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Topic: NFKB

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	NFkB and IkB antibodies from Research Diagnostics Inc
		Nuclear translocation of NFkB is confirmed by the use of electrophorectic mobility shift assays or by immunoblotting with nuclear extracts.
		The subunit composition of NFkB is confirmed by the use of antibodies that "supershift" the DNA/protein complex.
		Recognition is at the N-terminal region of the p52/p100 subunit of NFkB.
	www.researchd.com /miscabs/nfkbab.htm (1047 words)

	What is NFkB? It Could Kill You
		NFkB is the "big cheese" cell-signaling molecule for inflammation; its activation induces the expression of COX-2, which leads to tissue inflammation.
		NFkB resides in the cytoplasm of the cell and is bound to its inhibitor.
		One paper stated that NFkB is strongly linked to inflammatory and immune responses, regulation of cell proliferation and apoptosis, suggesting its role in tumor development and many other diseases, including atherosclerosis.
	www.chiroweb.com /archives/21/21/19.html (1072 words)

	BioCat - We Catalyze Innovation in Biosciences
		Nuclear Factor kappa B (NFkB) is a member of the rel family of transcription factors.
		NFkB is activated by a wide variety of different stimuli such as pro inflammatory cytokines, oxidant free radicals, inhaled particles, ultraviolet radiation and bacterial or viral products.
		The NFkB protein then translocates to the nucleus where it binds to its specific DNA motifs and initiates transcription of genes.
	www.biocat.de /cgi-bin/adm/prod.pl?prod=RC0002-PA (408 words)

	The Rockefeller University - Gene may protect against heart disease rather than be harmful as previously thought (Site not responding. Last check: 2007-10-20)
		In the recent study, the Breslow lab focused on the NFkB (Nuclear Factor Kappa-B) pathway and the A20 gene that regulates this pathway.
		NFkB, a protein that controls the inflammatory response, is activated as part of the body's natural response to the fatty streaks that accumulate in the blood vessels and arteries as the first stage of heart disease.
		Because the NFkB pathway turns on inflammatory genes and inflammation is associated with atherosclerosis, some scientists have focused on this pathway as one route that promotes heart disease.
	www.rockefeller.edu /pubinfo/112603.php (1083 words)

	Regulation of NF (kappa) B-dependent Cell Survival Signals Through the SCF (slimb) Ubiquitin Ligase Pathway - Storming ...
		Abstract: NFkB is a transcription factor that functions to block the apoptotic response.
		NFkB activity is negatively regulated by a signaling pathway that responds to extracellular signals, including cytokines.
		Normally, NFkB is held in the cytoplasm by its inhibitor, IkB.
	www.stormingmedia.us /43/4346/A434693.html (217 words)

	Colorimetric NFkappaB p65 Transcription Factor Assay: sgt520
		However, because of the conservation in the NFkB DNA binding site and the fact that the antibodies contained in the kit cross react with rat and mouse NFkB, the kit is expected to work with samples from rat and mouse as well as human.
		The transcription factor NFkB (Nuclear Factor kappa B) is involved in the expression and regulation of a number of important cellular and physiological processes such as growth, development, apoptosis, immune and inflammatory response, and activation of various viral promoters including human immunodeficiency virus long terminal repeats1,2.
		NFkB represents a group of structurally related and evolutionarily conserved proteins related to the proto-oncogene c-Rel with five members in mammals that include Rel (cRel), RelA (p65), RelB, NFkB1 (p50 and its precursor p105), and NFkB2 (p52 and its precursor p100)1, 2.
	www.chemicon.com /product/productdatasheet.asp?productitem=sgt520 (1171 words)

	NFkappaB [Rel A] , p65 subunit, active subunit , clone 12H11 : MAB3026
		NFkB consists of two subunits which are named according to their molecular weight, p50 and p65 (Kawakami et al., 1988).
		In quiescent cells, NFkB resides in the cytosol in an inactive form which can be activated in vivo by treatment of cells with cytokines or protein kinase activators.
		After activation NFkB translocates from the cytosol to the nucleus of the cell, binds to specific DNA sequences and initiates transcription.
	www.chemicon.com /Product/ProductDataSheet.asp?ProductItem=MAB3026 (890 words)

	fourapport2.html (Site not responding. Last check: 2007-10-20)
		NFkB exists in the cytoplasm in an inactive form and can be activated through the signal-induced proteolitic degradation of IkB.
		NFkB increases the expression of the genes for many cytokines (TNFa, IL-1, IL-2, 3, 6, 8, 12), enzymes (inducible nitric oxide synthase, inducible cyclooxygenase-2) and adhesion molecules involved in chronic inflammatory diseases.
		NFkB p65 protein levels were significantly upregulated in lamina proprea macrophages and endothelial cells from IBD patients that was accompanied by an increased production of the proinflammatory cytokines Il-1b, IL-6 and TNF-a.
	wwwhost.gu.se /cgf/fourapport2.html (1963 words)

	Grouppe Kurosawa Natural Medicines Blog: Thursday, March 24, 2005
		The increased level of NFKB in pancreatic cancer cells may be rapidly induced by the chemo drugs or naturally elevated, like melanoma cells, during the process of cancer development.
		In pancreatic cancer, NFKB levels are high, probably as a consequence of their particular growth pattern.
		The NFKB blocks normal cell death and interferes with the "imposed" cell death we are trying to accomplish with chemo and radiation.
	www.grouppekurosawa.com /blog/2005_03_24_ (2214 words)

	Welcome to Tata Memorial Centre (Site not responding. Last check: 2007-10-20)
		The effect of HIV-1 and HIV-2 infection on NFkB activation is being studied using CRIT2 as a system to show constitutive activation of NFkB and the T cell line Jurkat as a system to show inducible activation of NFkB.
		NFkB activation in HIV infection may thus be contextual and a function of various host cell and viral factors, whose interplay may result in different observations in different systems.
		While investigating the activation profile of NFkB in HIV-2 infection, it is found that 2 indigenously developed cell lines, CRIT2 (a CD4+ T cell line) and PJH6 (an EBV transformed B cell line with very high copy integrated HHV-6), show unusually high constitutive level of NFkB activation.
	www.tatamemorialcentre.com /ACTREC/researchgrp/virology.htm (935 words)

	Antibodies to the NFkB: News from Rockland Immunochemicals
		Growing evidence indicates that the dysregulation of NFkB may be key to a number of diseases including arthritis, Alzheimer's, atherosclerosis and cancer.
		NFkB is widely recognised as a critical mediator of immune and inflammatory responses.
		Growing evidence indicates that the dysregulation of NFkB may be key to a number of diseases including arthritis and other inflammatory diseases, Alzheimer's, atherosclerosis and cancer.
	www.laboratorytalk.com /news/roa/roa102.html (250 words)

	NFkB p65 (C20) Antibody-Delta Biolabs
		In resting cells, NFkB is retained in the cytoplasm bound to inhibitory proteins of the IkB family.
		NFkB p65 (C20) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the carboxy terminus of human NFkB p65.
		NFkB p65 (C20) DB033 reacts with NFkB p65 of mouse, rat, and human origin by western blotting, immunoprecipitation and immunohistochemistry.
	www.deltabiolabs.com /commerce/catalog/product.jsp?product_id=1157 (701 words)

	Transcription factor stable reporter cell lines: News from Cambridge BioScience
		NFkB stable reporter cell lines are available in human 293T and A549 cells and the Stat3 stable reporter cell line in HeLa cells.
		Nuclear Factor kappa B (NFkB) is a member of the rel family of transcription factors and plays a key role in the regulation of inflammatory response, apoptosis or tumorigenesis.
		Signal transducers and activators of transcription (Stats) are transcription factors that are phosphorylated by JAK kinases in response to cytokine activation of cell surface receptors.
	www.laboratorytalk.com /news/cmr/cmr167.html (337 words)

	Inflammation and Cancer
		NFkB has been identified as a key transcription factor - a DNA binding protein which regulates the expression of many genes which play a role in immunity and inflammation e.g.
		This project entails a full characterisation of the mechanism by which IL1 and TNF activate the NFkB system.
		This may be important in drug resistance, and the possibility that limiting this response may improve drug efficacy is being investigated.
	www.irishscientist.ie /TCDLO148.htm (418 words)

	GTX26555-NFkB-GeneTex Inc. (Site not responding. Last check: 2007-10-20)
		Growing evidence indicates that the disregulation of NFkB may be key to a number of diseases including arthritis and other inflammatory diseases, Alzheimer's disease, atherosclerosis and cancer.
		NFkB p65 (Rel A) peptide (region near the C-terminus of the human protein).
		NFkB cRel peptide (region near the C-terminus of the human protein).IkBa peptide (region near the C-terminus of the human protein).All conjugated to Keyhole Limpet Hemocyanin (KLH).
	www.genetex.com /ccp1034-nfkb---ab6555-ab6555-gtx26555.htm (350 words)

	Anti-NFkB, NFkB, NFkB antibody
		Nuclear factor kappa-B DNA binding subunit; Nuclear factor of kappa light chain gene enhancer in B-cells 1 (p105).
		NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states.
		NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products.
	www.prosci-inc.com /Antibody-XW-TDS/XW-7407.html (186 words)

	Warren S.-L. Liao, Ph.D. (Site not responding. Last check: 2007-10-20)
		Interestingly, while C/EBP and NFkB function synergistically, YY1 functions as a transcriptional silencer by antagonizing NFkB's function.
		Similarly, IL-1 and TNF fail to activate NFkB in MEKK3(-/-) cells, suggesting their importance in transducing cytokine signals.
		Liu, Z., and Su, B. Disruption of MEKK3 Defines its Crucial Role in TNF-Induced NFkB Activation.
	gsbs.gs.uth.tmc.edu /tutorial/liao_w.html (604 words)

	Welcome to Winters Center for Heart Failure Research (Site not responding. Last check: 2007-10-20)
		The major focus of Dr. Sivasubramanian's laboratory is to characterize the aberrant NFKB transcriptional control mechanism(s) which occur in the failing human heart.
		NFKB is a cytoprotective transcription factor involved in regulating the expression of vital genes during organ injury.
		By studying and characterizing the proteins which modulate NFKB transcriptional activity, our laboratory is trying to understand how NFKB proteins are activated during myocardial injury and during heart failure.
	www.bcm.edu /winterscenter/bio_natsiv.html (397 words)

	The SUMO-4 gene and type 1 diabetes
		The newly discovered gene, SUMO-4, controls the activity of NFkB, a molecule that in turn controls the activity of cytokines, proteins that regulate the intensity and duration of the immune response, according to research published in the journal Nature Genetics.
		By examining the transmission of genes from parents to children in nearly 1000 diabetic families from around the world, researchers at the Medical College of Georgia, USA, found that a certain natural mutation of that SUMO-4 gene increases the risk of type 1 diabetes.
		It was already known that NFkB regulates the production of certain cytokines and that cytokines have a role in type 1 diabetes as well as other autoimmune diseases.
	www.wellcome.ac.uk /en/genome/genesandbody/hg06n016.html (488 words)

	PharmExec - Generic Treatment Claims: Do They Hold Water? (Site not responding. Last check: 2007-10-20)
		Baltimore and a team of inventors discovered the NFKB protein in 1986 and showed that it acts to increase the expression of several other genes important in inflammation and immune responses.
		Although it was not known until 1998 that ibuprofen inhibited NFKB, knowledge of that fact is not required under existing patent law principles of inherency.
		NFKB inhibitors that people have used for thousands of years include garlic, red wine, capsaicin (the "hot" ingredient in peppers), and caffeic acid (from honeybee propolis, the material used to seal the honeycomb).
	www.pharmexec.com /pharmexec/article/articleDetail.jsp?id=53001 (759 words)

	Join Lee Now (Site not responding. Last check: 2007-10-20)
		NFkB is an important regulatory pathway associated with many immune derangements such as cancer and AIDS.
		In addition, using spleen cells from non-diabetic mice, Dr. Faustman and her colleagues have been able to “re-educate” the immune system of recipient NOD mice and stop the destruction of islet cells.
		Recently, the validity of their work has been strengthened by the research of a separate laboratory which showed that in human diabetes, a key mutation that may cause diabetes, is located on the NFkB pathway.
	www.joinleenow.org /html/trials.php (430 words)

	Genomatix Software GmbH: Tutorial on Expression Array Analysis (Site not responding. Last check: 2007-10-20)
		Seven of these 10 models include NFKB as one element, which suggests that NFKB plays a crucial role in the coregulation of the clustered genes.
		In both cases NFKB binding site is involved in the regulation of the gene.
		Furthermore the cooperation of SP1, SORY (HMGI/Y) and NFKB in the transcriptional regulation of GRO1 is described ( Nirodi et al., 2001 ; Wood et al., 1995).
	www.genomatix.de /online_help/tutorial/expression_array_tutorial.html (2204 words)

	NFkB p65 (C-20) Staining Protocol (Site not responding. Last check: 2007-10-20)
		Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NFkB (p50 and p65) and the Drosophila maternal morphogen, dorsal.
		Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp kB sequence in the immunoglobulin ê light chain enhancer.
		The DNA-binding activity of NFkB is activated and rapidly transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors.
	www.ihcworld.com /_protocols/antibody_protocols/nfkb_p65_santa_cruz.htm (415 words)

	[No title] (Site not responding. Last check: 2007-10-20)
		NFkB decoy ODN were incorporated into the XS106 cells in a time- and temperature-dependent fashion and they inhibited UV-induced production of each of the above cytokines in a dose-dependent manner, with optimal inhibition at 10-30
		Likewise, NFkB decoy ODN inhibited UV-induced VEGF secretion by Pam 212 keratinocytes and IL-6 and VEGF secretion by NS47 fibroblasts.
		These observations introduce a new concept that UV-activated NFkB pathway plays both direct and indirect regulatory roles in UV-induced alteration of LC function.
	www.kumc.edu /POL/ASP_Home/Meetings/Annual2000/Sunday/view_abstract20.html (237 words)

	Role of nuclear factor-kB in the regulation of c-myc gene transcription.
		Upon induction of NFkB, stimulation of transiently transfected thymidine kinase promoter-driven chloramphenicol acetyl transferase (CAT) gene constructs containing multiple copies of the URE indicated that the URE is a functional NFkB element, mediating positive activation of transcription.
		The URE is one of two NFkB sites present in the gene; the other is termed IRE and is located within exon 1 at +440 to +459 bp.
		To assess the role of NFkB in regulation of c-myc transcription, the effect of the human T-cell leukemia virus type I tax protein, which induces NFkB expression, was examined.
	www.aegis.com /aidsline/1993/feb/M9320862.html (530 words)

	APStracts 4:0260L, 1997. (Site not responding. Last check: 2007-10-20)
		The transcription factor, nuclear factor kappa beta (NFkB), frequently mediates regulation of gene expression by TPA and TNF-[alpha].
		In the current study, electrophoretic mobility shift assays (EMSAs) and pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkB activation, were utilized to determine the role of NFkB activation in TPA and TNF -[alpha] inhibition of the surfactant proteins in NCI-H441 cells.
		The effects of PDTC and PTX on NFkB and on the surfactant proteins, suggest that NFkB activation does not mediate TPA or TNF-[alpha] inhibition of SP-A and SP-B mRNA accumulation.
	www.uth.tmc.edu /apstracts/1997/lung/December/260L.html (260 words)

	Untitled (Site not responding. Last check: 2007-10-20)
		The mechanism of activation of NFkB is under investigation in lymphocytes, endothelial, glial and neuronal cells, using such stimuli as IL1, TNF, hydrogen peroxide and anthracycline anti-cancer agents.
		How such changes relate to alterations in gene expression and the potential role of NFkB in the responses of cells to anti-cancer agents in the context of apoptosis is also being explored.
		Evidence for oxidation of glutathione in the mechanism of inhibition of NFkB by PDTC.
	www.uni-regensburg.de /Fakultaeten/Medizin/Innere_1/ecil1/luke.htm (618 words)

	Diabetic Complications (Site not responding. Last check: 2007-10-20)
		For NFkB determination cells were incubated in low glucose, high glucose, high glucose + benfotiamine for 6 hrs.
		NFkB was determined by a fluorescence in situ DNA-protein binding assay and fluorescence/cell was determined using Scanalytics.
		NFKB was decreased 85% to below control levels.
	www.emuhealthproducts.com /diabeticcomplications.html?s=2721083f9983eb89c15589e0bedc63f4 (1016 words)

	APStracts 6:0166L, 1999. (Site not responding. Last check: 2007-10-20)
		Interleukin-10 inhibits pulmonary nfkb activation and lung injury induced by hepatic ischemia/reperfusion.
		The objective of the current study was to determine whether IL-10 could suppress pulmonary NFkB activation and ensuing lung injury induced by hepatic ischemia/reperfusion.
		Administration of IL-10 suppressed lung NFkB activation, reduced TNF[alpha] and MIP-2 mRNA expression, and decreased pulmonary neutrophil recruitment and lung injury.
	www.uth.tmc.edu /apstracts/1999/lung/June/166l.html (215 words)

	Laboratory study explains clinical promise of anti-angiogenesis cancer drug
		In one, rings cut from the aortas of rats (a kind of tissue that's likely to form new blood vessels) were bathed in a culture of inflammatory breast cancer cells.
		In the cancer cell culture, NFkB activity was 2.5 times greater than that in the breast cell culture, but when TM was added to the disk, NFkB activity went down almost twice as much in cancer cells as in normal cells.
		And when they looked at the interleukin and growth factor molecules whose transcription NFkB usually controls, the levels were lower in the presence of TM too.
	www.eurekalert.org /pub_releases/2002-09/uomh-lse090602.php (1102 words)

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