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Topic: Myelodysplasia

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	Lancet - Evidence Supports Association Between Leukemia And Exposure To Cosmic Radiation In Aircrew Harvey McConnell / ... (Site not responding. Last check: 2007-10-12)
		Deletion or loss of chromosome 7 was found in four of seven aircrew with myelodysplasia or acute myeloid leukaemia, and in eight of 19 patients with the disorders after radiotherapy alone.
		We studied the karyotypes of seven aircrew treated for myelodysplasia or acute myeloid leukaemia between 1987 and 1999 (table 1), and compared them with the karyotypes, previously published, of 19 cases of myelodysplasia or acute myeloid leukaemia after radiotherapy alone at one of our institutions between 1980 and 1998 (table 2).
		Compared with unselected patients with myelodysplasia or acute myeloid leukaemia, a significant excess of chromosome 7 abnormalities was found in aircrew with leukaemia (p=0·004, Fisher's exact test, two-sided) as well as in the 19 patients with leukaemia related to radiotherapy (p<0·001).
	www.mindfully.org /Health/Leukemia-Cosmic-Radiation-Aircrew.htm (1043 words)

	NoBlood - View Single Post - treatment for myelodysplasia
		Myelodysplasia (MDS) refers to a group of disorders in which the bone marrow does not function normally and produces insufficient number of normal blood cells.
		About 50 percent of pediatric myelodysplasia can be classified in five types of MDS: refractory anemia, refractory anemia with ring sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia.
		Therefore, a topotecan and thalidomide combination therapy is promising, although further studies are needed to determine the optimum doses and schedule.
	www.noblood.org /6336-post2.html (1051 words)

	'Common' Uncommon Anemias - February 15, 1999 - American Academy of Family Physicians
		Iron deficiency was under-recognized because of an insufficient history, a lack of stool examination for blood or poor responses to iron therapy because of continued blood loss or the suboptimal use of iron supplements.
		Such cells can be seen in patients with myelodysplasia; however, they are nonspecific and can also appear in patients with folic acid and vitamin B12 deficiency, thyroid deficiency, myeloproliferative diseases, uremia and hereditary hypersegmentation.
		This cell is a bilobular polymorphonuclear leukocyte that may occur on a congenital basis (without clinical significance) or may be acquired in myelodysplasia, in myeloproliferative diseases or with toxic stress on the bone marrow, as a result of treatment with chemotherapeutic drugs.
	www.aafp.org /afp/990215ap/851.html (3068 words)

	Myelodysplasia - Children's Healthcare of Atlanta (Site not responding. Last check: 2007-10-12)
		Myelodysplasia occurs when the spinal cord, its coverings and the vertebrae fail to form properly.
		The Myelodysplasia Clinic at Children's, located on the Scottish Rite campus, provides medical, surgical, rehabilitative, psychological and support services during each stage of a child's development, from birth to age 21.
		At the Myelodysplasia Clinic, our patients are seen by team members from one or more of the following specialties, according to their needs: genetics, neurosurgery, orthopaedics, orthotics, physical therapy, psychology, social work, urology, nursing and clinical nutrition.
	www.choa.org /default.aspx?id=923 (205 words)

	Kathy Hinderer's Home Page (Site not responding. Last check: 2007-10-12)
		I was the research physical therapist in the Myelodysplasia Clinic from 1983-1987.
		Conducting this study was a unique opportunity because baseline data which were obtained during the childhood and adolescence of study participants utilizing the standardized PDMS format were made available to us to determine changes which had occurred in the interim between adolescence and adulthood.
		individuals with myelodysplasia) to determine their functional problems, the relationship of function to impairment, and the efficacy and efficiency of therapeutic interventions to improve function, 3) orthotic management techniques (e.g.
	www-personal.umich.edu /~hinderer/cvpage14.html (1619 words)

	Myelodysplasia and Me
		I am unaware of any studies on trying Coriolus in myelodysplasia and hope to write up soon a case report on my experience with Coriolus.
		Bone marrow: Histopathology studies of marrow (examination of marrow cells under microscope) have repeatedly shown myelodysplasia (refractory anemia).
		Cytogenetic (chromosome study) results for my marrow are helpful in demonstrating the condition of the chromosomes.
	members.aol.com /myelodysplasia/index.html (5174 words)

	Glossary M - Randy Ramage's Aplastic Anaemia and Myelodyplasia Glossary
		Myelodysplasia is generally a disease of the elderly, and may also be seen after chemotherapy for cancer.
		As one might expect, the overgrowth of one type of cell often develops into leukaemia, which is a cancer of a bone marrow cell type.
		Because the anaemia in myelodysplasia cannot usually be treated, except by bone marrow transplant, it is often necessary to give people with this condition repeated blood transfusions.
	www.citylightsnews.com /randy/glossary/glossary_m.htm (2867 words)

	Clinical Trial: Antithymocyte Globulin and Cyclosporine to Treat Myelodysplasia
		Myelodysplasia is thought to result from an immune system abnormality in which cells called lymphocytes attack the marrow's blood-forming cells.
		Various therapies, such as blood transfusions for anemia and bleeding, antibiotics for infection, chemotherapy and bone marrow transplantation are used to treat myelodysplasia, but all have disadvantages and some carry serious risks.
		Patients 18 years of age and older with myelodysplasia may be eligible for this study.
	clinicaltrials.gov /ct/show/NCT00005937 (895 words)

	Skin Care in Myelodysplasia - Children's Healthcare of Atlanta
		This information explains the role of the skin and the causes (“risk factors”) of skin breakdown in children with myelodysplasia.
		Because of the possibility of decreased sensation and movement, those with myelodysplasia are often at high risk for skin irritation and pressure sores.
		Prominent, bony parts of the body are the most likely places for pressure sores to form because these places have the least amount of cushioning between the bones and the skin.
	www.choa.org /default.aspx?id=933 (1467 words)

	Myelodysplasia - New Treatments, January 2, 2007
		Myelodysplastic syndromes are characterized by pancytopenia with a hypercellular bone marrow.
		But if you look at an amalgam of the world’s experience up to about 10 years ago or so, the response rate in myelodysplasia was about a 17% complete remission and about a 35% overall response rate.
		The doses that are used for myelodysplasia are significantly lower.
	www.ccspublishing.com /journals_6a/myelodysplasia.htm (1052 words)

	eMedicine - Myelodysplasia : Article by Scott C Howard, MD (Site not responding. Last check: 2007-10-12)
		Background: Myelodysplasia encompasses a heterogenous group of disorders that result in ineffective hematopoiesis.
		Emanuel PD: Myelodysplasia and myeloproliferative disorders in childhood: an update.
		McKenna RW: Myelodysplasia and myeloproliferative disorders in children.
	www.emedicine.com /ped/topic1526.htm (5058 words)

	Myelodysplastic syndrome - Wikipedia, the free encyclopedia
		Myelodysplasia is a diagnosis of exclusion and must be made after proper determination of iron stores, vitamin deficiencies, and nutrient deficiencies are ruled out.
		All of these conditions are characterized by abnormalities in the production of one or more of the cellular components of blood (red cells, white cells other than lymphocytes and platelets or their progenitor cells, megakaryocytes).
		"A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcome.".
	en.wikipedia.org /wiki/Myelodysplasia (1885 words)

	Myelodysplasia progressing to acute myeloblastic leukemia in an HTLV-III virus-positive homosexual man with ...
		Myelodysplasia progressing to acute myeloblastic leukemia in an HTLV-III virus-positive homosexual man with AIDS-related complex.
		The authors report a patient with AIDS-related complex and myelodysplasia who rapidly progressed to acute myeloblastic leukemia.
		The association of HTLV-III infection with myelodysplasia and acute myeloblastic leukemia may have been coincidental in this reported case, but it is also possible that the leukemia was secondary to the HTLV-III infection.
	www.aegis.com /aidsline/1987/mar/M8730133.html (347 words)

	Autoimmune manifestations in human myelodysplasia: a positive correlation with interferon regulatory factor-1 (IRF-1) ...
		Autoimmune manifestations in human myelodysplasia: a positive correlation with interferon regulatory factor-1 (IRF-1) expression -- Giannouli et al.
		Myelodysplasia patients from group B have decreased levels of full length IRF-1 mRNA expression in association with exon skipped products, as in case 1 and 4 (arrows).
		is involved in the pathogenesis of AIM in myelodysplasia.
	ard.bmj.com /cgi/content/full/63/5/578 (2611 words)

	health.iafrica.com \| your health \| blood diseases \| q&a Myelodysplasia
		I spent quite a long time searching for information on myelodysplasia in a form which would be accessible and could find nothing which would be at all helpful, and very little on the sites aimed at professionals either.
		Myelodysplasia, or myelodysplastic syndrome, describes a group of disorders, all characterised by unexplained anaemia, and abnormalities of certain of the blood cells such as platelets and white blood cells.
		The platelets are involved in blood clotting and the white blood cells are involved in the body's response to infection.
	health.iafrica.com /illness_condition/blood_diseases/q_a/56343.htm (451 words)

	MeritCare \| Coordinated Treatment: Myelodysplasia (Spina Bifida)
		A comprehensive report is sent to the referring physician and to the patients.
		The Myelodysplasia Outpatient Service is offered once a month in the Coordinated Treatment Center at MeritCare Medical Center.
		The Myelodysplasia Outpatient Service is a program of the MeritCare Children's Hospital, a specialty hospital within MeritCare Medical Center.
	www.meritcare.com /specialties/more/ctc/myelodysplasia.aspx (330 words)

	NoBlood - View Single Post - treatment for myelodysplasia
		A patient came in anemic with a hemoglobin of 6.9 and was transfused after 6 days.
		Over six days hemoglobin dropped to 6.1 (scoped found polyps/removed) then gradually began to climb up to 6.3 at which time he was transfused; now at 9.5 and stable.
		Now he is diagnosed with myelodysplasia currently being treated with vitamin B-12.
	www.noblood.org /6335-post1.html (66 words)

	St. Jude Children's Research Hospital - Copyright 2003 (Site not responding. Last check: 2007-10-12)
		Allogeneic hematopoietic stem cell transplantation (transfusions using marrow, peripheral blood or cord blood from a compatible donor) is the most effective form of treatment for most types of myelodysplasia.
		Most St. Jude myelodysplasia patients are enrolled on our front-line AML or hematopoietic stem cell transplantation protocols.
		If you have or suspect you may have a health problem, you should consult your health care provider.
	www.stjude.org /print/0,2510,404_2165_2991,00.html (359 words)

	Dr. Rose's Peripheral Brain--LEUKEMIAS
		In some cases the rate of cell division in BM is lower than normal ("hypoplastic myelodysplasia")--difficult to distinguish BM findings from those of Aplastic Anemia.
		Wide variation in speed of progression to leukemia; in fact, not all cases of myelodysplasia end in leukemia.
		Those patients with the specific cytogenetic abnormality of an isolated deletion of long arm of chromosome 5 ("5q-") have a typically indolent course with only about 25% developing overt leukemia.
	faculty.washington.edu /momus/PB/leukemia.htm (1411 words)

	Myelodysplasia (Spina Bifida) Clinic - Clinical Services - Children's Hospital Boston
		Myelodysplasia, also called spina bifida, refers to a number of conditions caused by neural tube defects.
		The Myelodysplasia Program at Children's is one of the oldest and largest comprehensive, interdisciplinary centers for the care of children with spina bifida in the country.
		This spring Kaitlyne McNamara, who was born with spina bifida, is planning for her junior prom with excitement.
	www.childrenshospital.org /clinicalservices/Site1169/mainpageS1169P0.html (165 words)

	Aplastic Anemia and Myelodysplasia Association of Canada
		Myelodysplasia is similar to aplastic anemia in that production of blood cells is decreased; however, the blood cells which are produced in myelodysplasia may not function properly.
		Myelodysplasia is more common, with the majority of patients being over the age of 50.
		Although some myelodysplasia patients have responded to experimental drug therapies, bone marrow transplantation remains the only cure for the disease.
	www.aamac.ca (863 words)

	Myelodysplasia with ringed sideroblasts :: The Doctors Lounge(TM)
		The syndrome may arise de novo, or secondarily after treatment with Chemotherapy and/or radiation therapy for other diseases.
		Secondary Myelodysplasia usually has a poorer prognosis than does de novo Myelodysplasia.
		Judicious use of platelet and blood transfusions may prevent or delay alloimmunization and iron overload.
	www.thedoctorslounge.net /oncology/forums/viewtopic.php?t=33 (564 words)

	Social Aspects of Myelodysplasia - Children's Healthcare of Atlanta (Site not responding. Last check: 2007-10-12)
		Children with myelodysplasia have very special physical needs, which can raise many everyday challenges for families.
		While facing those challenges, it is important for parents to remember that all members of the family have psychological needs that should be considered.
		The Myelodysplasia Clinic located on the Scottish Rite campus is staffed with psychologists and a social worker who understand the challenges of dealing with myelodysplasia throughout a child’s life.
	www.choa.org /default.aspx?id=934 (339 words)

	Burkitt cell leukemia with myelodysplasia as a presentation of HIV infection.
		Burkitt cell leukemia with myelodysplasia as a presentation of HIV infection.
		Hematologic manifestations of human immunodeficiency virus (HIV) infection include cytopenias, non-Hodgkin's lymphoma, and myelodysplasia.
		We describe a patient who presented with Burkitt cell leukemia and myelodysplasia as her initial manifestation of HIV infection.
	www.aegis.com /aidsline/1992/sep/M9290335.html (327 words)

	Clinical Trial: Study of Velcade and Thalidomide in Patients With Myelodysplasia
		Primary Outcomes: The primary objective is to establish the maximally tolerated dose of bortezomib that can be administered with thalidomide in patient with myelodysplasia.
		Initial studies using Velcade in myelodysplasia with early results demonstrating that 35% had a partial response and 25% had stable disease.
		This is a phase 1, prospective, open-label, dose escalation study to evaluate the DLT and MTD of velcade with given in combination with thalidomide in patients with myelodysplasia.
	clinicaltrials.gov /ct/show/NCT00271804 (501 words)

	Clinical Trials (PDQ®) - National Cancer Institute
		Phase II Study of VNP40101M in Patients With Acute Myelogenous Leukemia or High-Risk Myelodysplasia
		A total of 230 patients (100 with acute myelogenous leukemia (AML) or high-risk myelodysplasia and 130 with AML in first relapse) will be accrued for this study.
		Patients are stratified to acute myelogenous leukemia (AML) or high risk myelodysplasia (MDS) patients â¥ 60 years old with no prior treatment vs AML patients any age in first relapse.
	www.cancer.gov /clinicaltrials/VION-CLI-033 (553 words)

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