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Topic: Neurofibroma

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	Neurofibroma - Wikipedia, the free encyclopedia
		Neurofibromas are moderately firm, benign, encapsulated, slow-growing tumors of the nervous system arising from the supporting cells (Schwann cells) of peripheral nerves.
		Single neurofibromas often occur in middle and old age and grow at the margins of the peripheral nerves, displacing the nerve's main body.
		The cases of occurrence of "neurofibromas" are however marginally rare affecting one in thousand.
	en.wikipedia.org /wiki/Neurofibroma (136 words)

	Bonetumor.org - The Web's Most Comprehensive Bone Tumor Resource
		Neurofibroma is a benign lesion of unknown origin that may occur in peripheral nerve, soft tissue, skin or bone.
		Plexiform neurofibromas are multifocal myxoid lesions that are often described as a "bag of worms".
		Plexiform neurofibromas are diagnostic of von Recklinghausen's disease.
	www.bonetumor.org /tumors/pages/page87.html (401 words)

	Neurofibroma
		The oral or pharyngeal neurofibroma is usually diagnosed in teenagers and young adults, although all ages are susceptible.
		Neurofibromas have been reported as well-demarcated radiolucencies within the jawbones, usually within the mandible, in patients with neurofibromatosis (Figure 3).
		Distinguishing the neurofibroma from benign fibrous proliferations is usually not difficult because the latter lack the unique wavy appearance of lesional cell nuclei.
	www.maxillofacialcenter.com /BondBook/softtissue/neurofib.html (965 words)

	Neurofibromatosis type I - Wikipedia, the free encyclopedia
		A solitary neurofibroma may also occur in a deeper nerve trunk, and only be seen on cross-sectional imaging (e.g.
		The hallmark lesion of NF-1 is the plexiform neurofibroma.
		In practice, the major distinction between a schwannoma and a solitary neurofibroma is that a schwannoma can be resected while sparing the underlying nerve, while resection of a neurofibroma requires the sacrifice of the underlying nerve.
	en.wikipedia.org /wiki/Neurofibromatosis_type_I (1229 words)

	Neurofibroma
		Neurofibroma is a tumor or growth located along a nerve or nervous tissue.
		If left unchecked, a neurofibroma can cause severe nerve damage leading to loss of function to the area stimulated by that nerve.
		The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.
	www.stv.org /adam/encyclopedia/imagepages/9694.htm (108 words)

	Neurofibroma - Children's Hospital Boston (Site not responding. Last check: 2007-10-13)
		Neurofibroma is one of the two most common types of benign tumors that arise from nerves.
		Neurofibromas usually affect nerves that are close to the surface of the body such as nerves of the skin or tissue just beneath the skin.
		Neurofibromas are not seen well on x-rays, but an x-ray should be obtained to ensure that the adjacent bone is not involved.
	www.childrenshospital.org /az/Site1085/printerfriendlypageS1085P0.html (474 words)

	Rare Pediatric Disease Database (Site not responding. Last check: 2007-10-13)
		By definition, plexiform neurofibromas are tumors of the peripheral nerve sheath (the insulating material around nerves) that form along large nerve trunks, multiple small branches of nerves, or spinal roots (nerves that arise from the spinal cord) causing enlargement.
		Plexiform neurofibromas are a common complication of NF-1, yet the frequency among pediatric patients seems to increase as the children near adolescence.
		Resection of benign neurofibroma plexiform tumors should be considered with great caution because of the significant chance of producing injury.
	www.madisonsfoundation.org /content/3/1/display.asp?did=336 (1657 words)

	Otolaryngologic Manifestations of Neurofibromatosis
		Neurofibromas are usually multiple, are not encapsulated and the axons seem to be incorporated into the tumor.
		Stapes fixation by an intralabyrinthine "seedling" neurofibroma as a cause of conductive deafness in a case of von Recklinghausen's disease.
		Congenital retropharyngeal neurofibroma causing laryngeal obstruction in a newborn.
	www.bcm.edu /oto/grand/8692.html (1219 words)

	Understanding NF1 \| Consultation Transcripts
		So in plexiform neurofibromas, there can be a whole region of the body that is affected, causing sometimes overgrowth of part of the body -- the face, an arm or a leg, for example -- and sometimes invasion of surrounding tissues by the neurofibroma growth, causing soft tissues to become overgrown and swollen.
		The plexiform neurofibromas are believed to be present from birth and by this age, if that particular kind of plexiform neurofibroma were going to occur, you would already have seen it.
		We can say that she doesn't have plexiform neurofibromas that are visible from the surface, but there's no way that we can know whether other plexiform neurofibromas might exist deeper inside the body where they would not be visible on the surface.
	www.understandingnf1.org /transcripts (4446 words)

	David F. Muir, Ph.D.
		NF1 is characterized by abnormal cell proliferation and a high incidence of neurofibroma, a peripheral nerve sheath tumor composed predominantly of Schwann cells.
		Neurofibromas are benign tumors which arise from nerve elements, most often in the form of palpable dermal tumors.
		Furthermore, plexiform neurofibromas, which develop in as many as 10-20% of NF1 patients, are highly cellular masses and have a significant risk of progressing to malignant peripheral nerve sheath tumors.
	www.mbi.ufl.edu /~muir/PNSTumors.html (1337 words)

	BrainTF26-Trigeminal Schwannoma - Text
		The MR characteristics of neurofibromas are quite varied and usually simulate schwannomas.
		The margins of a neurofibroma appear less distinct than the margins of a schwannoma because neurofibromas lack a capsule.
		It may be impossible to differentiate a neurofibroma from a schwannoma on the basis of MR characteristics.
	www.mribhatia.com /braintf26/braintf26_text.html (776 words)

	Diffuse plexiform neurofibroma in a 13-year-old girl
		Diffuse plexiform neurofibroma, also known as elephantiasis neurofibromatosa [1], has an overgrowth of epidermal and subcutaneous tissue associated with a wrinkled and pendulous appearance.
		Plexiform neurofibromas need to be monitored frequently because 5 percent develop into malignant peripheral nerve sheath tumors [3].
		However, one should keep in mind that in plexiform neurofibromas, dangerous bleeding may complicate surgical procedures, and therefore, extreme caution should be exercised during surgery [5].
	dermatology.cdlib.org /95/case_presentations/plexiform/khachemoune.html (737 words)

	SERGG - Neurofibromatosis - A Case Report
		In addition to multiple cafe-au-lait maculae and subcutaneous neurofibromas, he had a hair whorl over the spine at a level which corresponded to a deep mediastinal mass demonstrated by CT scan and MR examination.
		Infrequently, a neurofibroma may arise from an intercostal nerve, presenting as an extra-pleural mass involving other portions of the mediastenium.
		Diffuse plexiform neurofibromas are congenital, although they become obvious at various times during the life of patients with NF-1.
	www.circ.uab.edu /sergg/f95/neuro4.htm (655 words)

	Neurofibroma (Site not responding. Last check: 2007-10-13)
		Neurofibroma: Composed mainly of proliferating Schwann cells within their nerve sheath, neurofibromas can occur throughout the body, including the orbit and eyelid.
		Plexiform neurofibromas are associated with von Recklinghausen's disease and are infiltrative in nature.
		Plexiform neurofibromas of the lateral upper eyelid can give the lid an S-configuration and clinically have the consistency of a "bag of worms".
	w3.ouhsc.edu /ocupath/orbit/html/Neurofibroma.html (200 words)

	Best Cases from the AFIP: Plexiform Neurofibroma of the Bladder -- Wilkinson et al. 24 (Supplement 1): S237 -- ...
		Neurofibromas are composed of nerve sheath cells interspersed
		Neurofibroma of the genitourinary tract is relatively rare,
		Neurofibromas are common benign peripheral nerve sheath tumors.
	radiographics.rsnajnls.org /cgi/content/full/24/suppl_1/S237 (2082 words)

	NEURILEMMOMA (Site not responding. Last check: 2007-10-13)
		Grossly, cutaneous neurofibroma appears as raised, nodular and sometimes pedunculated skin lesions that may be associated with hyperpigmentation.
		The solitary neurofibromas arising from peripheral nerves resemble the cutaneous neurofibromas.
		Plexiform neurofibromas occur in association with the neurofibromatosis and have a risk of becoming malignant.
	www.bioscience.org /atlases/tumpath/nervsys/pns/3/synopsis.htm (294 words)

	Tumorigenic Properties of Neurofibromin-Deficient Neurofibroma Schwann Cells -- Muir et al. 158 (2): 501 -- American ...
		Dermal and plexiform neurofibromas are peripheral nerve sheath tumors
		and 16 plexiform neurofibromas and subcultured for enrichment
		SC cultures from neurofibromas were transplanted into the nerves of immunodeficient mice.
	ajp.amjpathol.org /cgi/content/full/158/2/501 (6146 words)

	Apria - resources - News (Site not responding. Last check: 2007-10-13)
		Plexiform neurofibroma is a neoplasm of the uterine cervix
		A small plexiform neurofibroma, which was not grossly visible, was confined to the uterine cervix and coexisted with a uterine leiomyoma and adenomyosis.
		The researchers concluded: "Plexiform neurofibroma is a neoplasm that should be considered in the differential diagnosis of spindle cell neoplasms of the uterine cervix, especially in specimens from patients with neurofibromatosis."
	www.apria.com /resources/1,2725,494-355569,00.html (316 words)

	It takes two to tango: mast cell and Schwann cell interactions in neurofibromas -- Viskochil 112 (12): 1791 -- Journal ...
		Neurofibromas are benign tumors comprised primarily of Schwann
		It is known that mast cells are activated in neurofibromas and degranulate; however it is yet to be determined if and how the presence of mast cells induces tumor progression.
		Possible involvement of c-kit receptor and its ligand in increase of mast cells in neurofibroma tissues.
	www.jci.org /cgi/content/full/112/12/1791 (1833 words)

	Phase II Trial of R115777 in Pediatric Patients, Cincinnati Children's Hospital Medical Center (Site not responding. Last check: 2007-10-13)
		Patients with NF1 and progressive plexiform neurofibromas that have the potential to cause significant morbidity, such as (but not limited to) head and neck lesions that could compromise the airway or great vessels, brachial or lumbar plexus lesions that could cause nerve compression and loss of function, lesions that could result in major deformity (e.g.
		Note: In this study a plexiform neurofibroma is defined as a neurofibroma that has grown along the length of a nerve and may involve multiple fascicles and branches.
		Patients who underwent surgery for a progressive plexiform neurofibroma will be eligible to enter the study after the surgery, provided the plexiform neurofibroma was incompletely resected and is measurable.
	www.cincinnatichildrens.org /svc/alpha/c/cancer/trials/neurofibromatosis/t-99-0090.htm?view=content (1557 words)

	Malignant peripheral nerve sheath tumour arising within neurofibroma. An immunohistochemical analysis in the comparison ...
		Staining in the neurofibroma (B) is negative, whereas that in the MPNST (A) is graded as 1+ (case 8) (original magnification,
		Plexiform neurofibroma with and without associated malignant peripheral nerve sheath tumor: a clinicopathologic and immunohistochemical analysis of 54 cases.
		Hepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas.
	jcp.bmjjournals.com /cgi/content/full/54/8/631 (2678 words)

	Benign & Malignant Mesenchymal Neoplasms in Bladder \| Webpathology.cfm (Site not responding. Last check: 2007-10-13)
		Most lesions are small and can be effectively treated by biopsy and fulguration of the site.
		Remarks: This is a bladder biopsy from a teenage boy with Neurofibromatosis Type 1 showing a diffuse neurofibroma.
		Neurofibroma of urinary bladder generally presents in the setting of neurofibromatosis type 1 in early childhood.
	www.webpathology.com /case.cfm?case=61 (494 words)

	Final Diagnosis -- Case 73
		This case represents another solitary intraparotid plexiform neurofibroma of the facial nerve in an adult patient without a personal stigmata or family history of NF 1.
		Besides the connection with NF 1, plexiform neurofibromas should be distinguished due to their risk of malignant transformation seen in up to 15% of patients.
		At least three cases of solitary plexiform neurofibromas, two in the skin and one in the parotid gland, have been reported in patients without other stigmata of NF 1 (1, 5, 7).
	path.upmc.edu /divisions/neuropath/bpath/cases/case73/dx.html (712 words)

	Molecular Profiles of Neurofibromatosis Type 1-Associated Plexiform Neurofibromas: Identification of a Gene Expression ... (Site not responding. Last check: 2007-10-13)
		Neurofibromas are heterogeneous tumors mainly composed of Schwann
		Target gene mRNA levels in the plexiform neurofibroma pool are expressed relative to the mean levels observed in the two pools of dermal neurofibromas.
		mRNA Expression of the 57 Up-Regulated Genes in 14 Plexiform Neurofibromas and 22 Dermal Neurofibromas.
	clincancerres.aacrjournals.org /cgi/content/full/10/11/3763 (4033 words)

	Eye Conditions > Neurofibroma -- EyeMDLink.com
		Orbital neurofibroma is usually an isolated tumor of nerve cells, and is not associated with neurofibromatosis.
		Orbital neurofibroma that is associated with neurofibromatosis also occurs, and this type is typically the plexiform neurofibroma, which begins in the eyelid.
		However, surgical excision of the diffuse and plexiform orbital neurofibromas is often necessarily incomplete.
	www.eyemdlink.com /Condition.asp?ConditionID=322 (136 words)

	Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1 -- Cunha ...
		Neurofibromas are complex benign tumours that arise from peripheral
		The appearance of neurofibromas in adolescence and in pregnancy
		There is a lack of staining in the cells of the superficial ductal (group B; neurofibroma number 4).
	jcp.bmjjournals.com /cgi/content/full/56/10/758 (2506 words)

	Atypical Neurofibroma
		Lymphoma and lymphangioma (a rare, benign tumor composed of dilated lymphatic channels and most often found in young children) must be included, as must nerve sheath tumors, such as schwannoma and neurofibroma.
		Neurofibromas are composed of spindle cells that arise from the Schwann cells.
		Neurofibroma is a benign entity, although it may recur locally.
	brighamrad.harvard.edu /Cases/bwh/hcache/368/full.html (543 words)

	Skinpatient.com neurofibroma info
		Recent studies, however, have drawn attention to the significant morbidity in terms of psychological well-being caused by the cutaneous neurofibromas themselves.
		With regard to neurofibroma removal, there seems to be no particular benefit derived from either surgical or laser treatment.
		of neurofibromas, especially if they are in a conspicuous place such as the face, neck or hands.
	www.skinpatient.com /ptinfo/N/neurofibroma.htm (548 words)

	From the Archives of the AFIP : Imaging of Musculoskeletal Neurogenic Tumors: Radiologic-Pathologic Correlation -- ...
		neurofibroma is a poorly defined lesion in the subcutaneous
		neurofibromas do not contain Antoni A and B regions (3,64,65).
		with diffuse neurofibroma because of its infiltrative growth.
	radiographics.rsnajnls.org /cgi/content/full/19/5/1253 (7409 words)

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