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Topic: Neurofibrosarcoma

	Neurofibrosarcoma (Peripheral Nerve Sheath Tumor) - My Child Has - Children's Hospital Boston (Site not responding. Last check: 2007-10-25)
		Neurofibrosarcoma is considered a soft tissue sarcoma, cancer that originates in soft tissue which includes fat, muscles, tendons, nerves, synovial tissue, blood vessels and other fibrous tissue.
		The exact cause of neurofibrosarcoma is not entirely understood, however, studies have indicated that genetic alterations may play a role in the formation of all soft tissue sarcomas.
		Neurofibrosarcoma may be localized, meaning it has not spread beyond the nerve tissue where it arose or metastatic, meaning it has spread, in this case usually to the lungs.
	www.childrenshospital.org /az/Site1086/mainpageS1086P0.html (1770 words)

	Patent 6,362,392
		A method for treating a neurofibrosarcoma tumor comprising administration of heparin and an angiostatic steroid is disclosed.
		This invention is directed to a method for treating, a neurofibrosarcoma tumor in an animal comprising administering an effective amount of a combination of heparin and an angiostatic steroid.
		The invention is also directed to a nude mouse implanted in its renal capsule with a human neurally-derived tumor, and the use of such a mouse as a model to study growth and evaluate treatment of the implanted tumors.
	www.pharmcast.com /Patents/Yr2002/Mar2002/032602/6362392_Mouse032602.htm (1902 words)

	CancerBACUP : What is a neurofibrosarcoma? (Site not responding. Last check: 2007-10-25)
		A neurofibrosarcoma is one of a family of cancers called soft tissue sarcomas.
		Neurofibrosarcomas are so-called because the arise from the cells which form the protective sheath around the nerves throughout the body.
		If the neurofibrosarcoma is in a part of the body where surgery is impossible or dangerous then radiotherapy is used and often combined with chemotherapy.
	www.cancerbacup.org.uk /QAs/SofttissuesarcomasQAs/AllQAs/related_faqs/QAs/377 (539 words)

	Table of Contents
		The effectiveness of AGM-1470, a potent, fungal-derived inhibitor of angiogenesis, in suppressing the neovascularization and growth of human Schwann cell tumors was tested in six schwannomas, seven neurofibromas, and one neurofibrosarcoma.
		In the one neurofibrosarcoma implanted into 52 mice, the change in average vascular grade in each group during the 6-week treatment period was +1.9 and -1.0, respectively (p
		Neurofibrosarcoma growth after 6 weeks of AGM-1470 treatment was only 8.5% of the growth found in the control animals (p
	www.thejns-net.org /jns/issues/v78n3/abs/n0780470_r.html (258 words)

	Metastatic multicentric neurofibrosarcoma of the lumbosacral plexus in a cow -- Sartin et al. 33 (3): 362 -- Veterinary ...
		Metastatic multicentric neurofibrosarcoma of the lumbosacral plexus in a cow -- Sartin et al.
		Metastatic multicentric neurofibrosarcoma of the lumbosacral plexus in a cow
		A metastatic multicentric neurofibrosarcoma of the lumbosacral plexus in an
	www.vetpathology.org /cgi/content/abstract/33/3/362 (194 words)

	Medical Dictionary: Neurofibrosarcoma - WrongDiagnosis.com - WrongDiagnosis.com
		Neurofibrosarcoma: A malignant tumor that arises from small cutaneous nerves, is locally aggressive, and has a potential for metastasis.
		Neurofibrosarcoma is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that Neurofibrosarcoma, or a subtype of Neurofibrosarcoma, affects less than 200,000 people in the US population.
	www.wrongdiagnosis.com /medical/neurofibrosarcoma_printer.htm (284 words)

	Soft tissue sarcomas
		The most common histological types of STS are fibrosarcomas, haemangiopericytomas, neurofibrosarcomas, schwanomas (also called malignant peripheral nerve sheath tumors), and malignant fibrous histiocytomas.
		In fact, at the light microscope level, it is difficult to distinguish between schwannoma and neurofibrosarcoma, and hemangiopericytomas are likely a form of peripheral nerve tumor.
		Tumors such as fibrosarcomas, neurofibrosarcomas (nerve sheath tumors), malignant fibrous histiocytomas, hemangiopericytomas, and myxosarcomas are referred to as soft tissue sarcomas.
	www.thensome.com /softissue.htm (603 words)

	Nude mouse model for the growth and treatment of human neurally-derived tumors - Patent 6362392
		The invention is directed in particular to a method for treatingy a neurofibrosarcoma comprising the administration of an effective amount of heparin, a heparin fragment, or a synthetic heparin substitute and an anLriostatic steroid or steroid derivative to an animal in need of such treatment.
		In this study, treatment of a human neurofibrosarcoma transplanted into nude mice was with heparin, hydrocortisone, and a combination of heparin and hydrocortisone was tested.
		A human neurofibrosarcoma was obtained at surgery from a patient with multiple plexiform neurofibromas but no "cafe-au-lait" spots, Lisch nodules, acoustic neuromas, or family history of neurofibromatosis.
	www.freepatentsonline.com /6362392.html (11353 words)

	MEDLINE Search on Medscape.com
		[Positron emission tomography in a patient with Von Recklinghausen disease and left dorsal neurofibrosarcoma]with Von Recklinghausen disease and recurrence of a left dorsal neurofibrosarcoma diagnosed by Positron Emission Tomography with...
		Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB.
		A study of the influence of newly synthesized acyclonucleosides and 1,2,3,4-tetrahydroisoquinoline derivatives on deoxythymidine and deoxycytidine kinase activities in human neurofibrosarcoma and ovarian cancer.
	search.medscape.com /medline-search?queryText=Neurofibrosarcoma (357 words)

	soft tissue sarcoma (Site not responding. Last check: 2007-10-25)
		It tends to occur in either the knee or thigh of a person under the age of 30.
		Neurofibrosarcoma — This tumor, also known as a malignant peripheral nerve-sheath tumor, resembles the protective cells that normally cover nerves.
		Neurofibrosarcoma most commonly affects people with a disease called neurofibromatosis type I. It usually appears in the trunk or extremities.
	www.aetnapharmacy.com /AP/ihtAP/r.WSHIW000/st.9339/t.25950.html (2640 words)

	Cancer Spectrum: Medline Abstract (Site not responding. Last check: 2007-10-25)
		BACKGROUND/PURPOSE: Neurofibrosarcoma is rare in children, and the natural history and prognostic factors are not well described.
		CONCLUSION: Neurofibrosarcoma remains a rare disease in children with insufficient contemporary numbers to assess efficacy of therapy.
		Prognosis remains poor with a high incidence of relapse, particularly in the lungs, suggesting that more aggressive therapies to control both local and distant relapses are needed.
	jncicancerspectrum.oxfordjournals.org /cgi/medline/pmid;12632346 (394 words)

	Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue.
		Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue.
		Because of this, the authors studied 20 cases of neurofibrosarcoma (NFS), 7 of leiomyosarcoma (LMS), 3 of fibrosarcoma (FS), 8 of malignant fibrous histiocytoma (MFH), 5 of monophasic spindle cell synovial sarcoma (MSS), 5 of neurilemmoma, and 5 of neurofibroma for Leu-7 reactivity, to determine its utility in differential diagnosis.
		Moreover, it would appear that in selected instances, smooth-muscle and neurogenic sarcomas must be separated on the basis of clinical, histopathologic, and ultrastructural features alone.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/5781449.html (247 words)

	OncoLink Ask the Experts—Cancer Symptoms, Cancer Prevention, Cancer Treatment (Site not responding. Last check: 2007-10-25)
		The cancer is in the upper thigh, her sciatic nerve and thigh muscle have been removed before Xmas but they had to go back in 2 weeks ago (end of January) and take out more.
		Neurofibrosarcoma, or a malignant peripheral nerve sheath tumor is a very difficult problem.
		The prognosis will depend on a number of factors including tumor grade, whether the patient has neurofibromatosis, the extent of surgery, presence of distant metastasis, etc. The general approach to treatment is to obtain a maximal resection, which could include amputation in some cases.
	www.oncolink.upenn.edu /experts/article.cfm?c=3&s=24&ss=104&id=1678 (300 words)

	Childhood Neurofibrosarcoma Clinical Trials Listings and Information at ClinicalTrialsSearch.org
		Childhood Neurofibrosarcoma Clinical Trials References presented on Clinical Trials Search is not designed to be a substitute for proven healthcare advice, trips or professional assistance using a genuine dr..
		Childhood Neurofibrosarcoma Clinical research trials and Childhood Neurofibrosarcoma health trials take place in a lot of of cities across the U.S.A..
		Childhood Neurofibrosarcoma Clinical Trials and other clinical trials permit volunteers to have medical treatment options before they are available to the masses.
	www.clinicaltrialssearch.org /childhood_neurofibrosarcoma_clinical_trials.html (372 words)

	Table of Contents
		A human neurofibrosarcoma was removed at surgery from a patient with neurofibromatosis and implanted into the subrenal capsule of female nude mice (nu/nu).
		A solid tumor grew and was transferred to 78 additional mice for this study.
		These studies suggest that angiogenesis modulators are worthy of further study as a feasible means of treating human neurofibrosarcoma.
	www.thejns-net.org /jns/issues/v73n3/abs/n0730429_r.html (242 words)

	Pathology Cases for Diagnosis (Site not responding. Last check: 2007-10-25)
		Neurofibrosarcomas are aggressive tumors causing pain and weakness in the muscle innervated by the nerve involved.
		Once the diagnosis of NF-1 is established, periodic screening exams are necessary to check for neurofibrosarcoma and optic nerve glioma.
		Presently, prognosis is poor for NF-1 patients with neurofibrosarcoma.
	www.usuhs.mil /pat/surg_path/s97-04/97-04.html (885 words)

	Figures
		Axial Gd-enhanced MR image demonstrating an atypical meningioma invading middle fossa skull base, skeletal muscle, and neural sheath of the trigeminal nerve (V2 and V3).
		Coronal Gd-enhanced MR image revealing the jugular foramen/infratemporal fossa neurofibrosarcoma shown in Fig.
		Coronal Gd-enhanced MR image demonstrating an infratemporal fossa neurofibrosarcoma with involvement of the pinna and temporal bone, which necessitated resection of the pinna and external auditory canal.
	www.medscape.com /content/2002/00/43/61/436115/436115_fig.html (198 words)

	InteliHealth:
		It tends to occur in either the knee or thigh of a person under the age of 30.
		Neurofibrosarcoma — This tumor, also known as a malignant peripheral nerve-sheath tumor, resembles the protective cells that normally cover nerves.
		Neurofibrosarcoma most commonly affects people with a disease called neurofibromatosis type I. It usually appears in the trunk or extremities.
	www.intelihealth.com /IH/ihtIH/WSIHW000/9339/25950.html (2739 words)

	Electrophysiological Changes in NF1 - Storming Media
		Preliminary data on K currents of SC from a cutaneous neurofibroma raise the possibility that neurofibroma SC ion channels are not physiologically abnormal or that the ion channel phenotypes of normal, neurofibroma-derived and neurofibrosarcoma-derived SC represent a continuum that requires closer observation for differences between normal and neurofibroma- derived SC.
		The neurofibrosarcoma cell line T265 had tumored K currents like those of 3 other neurofibro-sarcoma-derived cell lines.
		T265 cells have proved useful in beginning experiments to understand the role of K channels in SC proliferation.
	www.stormingmedia.us /28/2887/A288783.html (208 words)

	Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene ...
		The NF1 gene is thought to be a tumour suppressor gene, yet no direct proof at the molecular level exists to support this hypothesis.
		Here we describe a neurofibrosarcoma from a patient with NF1 with loss of heterozygosity for all chromosome 17 polymorphisms tested.
		Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis.
	www.nature.com /doifinder/10.1038/ng0293-122 (620 words)

	neurofibrosarcoma Search Results From Healthline
		neurofibrosarcoma symptoms neurofibrosarcoma causes neurofibrosarcoma prevention neurofibrosarcoma risk factors
		Malignant schwannomas, neurofibrosarcomas, or neurogenic sarcomas are malignant tumors of the cells that surround a nerve.
		Malignant peripheral nerve sheath tumors (neurofibrosarcomas) usually occur in adolescents and adults.
	www.healthline.com /search?q1=neurofibrosarcoma (251 words)

	MXI1 - MAX interacting protein 1
		Mxi1 tumor suppressor gene is not mutated in primary pancreatic adenocarcinoma.
		Mxi1 is a potential cellular target of carcinogens and frequently mutated in experimental rat tumors and tumor cell lines.
		Missense mutations in the functional domain of Mxi1 in these cases may be involved in the pathogenesis of neurofibrosarcoma.
	www.pdg.cnb.uam.es /UniPub/iHOP/gi/90397.html (1926 words)

	[No title] (Site not responding. Last check: 2007-10-25)
		A study of the influence of newly synthesized acyclonucleosides and 1,2,3,4-tetrahydroisoquinoline derivatives on deoxythymidine and deoxycytidine kinase activities in human neurofibrosarcoma and ovarian cancer.
		The influence of the compounds was studied in the cytosol from intraoperatively excised human tumours — neurofibrosarcoma and ovarian cancer.
		While acyclonucleosides undergo phosphorylation in the cytosol by cellular kinases, with their triphosphates being active acyclonucleoside metabolites, active 1,3,4,5-tetrahydroisoquinoline derivatives (compounds not containing a deoxyribose moiety), cannot be phosphorylated.
	www.actabp.pl /html/4_2003/1175.html (336 words)

	Ohio Adult Neurofibrosarcoma Clinical Trials Listings and Information at ClinicalTrialsSearch.org
		Ohio Adult Neurofibrosarcoma Clinical Trials Data presented on Clinical Trials Search isn't intended to be a substitute for proven health advice, trips or professional assistance with a genuine dr..
		Ohio Adult Neurofibrosarcoma Clinical research trials and Ohio Adult Neurofibrosarcoma health trials happen in hundreds of Ohio localities.
		Ohio Adult Neurofibrosarcoma Clinical Trials and other clinical trials permit volunteers to access health treatment options before they are available to the general public.
	www.clinicaltrialssearch.org /ohio_adult_neurofibrosarcoma_clinical_trials.html (271 words)

	Posterior mediastinal neurofibrosarcoma in a patient with von Recklinghausen's disease
		Posterior mediastinal neurofibrosarcoma in a patient with von Recklinghausen's disease
		Repeated thoracotomy and subtotal excision of a recurrent neurofibrosarcoma.
		Post mortem: neurofibrosarcoma with pulmonary and pericardial metastases and double gastric and jejunal neurofibromas.
	www.smw.ch /docs/oeil/1999/129-21-288-99.html (290 words)

	Re: Neurofibrosarcoma [00054]
		On Thu, 21 Sep 1995 MylesGeo@aol.com wrote: I had a neurofibrosarcoma that was > removed with my left jaw in Feb. 93 it reocurred as a 1 x 4 cc brain tumor > in the V3 cranial nerve last June and was treated with gamma knife on July 17 > 1994.
		Since then MRI's in Oct. 94 and Feb. 95 have indicated that the main > tumor has stabilized or shrunk slightly but additional loss of facial muscle > function and a MRI in Sept. indicate that fingers of the tumor continue to > grow.
		Lorne Buhle is correct in talking about a link between neurofibrosarcoma and Von Recklinghausen's Disease and you should be checked for that.
	www.meds.com /archive/mol-cancer/1995/msg00054.html (1064 words)

	Taking Charge of Neurofibromatosis - University Hospital, Newark, NJ
		A less common type of tumor, the plexiform tumor, grows along the body’s peripheral nerves (the nerves that carry messages between the body and the brain); about 5 percent to 10 percent of the time, a plexiform tumor will degenerate into a neurofibrosarcoma, a rare type of malignant soft tissue sarcoma.
		When a previously painless tumor becomes painful or grows rapidly, it may indicate the degeneration of a benign tumor into neurofibrosarcoma.
		Surgical removal of a neurofibrosarcoma, in some cases followed by radiation therapy, can optimize a patient’s chances for survival.
	www.theuniversityhospital.com /healthlink/archives/articles/neurofibromatosis.htm (2304 words)

	Re: cancer-neurofibrosarcoma a rare type of lung cancer (Site not responding. Last check: 2007-10-25)
		In Reply to: cancer-neurofibrosarcoma a rare type of lung cancer posted by r.a.s.
		In 1989 I had a neurofibrosarcoma of the right medial nerve in my right arm.
		Grafts from ny leg wer taken to repalce the.
	www.cheshire-med.com /programs/pulrehab/forum/messages/20108.html (189 words)

	neurofibrosarcoma - OneLook Dictionary Search (Site not responding. Last check: 2007-10-25)
		We found 3 dictionaries with English definitions that include the word neurofibrosarcoma:
		Tip: Click on the first link on a line below to go directly to a page where "neurofibrosarcoma" is defined.
		neurofibrosarcoma : Dorland's Illustrated Medical Dictionary [home, info]
	www.onelook.com /?w=neurofibrosarcoma&ls=a (76 words)

	neurofibrosarcoma - OmniMedicalSearch.com - neurofibrosarcoma
		Soft tissue sarcomas may develop in any part of the body, but in young patients,.
		lists trials that are studying or have studied Neurofibrosarcoma.
		Lymphangiosarcomas are the malignant lymph vessel form of angiosarcomas.
	www.omnimedicalsearch.com /sr_neurofibrosarcoma.html (504 words)

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