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Topic: NADH dehydrogenase

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	NADH
		NADH is the reduced form of the molecule (carries electrons) and NAD+ is the...
		NADH dehydrogenase NADH dehydrogenase The NADH dehydrogenase (EC 1.6.5.3 (http://www.expasy.
		NADH Dehydrogenase Inhibitors suggested to be new Anti-Tubercular...
	www.perfume-shop.biz /subportals/NADH/NADH.html (777 words)

	Interaction of rhodanese with mitochondrial NADH dehydrogenase. (Site not responding. Last check: 2007-10-13)
		NADH dehydrogenase is an iron-sulfur flavoprotein which is isolated and purified from Complex I (mitochondrial NADH: ubiquinone oxidoreductase) by resolution with NaClO4.
		Rhodanese-mediated sulfide transfer was directly demonstrated when the reactivation of NADH dehydrogenase was performed in the presence of radioactive thiosulfate (labeled in the outer sulfur) and the 35S-loaded flavoprotein was re-isolated by gel filtration chromatography.
		The results indicated that the [35S]sulfide was inserted in NADH dehydrogenase and appeared to constitute the structural basis for the increase in enzymic activity.
	www.arclab.org /medlineupdates/abstract_6402020.html (190 words)

	United States Patent Application: 0040126857
		[0046] [4] The (R)-2-octanol dehydrogenase of [3], wherein the microorganism belonging to the genus Pichia is Pichia finlandica.
		[0047] [5] The (R)-2-octanol dehydrogenase of [3], wherein the microorganism belonging to the genus Pichia is Pichia jadinii.
		[0049] [7] The (R)-2-octanol dehydrogenase of [3], wherein the microorganism belonging to the genus Ogataea is Ogataea wickerhamii.
	appft1.uspto.gov /netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1="20040126857".PGNR.&OS=DN/20040126857&RS=DN/20040126857 (13942 words)

	NADH dehydrogenase - Wikipedia, the free encyclopedia
		NADH dehydrogenase (EC 1.6.5.3), Complex I of the mitochondrial electron transfer chain, catalyzes the transfer of electrons from NADH to coenzyme Q (CoQ).
		Defects in the subunits of Complex I are associated with various mitochondrial diseases, including Leigh syndrome and Parkinson's disease.
		Amytal and rotenone inhibit the transfer of electrons from Complex I (NADH dehydrogenase) to Complex III (Coenzyme Q - cytochrome c reductase complex).Piercidin, an antibiotic inhibits electron flow from the iron sulfur centres to the ubiquinone molecule.
	en.wikipedia.org /?title=NADH_dehydrogenase (204 words)

	NADH com:pg180 anti-aging research, cell longevity found with nadh coenzyme 1 diet supplement
		NADH is being tested for use in the medical treatments of chronic fatigue syndrome.
		NADH is the abbreviation for nicotinamide adenine dinucleotide.
		The reduction of equivalents of cytosolic NADH are transferred to the cytosolic oxaloacetate forming maleate by activity of cytosolic maleate dehydrogenase.
	www.nadh.com /newenrgy/Enrgy180.htm (727 words)

	Bioc 811
		The mitochondrial sn-glycerophosphate dehydrogenase is part of the glycerophosphate shuttle for moving electrons from cytosolic NADH into the electron transfer pathway.
		Remember that NADH does not cross the mitochondrial inner membrane, so the electrons are fed in from the periplasmic space in the form of glycerol 3 phosphate.
		The soluble and the membrane bound glycerophosphate dehydrogenases together form the glycerophosphate shuttle shown in fig 18.37 Electrons from cytosolic NADH are transferred to DHAP to form glycerophosphate and then back to the membrane bound glycerophosphate dehydrogenase FAD coenzyme and then on to ubiquinone in the membrane.
	drnelson.utmem.edu /etransport2002.html (4661 words)

	In Vivo Analysis of the Mechanisms for Oxidation of Cytosolic NADH by Saccharomyces cerevisiae Mitochondria -- Overkamp ...
		Although the outer mitochondrial membrane is permeable to NADH (17), the inner membrane is not (35).
		for oxidation of cytosolic NADH is the glycerol-3-phosphate shuttle
		reoxidation of cytosolic NADH to the mitochondrial respiratory
	jb.asm.org /cgi/content/full/182/10/2823 (3791 words)

	BIFC 3521: Lecture
		The pyruvate dehydrogenase enzyme complex catalyzes the conversion of pyruvate to acetyl CoA via oxidative decarboxylation (see PDH Reaction and CoA Structure).
		Succinate dehydrogenase (SDH) is the third of four oxidation-reduction reactions in the cycle.
		Although the reaction is endergonic, the rapid removal of oxaloacetate by citrate synthetase and oxidation of NADH by the respiratory chain (Chpt 21) pulls the reaction to the right.
	www.library.csi.cuny.edu /~davis/Biochem_3521/lect17/lect17.html (1939 words)

	Decreased NADH dehydrogenase and ubiquinol-cytochrome c oxidoreductase in peripheral arterial disease -- Brass et al. ...
		Decreased NADH dehydrogenase and ubiquinol-cytochrome c oxidoreductase in peripheral arterial disease -- Brass et al.
		Reducing equivalents from NADH are removed by the NADH dehydrogenase (NADH DH) in complex I and from succinate by the succinate dehydrogenase (SDH) of complex II.
		NADH DH and SDH measure the initial portion of complexes I and II, respectively, by using NADH and succinate as donors but artificial acceptors.
	ajpheart.physiology.org /cgi/content/full/280/2/H603 (3624 words)

	New Insights into Type II NAD(P)H:Quinone Oxidoreductases -- Melo et al. 68 (4): 603 -- Microbiology and Molecular ...
		Acidianus ambivalens type-II NADH dehydrogenase: genetic characterisation and identification of the flavin moiety as FMN.
		A new type-II NADH dehydrogenase from the archaeon Acidianus ambivalens: characterization and in vitro reconstitution of the respiratory chain.
		Characterization of the respiratory NADH dehydrogenase of Escherichia coli and reconstitution of NADH oxidase in ndh mutant membrane vesicles.Biochemistry 20:3621-3268.
	mmbr.asm.org /cgi/content/full/68/4/603 (7285 words)

	Tight Control of Respiration by NADH Dehydrogenase ND5 Subunit Gene Expression in Mouse Mitochondria -- Bai et al. 20 ...
		in one of the genes encoding subunits of the respiratory NADH
		The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme.
		Use of transmitochondrial cybrids to assign a complex I defect to the mitochondrial DNA-encoded NADH dehydrogenase subunit 6 gene mutation at nucleotide pair 14459 that causes Leber hereditary optic neuropathy and dystonia.
	mcb.asm.org /cgi/content/full/20/3/805 (8033 words)

	Biochemistry Detectives (Site not responding. Last check: 2007-10-13)
		NADH from glycolysis and TCA are funneled to oxidative phosphorylation.
		Since the NADH binding sites of NADH dehydrogenase of complex I is in the matrix side of the mitochondria, NADH generated in the cytosol has to be transported through the impermeable inner membrane of the mitochondria through special shuttles.
		NADH to FMN to UQ Flow of electron from complex I to UQ to complex III accompanied by flow of H+ from mitochondrial matrix to the outer cytosolic side of the inner mitochondrial membrane (intermembrane space).
	chemistry.gsu.edu /CAISER/course/biochemistry/biodetctive2.html (1131 words)

	Modulation of Mitochondrial Gene Expression in Pulmonary Epithelial Cells Exposed to Oxidants (Site not responding. Last check: 2007-10-13)
		NADH dehydrogenase was identified using additional differential display reactions (not shown here).
		Relative decreases in NADH dehydrogenase mRNA induced by 300 µM and 1 mM spermine NONOate, respectively, compared to sham controls are 29 and 13% after 2 hr, and 45 and 60% after 4 hr.
		Further investigation into the mechanisms of regulation of 16S rRNA and NADH dehydrogenase transcription, as well as the consequence of altered expression of these genes, is needed to address this question.
	ehp.niehs.nih.gov /members/1998/Suppl-5/1191-1195janssen/janssen-full.html (3904 words)

	THE ELECTRON TRANSPORT CHAIN
		The oxidation of NADH occurs in a stepwise manner involving an electron transport chain.
		Model is reactions such as glyceraldehyde phosphate dehydrogenase and pyruvate dehydrogenase where a redox reaction directly generates a high energy chemical intermediate, ie: diphosphoglyceric acid and acetyl-lipoate respectively.
		The formate is oxidized via formate dehydrogenase to give 2[H] plus CO The reducing equivalents travel via the cytochrome b of the FDH complex to a quinone.
	www.science.siu.edu /microbiology/micr425/425Notes/07-Respire.html (3207 words)

	Characterization of the Overproduced NADH Dehydrogenase Fragment of the NADH:Ubiquinone Oxidoreductase (Complex I) from ... (Site not responding. Last check: 2007-10-13)
		Characterization of the Overproduced NADH Dehydrogenase Fragment of the NADH:Ubiquinone Oxidoreductase (Complex I) from Escherichia coli
		The water-soluble NADH dehydrogenase fragment has a molecular mass of approximately 170 000 Da and consists of the subunits NuoE, F, and G. The fragment harbors the FMN and probably six iron-sulfur clusters, four of them being observable by EPR spectroscopy.
		Two binuclear (N1b and N1c) and two tetranuclear (N3 and N4) iron-sulfur clusters were detected by EPR in the NADH reduced preparation with spectral characteristics identical with those of the corresponding clusters in complex I. The preparation fulfills all prerequisites for crystallization of the fragment.
	pubs.acs.org /cgi-bin/abstract.cgi/bichaw/1998/37/i07/abs/bi971176p.html (265 words)

	[No title] (Site not responding. Last check: 2007-10-13)
		The NADH and FADH2 are principally used to drive the processes of oxidative phosphorylation, which are responsible for converting the reducing potential of NADH and FADH2 to the high energy phosphate in ATP.
		The detection of NADH production can be conveniently measured by transferring an electron from the reduced NADH to an electron acceptor molecule, such as an electron acceptor dye molecule to produce a change in signal from the molecule, such as absorbance of the electron acceptor dye molecule.
		There was no evidence of co-precipitation of the 2- oxo-acid dehydrogenase from the gel profiles or from sequencing of bands to ensure that subunits of this enzyme were not co-migrating with PDH subunits.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=04/21000.040617&ELEMENT_SET=DECL (9542 words)

	Plant Physiology Online: The Electron Transport Chain of Plant Mitochondria Contains Multiple NAD(P)H Dehydrogenases
		Instead they have a Ca -dependent glycerol-3-phosphate dehydrogenase on the outer surface of the inner membrane, which donates electrons directly to the ubiquinone pool, bypassing complex I. The dihydroxyacetone phosphate formed is converted back into glycerol-3-phosphate by a cytosolic NAD-dependent glycerol-3-phosphate dehydrogenase.
		None of the external dehydrogenases pump protons, which means that at most two sites of proton pumping are involved when the electrons move from the dehydrogenases to oxygen at the cytochrome oxidase (see Web Figure 11.2.A).
		The oxidation of exogenous NADH or NADPH by most plant mitochondria requires Ca, and, as a result, is inhibited by EDTA and EGTA, chelators of di- and trivalent cations (Møller et al.
	www.plantphys.net /article.php?ch=11&id=147 (1238 words)

	The Saccharomyces cerevisiae NDE1 and NDE2 Genes Encode Separate Mitochondrial NADH Dehydrogenases Catalyzing the ...
		The Saccharomyces cerevisiae NDE1 and NDE2 Genes Encode Separate Mitochondrial NADH Dehydrogenases Catalyzing the Oxidation of Cytosolic NADH -- Luttik et al.
		Generation of Ethanol-free NADH in Oxygen Uptake Studies-- According to the literature, commercial preparations of NADH are contaminated with ethanol (36).
		NADH dehydrogenase (7) was compared with the entire S.
	www.jbc.org /cgi/content/full/273/38/24529 (4950 words)

	[No title]
		The soluble and the membrane bound glycerophosphate dehydrogenases together form the glycerophosphate shuttle shown in fig 21.33 2nd ed.
		1st ed.) Electrons from cytosolic NADH are transferred to DHAP to form glycerophosphate and then back to the membrane bound glycerophosphate dehydrogenase FAD coenzyme and then on to ubiquinone in the membrane.
		This is absolutely required since NADH is an obligatory 2 electron donor(see pages 588-589 2nd ed, 468-469 1st ed about hydride transfer) and Fe3+ is an obligatory one electron acceptor.
	drnelson.utmem.edu /oxphos.2001.gandg.html (4806 words)

	Novel FMN-Containing Rotenone-Insensitive NADH Dehydrogenase from Trypanosoma brucei Mitochondria: Isolation and ... (Site not responding. Last check: 2007-10-13)
		A rotenone-insensitive NADH dehydrogenase has been isolated from the mitochondria of the procyclic form of African parasite, Trypanosoma brucei.
		Hypotonic treatment of intact mitochondria revealed that the NADH dehydrogenase is located in the inner membrane/matrix fraction facing the matrix.
		The treatment of mitochondria with increasing concentrations of digitonin suggested that the NADH dehydrogenase is loosely bound to the inner mitochondrial membrane.
	pubs.acs.org /cgi-bin/abstract.cgi/bichaw/2002/41/i09/abs/bi015989w.html (232 words)

	Search Results (Site not responding. Last check: 2007-10-13)
		Weidner,U., Geier,S., Ptock,A., Friedrich,T., Leif,H. and Weiss,H. The gene locus of the proton-translocating NADH: ubiquinone oxidoreductase in Escherichia coli.Organization of the 14 genes
		Residues 42-539 are 98% similar to NADH dehydrogenase I,M subunit from Neisseria meningitidis MC58 (gbAAF40712.1).
		NG1738 is paralogously related to NG1740 (NADH dehydrogenase I chain L (ubiquinone oxidoreductase)) (1e-21) and NG1737 (probable NADH dehydrogenase I (ubiquinone)) (1e-20).
	www.stdgen.lanl.gov /cgi-bin/gene_id_search.cgi?dbname=ngon&gene_id=NG1738 (444 words)

	EC 1.8.1.4
		In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase, and catalyses oxidation of its dihydrolipoyl groups.
		Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system (click here for diagram), in which it acts, together with EC 1.4.4.2, glycine dehydrogenase (decarboxylating), and EC 2.1.2.10, aminomethyltransferase, to break down glycine.
		This enzyme was first shown to catalyse the oxidation of NADH by methylene blue; this activity was called diaphorase.
	www.chem.qmul.ac.uk /iubmb/enzyme/EC1/8/1/4.html (237 words)

	TCA Cycle and Oxidative Phosphorylation
		b) electrons from NADH produced in the cytoso (ie glycolysis) must be transfered to the matrix through the Glycerol 3 Phosphate or Malate/Aspartate shuttles because the inner mitochondrial membrane is impermeable to NADH.
		a) e- are passed from NADH to FMN of Complex I. b) e- are passed from Complex I to CoQ (the mobile carrier).
		NADPH is consumed in the detoxification instead of generating NADH in the metabolization.
	umed.med.utah.edu /MS1/biochem/study/tca_oxphos.html (2934 words)

	Mitochondrial complex I, aconitase, and succinate dehydrogenase during hypoxia-reoxygenation: modulation of enzyme ...
		NADH dehydrogenase activity was measured in mitochondrial samples
		NADH dehydrogenase activity in the control group averaged 1,564 ± 190 nmol K
		Neither hypoxia (95 ± 9% of control) nor reoxygenation (91 ± 15% of control) caused a significant decrease in NADH dehydrogenase activity in cells that had been transfected with 100 multiplicities of infection (MOI) Ad.MnSOD.
	ajplung.physiology.org /cgi/content/full/285/1/L189 (5531 words)

	JBPC Journalclub » Trichomonas hydrogenosomes contain the NADH dehydrogenase module of mitochondrial complex I. (Site not responding. Last check: 2007-10-13)
		In some versions of endosymbiotic theory they are suggested to be homologues of mitochondria2-4, but alternative views suggest they arose from an anaerobic bacterium that was distinct from the mitochondrial endosymbiont5, 6.
		Here we show that the 51-kDa and 24-kDa subunits of the NADH dehydrogenase module in complex I, the first step in the mitochondrial respiratory chain7, are active in hydrogenosomes of Trichomonas vaginalis.
		Like mitochondrial NADH dehydrogenase, the purified Trichomonas enzyme can reduce a variety of electron carriers including ubiquinone, but unlike the mitochondrial enzyme it can also reduce ferredoxin, the electron carrier used1 for hydrogen production.
	jbpc.mbl.edu /journalclub/index.php?p=22 (223 words)

	[No title] (Site not responding. Last check: 2007-10-13)
		Encoded by the gene nuo (NADH Ubiquinone Oxidoreductase).
		The mitochondrial enzyme resembles NADH I of E. coli except that it has FMN instead of FAD.
		Flavoprotein dehydrogenases are linked to the ETC. In contrast, flavoprotein oxidases are not linked to the ETC and may be reoxidized directly by O2 (hence no energy is generated) e.g., aldehyde oxidase, glucose oxidase.
	www.science.siu.edu /microbiology/micr425/ETCPMF99 (3513 words)

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