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| | Safe and Effective Stimulation of Neural Tissue: National Institute of Neurological Disorders and Stroke (NINDS) |
 | | In order to minimize tissue damage, more information is needed on methods of preventing damage, the safety of new biomaterials, as well as better methods of physically stabilizing microelectrodes in neural tissue. |
 | | Determine the relationships between tissue damage at various microelectrode depths and in various cerebral cortical regions, and the stimulus variables of pulse frequency, charge density, charge per phase, and current density (based on geometric, and if possible, on real exposed microelectrode area) using current regulated, chronic stimulation. |
 | | Examine possible mechanisms of tissue damage including mechanical trauma, mass activation of cortical neurons and changes in the composition of key constituents of the extracellular fluid surrounding the neurons including glucose using stimulation levels at or below those known to cause histopathological damage using the above described microelectrodes. |
| www.ninds.nih.gov /funding/research/npp/sow/SafeStim97SOW.htm (1243 words) |
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