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Topic: Myxedema

Related Topics

Hypothyroidism

Autoimmune disorder

Opthalmoplegia

Rash

October 6

	Pretibial Myxedema
		TSH receptor transcripts and TSH receptor-like immunoreactivity in orbital and pretibial fibroblasts of patients with Graves' ophthalmopathy and pretibial myxedema.
		Case 2 had had pretibial myxedema for the past 20 years and myxedema tuberosum at the right shoulder for the past 10 years, and on admission showed exophthalmos and digital clubbing with thyroid gland demonstrating histological picture of chronic thyroiditis.
		Therefore, this study suggests that intravenous immunoglobulins are effective in the treatment of pretibial myxedema and may have an immunomodulant action in patients with Graves' disease and related disorders.
	www.thedoctorsdoctor.com /diseases/pretibial_myxedema.htm (3626 words)

	Pretibial Myxedema
		In Grave's disease, myxedema tends to occur in the presence of ophthalmopathy at a later stage in the disease.
		Myxedema in both hyperthyroid and hypothyroid conditions results from the accumulation of increased amounts of hyaluronic acid and chondroitin sulfate in the dermis in both lesional and normal skin.
		The mechanism that causes myxedema is unclear although animal model studies suggest that thyroid hormones affect the synthesis and catabolism of mucopolysaccharides and collagen by dermal fibroblasts.[2,3] The fibroblasts in the orbital and pretibial dermis share antigenic sites that underlie the autoimmune process that causes Grave's disease.
	dermatology.cdlib.org /DOJvol7num1/NYUcases/myxedema/chung.html (597 words)

	Myxedema - Wikipedia, the free encyclopedia
		Myxedema is a skin and tissue disorder usually due to hypothyroidism.
		Myxedema stemming from both hyperthyroid and hypothyroid conditions, results from the accumulation of increased amounts of hyaluronic acid and chondroitin sulfate in the dermis in both lesional and normal skin.
		The mechanism that causes myxedema is still not yet understood, although animal model studies suggest that thyroid hormones affect the synthesis and catabolism of mucopolysaccharides and collagen by dermal fibroblasts.
	en.wikipedia.org /wiki/Myxedema (209 words)

	Myxedema Coma: Diagnosis and Treatment American Family Physician - Find Articles
		Myxedema coma is an extreme complication of hypothyroidism in which patients exhibit multiple organ abnormalities and progressive mental deterioration.
		Myxedema also refers to the swelling of the skin and soft tissue that occurs in patients who are hypothyroid.
		However, myxedema coma is a misnomer because most patients exhibit neither the nonpitting edema known as myxedema nor coma.(1,2) Instead, the cardinal manifestation of myxedema coma is a deterioration of the patient's mental status.
	findarticles.com /p/articles/mi_m3225/is_11_62/ai_67503331 (717 words)

	Hypothyroidism MEDSTUDENTS-ENDOCRINOLOGY
		Myxedema coma is the end stage of untreated hypothyroidism.
		Myxedema coma is an acute medical emergency and should be treated in the intensive care unit.
		The course of untreated myxedema is one of slow deterioration.
	www.medstudents.com.br /endoc/endoc4.htm (980 words)

	eMedicine - Myxedema Coma or Crisis : Article Excerpt by Elena Citkowitz
		The term myxedema has been applied to several clinical entities and is often used interchangeably with severe hypothyroidism, the common clinical condition in which the thyroid gland produces abnormally low levels of hormones (see Hypothyroidism).
		Myxedema coma is a rare consequence of untreated hypothyroidism and hypothyroidism is a common disorder in the older population.
		Myxedema coma/crisis is a metabolic and cardiovascular emergency.
	www.emedicine.com /med/byname/myxedema-coma-or-crisis.htm (1126 words)

	Myxedema and pericardial effusion with cardiac tamponade (a case report). Retnam VJ, Chichgar JA, Patkar LA, ...
		Myxedema heart disease as a distinct entity was first described by Zondek[10] in 1918 and defined completely by Fahr[4] in 1925.
		Kern et al[5] described pericardial effusion as a "constant, early and major factor in myxedema heart." Its presentation is similar to that of congestive cardiac failure.
		The rarity of cardiac tamponade[2], [8], [9] in myxedema patients with pericardial effusion is attributed to the slow accumulation of fluid and the remarkable distensibility of the pericardium.
	www.jpgmonline.com /article.asp?issn=0022-3859;year=1983;volume=29;issue=3;spage=188;epage=190B;aulast=Retnam (1088 words)

	Thyroiditis, Myxedema, and Graves' Disease as Autoimmune Diseases
		Thyroiditis, Myxedema, and Graves' Disease as Autoimmune Diseases
		Thus, idiopathic myxedema is probably the end result of Hashimoto's thyroiditis, in which the phase of thyroid enlargement was minimal or was overlooked.
		We may assume that in idiopathic myxedema the cell‑destructive T cell-mediated immune response is an important pathogenic factor in the illness, and that cytotoxic antibodies and TSH blocking antibodies contribute to the development of hypothyroidism, but perhaps in only a proportion.
	www.thyroidmanager.org /Chapter7/ch01s08.html (1088 words)

	Myxedema Madness: When Being Crazy Isn't In Your Head, But In Your Thyroid.
		Myxedema, the medical term for hypothyroidism, is most commonly recognized by well-known physical symptoms: weight gain, puffiness about the face, dry skin, fatigue and a general slowing of the metabolism.
		Myxedema Madness is a catchall phrase, coined by Dr. Richard Asher in 1940, that encompasses a broad swath of emotions ranging from minor anxieties, doubts and worries to full-blown panic attacks and classic psychiatric conditions like schizophrenia.
		Myxedema Madness typically manifests as a simple bout of depression and is often treated as such, with antidepressants and advice to, "Slow down - take it easy for a bit." Unfortunately, neither the pills nor the pontification strike at the root of the issue.
	www.articledashboard.com /Article/Myxedema-Madness---When-Being-Crazy-Isn-t-in-Your-Head--But-in-Your-Thyroid-/124265 (727 words)

	Thyroid Eye Disease - Course and Treatment
		The principal abnormality in pretibial myxedema is the marked increase in GAG concentration in the skin.
		Immunoglobulin G from patients with pretibial myxedema was shown to stimulate proteoglycan synthesis by human skin fibroblasts.
		In a patient with very severe and debilitating pretibial myxedema a combined treatment of surgical excision and octreotide treatment showed a successful effect that was still present after 9 years of follow-up 172d.
	www.thyroidmanager.org /Chapter12/Ch-12-3.htm (1673 words)

	Emergency Medicine
		Myxedema coma is a severe, life-threatening sequela of profound hypothyroidism.
		Myxedema coma often occurs during the winter months, which suggests that significant environmental factors such as low temperatures may precipitate decompensation of underlying hypothyroidism.
		Given the high mortality associated with myxedema coma, we recommend that treatment be initiated as soon as the diagnosis is suspected.
	www.emedmag.com /html/pre/cov/covers/021503.asp (3081 words)

	eMedicine - Myxedema Coma or Crisis : Article by Elena Citkowitz
		Myxedema crisis/coma is a life-threatening condition; therefore, patients with this condition must be stabilized in an intensive care unit.
		In cold climates, inadequately heated residences are a significant cause of myxedema coma/crises in patients with undiagnosed or inadequately treated hypothyroidism.
		Myxedema coma/crisis occurs in the setting of untreated or undertreated hypothyroidism and is precipitated by some additional insult (eg, cold environmental temperature, infection).
	www.emedicine.com /med/topic1581.htm (4161 words)

	Hypothyroidism - Health Centers News Story - WKMG Orlando
		Myxedema coma is a medical emergency that occurs when the body's level of thyroid hormones becomes extremely low.
		Myxedema coma, the most severe form of hypothyroidism, is rare.
		It may be caused by an infection, illness, exposure to cold, or certain medications in an individual with untreated hypothyroidism.
	www.local6.com /encyclopedia/6860000/detail.html (935 words)

	MedlinePlus Medical Encyclopedia: Hypothyroidism
		Myxedema coma is a medical emergency that occurs when the body's level of thyroid hormones becomes extremely low.
		Myxedema coma, the most severe form of hypothyroidism, is rare.
		It may be caused by an infection, illness, exposure to cold, or certain medications in an individual with untreated hypothyroidism.
	www.nlm.nih.gov /medlineplus/ency/article/000353.htm (738 words)

	Myxedema - WrongDiagnosis.com
		Myxedema: Skin and tissue disorder usually due to hypothyroidism.
		The full text of published medical book sections related to Myxedema is available from the following published medical books for more detailed information about Myxedema.
		Underlying medical conditions are other medical conditions that may possibly cause Myxedema.
	www.wrongdiagnosis.com /m/myxedema/intro.htm (1120 words)

	Mind-Sharpeners Directed Learning Modules
		Myxedema coma can be be difficult to differentiate from other abnormalities, such as hypoglycemia, hyponatremia, hypercapnia, and hypoxemia, which often are associated with myxedema coma.
		Answer: The most important factor underlying the ventilatory abnormality in myxedema is a depression of the hypoxic respiratory drive, which may be accompanied by a depressed ventilatory response to hypercapnia.
		Answer: Regardless of the cause, mechanical function in myxedema coma usually is reduced enough to require mechanically assisted ventilation, especially if narcotic or sedative drugs may be playing a role in the depressed ventilation.
	www.erworld.com /mindsharp/mindv_2.htm (1824 words)

	Myxedema Information - pretibial myxedema, myxedema coma, myxedema symptom, picture
		Myxedema is mainly a skin and tissue disorder usually due to hypothyroidism.
		Pretibial myxedema (PTM) or, more appropriately, thyroid dermopathy is a term used to describe localized lesions of the skin resulting from the deposition of hyaluronic acid, usually as a component of thyroid disease.
		Myxedema coma is considered a life-threatening complication of hypothyroidism and represents the far more serious side of the spectrum of thyroid disease.
	www.free-food-recipes.com /myxedema.htm (190 words)

	Myxedema - pretibial myxedema
		This constellation pretibial myxedema picture is usually referred to as "secondary hypothyroidism".
		Even rarer is tertiary hypothyroidism that is caused either by hypothalamic lesions or by interruption of signal transfer in the portal veins connecting the hypothalamus to the pituitary gland (Pickardt syndrome).
		In areas of the world where there is an iodine deficiency in the diet, severe hypothyroidism can be seen in 5 to 15% of the hypothyroidism myxedema picture population.
	www.medicalgeo.com /Med-Diseases-My---O/Myxedema.html (527 words)

	myxedema on Encyclopedia.com
		The incidence of pleural effusion in a well-defined region: epidemiologic study in central Bohemia.
		MYXEDEMA [myxedema], condition associated with severe hypothyroidism and lack of thyroid hormone in the adult.
		In the child it is known as cretinism.
	www.encyclopedia.com /html/m1/myxedema.asp (338 words)

	NLH - ENT and Audiology - Is there any effective treatment of pretibial myxoedema/myxedema in someone who is now ...
		We found a case study which states "Pretibial myxedema is typically associated with clinical hyperthyroidism, diffuse goiter, and ophthalmopathy in patients with Graves' disease.
		A case of biopsy-proved pretibial myxedema was encountered in a clinically euthyroid woman who had neither diffuse goiter nor exophthalmos.
		Dermopathy of Graves disease (pretibial myxedema): long-term outcome.
	www.library.nhs.uk /ent/ViewResource.aspx?resID=101979 (909 words)

	Hyperthyroidism and Graves' Disease
		Pretibial myxedema is a skin condition that may develop in patients with Graves’ disease.
		Pretibial myxedema usually becomes evident when raised lesions begin to appear on the skin that covers the front surfaces of the shins.
		In most cases of pretibial myxedema, continued growth of lesions leads to widespread thickening of the skin that covers the front surfaces of the shins.
	www.hopkinsmedicine.org /endocrine/graves/Answer.asp?QuestionID=61 (442 words)

	Pretibial Myxedema -Wounds
		Pretibial myxedema usually is a late, uncommon dermopathy of Gravesâ disease affecting 0.5 to 4.3 percent of patients.
		There are rare case reports of pretibial myxedema occurring prior to the diagnosis of Gravesâ disease and in the absence of ophthalmopathy.
		Early onset pretibial myxedema in the absence of ophthalmopathy: A morphologic evolution.
	www.woundsresearch.com /article/1073 (1869 words)

	NEJM -- Ventilatory control in myxedema and hypothyroidism
		Alveolar hypoventilation is known to occur in myxedema.
		To clarify the role of hypoxic ventilatory drive and hypercapnic ventilatory drive in thyroid hormone insufficiency states, 10 patients with myxedema and seven with hypothyroidism (thyroid ablation) were studied before and after thyroid replacement.
		We conclude that both myxedema and hypothyroid states produce depression of hypoxic ventilatory drive that is responsive to replacement therapy.
	content.nejm.org /cgi/content/abstract/292/13/662 (325 words)

	Myxedema Coma - Thyroid: health and medical information about Thyroid Disease, Hypothyroidism, Hyperthyroidism and ...
		Myxedema coma is a loss of brain function as a result of severe, longstanding hypothyroidism (a condition in which too little thyroid hormone is produced).
		Myxedema coma is considered a life-threatening complication of hypothyroidism and represents the far more serious side of the spectrum of thyroid disease.
		While common hypothyroidism without myxedema is usually treated with T4 replacement (the hormone produced in greatest quantity by the thyroid gland), in the case of myxedema coma, management is different.
	www.medicinenet.com /script/main/art.asp?articlekey=19712 (847 words)

	Dr. Schilling's Net Health Book - Hypothyroidism (="Myxedema")
		The most common form of hypothyroidism likely is due to a burnt out Hashimoto's thyroiditis, a common autoimmune disease where autoantibodies lead to a chronic inflammation and eventual fibrotic transformation of the thyroid gland.
		Myxedema coma should also be in the hands of an endocrinologist, who will initially use fairly high thyroid hormone replacement doses, which are then gradually tapered to a maintenance program.
		The sad story in the past was, before these sensitive TSH monitoring tests were available, that the patients entered into a deep depression due to hypothyroidism and died from suicide as a result of the intractable depression or else suddenly died of a myxedema coma.
	www.nethealthbook.com /hypothyroidism.html (1409 words)

	[No title] (Site not responding. Last check: 2007-10-08)
		Myxedema may respond to high potency steroids under occulsion, and I seem to remember a case melting with PUVA, and another witht he aromatic retinois.
		Diane Thaler -------------------- Apparently in hyperthyroidism (usually Graves disease) the myxedema is localized to the pre-tibial area.
		In hypothyroidism, generalized myxedema is reported, which is the case in my patient.
	dermatology.cdlib.org /rxderm-archives/pretibial-myxedema (433 words)

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