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Topic: Nabilone

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	NABILONE Faq
		Nabilone is a narcotic medication used to treat severe nausea and vomiting.
		Nabilone comes as 1 mg blue and white pulvules.
		Nabilone will add to the effects of alcohol and other central nervous system depressants such as sedatives, muscle relaxants, narcotics, medicines for seizures and antihistamines.
	www.tthhivclinic.com /nab.htm (492 words)

	Nabilone - Patient UK
		Nabilone is used to treat nausea (feeling sick) and vomiting (being sick) caused by cancer chemotherapy or radiotherapy.
		Nabilone should be taken at bedtime the night before treatment and again, the following day, one to three hours before treatment as directed.
		If nabilone is being taken to stop nausea caused by chemotherapy and radiotherapy, a dose should be taken one to two hours before treatment and followed by another dose twelve hours later.
	www.patient.co.uk /showdoc/30003681 (0 words)

	Nabilone Information on Healthline
		Nabilone should never be given to another person, especially someone who has a history of drug abuse or habitual marijuana use.
		Before taking nabilone, tell your doctor if you have high blood pressure, heart disease, a history of mental illness or drug addiction, or if you are also using other medicines that can affect your central nervous system, such as a tranquilizer, sleep medicine, or anti-psychotic medications.
		Nabilone is used to treat severe nausea and vomiting that is caused by cancer chemotherapy.
	www.healthline.com /multumcontent/nabilone (646 words)

	Trial of Nabilone in treating the symptoms of Huntington's disease
		Everything is in place to begin a clinical trial of nabilone at the Queen Elizabeth Psychiatric Hospital.
		Nabilone, swallowed as capsules, binds to the same receptors as the active ingredient in cannabis.
		Is nabilone an effective treatment for the movements and psychiatric symptoms found in Huntington's disease?
	www.hda.org.uk /research/rs038.html (358 words)

	News: Valeant Pharmaceuticals Acquires Rights to Nabilone in United Kingdom and Europe. Genetic Engineering News - ...
		Nabilone is indicated for use in the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional anti-emetic treatments.
		Nabilone should also be used with caution in patients with current or previous psychiatric disorders (including manic depressive illness, depression and schizophrenia), as the symptoms of these disease states may be unmasked by the use of cannabinoids.
		Nabilone should be used with caution in patients with a history of substance abuse, including alcohol abuse or dependence and marijuana use, since nabilone is similar to the active ingredient found in naturally occurring marijuana.
	genengnews.com /news/bnitem.aspx?name=12894871 (791 words)

	Nabilone - Encyclopedia, History, Geography and Biography
		It is an analog of dronabinol (also known as tetrahydrocannabinol or THC), the psychoactive ingredient in cannabis[1].
		In Canada, the United States, and the United Kingdom, nabilone is marketed as Cesamet.
		Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers ("trans").
	www.arikah.com /encyclopedia/Nabilone (136 words)

	RxMed: Pharmaceutical Information - CESAMET
		Nabilone is a synthetic cannabinoid with antiemetic properties which have been found to be of value in the management of some patients with nausea and vomiting associated with cancer chemotherapy.
		Since nabilone elevates supine and standing heart rates and causes postural hypotension, it should be used with caution in the elderly and in patients with hypertension or heart disease.
		The most frequently observed adverse reactions to nabilone and their incidences reported in the course of clinical trials were as follows: drowsiness (66.0%), vertigo (58.8%), psychological high (38.8%), dry mouth (21.6%), depression (14.0%), ataxia (12.8%), blurred vision (12.8%), sensation disturbance (12.4%), anorexia (7.6%), asthenia (7.6%), headache (7.2%), orthostatic hypotension (5.2%), euphoria (4.0%) and hallucinations (2.0%).
	www.rxmed.com /b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20C)/CESAMET.html (960 words)

	Patient Information Leaflet
		Nabilone Capsules are blue and white and have CL 3101 printed on them.
		Nabilone is a medicine which helps to stop you being sick (anti-emetic).
		Nabilone is only meant to be used to help reduce the nausea and vomiting which is caused by many anti-cancer drugs.
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?documentid=5231 (840 words)

	Clinical Studies and Case Reports (Site not responding. Last check: )
		A prospective randomised double blind crossover trial was conducted comparing the new synthetic cannabinoid nabilone with oral domperidone in a group of children receiving repeated identical courses of emetogenic chemotherapy for a variety of malignant diseases.
		The most common side effects of treatment with nabilone were somnolence and dizziness, with one patient being disturbed by hallucinations.
		The results indicate that nabilone is an effective antiemetic for children having chemotherapy, even for young children.
	www.acmed.org /studies/ww_en_db_study_show.php?s_id=123 (253 words)

	News \| TimesDaily.com \| TimesDaily \| Florence, AL
		Nabilone is a synthetic cannabinoid with therapeutic use as an antiemetic.
		Nabilone is not derived from the marijuana plant as is dronabinol.
		An older study revealed that nabilone was more effective than prochlorperazine in controlling nausea, though in this study, only 9% of nabilone patients had complete resolution of symptoms.
	www.timesdaily.com /apps/pbcs.dll/section?category=NEWS&template=wiki&text=nabilone (326 words)

	Result Content View
		The synthetic cannabinoid, nabilone (Cesamet), is officially indicated for the treatment of refractory chemotherapy-induced nausea and vomiting.
		The decision to prescribe nabilone was based on the presence of severe pain and symptom distress.
		Nonetheless, nabilone, when added to standard of care and taken longer-term, appears to offer significant alleviation of several symptoms in cancer patients, including pain, nausea, depression and anxiety, insomnia, fever/night sweats, and overall distress.
	www.abstracts2view.com /sabcs06/view.php?nu=SABCS06L_1211 (617 words)

	MedlinePlus Drug Information: Nabilone (Systemic) (Site not responding. Last check: )
		However, studies in animals have shown a decrease in successful pregnancies and a decrease in the number of live babies born, when nabilone was given in doses many times the usual human dose.
		However, nabilone is not recommended during breast-feeding because other medicines similar to nabilone that pass into the breast milk have been shown to cause unwanted effects in the nursing baby.
		Nabilone will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that make you feel drowsy or less alert).
	www.cheap-xenical.com /Ca/202385.html (1180 words)

	[No title] (Site not responding. Last check: )
		NEW YORK (Reuters Health) Dec 28 - Nabilone, a cannabinoid receptor agonist, reduces gamma-aminobutyric acid (GABA) reuptake in the globus pallidus (GPI) and reduces levodopa-induced dyskinesia in Parkinson's disease (PD), according to a report in the December 11th issue of Neurology.
		They administered nabilone or placebo in two split doses 12 hours and 1 hour before administration of levodopa and made assessments after the second dose of nabilone/placebo.
		The team observed no difference in the duration of the on period, and there was no effect on the antiparkinsonian action of levodopa with nabilone administration.
	www.mult-sclerosis.org /news/Jan2002/NabiloneForDyskinesia.html (215 words)

	IACM-Bulletin
		During a 14 week period patients received nabilone and placebo each for four weeks in addition to their standard medication.
		Nabilone is a synthetic cannabinoid with similar effects as the natural cannabinoid THC.
		The intake of nabilone was associated with a significant decrease in pain intensity of spinal origin, with a significant decrease of average headache intensity, and with an increase in quality of life.
	www.acmed.org /english/bulletin/ww_en_db_cannabis_artikel.php?id=224 (909 words)

	Prescribing Reference: New Product Releases - CESAMET
		Nabilone is an orally-active synthetic cannabinoid with pharmacologic effects similar to those of marijuana (Cannabis sativa L. It has complex effects on the CNS including alterations in mental state (eg, euphoria, psychosis, detachment, anxiety, panic, paranoia) and it has a high potential for abuse.
		Nabilone and its metabolites are primarily excreted via the biliary system.
		The safety and efficacy of nabilone in treating nausea and vomiting due to emetogenic cancer chemotherapy was studied in patients receiving a wide variety of chemotherapy regimens, including low-dose cisplatin.
	www.prescribingreference.com /products/showProducts/which/Cesamet (376 words)

	Medical Use of Cannabis and the Cannibinoids (Site not responding. Last check: )
		On the basis of this evidence nabilone was licensed and is available as a prescription medicine in the United Kingdom for this indication (see Box 4).
		According to Dr Kendall of the University of Nottingham, nabilone is not widely used to treat nausea (p 268).
		As many as 50 per cent have derived some pain relief from nabilone, but a significant number of patients are unable to tolerate the side effects of the drug (unpleasant psychoactive effects and drowsiness) (Q 400) and the overall success rate is about 30 per cent (p 104).
	www.druglibrary.org /Schaffer/LIBRARY/studies/hlords/15106.htm (3803 words)

	NABILONE
		At a typical anti-emetic dose of 2mg b.d, nabilone has bronchodilator activity in normal subjects and increases the ventilatory response to CO This respiratory stimulation occurs at the time of maximal cortical sedation.
		Thus subjects taking nabilone can feel relaxed and sleepy, and may have demonstrable reduction in PO as a result but, paradoxically, sensitivity to CO is increased.
		Because of possible hypotension and reflex tachycardia, nabilone is unsuitable for patients with atrial fibrillation or in heart failure, and possibly the elderly.
	www.palliativedrugs.com /content/monographs/NABILONE.html (476 words)

	Nabilone (Systemic) - MayoClinic.com
		However, studies in animals have shown a decrease in successful pregnancies and a decrease in the number of live babies born, when nabilone was given in doses many times the usual human dose.
		However, nabilone is not recommended during breast-feeding because other medicines similar to nabilone that pass into the breast milk have been shown to cause unwanted effects in the nursing baby.
		Nabilone will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that make you feel drowsy or less alert).
	www.mayoclinic.com /health/drug-information/DR202385 (0 words)

	Nabilone Drug Information
		However, studies in animals have shown a decrease in successful pregnancies and a decrease in the number of live babies born, when nabilone was given in doses many times the usual human dose.
		However, nabilone is not recommended during breast-feeding because other medicines similar to nabilone that pass into the breast milk have been shown to cause unwanted effects in the nursing baby.
		Nabilone will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that make you feel drowsy or less alert).
	www.drugs.com /cons/Nabilone_Systemic.html (1610 words)

	Clinical Trial: A Trial Assessing the Effect of Nabilone on Pain and Quality of Life in Patients With Fibromyalgia
		The purpose of the study is to determine whether or not the drug Nabilone significantly reduces pain and improves quality of life in patients with fibromyalgia.
		In Canada, Nabilone is approved for the treatment and management of severe nausea and vomiting associated with cancer chemotherapy and may be prescribed by physicians.
		Our hypothesis is that the synthetic canabinoid Nabilone will significantly reduce the pain experienced by patients with fibromyalgia and improve quality of life, compared to the placebo controlled group.
	www.clinicaltrials.gov /ct/show/NCT00272207?order=12 (611 words)

	ASHP Website : News Article
		Nabilone was first approved in 1985 for a more general purpose—the treatment of nausea and vomiting associated with cancer chemotherapy—but was not actually marketed in the United States, according to FDA.
		The product's labeling states that the usual nabilone dosage for adults is 1 or 2 mg taken orally twice daily while cancer chemotherapy is being given.
		Nabilone treatment should start one to three hours before receipt of chemotherapy; some patients may need to take their first dose the night before chemotherapy starts.
	www.ashp.org /news/ShowArticle.cfm?cfid=18306736&CFToken=26820850&id=15357 (342 words)

	Welcome to Zellers Pharmacy Online
		Nabilone is chemically related to marijuana and belongs to the class of medications called cannabinoids.
		Drowsiness/reduced alertness: Since nabilone will often reduce the mental or physical abilities needed to perform potentially hazardous tasks such as driving a car and operating machinery, people taking this medication should not drive or engage in dangerous activities until the effects of nabilone are no longer present.
		Emotional disorders: Nabilone should be used with extreme caution by people with non-psychotic emotional disorders, and not at all by people with psychotic emotional disorders.
	www.mediresource.com /zellers/health/DrugInfo.asp?BrandNameID=711&dowhat=accept_disclaimer (850 words)

	NORML New Zealand - IACM: Swiss to legalise medicinal cannabis
		According to research presented on 15 December at the San Antonio Breast Cancer Symposium the synthetic cannabinoid nabilone improved pain, nausea, appetite, anxiety and depression in cancer patients.
		While subjects in the nabilone group had significantly greater nausea at baseline, they experienced a significant reduction of this symptom, in contrast to non-cannabinoid subjects.
		Nabilone appeared also to be effective in improving insomnia, night sweats and distress.
	www.norml.org.nz /modules.php?name=News&file=print&sid=608 (1006 words)

	Nabilone
		Nabilone belongs to a group of medicines known as cannabinoids (due to the similarity of their chemical structure with cannabis).
		Nabilone has been found to be effective in the treatment of sickness (an anti-emetic), although the exact method by which it carries out this function is not fully understood.
		It is used to treat nausea and vomiting caused by medicines used in the treatment of cancer (chemotherapeutic agents).
	www.netdoctor.co.uk /medicines/100001783.html (0 words)

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