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| | Structure, absolute stereochemistry, and synthesis of conocurvone, a potent, novel HIV-inhibitory naphthoquinone trimer ... (Site not responding. Last check: 2007-10-16) |
 | | Bioassay-guided fractionation provided conocurvone (1), a novel trimeric naphthoquinone derivative, as the active anti-HIV constituent of an extract from a Conospermum sp. |
 | | The related naphthoquinone monomer teretifolione B (2) also was isolated from a Conospermum sp. |
 | | While compound 2 was inactive against HIV, the natural and synthetic conocurvone (1) and the synthetic trimeric analog 4 were all active and equipotent, preventing the cytopathic effects and replication of HIV in human T-lymphoblastic cells (CEM-SS) over a concentration range of 0.02-50 µM. Up to MTDP References |
| home.ncifcrf.gov /mtdp/Catalog/abstract/abs193.html (186 words) |
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