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Topic: Myeloproliferative disease

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Idiopathic thrombocytopenic purpura

	Sloan-Kettering - Uncommon Myeloproliferative Disorders
		Myeloproliferative disorders are diseases in which too many of certain types of blood cells -- monocytes, platelets, fibroblasts, red blood cells -- are made in the bone marrow, the spongy tissue inside the large bones in the body where red and white blood cells and platelets are made.
		CMML is classified either as a myeloproliferative disease or a myelodysplastic syndrome and its treatment depends in part on how it manifests itself, but often entails blood transfusions and sometimes oral or intravenous chemotherapy to control the disease.
		Polycythemia vera, a disease of the hematopoietic stem cells (cells that give rise to blood cells) is characterized by the overproduction of red blood cells by the bone marrow.
	www.mskcc.org /mskcc/html/5478.cfm (587 words)

	Myeloproliferative disease - Wikipedia, the free encyclopedia
		The myeloproliferative diseases are a group of diseases of the bone marrow where excess cells are produced.
		They are related to, and may evolve into, myelodysplastic syndrome and acute myeloid leukemia, although the myeloproliferative diseases on the whole have a much better prognosis than these conditions.
		The concept of myeloproliferative disease was first proposed in 1951 by the eminent hematologist William Dameshek.
	en.wikipedia.org /wiki/Myeloproliferative_disease (201 words)

	Myeloproliferative Disorders
		Myeloproliferative disorders (MPDs) are characterized by the clonal proliferation of one or more hematopoietic cell lineages, predominantly in the bone marrow but sometimes in the liver and spleen as well.
		The role and benefit of using chemotherapeutic agents early in the disease to reverse the fibrosis is highly controversial, and randomized clinical trials are needed to address this issue.
		The incidence of the disease (2.38/100,000 population/year in Olmsted County, MN) is the lowest among the chronic myeloproliferative disorders.
	www.clevelandclinicmeded.com /diseasemanagement/hematology/mdisorders/mdisorders.htm (4297 words)

	National Cancer Institute - Myelodysplastic/Myeloproliferative Diseases
		Myelodysplastic/myeloproliferative diseases are a group of diseases in which the bone marrow makes too many white blood cells.
		Chronic myelomonocytic leukemia is a disease in which too many myelocytes and monocytes (immature white blood cells) are made in the bone marrow.
		Myelodysplastic/myeloproliferative disease, unclassifiable, is a disease that has features of both myelodysplastic and myeloproliferative diseases but is not chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, or atypical chronic myelogenous leukemia.
	cancer.gov /cancertopics/pdq/treatment/mds-mpd/patient/allpages/print (4610 words)

	Society : Disease Information - Myeloproliferative Disorders (Site not responding. Last check: 2007-10-09)
		Myeloproliferative disorders are a group of blood diseases characterized by chronic increases in some or all of the blood cells.
		Myeloproliferative disorders begin with a change to the DNA of a single stem cell in the marrow, where blood cells are made.
		Polycythemia vera is a disease in which the red cells are the main cells that are increased beyond normal levels.
	www.leukemia-lymphoma.org /all_page.adp?item_id=311829 (315 words)

	National Cancer Institute - Myelodysplastic/Myeloproliferative Diseases
		Myelodysplastic/myeloproliferative diseases are diseases of the blood and bone marrow.
		Peripheral blood smear: A procedure in which a sample of blood is checked for the presence of blast cells, number and kinds of white blood cells, the number of platelets, and changes in the shape of blood cells.
		The cancer cells in myelodysplastic/myeloproliferative diseases do not contain the Philadelphia chromosome that is present in chronic myelogenous leukemia.
	www.cancer.gov /cancerinfo/pdq/treatment/mds-mpd/patient (604 words)

	Myeloproliferative disease (Site not responding. Last check: 2007-10-09)
		With regard to the PV, the author notes in the summary that a better understanding of the influence of various therapies on outcome of the disease has been achieved, and a better understanding of the transformation of the disease into other lesions has been forthcoming.
		With regard to the AMM, it is noted that the central role of the megakaryocyte in the pathology and pathophysiology of the disease seems unquestionable and that newer treatments for the disease have been proposed.
		Finally, with regard to the PT, it is noted that genetic studies of the lesion depict it as a clonal hemopathy and that numerous trials of therapy have now been reported.
	www.meb.uni-bonn.de /cgi-bin/mycite?ExtRef=ICDB/89656644 (121 words)

	Eosinophil Count
		Usually increased in allergy, parasitic infestations, tuberculosis, brucellosis, collagen disease, Hodgkin's disease, myeloproliferative diseases, and the acute hypereosinophilic syndrome; increased also in angioneurotic edema, dermatitis, thymic disorders, radiotherapy, splenectomy, convalescence from a febrile illness, and hypoadrenocorticism (Addison disease).
		Toxocaral disease (visceral larva migrans) is a typical parasitic disease in which eosinophil counts (eosinophils >30% on differential) are usually elevated.
		This condition may not be a true leukemic myeloproliferative disease, although concepts of HES are controversial.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/he001900.htm (537 words)

	Myelodysplastic/Myeloproliferative Diseases: (Site not responding. Last check: 2007-10-09)
		The myelodysplastic/myeloproliferative diseases (MDS/MPD) are clonal myeloid disorders that possess both dysplastic and proliferative features and that are not properly classified as either myelodysplastic syndromes (MDS) or chronic myeloproliferative disorders (CMPD).
		In general, the treatment of these diseases is tailored to the manifestations, myeloproliferative or myelodysplastic, that predominate in the individual patient.
		Myelodysplastic/Myeloproliferative Disease, Unclassifiable (MDS/MPD-U) (also known as mixed myeloproliferative/myelodysplastic syndrome, unclassifiable and â€œoverlapâ€ syndrome, unclassifiable) shows features of both myeloproliferative disease and myelodysplastic disease but does not meet the criteria for any of the other MDS/MPD entities.
	www.acor.org /cnet/334473.html (4425 words)

	eMedicine
		Myeloproliferative diseases (MPDs) are a group of disorders characterized by cellular proliferation of one or more hematologic cell lines distinct from acute leukemia.
		This multicenter trial is evaluating the efficacy of non-myeloablative allogeneic hematopoietic stem cell transplantation in patients with myelodysplastic syndromes or myeloproliferative disorders.
		A rapidly progressive chronic myeloproliferative disease with isolated trisomy 6.
	www.emedicine.com /rc/rc/i22/MPDs.htm (642 words)

	Bcr-Abl Efficiently Induces a Myeloproliferative Disease and Production of Excess Interleukin-3 and ...
		Detection of gfp in the genomic DNA of the peripheral WBCs from a Bcr-Abl-BMT mouse with the myeloproliferative disorder.
		Genomic DNA isolated from the unsorted WBCs (lane 1) and sorted GFP-negative (lane 2) and GFP-positive (lane 3) cells was subjected to PCR analysis using a mixture of primers that amplify the gfp gene (850 bp) and intron-3 of the mouse c-abl gene (500 bp).
		An expansion of macrophages in the liver was frequently observed in association with the myeloproliferative disease in the
	www.bloodjournal.org /cgi/content/full/92/10/3829 (7697 words)

	Bcr-Abl with an SH3 Deletion Retains the Ability To Induce a Myeloproliferative Disease in Mice, yet c-Abl Activated by ...
		diseased mice in the Bcr-Abl/p210 (b3a2) and Bcr-Abl/p210 (b3a3)
		vitro and in inducing a CML-like disease in vivo.
		Hematologic disease induced in BALB/c mice by a bcr-abl retrovirus is influenced by the infection conditions.
	mcb.asm.org /cgi/content/full/19/10/6918 (7728 words)

	NIH Guide: CELLULAR AND GENETIC DISCOVERY TOWARD CURATIVE THERAPY IN MYELOPROLIFERATIVE DISORDERS (MPD)
		MPD represents a broad range of clinical entities, which creats difficulties in prompt assignment of diagnosis, prediction of prognosis, characterization of disease evolution, and an orderly approach to research on the etiology and progression of disease.
		Myeloproliferative disorders are considered clonal hematopoietic stem cell disorders characterized by excessive proliferation and production of one or more of the myeloid cells and are classified according to the predominant cells, such as chronic myelogenous leukemia (CML), chronic eosinophilic leukemia (CEL), polycythemia vera (PV), essential thrombocythemia (ET), and chronic idiopathic myelofibrosis (CIMF).
		Laboratory and clinical correlative studies may be used to define meaningful disease characteristics that will improve early diagnosis and serve as basis for the development of novel, safer, and more effective therapy.
	grants.nih.gov /grants/guide/rfa-files/RFA-HL-04-034.html (3567 words)

	Hematological disoders (Site not responding. Last check: 2007-10-09)
		The 5q- is associated with an aggressive disease state with a poor patient prognosis.
		Monosomy 7 and del(7) are associated with an aggressive disease state with a poor patient prognosis.
		Trisomy of chromosome 8 is almost exclusively observed in acute nonlymphocytic leukemia (ANLL:FAB-M2, M4 and M5), as a secondary chromosome change in chronic myelocytic leukemia (CML), and in myeloproliferative and myelodysplastic diseases.
	www.phd.msu.edu /cyto/hemat.htm (1707 words)

	Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 ...
		One approach for investigating CML that is relevant to the disease is to use primary human tissue for study.
		Cells derived from the spleen of tertiary recipients that developed the myeloproliferative disease were transferred to quaternary recipients.
		of the disease was similar to that shown in Fig 3.
	www.bloodjournal.org /cgi/content/full/92/10/3780 (7757 words)

	The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative ... (Site not responding. Last check: 2007-10-09)
		The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl.These studies directly demonstrated the important roles of Bcr sequences in induction of MPD by Bcr-Abl.
		We found that the NH(2)-terminal coiled-coil (CC) domain was both essential and sufficient, even though not efficient, to activate Abl to induce an MPD in mice.
		We have also shown that the Abl kinase activity within Bcr-Abl is essential for Bcr-Abl leukemogenesis, yet activation of the Abl kinase without Bcr sequences is not sufficient to induce MPD in mice.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/8689994.html (270 words)

	Chronic neutrophilic leukaemia: 14 new cases of an uncommon myeloproliferative disease -- Böhm and Schaefer 55 ...
		Chronic neutrophilic leukaemia: 14 new cases of an uncommon myeloproliferative disease -- Böhm and Schaefer 55 (11): 862 -- Journal of Clinical Pathology
		Chronic neutrophilic leukaemia: 14 new cases of an uncommon myeloproliferative disease
		Neutrophilic-chronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction).
	jcp.bmjjournals.com /cgi/content/full/55/11/862 (1191 words)

	Adoptive immunotherapy of BCR-ABL-induced chronic myeloid leukemia-like myeloproliferative disease in a murine model -- ...
		Serial analysis of chimerism and leukemia were conducted as in panel A, from a representative mouse with mixed chimerism and CML-like myeloproliferative disease treated with early DLI.
		Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia.
		The Src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase.
	www.bloodjournal.org /cgi/content/full/104/13/4236 (5783 words)

	Familial Myeloproliferative Disease (Site not responding. Last check: 2007-10-09)
		The Myeloproliferative Disorders (MPDs) have been shown to arise from clonal expansion of a pluripotential hematopoietic precursor cell (PHPC) that possesses a growth advantage over other polyclonally derived PHPC's but still retains its pluripotentiality.
		The occurrence of mixed phenotypes in familial MPD is entirely consistent with the accepted theory of MPD as a disease of the pluripotential hematopoietic precursor cell that manifests phenotypic heterogeneity of the expanded clone.
		Transformations from one phenotypic variant to another during the course of MPD are common, and it would be surprising if only a single MPD variant were to appear in all involved members of a family with MPD.
	www.acor.org /diseases/hematology/MPD/Family.html (1994 words)

	Bcr-Abl with an SH3 Deletion Retains the Ability To Induce a Myeloproliferative Disease in Mice, yet c-Abl Activated by ...
		alone is sufficient to induce a myeloproliferative disease.
		Zhang, X., Wong, R., Hao, S. X., Pear, W. S., Ren, R. The SH2 domain of Bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype.
		Li, S., Gillessen, S., Tomasson, M. H., Dranoff, G., Gilliland, D. G., Van Etten, R. Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL.
	mcb.asm.org /cgi/content/abstract/19/10/6918 (777 words)

	Hematopathology (Site not responding. Last check: 2007-10-09)
		Such massive splenomegaly is usually indicative of some myeloproliferative disease such as chronic myelogenous leukemia or myelofibrosis.
		Congestive splenomegaly (as with portal hypertension in cirrhosis of the liver) is unlikely to increase the size of the spleen over 800 gm.
		A spleen >1000 gm suggests a myeloproliferative, lymphoproliferative, or hematopoietic disorder.
	www-medlib.med.utah.edu /WebPath/HEMEHTML/HEME047.html (63 words)

	The SH2 domain of Bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling ...
		The SH2 domain of Bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype -- Zhang et al.
		The SH2 domain of Bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype
		CML is a clonal myeloproliferative disorder (MPD) resulting from the neoplastic transformation of hematopoietic stem cells.
	www.bloodjournal.org /cgi/content/full/97/1/277 (7416 words)

	Chronic Myelogenous Leukemia and Myeloproliferative Disease -- O'Brien et al. 2004 (1): 146 -- Hematology
		Low-risk disease is defined by the absence of hemoglobin < 10 g/dL, circulating blasts, and severe constitutional symptoms.
		A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation.
		Serious myeloproliferative reactions associated with the use of thalidomide in myelofibrosis with myeloid metaplasia.
	www.asheducationbook.org /cgi/content/full/2004/1/146 (7648 words)

	Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease -- Chan et ...
		myeloproliferative diseases induced in murine bone marrow transplant
		cells (25) and the myeloproliferative disease observed with
		FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model.
	www.jci.org /cgi/pmidlookup?view=full&pmid=14966562 (6170 words)

	Disruption of the estrogen receptor {beta} gene in mice causes myeloproliferative disease resembling chronic myeloid ...
		gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis
		a disease of multipotent stem cells, it is not surprising that
		disease, because leukemia is a disease of transformed hematopoietic
	www.pnas.org /cgi/content/full/100/11/6694 (3342 words)

	Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid ...
		Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis.
		Thus the absence of ERbeta results in a myeloproliferative disease resembling human chronic myeloid leukemia with lymphoid blast crisis.
		Our results indicate a previously unknown role for ERbeta in regulating the differentiation of pluripotent hematopoietic progenitor cells and suggest that the ERbeta-/- mouse is a potential model for myeloid and lymphoid leukemia.
	www.arclab.org /medlineupdates/abstract_12740446.html (318 words)

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