| | Basic fibroblast growth factor (FGF2) in hypothalamus, neurohypophysis and choroid plexus: dehydration supports a ... |
 | | Using a rat model of chronic dehydration to test the hypothesis that FGF2 is involved in fluid balance, we show that in the neural lobe, the remodeling of extracellular matrix and increased number of pituicytes is accompanied by greater levels of immunoreactive FGF2 associated with basement membranes underlying blood vessels, pituicytes and other glial cells. |
 | | Disrupted water intake was thus accompanied by altered distribution of FGF2 in the neurohypophysis as well as in the fluid-forming choroid plexus. |
 | | Therefore FGF2 expression patterns in the neurohypophysis, AVP-containing magnocellular neurons and choroidal epithelium point to a role for centrally-synthesized FGF2, possibly coupled to that of AVP, in regulating water balance in various regions. |
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