotency and self-renewal capacity, and are investigating the control of the fate of these cells by both cell-extrinsic and cell-intrinsic factors.
		Our experimental approaches include in vitro clonal analysis, in vivo transplantation, and loss- and gain-of-function genetic manipulations in mouse and chick embryos.
	biology.caltech.edu /Members/Anderson (556 words)

	Cytomatrix - Cell Science
		/CD38- HPCs and the maintenance of their multipotent and immature phenotype for periods of up to three weeks in the absence of supplemented cytokines.
		This unique capability will be exploited in Phase I to examine the effects of specific cytokines (IL-3, IL-6 and stem cell factor), individually and in groups, on HPC biology.
		Operating from the hypothesis that the addition of cytokines to cultures of HPCs in vitro will affect HPC survival and multipotency, this project will specifically focus on measuring the survival, phenotype and multipotency of HPCs cultured in Cellfoam for periods of three days to six weeks in the presence and absence of supplemented cytokines.
	www.cytomatrix.com /Pages/GovReSubPages/10.html (215 words)

	Stem Cell-derived Neural Stem/Progenitor Cell Supporting Factor Is an Autocrine/Paracrine Survival Factor for Adult ... (Site not responding. Last check: 2007-10-10)
		potential and multipotency in the absence of FGF-2.
		multipotency of ANSCs in the absence of FGF-2.
		Assessment of self-renewal and multipotency of SDNSF-treated ANSCs.
	www.jbc.org /cgi/content/full/278/37/35491 (6166 words)

	The Longevity Meme -- ideas and actions for longer, healthier lives
		Scientists continue to better coax multipotent stem cells from hair follicles, as noted by EurekAlert!
		Using human embryonic stem cell culture conditions, the researchers isolated and grew a new type of multipotent adult stem cell from scalp tissue...
		The mutipotent stem cells grow as masses the investigators call hair spheres.
	www.longevitymeme.org /news/view_news_item.cfm?news_id=2532 (268 words)

	Cytomatrix - Cell Science
		HPCs cultured in Cellfoam without exogenous cytokines are expanded 8-10 fold while maintaining their viability and multipotency.
		HPCs can be cryopreserved in Cellfoam, thawed, re-cultured, and transduced efficiently with a retroviral vector.
		selected preparations of pooled CB samples to evaluate the survival, phenotype and multipotency of cells pre-cultured in Cellfoam without cytokines for up to four weeks and cryopreserved in the same units for one month.
	www.cytomatrix.com /Pages/GovReSubPages/7.html (174 words)

	Battle of the Bulge - Journal Watch Dermatology (Site not responding. Last check: 2007-10-10)
		Epithelial biologists have sought characterization of the elusive
		all epithelial cell types, supporting the multipotency of this
		The cells were labeled with GFP and isolated.
	dermatology.jwatch.org /cgi/content/full/2004/331/1 (365 words)

	Umbilical Cord Stem Cells and Multipotency Stem Cell Safety
		Umbilical Cord Stem Cells and Multipotency Stem Cell Safety
		The Steenblock Research Institute has been working with other scientists to develop safe and effective stem cells from cord blood.
		For more information feel free to Contact Us
	www.stemcelltherapies.org /research/safety-multipotency.htm (182 words)

Try your search on: Qwika (all wikis)