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| | PA-04-099: DIET, EPIGENETIC EVENTS, AND CANCER PREVENTION |
 | | Interestingly, the continuous feeding of a diet deficient in choline and methionine is recognized to lead to global DNA hypomethylation and cause hepatocellular carcinomas in rats in the absence of any exogenous carcinogen. |
 | | While long-term health implications remain to be determined, these studies demonstrate that feeding a methyl-supplemented diet to the mice increased levels of DNA methylation in the agouti LTR and increased the proportion of agouti to yellow mice. |
 | | Diet, in fact, has been implicated in many of the pathways of cancer, including apoptosis, cell cycle control, differentiation, inflammation, angiogenesis, DNA repair, and carcinogen metabolism. |
| grants.nih.gov /grants/guide/pa-files/PA-04-099.html (4468 words) |
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