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Topic: Myelofibrosis

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	Myelofibrosis
		Myelofibrosis is a rare disease of the bone marrow in which collagen builds up fibrous scar tissue inside the marrow cavity.
		Myelofibrosis occurs with equal frequency in women and men, but in children it affects girls twice as often as it does boys.
		Myelofibrosis is caused by an abnormality in a single stem cell, which causes it to grow out of control.
	www.healthatoz.com /healthatoz/Atoz/ency/myelofibrosis.jsp (1082 words)

	Myelofibrosis
		Myelofibrosis (also called agnogenic myeloid metaplasia) is a myeloproliferative disorder in which the bone marrow is initially over-active but then develops scar tissue (fibrosis).
		The term idiopathic means without known cause and differentiates this form of myelofibrosis from secondary myelofibrosis which may complicate other bone marrow diseases.
		In myelofibrosis this network is coarsened and thickened so that normal blood cell production is progressively reduced.
	www.lrf.org.uk /en/1/disfibhome.html (146 words)

	Myelofibrosis: Myeloproliferative Disorders: Merck Manual Home Edition
		Myelofibrosis is a disorder in which fibrous tissue replaces the blood-producing cells in the bone marrow, resulting in abnormally shaped red blood cells, anemia, and an enlarged spleen.
		As myelofibrosis progresses, the number of white blood cells may increase or decrease, and the number of platelets typically decreases.
		Myelofibrosis may develop on its own (in which case it is also called idiopathic myelofibrosis or agnogenic myeloid metaplasia) or may accompany other blood disorders, such as chronic myelocytic leukemia, polycythemia vera, thrombocythemia, multiple myeloma, lymphoma, and myelodysplasia; tuberculosis; or bone infections.
	www.merck.com /mmhe/sec14/ch178/ch178c.html (598 words)

	CIGNA - Myelofibrosis, Idiopathic
		Symptoms of idiopathic myelofibrosis may include abnormally low levels of circulating red blood cells (anemia), an abnormally large spleen (splenomegaly), an abnormally large liver (hepatomegaly), weight loss, weakness and fatigue due to replacement of normal bone marrow cells, and/or episodes of severe pain in the abdomen, bones, and joints.
		Myelofibrosis may be a connective tissue reaction to several types of injury resulting in bone marrow tissue death.
		Myelofibrosis may occur as a result of the spread of cancer (metastasis) to bone marrow from primary tumors.
	www.cigna.com /healthinfo/nord244.html (1878 words)

	Myelofibrosis definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms
		Myelofibrosis: Fibrosis (spontaneous scarring) of the bone marrow.
		Myelofibrosis is characterized by significant anemia and an enlarged spleen.
		Acute myelofibrosis is a distinct disorder characterized by acute inadequate blood cell production (pancytopenia), marrow fibrosis, but no enlargement of the spleen or liver.
	www.medterms.com /script/main/art.asp?articlekey=4480 (129 words)

	Chronic idiopathic myelofibrosis : Cancerbackup
		Myelofibrosis can develop because the bone marrow has been producing too many platelets (due to essential thrombocythaemia), or too many red blood cells (due to polycythaemia vera).
		Myelofibrosis may not cause any symptoms initially, and some people are diagnosed during a routine blood test, when they have no symptoms.
		Myelofibrosis is usually diagnosed by a haematologist (specialist in blood disorders).
	www.cancerbackup.org.uk /Aboutcancer/Pre-cancerousconditions/Chronicidiopathicmyelofibrosis (1858 words)

	KTNV Las Vegas News .:. Myelofibrosis
		Myelofibrosis is a disorder in which bone marrow tissue develops in abnormal sites because the bone marrow itself undergoes fibrosis or scarring.
		Myelofibrosis is characterized by the development of fibrous tissue, which replaces the bone marrow.
		Myelofibrosis is very serious, difficult to treat, and death is common within one year of diagnosis.
	www.ktnv.com /global/story.asp?s=1230809 (487 words)

	Myelofibrosis Information on Healthline
		Myelofibrosis is a rare disease of the bone marrow in which collagen builds up fibrous scar tissue inside the marrow cavity.
		Myelofibrosis can be associated with many other conditions including breast cancer, prostate cancer, Hodgkin's disease, non-Hodgkin's lymphomas, acute myelocytic leukemia, acute lymphocytic leukemia, hairy cell leukemia, multiple myeloma, myeloproliferative diseases, tuberculosis, Gaucher's disease, and Paget's disease of bone.
		Myelofibrosis is caused by an abnormality in a single stem cell, which causes it to grow out of control.
	www.healthline.com /galecontent/myelofibrosis (906 words)

	Myelofibrosis
		Myelofibrosis is thought to result from abnormal bone marrow stem cells.
		However, the cause of myelofibrosis which occurs independently from such disorders is unknown.
		Finally a small proportion of patients with myelofibrosis may develop acute myeloid leukaemia.
	www.doctoronline.nhs.uk /masterwebsite1Asp/targetpages/specialts/haem/myelofib.asp (482 words)

	Myelofibrosis, Idiopathic
		Myelofibrosis is a condition characterized by formation of fibrous tissue (fibrosis) within the bone marrow.
		Symptoms of idiopathic myelofibrosis may include abnormally low levels of circulating red blood cells (anemia), an abnormally large spleen (splenomegaly), an abnormally large liver (hepatomegaly), weight loss, weakness and fatigue due to replacement of normal bone marrow cells, and/or episodes of severe pain in the abdomen, bones, and joints.
		In many cases, myelofibrosis occurs in association with increased bone density and the formation of small sharp pieces of bone (spicules) within the marrow cavity and increased bone density (osteosclerosis).
	www.peacehealth.org /kbase/nord/nord244.htm (480 words)

	Myelofibrosis with Myeloid Metaplasia - New Treatments, January 2, 2007
		Myelofibrosis with myeloid metaplasia represents both agnogenic myeloid metaplasia and the fibrotic stages of polycythemia vera and essential thrombocythemia.
		Myelofibrosis with myeloid metaplasia is currently classified under the broad category of chronic myeloid disorders.
		Myelofibrosis with myeloid metaplasia is the least frequent among the chronic myeloproliferative disordersand its incidence is estimated to be 1.3/100,000/year in Olmstead County, Minnesota.
	www.ccspublishing.com /journals5a/myelofibrosis.htm (657 words)

	MF-FAQ myelofibrosis
		In the setting of a myeloproliferative disorder, myelofibrosis is accompanied by varying degrees of myeloid metaplasia (often seen as enlargement of spleen and/or liver), due to reactivation of fetal hematopoietic sites than are normally dormant in adult life.
		It is this combination that distinguishes myeloproliferative disease-related myelofibrosis from the secondary or interactive myelofibrosis that occurs in the setting of malignancy, chemical or physical injury, infection or infarction.
		Patients with idiopathic myelofibrosis who tend to do very well include those whose presenting hemoglobin levels are greater than 10 gm/dl, platelet counts greater than 100x3/ul and only modest enlargement of the liver.
	www.acor.org /mpd/mffaq.html (8155 words)

	Benzene Causes Myelofibrosis & Myeloid Metaplasia :.: Metzger Law Group, California Benzene Lawyers (Site not responding. Last check: )
		In 1995, Tondel reported a case of myelofibrosis in a 46-year-old man who had worked as a gas station attendant for 17 years and was exposed to benzene from fueling cars with gasoline and diesel and from inspecting the level of gasoline in arriving tanker trucks.
		A proportionate mortality ratio for myelofibrosis was not reported, probably due to an absence of data regarding incidence of the disease in the general population.
		Numerous case reports of benzene-induced myelofibrosis have been documented in the medical literature, and the causal association between exposure to benzene and myelofibrosis is supported by the available epidemiologic literature.
	www.toxictorts.com /benzene_info_benzene_and_myelofibrosis_mm.shtml (1309 words)

	Myelofibrosis - symptom, Treatment of Myelofibrosis and bone marrow
		Myelofibrosis is also called as agnogenic myeloid metaplasia.
		Myelofibrosis is a blood disorder in which fibrous tissue replaces the blood-producing cells in the bone marrow, resulting in abnormally shaped red blood cells, anemia, and an enlarged spleen.
		Myelofibrosis is ver rare, affecting less than 2 of 100,000 people in the United States.
	www.diseases-condition.com /diseases-m/myelofibrosis.htm (120 words)

	Myelofibrosis - Patient UK
		Myelofibrosis may be primary (idiopathic) or secondary to a variety of diseases, including:
		Idiopathic myelofibrosis is a chronic myeloproliferative disorder, along with chronic myelogenous leukaemia, polycythaemia rubra vera, and
		Kutti J, Ridell B; Epidemiology of the myeloproliferative disorders: essential thrombocythaemia, polycythaemia vera and idiopathic myelofibrosis.
	www.patient.co.uk /showdoc/40002420 (1494 words)

	MedlinePlus Medical Encyclopedia: Primary myelofibrosis
		Primary myelofibrosis is a disorder of the bone marrow, in which the marrow is replaced by fibrous (scar) tissue.
		In primary myelofibrosis, a progressive scarring (fibrosis) of the bone marrow occurs.
		In the end stages, myelofibrosis is a wasting, debilitating illness.
	www.nlm.nih.gov /medlineplus/ency/article/000531.htm (415 words)

	MPD (Myeloproliferative Disorders) Foundation
		“Rigorous laboratory work has once again prevailed by identifying JAK2 and other mutations involving the JAK-STAT signaling pathway in polycythemia vera, essential thrombocythemia, and primary myelofibrosis.
		The MyeloProliferative Disorders (MPD) Foundation recognized the importance of these discoveries early and allotted substantial funding for the three of us (Gilliland, Hoffman, Tefferi) to join forces in the fight against MPDs.
		Lastly, the foundation hopes to give patients and their families the information they need to manage their disorders and minimize the debilitating side effects until an initial cure is found.
	mpdfoundation.org (187 words)

	eMedicine - Agnogenic Myeloid Metaplasia With Myelofibrosis : Article by Asheesh Lal, MBBS
		Barosi G: Myelofibrosis with myeloid metaplasia: diagnostic definition and prognostic classification for clinical studies and treatment guidelines.
		Jacobson RJ, Salo A, Fialkow PJ: Agnogenic myeloid metaplasia: a clonal proliferation of hematopoietic stem cells with secondary myelofibrosis.
		Miller JB, Testa JR, Lindgren V: The pattern and clinical significance of karyotypic abnormalities in patients with idiopathic and postpolycythemic myelofibrosis.
	www.emedicine.com /MED/topic78.htm (5200 words)

	Myelofibrosis - MayoClinic.com
		Myelofibrosis is a serious bone marrow disorder that disrupts your body's normal production of blood cells.
		You may also hear myelofibrosis referred to as agnogenic myeloid metaplasia or idiopathic myelofibrosis.
		There's no known way to prevent myelofibrosis, and risk factors for it are unclear.
	www.mayoclinic.com /health/myelofibrosis/DS00886 (220 words)

	Primary myelofibrosis
		Primary myelofibrosis is a disorder of the bone marrow in which the marrow is replaced by fibrous (scar) tissue.
		In primary myelofibrosis, a progressive scarring (fibrosis) of the bone marrow occurs.
		In the end stages, myelofibrosis is a wasting, debilitating illness.
	www.pennhealth.com /ency/article/000531.htm (384 words)

	myelofibrosis : signs - symptoms and disease information
		Myelofibrosis is a condition in which the bone marrow cells which produce red cells, white cells and platelets are gradually replaced by fibrous tissue.
		In primary myelofibrosis, the disorder usually develops gradually and is most commonly seen in people over 50 years of age.
		Secondary myelofibrosis develops from some other disease which damages the bone marrow.
	www.myelectronicmd.com /get_reference.php?Id=791&condition=Myelofibrosis&typ=3&symname=Irregular%20or%20Rapid%20Heartbeat&pcid=82&box_num=10 (404 words)

	MPD (Myeloproliferative Disorders) Foundation: About MPDs
		Polycythemia Vera is a clonal chronic progressive myeloproliferative disorder characterized by an absolute increase in the red cell mass and usually by an elevated leukocyte count, an elevated platelet count and an enlarged spleen.
		The most common causes of morbidity and mortality is the predisposition of polycythemia vera patients to develop life threatening arterial (heart attacks, strokes, intestinal gangrene) and venous (thromboses of the portal and /or hepatic veins, pulmonary embolism) thromboses.
		MMF and marrow fibrosis are thought to be a response to a malignant proliferation of hematopoietic stem cells.
	mpdfoundation.org /about_mpd.htm (445 words)

	Myelofibrosis Information - Bone Marrow Transplant Center at Rush in Chicago
		Myelofibrosis is the replacement of bone marrow by fibroblastic cells or fibrous tissue.
		Myelofibrosis is the primary form of the disorder myeloid metaplasia, which may be associated with leukemia or carcinoma.
		Splenectomy (removal of the spleen) may be indicated where enlargement of the spleen causes symptoms related to the organ’s size.
	www.rush.edu /rumc/page-1124119150045.html (343 words)

	Myelofibrosis with Myeloid Metaplasia Treatment - Mayo Clinic
		Deciding how to treat myelofibrosis is a difficult decision for the patient and physician to make together.
		Additionally, Mayo researchers (see Research on Myelofibrosis) are actively evaluating possible new therapies for myelofibrosis in the laboratory.
		Most myelofibrosis patients, because of age, stability of the disease or other health problems, will not qualify for this treatment.
	www.mayoclinic.org /myelofibrosis/treatment.html (405 words)

	Dr. Koop - Primary myelofibrosis
		Primary myelofibrosis is a disorder of the bone marrow in which the marrow is replaced by fibrous (scar) tissue.
		In primary myelofibrosis, a progressive scarring (fibrosis) of the bone marrow occurs.
		This causes blood formation to take place in sites other than the bone marrow, such as the liver and spleen, causing enlargement of these organs.
	www.drkoop.com /ency/93/000531.html (297 words)

	Diet Myelofibrosis Supplement
		To formulate a diet myelofibrosis supplement pour the nitro-tech most powerful weapon the most important.
		Study diet myelofibrosis supplement subjects using and the only instead of a quot the best.
		Diet myelofibrosis supplement the result is results you can.
	www.cheetahresearch.co.za /diet/diet_myelofibrosis_supplement.html (662 words)

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