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Topic: Naltrexone

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	Frequently Asked Questions about Naltrexone
		Naltrexone is a medication that blocks the effects of drugs known as opioids (a class that includes morphine, heroin or codeine).
		Naltrexone should not be used with pregnant women, individuals with severe liver or kidney damage or with patients who cannot achieve abstinence for at least 5 days prior to initiating medications.
		Naltrexone may reduce the feeling of intoxication and the desire to drink more, but it will not cause a severe physical response to drinking.
	www.well.com /user/woa/revia/reviafaq.htm (1084 words)

	Naltrexone - Wikipedia, the free encyclopedia
		Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
		Naltrexone, and its active metabolite 6-β-naltrexol, are competitive antagonists at μ- and κ-opioid receptors, and to a lesser extent at δ-opioid receptors.
		Naltrexone is sometimes used for rapid detoxification ("rapid detox") regimens for opioid dependence.
	en.wikipedia.org /wiki/Naltrexone (1022 words)

	Naltrexone Detox - MRODS, Rapid Detox Specialists
		In clinical trials evaluating the effectiveness of naltrexone, patients who received naltrexone were twice as successful in remaining abstinent and in avoiding relapse as patients who received placebo-an inactive pill.
		Otherwise, naltrexone is likely to have little impact on other medications patients commonly use such as antibiotics, non-opioid analgesics (e.g., aspirin, acetaminophen, ibuprofen), and allergy medications.
		Because naltrexone is broken down by the liver, other medications that can affect liver function may affect the dose of naltrexone.
	www.mrods.com /naltrexone.html (1320 words)

	Naltrexone - An Antagonist Therapy for Heroin Addiction
		Naltrexone is an ideal opioid antagonist treatment medication: It is a pure, potent mu antagonist that can be taken by mouth once daily or every other day, and has minimal side effects.
		Naltrexone was approved by the FDA in 1984 on the basis of its pharmacological efficacy as a narcotic antagonist and its safety profile.
		In 1995, Naltrexone was approved by the FDA for the new indication of preventing relapse to alcohol use in formerly dependent alcoholic patients (Vocci).
	www.drugabuse.gov /MeetSum/naltrexone.html (1566 words)

	NCADI: Naltrexone And Alcoholism Treatment
		Naltrexone has demonstrated efficacy as an important adjunct to the treatment of alcohol dependence, and it is available for general practitioners to prescribe.
		Naltrexone may be more readily accepted by mental health systems and their patients or opioid treatment programs that already rely on pharmacotherapy as an appropriate treatment adjunct.
		The response to naltrexone among these patients with coexisting disorders was impressive, with 59 patients (82 percent) achieving at least a 75-percent reduction in alcohol intake and only 2 patients (2.8 percent) having less than a 25-percent reduction in their alcohol consumption.
	ncadi.samhsa.gov /govpubs/BKD268/28k.aspx (3279 words)

	MedlinePlus Drug Information: Naltrexone
		Naltrexone is used to help people who have a narcotic or alcohol addiction stay drug free.
		Naltrexone is used after the patient has stopped taking drugs or alcohol.
		A small dose of naloxone (a drug similar to naltrexone) will be injected into your vein or under your skin, and you will be watched for symptoms of drug withdrawal.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a685041.html (890 words)

	Naltrexone
		Naltrexone is a commercially avaliable prescription drug, approved by the FDA since the early 1980s, which is manufactured by DuPont and made available under the trade name of ReVia.
		Dr Bihari began to use naltrexone in cancer in 1985 in a patient with NH lymphoma that recurred and the patient refused further chemo.
		Naltrexone for cancer is used at 3 mg per day, once a day, at bedtime.
	www.geocities.com /~vera_b/alts/naltrexone.html (1547 words)

	NALTREXONE
		Naltrexone treatment should be initiated by a specialist experienced in the management of opioid dependence.
		Naltrexone ‘is indicated as an adjunctive prophylactic therapy in the maintenance of detoxified, formerly opioid-dependent patients.'
		Naltrexone was compared to a number of different treatment strategies, but due to extensive heterogeneity among the studies, meta-analysis was performed on only a limited number of studies and outcomes.
	www.keele.ac.uk /depts/mm/MTRAC/ProductInfo/verdicts/N/NALTREXONEv.html (513 words)

	Naltrexone helps alcoholics moderate their drinking
		Naltrexone, which is not addictive, "should be accepted as a short-term treatment for alcoholism," say authors Dr. Manit Srisurapanont and Dr. Ngamwong Jarusuraisin of Thailand's Chiang Mai University.
		The review's conclusions are based on "high-quality evidence" that naltrexone reduces by 36 percent the risk of an alcoholic relapsing to heavy drinking in the first three months of recovery.
		Naltrexone blocks the brain's receptors for natural painkillers, known as opioids, which normally create the feeling of wellbeing associated with drinking.
	www.news-medical.net /print_article.asp?id=7837 (711 words)

	Naltrexone - A short overview
		Naltrexone (17-(cyclopropylmethyl)-4,5 alpha-epoxy-3, 14 dihydroxymorphinan-6-one) is an analogue of Naloxone and is a relatively pure narcotic antagonist.
		Naltrexone is primarily employed as an adjunct in the therapy of social and psychosocial rehabilitation during the recovery of narcotic addicts, and also partly in the treatment of alcohol dependence.
		Bullingham et al 1983, observed that Naltrexone is metabolised in the liver to Beta-Naltrexol which is a weaker antagonist but may contribute to the long duration of action.
	osiris.sunderland.ac.uk /autism/naltrexo.htm (971 words)

	Alcoholism and Medication
		Naltrexone, which was approved to treat the disease in 1994, failed to prevent drinking relapses in a study that left its chief author "flabbergasted."
		The study, appearing in the Dec. 13 issue of The New England Journal of Medicine, says naltrexone fails to prevent drinking relapses as well as previously believed, and, in fact, is no better than sugar pills at keeping hardened alcoholics on the wagon.
		The veterans were split into three groups: some took 50 milligrams a day of naltrexone for three months, some took the same dose for a year, and the rest were given sugar pills.
	www.twilightbridge.com /thetimes/alcohol.htm (693 words)

	The Body: Low-dose Naltrexone and Lipodystrophy
		Bihari speculates that the reduction in lipodystrophy side effect is a result of a protective effect of naltrexone, and that the low-dose administration of the drug may be effective in preventing or reversing the side effect of lipodystrophy.
		Naltrexone is an FDA-approved drug used by recovering heroin or opiate addicts to help keep them off drugs.
		Naltrexone must be "compounded" into a liquid formulation to get the dosage down to three mg.
	www.thebody.com /step/ezine_51900/naltrexone.html (1052 words)

	The Low Dose Naltrexone Homepage
		Naltrexone itself was approved by the FDA in 1984 in a 50mg dose for the purpose of helping heroin or opium addicts, by blocking the effect of such drugs.
		Naltrexone in the large 50mg size, originally manufactured by DuPont under the brand name ReVia, is now sold by Mallinckrodt as Depade and by Barr Laboratories under the generic name naltrexone.
		Unless the low dose of naltrexone is in an unaltered form, which permits it to reach a prompt "spike" in the blood stream, its therapeutic effects may be inhibited.
	www.lowdosenaltrexone.org (2972 words)

	Assisted Recovery Centers of America - St. Louis, MO - Naltrexone Information
		Naltrexone is the first opiate-antagonist/anti-craving medication approved by the U.S. Food and Drug Administration (FDA) for use in the treatment of alcoholism and opiate addiction.
		Naltrexone blocks the 'high' and all other effects associated with opiate consumption, thereby reducing the incentive to try to use alcohol or opiates while on the medication.
		Naltrexone is a non-habit forming medication which does not cause physical/psychological dependence, and can be discontinued at any time.
	www.arcamidwest.com /naltrexone.htm (184 words)

	Using naltrexone to treat alcoholics with a 'Mediterranean drinking pattern'
		Naltrexone is a medication that has been used in the United States for the treatment of alcoholism since its 1994 approval by the federal Food and Drug Administration.
		Naltrexone acts as an opioid antagonist within the opioid neurotransmitter system, which is a part of the brain's reward system.
		The adverse effects known to be associated with naltrexone use (nausea, headache, abdominal discomfort, sleepiness) were low among those treated, confirming previous studies of naltrexone's safety and tolerability.
	www.eurekalert.org /pub_releases/2002-09/ace-unt091002.php (830 words)

	DPB Treatment Options - Naltrexone in NSW
		Naltrexone is used in the detoxification treatment of people who are dependent on opioids such as heroin.
		Naltrexone appears to be an effective pharmacotherapy in opioid relapse prevention for well motivated, stable patients.
		The use of naltrexone anaesthesia to achieve rapid detoxification is not supported by the Health Department at this point due to concerns about safety, and the paucity of evidence of effectiveness.
	www.health.nsw.gov.au /public-health/dpb/treatment/naltrexoneNSW.htm (304 words)

	DrugInfo Clearinghouse (ADF) - Drug facts - Naltrexone (Site not responding. Last check: 2007-10-09)
		Naltrexone has also been used as a treatment to support abstinence for people who are dependent on alcohol.
		Naltrexone is one of a number of treatments for heroin dependence.
		If a naltrexone dose is skipped, it is important to remember that the blocking effect wears off gradually (for example, the usual daily dose of 50mg will wear off in 24-72 hours).
	www.druginfo.adf.org.au /article.asp?ContentID=naltrexone (1595 words)

	NCADI: Naltrexone And Alcoholism Treatment
		Naltrexone has been approved as an adjunct to psychosocial treatment and should not be seen as a replacement for psychosocial interventions.
		Naltrexone may be restarted if the patient and the treating clinicians feel that it may be helpful in preventing relapse.
		Although research on the use of naltrexone for alcohol abuse disorders is ongoing, this TIP presents the "state of the art" from the country's leading experts on this important advance in substance abuse treatment.
	ncadi.samhsa.gov /govpubs/BKD268/28c.aspx (3070 words)

	Encyclopedia: Naltrexone (Site not responding. Last check: 2007-10-09)
		Drug addiction, or dependency is the compulsive use of drugs, to the point where the user has no effective choice but to continue use.
		Naltrexone is only one part of a comprehensive treatment program, which should include regular counselling.
		Naltrexone implants can be used to ensure regular dosage.
	www.nationmaster.com /encyclopedia/Naltrexone (1865 words)

	NALTREXONE
		Naltrexone (Trexan, ReVia) is an opiate antagonist that reduces cravings for alcohol.
		However, the authors go on to conclude: "The results of this study indicate that naltrexone was well tolerated and efficacious in preventing relapse among this group of older alcoholic patients." The study involved veterans aged 50 to 70, and only about 20 were on the drug, the others given a placebo.
		In British Columbia in 1997, for example, the cost for 50 mg of Naltrexone was $5.70 a day (one tablet) or over $500 for a 3 month period; in Yukon the formulary cost for 50 mg was 5.00 a tablet or $450 (8, 9) Costs in other provinces will vary.
	www.agingincanada.ca /naltrexone.htm (758 words)

	WhatMeds.com - Naltrexone
		Naltrexone is a narcotic agonist: a drug that blocks the effects of opiods by competing with them for opiod receptors in the brain.
		Naltrexone suppresses the "high" of alcohol and narcotics, but does not reduce the mental impairment normally caused by taking narcotics or drinking.
		For Pregnant or Nursing Mothers: naltrexone’s effects on pregnancy are not specifically known, but animal studies indicate that high doses of naltrexone may cause problems.
	www.whatmeds.com /meds/naltrexone.html (357 words)

	eMJA: Bell et al, A pilot study of naltrexone-accelerated detoxification in opioid dependence
		Naltrexone was given at a dose of 50 mg/day from Day 2 onwards.
		The increase in initial naltrexone dose from 12.5 mg to 50 mg after the first five patients caused withdrawal to be shorter but no obvious change in severity.
		Eight patients who discontinued naltrexone (and are therefore not included in these retention figures) underwent repeat accelerated detoxification, including two who underwent a third detoxification.
	www.mja.com.au /public/issues/171_1_050799/bell/bell.html (3314 words)

	Is Naltrexone A Cure? (Site not responding. Last check: 2007-10-09)
		Naltrexone displaces heroin from opioid receptors in the brain, blocking the effects of any opioid agonists while the patient continues to take it.
		Renewed enthusiasm for naltrexone was based on the claim that it can be used to accelerate withdrawal from heroin & other opioids, allowing immediate induction onto naltrexone maintenance.
		The role of naltrexone (& other agents to assist in opiate withdrawal) in opioid dependence should be clearer on completion in 2001 of controlled trials of the combined procedure, with & without anaesthesia, as part of the National Evaluation of Pharmacotherapies for Opioid Dependence.
	www.open-mind.org /bbs/Messages/1646.htm (872 words)

	Naltrexone: The ABCs (Site not responding. Last check: 2007-10-09)
		Naltrexone is usually prescribed for three months, if the person benefits from its use.
		Although naltrexone may help in the treatment of problem drinking or opioid dependence, it is not a cure.
		Naltrexone is not recommended for people with liver or kidney damage, people in withdrawal, people who cannot stay sober for at least five days before starting naltrexone, people who are currently using heroin or narcotic pain killers, and pregnant women (unless the potential benefit is worth the potential risk).
	corp.aadac.com /other_drugs/the_basics_about_other_drugs/naltrexone_abcs.asp (560 words)

	Naltrexone Information - The Compounder Pharmacy - Aurora, IL - 630-859-0333 (Site not responding. Last check: 2007-10-09)
		Naltrexone has traditionally been used to treat certain types of addictions - in doses of 50mg and up.
		Naltrexone is a prescription drug, so your physician would have to give you an Rx.
		Naltrexone is compounded in a variety of strengths.
	www.thecompounder.com /diseasenaltrexone.html (1131 words)

	Naltrexone: a New Assault on Addiction
		And a few mavericks are now claiming that their own naltrexone regimen can get heroin addicts through withdrawal in a matter of hours, enabling them to start new lives the next day.
		And when the naltrexone takers did revert to drinking, they were only half as likely to drink heavily.
		And when test doses of a drug resembling naltrexone no longer affected her, the doctors knew her withdrawal was complete.
	www.unhooked.com /sep/naltrex1.htm (859 words)

	LDN and Multiple Sclerosis
		Naltrexone was licensed in 1984 by the FDA in a 50 mg dose as a treatment for heroin addiction.
		It is a pure opiate antagonist (blocking agent) and its purpose was to block the opioid receptors that heroin acts on in the brain.
		Naltrexone, when given to mice and people at high doses, raises endorphin levels in the body's effort to overcome the naltrexone blockade.
	www.lowdosenaltrexone.org /ldn_and_ms.htm (1873 words)

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