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Topic: Myelodysplastic syndrome

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  Myelodysplastic Syndrome
Like leukemia, myelodysplastic syndrome is a disorder of the bone marrow, the spongy tissue inside bones where all blood cells are formed, and blood.
A diagnosis of myelodysplastic syndrome is made through the examination of the peripheral blood (circulating blood in veins and arteries) and the bone marrow.
Children with myelodysplastic syndrome are usually treated with intensive chemotherapy (treatment with anticancer drugs) similar to that of acute myeloid leukemia.
hopkinskimmelcancercenter.org /scout/types/myelodysplasticsyndrome.cfm   (311 words)

 Myelodysplastic Syndromes Treatment - National Cancer Institute
Myelodysplastic syndromes are a group of diseases in which the bone marrow does not make enough healthy blood cells.
Myelodysplastic syndromes are diagnosed based on certain changes in the blood cells and bone marrow.
Myelodysplastic syndromes are diseases of the blood and bone marrow.
www.cancer.gov /cancerinfo/pdq/treatment/myelodysplastic/patient   (1076 words)

 Leukemia & Lymphoma Society - Disease Information - Myelodysplastic Syndrome
Myelodysplastic syndromes (MDS) are a group of diseases that originate in an early blood-forming cell in the marrow.
In the myelodysplastic syndromes, the maturing blood cells often die in the marrow before they reach full maturity and enter the blood, accounting for the low blood cell concentrations.
Although myelodysplastic syndrome covers a spectrum of neoplastic myeloid diseases, most cases can be placed into several subgroups based on the blood cell counts and the appearance of blood cells under the microscope.
www.leukemia-lymphoma.org /all_page?item_id=55442   (877 words)

 Myelodysplastic Syndrome
The myelodysplastic syndromes may change into acute myeloid leukemia, a form of cancer in which too many white blood cells are made.
Myelodysplastic syndromes are grouped together based on how the bone marrow cells and blood cells look under a microscope.
There are five types of myelodysplastic syndromes: refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia.
clevelandclinic.org /health/health-info/docs/1400/1421.asp?index=6192   (992 words)

 Myelodysplastic syndromes: Causes - MayoClinic.com
People with this myelodysplastic syndrome have anemia due to low numbers of red blood cells, but their white cells and platelets are normal.
In this myelodysplastic syndrome, two of the three types of blood cells are abnormal, and less than 1 percent of the cells in the bloodstream are immature cells (blasts).
Syndromes with an identifiable cause are called secondary myelodysplastic syndromes and are usually more difficult to treat than are myelodysplastic syndromes without a known cause (primary, or de novo, myelodysplastic syndromes).
www.mayoclinic.com /health/myelodysplastic-syndromes/DS00596/DSECTION=3   (1220 words)

 Myelodysplastic syndromes - WrongDiagnosis.com
Myelodysplastic syndromes is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
The myelodysplastic syndromes (MDS, formerly known as "preleukemia") are a diverse collection of haematological conditions united by ineffective production of blood cells and varying risks of transformation to acute myelogenous leukemia.
The prognosis of Myelodysplastic syndromes may include the duration of Myelodysplastic syndromes, chances of complications of Myelodysplastic syndromes, probable outcomes, prospects for recovery, recovery period for Myelodysplastic syndromes, survival rates, death rates, and other outcome possibilities in the overall prognosis of Myelodysplastic syndromes.
www.wrongdiagnosis.com /m/myelodysplastic_syndromes/intro.htm   (830 words)

 Myelodysplastic syndromes   (Site not responding. Last check: 2007-09-08)
Some younger people with myelodysplastic syndromes who are in otherwise good health may be candidates for a bone marrow transplant, which may help prolong life.
The first step in diagnosing myelodysplastic syndromes is usually a routine blood test (complete blood count) that checks the number of red blood cells and platelets, the number and type of white blood cells, and the amount of hemoglobin that your red blood cells contain.
Myelodysplastic syndromes are also staged, but because abnormal cells are likely to circulate throughout the bloodstream, a different method, the International Prognostic Scoring System, was developed specifically for these disorders.
www.prescriptiondrugchat.com /showthread.php?t=1453   (3200 words)

 Myelodysplastic Syndrome
CMML was also formally separated from the myelodysplastic syndromes, and a cytogenetically-defined MDS subgroup, the 5q- syndrome (which confers a good prognosis, is associated with normal or elevated platelet counts, and is found in 5-10% of patients) was identified.
Myelodysplastic syndromes: analysis of 131 cases according to the FAB classification.
Biological significance of proliferation, apoptosis, cytokines, and monocyte/macrophage cells in bone marrow biopsies of 145 patients with myelodysplastic syndrome.
clevelandclinicmeded.com /diseasemanagement/hematology/myelo/myelo.htm   (2436 words)

 Myelodysplastic syndrome definition - Medical Dictionary definitions of popular medical terms
Myelodysplastic syndrome: A group of bone marrow disorders characterized by the underproduction of one or more types of blood cells due to dysfuntion of the marrow.
The myelodysplastic syndromes (MDS) may arise de novo (newly) or be secondary to treatment with chemotherapy or radiation therapy for another disease.
The 7 recognized types of MDS are refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, chronic myelomonocytic leukemia, chronic myelomonocytic leukemia in transformation, and unclassified myelodysplastic syndrome.
www.medterms.com /script/main/art.asp?articlekey=4479   (354 words)

 Myelodysplastic Syndrome or MDS, Myelodysplasia, and Myelodysplastic Syndrome Information
Myelodysplastic syndrome ymptoms vary depending on the individual and the extent of the disease.
Hypoplastic MDS is a syndrome that is similar to a type of anemia, and patients with this syndrome have low numbers of blood cells in the bone marrow, where these cells are produced.
Other syndromes include MDS with myelofibrosis (a condition in which bone marrow cells grow inside the spleen and liver and in which the bone marrow is replaced by fibrous tissue) and MDS with prominent eosinophilia or monocytosis (an exces of types of white blood cells).
www.leukemia-web.org /mds-myelodysplastic-syndrome.htm?GAW-MDS   (853 words)

 Myelodysplastic syndromes
The bone marrow in myelodysplastic syndrome is typically more active than normal and yet the numbers of blood cells in the circulation are reduced.
CMML is considered to be a form of myelodysplastic syndrome because the bone marrow shows features similar to those seen in other forms of the disease, but it also shows features of the related diseases known as the myeloproliferative disorders.
The myelodysplastic syndromes result from production of large numbers of defective cells in the bone marrow which leads to the paradox of a very active marrow but with reduced numbers of healthy cells in the circulating blood.
www.lrf.org.uk /en/1/infdispatmye.html   (3670 words)

 Medical Dictionary: Myelodysplastic syndrome - WrongDiagnosis.com
Myelodysplastic syndrome: A myelodysplastic syndrome characterized mainly by dysplasia of the erythroid series.
Myelodysplastic syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
This means that Myelodysplastic syndrome, or a subtype of Myelodysplastic syndrome, affects less than 200,000 people in the US population.
www.wrongdiagnosis.com /medical/myelodysplastic_syndrome.htm   (357 words)

 Myelodysplastic Syndrome Information - Bone Marrow Transplant Center of Chicago
Myelodysplastic syndrome (or MDS) is not a single disease but a group of disorders primarily affecting the bone marrow, with the abnormality most prominently reflected in decreased red cell, white cell and platelet counts.
Whereas primary myelodysplastic syndrome has no known cause, secondary MDS follows known or documented exposure to toxic or chemical agents such as chemotherapy or radiation.
Certain patients with myelodysplastic syndrome may be eligible for allogeneic stem cell transplantation.
www.rush.edu /rumc/page-1124119149966.html   (506 words)

 Myelodysplastic Syndromes
The myelodysplastic syndromes (MDS) are a group of disorders characterized by one or more peripheral blood cytopenias secondary to bone marrow dysfunction.
Hellström-Lindberg E: Efficacy of erythropoietin in the myelodysplastic syndromes: a meta-analysis of 205 patients from 17 studies.
Saunthararajah Y, Nakamura R, Nam JM, et al.: HLA-DR15 (DR2) is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome.
www.meb.uni-bonn.de /cancer.gov/CDR0000062929.html   (5871 words)

 Myelodysplastic syndrome (MDS)   (Site not responding. Last check: 2007-09-08)
Myelodysplastic syndrome (MDS) describes a group of bone marrow disorders that are characterised by a defect in stem cells.
In Myelodysplastic syndrome (MDS) the stem cells become mutant and are no longer able to divide effectively into each of the blood cells.
The true incidence of Myelodysplastic syndrome (MDS) is difficult to estimate as it has only recently been regarded as a distinct class of disorders and controversies exist regarding its classification.
www.virtualcancercentre.com /diseases.asp?did=68   (1104 words)

 Sloan-Kettering - Myelodysplastic Syndrome
Myelodysplastic syndrome (MDS) is the name given to a group of closely related diseases that arise in the bone marrow and involve hematopoietic stem cells, the immature cells from which all blood cells develop.
Myelodysplastic syndrome is often not diagnosed until the patient is seen by a hematologist.
Patients who have myelodysplastic syndrome should be carefully monitored for any changes in the status of their disease.
www.mskcc.org /mskcc/html/8189.cfm   (404 words)

 Myelodysplastic syndromes: Treatment - Patient Information [NCI PDQ]
Treatment is based on whether the disease developed after the patient was exposed to factors that cause myelodysplastic syndrome or whether the disease was previously treated.
Secondary myelodysplastic syndromes develop after the patient was treated with chemotherapy or radiation therapy for other diseases or after being exposed to radiation or certain chemicals that are linked to the development of myelodysplastic syndromes.
Secondary myelodysplastic syndromes may be harder to treat than de novo myelodysplastic syndromes.
www.everettclinic.com /kbase/nci/ncicdr0000378089.htm   (2466 words)

 Crohn Disease and the Myelodysplastic Syndrome -- Boberg et al. 122 (5): 395 -- Annals of Internal Medicine
Crohn Disease and the Myelodysplastic Syndrome -- Boberg et al.
The association between the myelodysplastic syndromes and Crohn disease.
Proposals for the classification of the myelodysplastic syndromes.
www.annals.org /cgi/content/full/122/5/395   (508 words)

 Diagnosing Myelodysplastic Syndromes - Cancer Overview - Greenebaum Cancer Center
If signs and symptoms suggest a patient may have myelodysplastic syndrome or myeloproliferative disorder, the doctors will need to examine cells from the patient's blood and bone marrow in order to be certain of this diagnosis.
Even though these findings suggest a myelodysplastic syndrome, these conditions cannot be diagnosed for sure without examining a sample of bone marrow cells.
In some cases of myelodysplastic syndrome one or more chromosomes or parts of chromosomes may be missing.
www.umm.edu /cancer/overview/mds_diagnosis.html   (489 words)

 Mayo Clinic: Myelodysplastic Syndrome - Information and treatment options at mayoclinic.org
Although myelodysplastic syndromes are relatively rare, Mayo Clinic physicians care for more than 1,600 patients with these syndromes each year.
The chances of developing leukemia depend on the subtype of myelodysplastic syndromes and the specific genetic injury that occurred in the bone marrow cells.
Myelodysplastic syndromes comprise a set of bone marrow conditions that cause inadequate production of normal blood cells (i.e., oxygen-carrying red cells, infection-fighting white cells, and platelets that stop bleeding).
www.mayoclinic.org /myelodysplastic-syndromes   (437 words)

 myelodysplastic syndrome
Historically, the myelodysplastic syndromes (MDS) have been referred to as oligoblastic leukemia, refractory anemia, smoldering acute leukemia, or preleukemia.
A macrocytic or normocytic anemia is found in nearly all MDS patients, and frequently is accompanied by thrombocytopenia, leukopenia, or both.
In addition, a subset of MDS, chronic myelomonocytic leukemia, which actually represents an overlap syndrome with myeloproliferative disorders, may cause splenomegaly and subsequent complaints of left upper-quadrant abdominal pain and early satiety.
cms.clevelandclinic.org /body.cfm?id=549   (1019 words)

 eMedicine - Myelodysplastic Syndrome : Article by Prasad Mathew, MBBS, DCH   (Site not responding. Last check: 2007-09-08)
Background: Myelodysplastic syndrome (MDS) in childhood encompasses a diverse group of bone marrow disorders that share a common clonal defect of stem cells and that which results in ineffective hematopoiesis with dysplastic changes in the marrow.
Down syndrome: MDS and AML in DS are closely linked with biological and clinical features distinct from the diseases in non-DS children, and they are now recognized as a single specific entity, myeloid leukemia of Down syndrome (ML-DS) in the proposed WHO classification (Hasle, Leukemia, 2003).
Shwachman syndrome (7%) is pancreatic insufficiency with neutropenia.
www.emedicine.com /ped/topic1527.htm   (5165 words)

 Myelodysplastic syndrome   (Site not responding. Last check: 2007-09-08)
The myelodysplastic syndromes (MDS, formerly known as "preleukemia") are a diverse collection of haematological conditions united by ineffective production of blood cells.
5q- syndrome, typically seen in older women with normal or high platelet counts and isolated deletions of the long arm of chromosome 5 in bone marrow cells, was added to the classification.
All of these conditions are characterized by abnormalities in the production of one or more of the cellular components of blood (red cells, white cells other than lymphocytes and platelets or their progenitor cells, megakaryocytes).
myelodysplastic-syndrome.kiwiki.homeip.net   (1288 words)

 Myelodysplastic Syndrome (MDS)
Myelodysplastic syndrome (MDS), also referred to as myelodysplasia, is an umbrella term for several conditions in which the bone marrow does not function normally, causing shortages of one or more cell types in the blood.
Bone marrow is the spongy tissue inside the bones of the body where red and white blood cells and platelets are made.
Hutchinson Center myelodysplastic syndrome (MDS) research includes clinical research to develop effective new treatments and fundamental studies to learn more about how MDS develops and progresses to leukemia, which will help scientists develop better strategies for diagnosing and treating these diseases.
www.fhcrc.org /research/diseases/myelodysplastic   (1280 words)

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