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| | The Nernst/Goldman Equation Simulator |
 | | Although absolute values for ionic permeability have been determined for selected cell types (under ‘selected conditions’), permeability ratios, that is, the relative permeability of a membrane to selected ions, are far more pertinent to understanding the impact of ion gradients on the electrical potential across a membrane. |
 | | It’s also worth noting that When a membrane is permeable to only one species, the Nernst equation applies. |
 | | However, when more than one ionic species can cross the membrane in response to prevailing electrochemical gradients, the GHK equation applies (within the limits imposed by the assumptions behind its derivation; see B. Hille, Ion Channels of Excitable Membranes, 3rd Ed., 2001), and the ratio of permeabilities is the relevant parameter. |
| www.nernstgoldman.physiology.arizona.edu /using (1302 words) |
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