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Topic: Neurofilament

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	The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and ...
		Neurofilaments, microtubules, and cortical actin are interlinked by plectinlike linkers (orange; Errante et al., 1994; Svitkina et al., 1996).
		Neurofilaments and microtubules interconnect in the axonal cytoskeleton
		Neurofilament deficiency in quail caused by nonsense mutation in neurofilament-L gene.
	www.jcb.org /cgi/content/full/163/5/1021 (7055 words)

	Chemicon - Product #AB1987 - Anti-Neurofilament M (145 kDa), C-terminus
		Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm.
		Neurofilaments (10nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexs of monomeric proteins.
		The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific.
	www.chemicon.com /Product/ProductDataSheet.asp?ProductItem=AB1987 (589 words)

	OhioLINK ETD: Yan, Yanping
		Neurofilament proteins are the major cytoskeletal component of most neurons and they are transported by slow axonal transport, whose mechanism is still controversial.
		All moving neurofilaments had the epitope distributed along almost their entire length and quantitative comparison of RT97 immunofluorescence intensity along moving and splayed neurofilaments further confirms that moving neurofilaments are not hypophosphorylated at this epitope relative to the overall population.
		I conclude (1) that neurofilament proteins move in the form of single assembled polymers, (2) that moving and pausing neurofilaments are complex heteropolymers comprised of at least four different subunit proteins, and (3) that phosphorylation at the RT97 epitope is not a key regulator of neurofilament movement in cultured sympathetic neurons.
	www.ohiolink.edu /etd/view.cgi?osu1134349238 (366 words)

	Definition: neurofilament from Online Medical Dictionary (Site not responding. Last check: 2007-11-04)
		In vertebrates assembled from three distinct protein subunits.
		(neurofilament L, 68 kD, neurofilament M, 160 kD, and neurofilament H 200 kD) These proteins, if introduced into fibroblasts, will incorporate into the vimentin filament system.
		Published at the Centre for Cancer Education, University of Newcastle upon Tyne
	cancerweb.ncl.ac.uk /cgi-bin/omd?query=neurofilament (70 words)

	Slow Axonal Transport of Neurofilament Protein in Cultured Neurons -- Koehnle and Brown 144 (3): 447 -- The Journal of ...
		Thus, the proximal and distal accumulation ratios are each a measure of the accumulation or depletion of neurofilament protein in the constricted axon relative to its nonconstricted sister.
		An accumulation ratio >1 indicates an accumulation of neurofilament protein in the constricted axon relative to the control sister axon and an accumulation ratio <1 indicates a depletion.
		swellings proximal and distal to the constriction and neurofilament
	www.jcb.org /cgi/content/full/144/3/447 (8341 words)

	Fischer, Mol Vis 2004; 10:973-986. (Site not responding. Last check: 2007-11-04)
		In retinas from saline injected eyes, levels of GFAP immunoreactivity was minimal and neurofilament immunoreactivity was confined to the somata and axons of ganglion cells, neurites in the inner plexiform layer (IPL), and the axons of efferent target cells at the distal border of the IPL Figure 1A [19,21-23].
		Neurofilament immunolabeling was apparent at 2 days (data not shown) and 3 days after toxin treatment (Figure 1G-I) and subsided by 5 days after treatment (results not shown), consistent with our previous report [14].
		The expression of neurofilament by Müller glia-like cells was minimal in eyes that received 3 consecutive daily injections of EGF alone (Figure 3G, Table 2), CNTF alone, or the combination of CNTF and insulin (Table 2).
	www.molvis.org /molvis/v10/a116 (6291 words)

	Ryugo Lab - Auditory Anatomy & Physiology (Site not responding. Last check: 2007-11-04)
		Neurofilament antibodies and spiral ganglion neurons of the mammalian cochlea.
		Because antibodies against the 200-kD neurofilament protein preferentially labeled type II neurons and because 200-kD neurofilament is highly phosphorylated, we treated cochlear tissue with alkaline phosphatase in order to remove phosphate groups.
		Populations of neurons may thus differ in their neurofilament epitopes and monoclonal antibodies can be used to mark such differences.
	www.jhu.edu /ryugolab/abs/berglund_ryugo_1991.html (256 words)

	Neurofilament - Wikipedia, the free encyclopedia
		Neurofilaments are the type IV family of intermediate filaments that is found in high concentrations along the axons of vertebrate neurons.
		The three types of neurofilament proteins coassemble in vivo, forming a heteropolymer that contain NF-L plus one of the others.
		During axonal growth, new neurofilament subunits are incorporated all along the axon in a dynamic process that involves the addition of subunits along the filament length, as well as the addition of subunits at the filament ends.
	en.wikipedia.org /wiki/Neurofilament (270 words)

	NEFL - neurofilament, light polypeptide 68kDa - Genetics Home Reference (Site not responding. Last check: 2007-11-04)
		Neurofilaments, which are assembled from light, medium, and heavy subunits, are essential for normal nerve function.
		Cross-linking or bridging between neurofilaments maintains the diameter of the fiber, or axon, that extends from a nerve cell.
		Altered neurofilament light subunits likely disrupt the assembly of neurofilaments or their transport to the axon.
	ghr.nlm.nih.gov /gene=nefl (562 words)

	Neurofilament table, part 1
		Neurofilament polypeptide with a molecular weight of 150kDa, on axons and cell bodies of neurons
		IH(F,P) 140/160 kD Neurofilament, in nerves and human brain, not with cytokeratins, GFAP or intermediate filaments.
		IH(P) 68 and 200 kD Neurofilament, in nerves and human brain, normal and abnormal tissues, not GFAP, keratin, vimentin or desmin.
	www.alzforum.org /res/com/ant/Neurofilament/NEUROFIL1-tableC.html (1214 words)

	Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis -- Lycke et al. 64 ...
		Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis
		The neurofilament protein is a major structural protein of neurons and a marker for axonal damage.
		The neurofilament is a major structural protein of neurons that maintains neuronal size, shape, and axonal calibre.
	jnnp.bmjjournals.com /cgi/content/full/64/3/402 (2018 words)

	Relating Interactions between Neurofilaments to the Structure of Axonal Neurofilament Distributions through Polymer ...
		Influence of the phosphorylation state of neurofilament proteins on the interactions between purified filaments in vitro.
		Dephosphorylation of the largest neurofilament subunit protein influences the structure of crossbridges in reassembled neurofilaments.
		Regulation of neurofilament interactions in vitro by natural and synthetic polypeptides sharing lys-ser-pro sequences with the heavy neurofilament subunit NF-h: neurofilament crossbridging by antiparallel sidearm overlapping.
	www.biophysj.org /cgi/content/full/82/5/2360 (6192 words)

	Arrival, Reversal, and Departure of Neurofilaments at the Tips of Growing Axons -- Uchida and Brown 15 (9): 4215 -- ...
		Neurofilaments were visualized using RMO255 monoclonal antibody, which is specific for NFM, and GFP was visualized using a polyclonal antiserum (see Materials and Methods).
		Neurofilaments were present throughout the distal axons at all times (B, D, F, and H).
		The solid lines represent the movement of the neurofilaments and the dotted lines represent the movement of the growth cones (tracked by measuring the location of the base of the growth cone).
	www.molbiolcell.org /cgi/content/full/15/9/4215 (6416 words)

	Chemicon - Product #MAB5254 - Anti-Neurofilament 160 kD, clone NN18
		The antibody reacts with neurofilament 160 kD (Debus et al., 1982; Shaw et al., 1984).
		Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model.
		Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions.
	www.chemicon.com /Product/ProductDataSheet.asp?ProductItem=MAB5254 (551 words)

	Neurofilament protein levels in CSF are increased in dementia -- Rosengren et al. 52 (5): 1090 -- Neurology
		Neurofilament protein levels in CSF are increased in dementia -- Rosengren et al.
		Neurofilament protein levels in CSF are increased in dementia
		Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS
	www.neurology.org /cgi/content/abstract/52/5/1090 (296 words)

	Anti-myelin-associated glycoprotein antibodies alter neurofilament spacing -- Lunn et al. 125 (4): 904 -- Brain
		Neurofilaments in the normal axons (A) are more widely spaced than those from demyelinated axons in inflammatory neuropathy (B) or axons with widely spaced myelin in PDPN (C).
		Neurofilaments (arrows) have visible extensions thought to be sidearms of NF-M (neurofilament medium) and NF-H (neurofilament heavy).
		Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber.
	brain.oxfordjournals.org /cgi/content/full/125/4/904 (3849 words)

	Rapid Intermittent Movement of Axonal Neurofilaments Observed by Fluorescence Photobleaching -- Wang and Brown 12 (10): ...
		To observe neurofilaments by fluorescence microscopy, we transfected cultured neurons from the superior cervical ganglia of
		the neurofilaments from bovine spinal cord, and antibodies and
		The significance of the retrograde movement of neurofilaments in axons is presently unclear.
	www.molbiolcell.org /cgi/content/full/12/10/3257 (6740 words)

	University at Albany Biological Sciences Department
		Neurofilaments are one of the principal components of the axonal cytoskeleton, and their molecular composition changes during axonal development.
		To explore this hypothesis, we study the neurofilaments of axons in the frog, Xenopus laevis.
		In mammals, the neurofilaments of injured peripheral axons, which can regenerate, resemble those of newly developing axons; whereas the neurofilaments of mammalian central nervous system axons, which cannot regenerate, remain adult-like after injury.
	www.albany.edu /~bgs86 (742 words)

	--< SYnaptic SYstems >--Neurofilament L antibody
		CSF neurofilament proteins in the differential diagnosis of dementia.
		Differential subcellular localization of phosphorylated neurofilament and tau proteins in degenerating neurons of the human entorhinal cortex.
		Neurofilament protein is differentially distributed in subpopulations of corticocortical projection neurons in the macaque monkey visual pathways.
	www.sysy.com /neurofil-l/neurofil_ref.html (214 words)

	Rabbit Polyclonal against Neurofilament Subunit NF-M from EnCor Biotechnology Inc.
		They are composed a mixture of subunits which often includes the neurofilament triplet proteins, NF-L, NF-M and NF-H. Neurofilaments may also include peripherin, alpha-internexin, nestin and in some cases vimentin.
		Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are quite abundant, biochemically stable.
		Harris, J., Ayyub, C. and Shaw G. A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M and NF-H. J Neurosci Res 30:47-62 1991.
	www.encorbio.com /rpolyclonal/RPCA-NF-M.htm (377 words)

	Medical News: HAART Protects the Brain From AIDS-Related Degeneration - in Geriatrics, Dementia from MedPage Today
		The investigators had previously shown that levels of neurofilament light protein were significantly increased in the cerebrospinal fluid of patients with AIDS dementia complex, and that the levels correlated with severity of neurologic symptoms.
		Among the 32 patients with normal levels of neurofilament light protein at baseline, all but one continued to have normal levels at follow-up.
		"These effects on CSF neurofilament light protein were seen in association with clinical improvement in AIDS dementia complex patients, decreases in plasma and CSF HIV-1 RNA and CSF neopterin, and increases in blood CD4 T-cell counts," the authors wrote.
	www.medpagetoday.com /Geriatrics/Dementia/tb/6905 (598 words)

	Neurofilament inclusion body disease: a new proteinopathy?
		We describe four cases of a new clinicopathological entity presenting with either a frontotemporal dementia or corticobasal degeneration syndrome with a mean age of onset of 45 years (range 41-50) characterized pathologically by deposition of neurofilament proteins.
		Immuno histochemistry revealed that the inclusions were immunoreactive with antibodies to neurofilament heavy and light chain subunits and to ubiquitin, but not with antibodies to tau and alpha-synuclein.
		These neurofilament- and ubiquitin-positive inclusions were widespread, specific to neurons and occasionally intranuclear.
	www.medscape.com /medline/abstract/12876145?src=emed_ckb_ref_0 (369 words)

	GTX27256-160 kD Neurofilament Medium antibody [3H11]-Neuronal Marker-GeneTex Inc.
		Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-M is the middle or medium neurofilament subunit and runs on SDS-PAGE gels in the range 145-170kDa, with some variation in different species.
		Antibodies to NF-M are useful to identify this protein and identify neurons and their processes in tissue sections and in tissue culture.
		NF-M can also be useful in studies of neurofilament accumulations seen in many neurological diseases, such as Lou Gehrig's disease or Alzheimer's disease.
	www.genetex.com /ccp23078-160-kd-neurofilament-medium-antibody-5b3h115d-neuro-nb-300-134-gtx27256.htm (201 words)

	Slow transport of unpolymerized tubulin and polymerized neurofilament in the squid giant axon -- Galbraith et al. 96 ...
		Slow transport of unpolymerized tubulin and polymerized neurofilament in the squid giant axon -- Galbraith et al.
		Rhodamine-labeled neurofilaments and tubulin were prepared for injection by diluting a 2-µl aliquot of protein with 2-3 µl
		The active transport of tubulin and neurofilament was manifested as an anterograde movement of the peak of the fluorescent
	www.pnas.org /cgi/content/full/96/20/11589 (4193 words)

	Department of Biological Sciences - University at Albany - State University of New York
		We have shown that the neurofilament composition of these injured axons resembles that of newly developing ones.
		Moreover, we discovered that these regenerating axons modulate their neurofilament compositions in response to cues emanating from other cells along the visual pathway.
		We believe that studying what regulates neurofilament protein expression may provide clues to the riddle of why axons vary in their ability to regenerate.
	www.albany.edu /faculty/bgs86/research.html (355 words)

	ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human ...
		Neurofilaments L, M, and H are the three protein subunits that form 8-10 nm intermediate filaments in mature neurons.
		Phosphorylation of neurofilament proteins in intact neurons: Demonstration of phosphorylation in cell bodies and axons.
		The human mid-size neurofilament subunit: A repeated protein sequence and the relationship of its gene to the intermediate filament gene family.
	www.genesdev.org /cgi/content/full/13/4/449 (7025 words)

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