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Topic: Myeloma multiplex

	Research Progress Report: Dr. Ivan Van Riet
		To answer the question whether the restricted localization of myeloma cells in the bone marrow is the result of selective migration towards bone marrow or/and selective survival in the bone marrow, we performed a study in the in vivo 5T2-mouse MM model.
		Myeloma cell migration was partially blocked by peptide 11, a synthetic nonapeptide derived from this amino sequence and not by a scrambled (control) peptide.
		We conclude that 67LR on the surface of myeloma cells is involved in the laminin-1 induced migration of myeloma cells and that this mechanism might be important during the extravasation of circulating myeloma cells.
	www.myeloma.org /spider_articles/1403.html (1995 words)

	A Novel Multiplex Drug Screening Assay (MDSA) of compounds related to Multiple Myeloma
		We are proposing a new, more comprehensive anticancer drug screening assay that is based on simultaneous testing of up to 100 myeloma cell secreted factors important for in vivo myeloma cell proliferation, survival, and progression.
		Myeloma cell conditioned medium is a rich source of tumor-produced molecules and could be highly informative about tumor cell ability to produce angiogenic factors, growth factors, cytokine, chemokines, and MMP's that are essential for myeloma proliferation, survival, and disease progression.
		The multiplex analytic panel can be extended by incorporation of new important targets.
	www.multiplemyeloma.org /research/abstracts/5.07.109.html (193 words)

	Lifespan's A - Z Health Information Library - Distal median nerve dysfunction (Site not responding. Last check: 2007-09-28)
		Dysfunction of a single nerve group, such as the distal median nerve, is classed as mononeuropathy.
		Mononeuropathy implies a local cause of the nerve damage, although occasionally systemic disorders may cause isolated nerve damage (such as the damage that occurs with mononeuritis multiplex).
		The nerve can also be compressed at the wrist by tendonitis, arthritis, or conditions that affect connective tissue or cause deposits in the tissues (such as multiple myeloma, pregnancy, acromegaly, and hypothyroidism).
	www.lifespan.org /adam/healthillustratedencyclopedia/1/000691.html (809 words)

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