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Topic: NSAIDs

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	Nonsteroidal Antiinflammatory Drugs (NSAIDs) - drug class, medical uses, medication side effects, and drug ...
		NSAIDs are used primarily to treat inflammation, mild to moderate pain, and fever.
		NSAIDs vary in their potency, duration of action, and the way in which they are eliminated from the body.
		NSAIDs reduce blood flow to the kidneys and therefore reduce the action of diuretics and decrease the elimination of lithium (Eskalith) and methotrexate (Rheumatrex).
	www.medicinenet.com /nonsteroidal_antiinflammatory_drugs/article.htm (952 words)

	CCFA.org: nsaids
		NSAIDs (pronounced "en-seds") are probably the most widely used class of drugs in the country.
		As their name implies, NSAIDs work by checking inflammation, which is the immune system's way of responding to injury.
		In short, that means that although NSAIDs can ease joint pain (for example), they also may cause damage to the mucosa in healthy people or reactivate the symptoms of disease in IBD patients.
	www.ccfa.org /info/treatment/nsaids (1276 words)

	THE DANGERS OF ASPIRIN & NSAIDs - Patients - American College of Gastroenterology
		NSAIDS were found to have an additional benefit of reducing inflammation, and so helped alleviate not only the symptom of pain, but also served to reduce the actual cause of the pain, for example, reducing joint inflammation in arthritis.
		In this regard, aspirin and NSAIDs have been found to cause damage to the lining (or mucosa) of the digestive tract primarily in the stomach and upper intestine.
		Patients who need to use NSAIDs regularly should consult regularly with their physician to be alert for any potential GI effects.
	www.acg.gi.org /patients/women/asprin.asp (1679 words)

	The Analyst - Internet Health Report: Treatment: NSAIDs
		NSAIDs are medications for arthritis and other painful inflammatory conditions in the body.
		Due to the detrimental effects of NSAIDs on the body, most physicians resort to a game of "NSAID musical-chairs," taking a patient off one NSAID as soon as side effects become evident or the drug stops working, then treating the patient with another of the 10 most widely prescribed propionic acid-derived NSAIDs.
		NSAIDs cause ulcers by interfering with prostaglandins in the stomach.
	www.digitalnaturopath.com /treat/T115329.html (1670 words)

	Non-steroidal Anti-Inflammatory Drugs (NSAIDs) (Site not responding. Last check: 2007-11-07)
		NSAIDs is an acronym for "non-steroidal anti-inflammatory drugs." The steroids referred to here are not those employed by wayward Olympians, but rather those of the adrenalcortical steroid family such as hydrocortisone, prednisone, and betamethasone.
		Manufacturers of non-prescription (over-the-counter) NSAIDs are being asked to revise their labeling to provide more specific information about the potential CV and GI risks of their individual products and remind patients of the limited dose and duration of treatment of these products in accordance with the package instructions.
		NSAIDs have become a very important weapon in the control of inflammation and pain in joint disease, and in other chronic, painful conditions.
	www.aboutgerd.org /nsaids.html (1970 words)

	Medinfo: Non Steroidal Anti-Inflammatory Drugs
		NSAIDs can be used as simple pain killers (analgesics), but paracetamol is usually preferable, as it is likely to have less unwanted effects, and costs less.
		Paracetamol is often adequate for osteoarthritis, but NSAIDs are particularly useful in the inflammatory forms of arthritis (eg rheumatoid arthritis) and, sometimes, in the more severe forms of osteoarthritis.
		Unfortunately the same group of chemicals are involved in the stomach, and so the NSAIDs tend to cause indigestion, and may even cause duodenal or stomach ulceration.
	www.medinfo.co.uk /drugs/nsaids.html (776 words)

	Public Health Advisory: Non-Steroidal Anti-Inflammatory Drug Products (NSAIDS)
		While the results of these studies are preliminary and conflict with other study data on the same drugs, FDA is providing this advisory as an interim measure, pending further review of data that continue to be collected.
		If use of an OTC NSAID is needed for longer than ten days, a physician should be consulted.
		As prescription drugs, many are approved for short-term use in the treatment of pain and primary dysmenorrhea (menstrual discomfort), and for longer-term use to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.
	www.fda.gov /cder/drug/advisory/nsaids.htm (391 words)

	NSAIDs
		The best known NSAID is aspirin, which is the original and oldest NSAID, in use since the last century before the Food and Drug Administration (FDA) was formed.
		By using only a few NSAIDs, the doctor is more familiar with the dosage variations and usual side effects; this frequently results in better treatment than if she or he uses many NSAIDs on an infrequent basis and is not as familiar with individual variations of each one.
		NSAIDs cause anemia in 2 or 3 percent of people, though it's difficult to know whether the anemia is due to the arthritis or the medicine.
	www.webmd.com /content/article/4/1680_50448.htm (1530 words)

	NSAIDs Non-Steroidal Anti-Inflammatory Drugs
		NSAIDs are administered with the intent to control acute inflammation and relieve pain.
		This process appears to involve three mechanisms: (1) an increased release of amino acids by the muscle, (2) a decrease of DNA and protein synthesis at the translation level, and (3) a reduction of amino acid uptake in the muscle.
		The antioxidants act by scavenging oxidants and free radicals, and possess a unique ability to preserve collagen molecules, which are a major component of the soft tissue structures and are compromised at the time of injury.
	www.nsaids.com (1253 words)

	NSAIDs
		NSAID's have been used for many years to treat a variety of inflammatory conditions such as arthritis and tendonitis for years.
		Although NSAID's are reasonably safe medications, it is important that you are aware of the potential side effects.
		NSAIDs are often used in conjunction with DMARDs, prednisone and/or muscle relaxants.
	www.polychondritis.com /Medications/NSAIDs.html (277 words)

	Non-Steroidal Anti-Inflammatory Medications (NSAIDs)
		NSAIDs are used to treat a variety of conditions that cause pain and swelling of joints, such as rheumatoid arthritis and tendinitis.
		NSAIDs are effective in treating pain caused by slow, prolonged tissue damage, such as the pain associated with an arthritic joint.
		When taking NSAIDs for long periods of time, you should be carefully monitored by your health care provider so he or she can detect the development of harmful side effects and modify your treatment if necessary.
	www.clevelandclinic.org /health/health-info/docs/3100/3198.asp?index=11086 (1397 words)

	LUPUS FOUNDATION OF AMERICA
		While NSAIDs are not approved specifically for SLE by the Food and Drug Administration, they are approved for use in many musculoskeletal pain conditions such as arthritis and tendinitis, which also afflict people with lupus.
		NSAIDs work primarily by preventing the formation of substances called prostaglandins.
		These specific NSAIDs are effective for treatment of musculoskeletal pain and are without many of the side effects associated with the traditional agents.
	www.lupus.org /education/brochures/nsaid.html (374 words)

	NSAIDS, Aspirin & Infertility - Journal Abstracts
		Non-steroidal anti-inflammatory drugs (NSAIDs), widely used due to their analgesic and anti-inflammatory properties, consistently inhibit ovulation in all mammalian species investigated so far, likely due to the inhibition of cyclooxygenase 2 (COX-2), the inducible isoform of COX, that is the rate-limiting enzyme in prostaglandin (PG) synthesis.
		Reduced dose of a NSAID and temporary stop of drug treatment early in the menstrual cycle, or alternative drug treatment, may be a solution.
		It is suggested that NSAID therapy may be an important and frequently overlooked cause of anovulation and infertility.
	www.fertilityplus.com /faq/nsaids.html (1738 words)

	Caring Medical - Sports Injuries - NSAIDs: Why We Do Not Recommend Them
		NSAIDs have been shown to delay and hamper the healing in all the soft tissues, including muscles, ligaments, tendons, and cartilage.
		NSAIDs are used because they decrease pain, but they do so at the expense of hurting the healing of the injured soft tissue.
		Up until the present, too many studies were advocating NSAID use when it came to ligament injuries, because they were such great pain-relievers, when in fact they were and are stopping the healing mechanisms of the body.
	www.caringmedical.com /sports_injury/nsaids.asp (1406 words)

	ACS :: Uncertainty Surrounds NSAIDs and Breast Cancer Risk
		Women who developed breast cancer tended to have smaller tumors and less chance of having a cancer that had spread to other parts of the body if they had used significant amounts of the drugs in the years before they were diagnosed, according to the study.
		One such drug, celecoxib, has already been approved to suppress formation of pre-malignant adenomatous polyps in people with familial adenomatous polyposis, a rare inherited condition that causes hundreds of polyps to form and leads to colon cancer if preventive surgery is not done.
		Randomized clinical trials are more difficult to organize and more costly to conduct, but their results are more reliable in assessing the effectiveness of cancer prevention strategies.
	www.cancer.org /docroot/NWS/content/NWS_1_1x_Uncertainty_Surrounds_NSAIDs_and_Breast_Cancer_Risk.asp (679 words)

	Non-steroidal anti-inflammatory drugs (NSAIDs)
		This is a newer class of NSAID that works by stopping the chemical reaction that leads to inflammation in the body, but (unlike other NSAIDs) does not harm the chemical production of the protective stomach lining.
		NSAIDs are cleared from the blood stream by the kidney, so it is very important that patients over 65 years of age or patients with kidney disease consult a physician prior to taking the medication.
		If patients take an NSAID for an extended period of time (six months or more), a blood test needs to be performed to check for early signs of kidney damage.
	www.spine-health.com /topics/conserv/overview/med/med021.html (1133 words)

	UMHS Adult Pain Management - Patient Education
		Second, NSAIDs work like other pain medicines such as narcotics to alter the way in which the central nervous system- the spinal cord and brain- interpret the pain signals coming from the nerves so that the intensity of the pain signal can be reduced or eliminated.
		If your physician prescribes NSAIDs for you on a regular time schedule (for example, every 6 or 12 hours), it is advisable to keep to the schedule even when your pain does not feel too bad.
		Your physician may be able to change your NSAID prescription to one that is less likely to upset you stomach or cause bleeding.
	www.med.umich.edu /pain/nsaids.htm (755 words)

	UltRunR - NSAIDS
		NSAIDs are great analgesics, mainly because their primary action is to relieve inflammation that can lead to pain ("pressure").
		NSAIDS during an event are not advisable for most people because of the pain-deadening effect and the possibility of injury.
		I consider the use of NSAIDS during an ultra to be risky business because of the potential for bleeding from the stomach in the worst case, and much more commonly for the nausea and stomach problems many runners have during and after runs.
	www.ultrunr.com /nsaids.html (9938 words)

	NSAIDs - Page 2
		NSAIDs are used frequently to alleviate pain and inflammation.
		NSAIDs usually take four to 24 hours to be effective, although as many as three weeks of continuous use may be necessary for maximum benefit.
		NSAIDs should not be given to patients immediately after a coronary artery bypass graft.
	pain.health.ivillage.com /painmedications/nsaids2.cfm (681 words)

	[No title]
		The researchers concluded that the MN was directly caused by the NSAIDs in 13 of the patients.
		The researchers conclude that the use of NSAIDs should always be investigated in patients diagnosed with MN as their withdrawal may result in prompt and complete recovery.
		When sustained over several years of NSAID use, this elevation could "...be associated with a substantial increase in the risk of stroke and coronary heart disease events," according to Johnson's report in the November issue of Drug Safety.
	www.chiro.org /abstracts/nsaids.htm (2140 words)

	NSAIDs and Musculoskeletal Treatment
		NSAIDs are commonly prescribed for the treatment of musculoskeletal complaints such as muscle injuries, ligament sprains, tendon injuries, low-back pain, and osteoarthritis.
		NSAIDs were beneficial in half of these single-joint studies (2 of the 6 that examined ankle ligament sprains and the 2 that focused on knee ligament injuries).
		NSAIDs are frequently used to treat common musculoskeletal conditions, such as low-back pain and osteoarthritis, though they are not classically sports-related injuries.
	www.chiro.org /LINKS/DISCONTINUED/NSAIDs_and_Musculoskeletal_Treatment.html (3671 words)

	CERTs Research: Nonsteroidal Antiinflammatory Drugs (NSAIDs): Program Brief
		The side effects of NSAIDS increase with age; research on NSAIDS has been completed and is being carried out by Centers for Education & Research on Therapeutics (CERTs).
		Of chronic NSAID users with two or more risk factors for GI complications (75 years of age and over, history of GI bleeding, or taking multiple medications at the same time), only 30 percent were treated with gastroprotective therapy.
		To better understand what people are doing for their health and to reduce the risk of adverse drug reactions, physicians need to routinely ask patients about OTC medications, and patients need to be proactive about discussing with their physicians what medicines they are taking.
	www.ahrq.gov /clinic/certsnsaid.htm (2382 words)

	Lupus Treatment
		Since then numerous NSAIDs have been introduced, all of which are more potent than aspirin, so fewer pills are needed to achieve the same effect.
		NSAIDs work by inhibiting the production of prostaglandins, substances that are mediators during the inflammatory process.
		NSAIDs can induce erosions in the stomach, and this may lead to bleeding ulcers, taking NSAIDs that have a sugar coating on them can help to reduce this risk, and also take them along with food.
	www.uklupus.co.uk /nsaid.html (511 words)

	Nonsteroidal Anti-Inflammatory Drugs
		Nonsteroidal anti-inflammatory drugs (NSAIDs) are a family of medications used to treat rheumatoid arthritis, osteoarthritis, mild-to-moderate pain, menstrual cramps, bursitis, gout, and migraine headaches, as well as other conditions.
		NSAIDs are divided into two categories, based on their action within the body: COX-1 and COX-2 inhibitors.
		Most NSAIDs inhibit the excretion of lithium from the body, resulting in higher blood levels of the mineral, though sulindac may have an opposite effect.
	www.publix.com /wellness/notes/Display.do?id=Drug&childId=NSAIDs (625 words)

	Arthritis Today's Drug Guide 2006
		All NSAIDs work by blocking prostaglandins — hormone-like substances that contribute to pain, inflammation, fever and muscle cramps.
		Like traditional NSAIDs, COX-2 inhibitors help reduce pain and inflammation but are designed to be safer for the stomach.
		In the meantime, the FDA has asked manufacturers of all NSAIDs to highlight warnings on their labels in a fl box and to provide consumers with medication guides.(See "COX-2 Update")
	www.arthritis.org /conditions/DrugGuide/about_nsaids.asp (502 words)

	NSAIDs, I4
		NSAIDs inhibit part of the inflammatory response by blocking the active sites of the COX enzymes, preventing the conversion of fatty acids to prostaglandins.
		NSAIDs vary in their strength, duration of action, and the way in which they are eliminated from the body.
		NSAIDs and HD Because increased inflammatory activity has been observed to be associated with damage in HD brains, NSAID treatment may have beneficial effects on people with HD.
	www.stanford.edu /group/hopes/treatmts/antinflm/i4.html (1842 words)

	Arthritis Research Campaign \| Drugs for Arthritis: Non-Steroidal Anti-Inflammatory Drugs (Site not responding. Last check: 2007-11-07)
		The COX-2-specific NSAIDs – examples include celecoxib (Celebrex) and etoricoxib (Arcoxia) – perform the same function as standard NSAIDs in that they reduce inflammation, but they are less likely to cause stomach upsets, heartburn, and indigestion than standard NSAIDs.
		Although the increased risk is small, you should not take COX-2-specific NSAIDs if you have heart disease, if you have had a heart attack or stroke in the past, or if you have peripheral vascular disease (circulation problems in the limbs, usually in the legs).
		It is possible that standard NSAIDs are also associated with a small increased risk of heart attack and stroke, especially when used in high doses and for long periods.
	www.arc.org.uk /about_arth/infosheets/6248/6248.htm (1172 words)

	Alert Center: NSAIDs and Cardiovascular Effects
		CME Breast Cancer Risk May Decrease With Increasing Duration of NSAID Use A case-control study shows that risk is generally lowest for 7 years or more of use of nonsteroidal anti-inflammatory drugs, and both aspirin and nonaspirin use was associated with reduced risks.
		NSAIDs Variably Affect Cardiovascular Outcomes Different nonsteroidal anti-inflammatory drugs (NSAIDs) confer different thrombotic risk in patients with osteoarthritis, and risk varies depending on use of aspirin to prevent cardiovascular events, according to a report in the June issue of the Annals of the Rheumatic Diseases.
		Discuss the cardiovascular and gastrointestinal risks of selective COX-2 inhibitors and some traditional NSAIDs, describe current research developments and expert recommendations regarding the clinical use of traditional NSAIDs and selective COX-2 inhibitors, and illustrate the management strategies for patients with cardiovascular and/or gastrointestinal risks for which NSAID therapy is warranted.
	www.medscape.com /pages/editorial/public/alertcenters/coxib (1089 words)

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