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Topic: Neuronal interstitial dysplasia

Related Topics

hip dysplasia

otospondylomegaepiphyseal dysplasia

Arrhythmogenic right ventricular dysplasia

Septo optic dysplasia

Craniodiaphyseal dysplasia

Skeletal dysplasias

Ectodermal dysplasia Berlin type

Connective tissue dysplasia Spellacy type

Thanatophoric dysplasia Glasgow variant

Localized epiphyseal dysplasia

Spondyloperipheral dysplasia short ulna

Epimetaphyseal skeletal dysplasia

In the News (Sun 20 Dec 09)

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	eMedicine - Interstitial Cystitis : Article by Eric S Rovner
		Interstitial cystitis (IC) is a clinical syndrome characterized by daytime and nighttime urinary frequency, urgency, and pelvic pain of unknown etiology.
		Indications for surgical intervention in interstitial cystitis (IC) are limited to (1) cystoscopy for both diagnosis and therapeutic purposes, (2) neuromodulation for urgency or frequency symptoms, and (3) urinary reconstruction, (4) urinary diversion, or both for the rare patient who may benefit from these procedures.
		Interstitial cystitis (IC) is a chronic condition with a variable course, which, unfortunately, responds poorly to treatment in many cases.
	www.emedicine.com /MED/topic2866.htm (0 words)

	MerckMedicus : Dorland's Medical Dictionary
		dysplasia of the cerebral cortex, such as is seen in polymicrogyria and ulegyria.
		dysplasia with fibrosis of the muscular layer of an artery wall, with collagen deposition and hyperplasia of smooth muscle, causing stenosis and hypertension.
		renal dysplasia with multiple cysts, usually unilateral and seen in children; the affected kidney is nonfunctional but often asymptomatic.
	www.merckmedicus.com /pp/us/hcp/thcp_dorlands_content.jsp?pg=/ppdocs/us/common/dorlands/dorland/dmd_d_32.htm (3828 words)

	MerckMedicus : Dorland's Medical Dictionary
		dysplasia of the cerebral cortex, such as is seen in polymicrogyria and ulegyria.
		dysplasia with fibrosis of the muscular layer of an artery wall, with collagen deposition and hyperplasia of smooth muscle, causing stenosis and hypertension.
		renal dysplasia with multiple cysts, usually unilateral and seen in children; the affected kidney is nonfunctional but often asymptomatic.
	merckmedicus.com /pp/us/hcp/thcp_dorlands_content.jsp?pg=/ppdocs/us/common/dorlands/dorland/dmd_d_32.htm (3828 words)

	[No title]
		de Morsier syndrome, or septo-optic dysplasia, is a developmental malformation complex characterized by optic nerve hypoplasia, dysgenesis of the septum pellucidum, and hypothalamic-pituitary dysfunction.
		New mesomelic dysplasia with absent fibulae and triangular tibiae.
		Neurons of the cerebral cortex, cerebellar cortex, and some brain stem nuclei were lost in moderate to severe degrees, and there were relatively few neuroaxonal spheroids in the gray matter.
	genetics.rusmedserv.com /add/article_22.html (13386 words)

	Rat Genome Database: References
		Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cord.
		Expression of the survival of motor neuron (SMN) gene in primary neurons and increase in SMN levels by activation of the N-methyl-D-aspartate glutamate receptor.
		Metastasis-associated S100A4 (Mts1) protein is expressed in subpopulations of sensory and autonomic neurons and in Schwann cells of the adult rat.
	rgd.mcw.edu /tools/references/references_view.cgi?author=Li&initials=M&action=cache&override=yes (6947 words)

	Congenital interstitial cell of cajal hyperplasia with neuronal intestinal dysplasia.
		Congenital interstitial cell of cajal hyperplasia with neuronal intestinal dysplasia.
		Interstitial cells of Cajal (ICCs) are intestinal pacemaker cells that initiate peristalsis in the stomach and intestine, and are considered to be precursors of gastrointestinal stromal tumors (GISTs).
		In addition, the changes of the submucosal plexus fulfilled the histologic criteria of neuronal intestinal dysplasia type B. To our knowledge, this is the first reported case of congenital ICC hyperplasia.
	www.medscape.com /medline/abstract/11075862 (0 words)

	[No title]
		Dysplasia or dysgenesis - often associated with neuroectodermal defects 1.
		Neuronal degeneration - Retinal ganglion cells undergo the same degenerative reactions to injury as cerebral neurons.
		Infectious Bovine Rhinotracheitis (IBR) Disease of cattle caused by a herpesvirus.
	www.afip.org /CLDavis/syllabi/eye.txt (8075 words)

	Hirschsprung Disease
		The aim of the study was to detect possible alterations in frequency and topographic distribution of enteric neurons and interstitial cells of Cajal in an experimental model (the lethal spotted mouse displaying a short rectal aganglionosis) for Hirschsprung's disease.
		Because a reduced number of interstitial cells of Cajal was commonly associated with HD in 84.2%, hypoganglionosis in 40%, and IND-B in 76.9% of cases, it might be a preceding or aggravating factor related to an IPO.
		Interstitial cells of Cajal that carry the tyrosine kinase receptor (c-Kit) develop as either myenteric ICCs or muscular ICCs under the influence of the kit ligand, which can be provided by neuronal and nonneuronal cells, for example, smooth muscle cells.
	www.thedoctorsdoctor.com /diseases/hirschsprung_disease.htm (6749 words)

	Clinicopathological Conference (CPC's)
		Aspergillus lung disease, with bronchocentric granulomatosis, interstitial (hypersensitivity) pneumonitis, fungal colonization of a preexisting emphysematous bulla, and probably invasive aspergillosis (radiologic evidence).
		Rheumatoid lung disease, with rheumatoid nodules, pleuritis, and interstitial fibrosis.
		Usual interstitial pneumonitis (fibrosing alveolitis) entering the accelerated phase, consistent with the clinical diagnosis of acute exacerbation of idiopathic pulmonary fibrosis.
	www.mgh.harvard.edu /pathrecords/cpc_archive00-03.htm (3170 words)

	Membrane Capacitance of Cortical Neurons and Glia During Sleep Oscillations and Spike-Wave Seizures -- Amzica and ...
		In synchrony with the onset of the neuronal depolarization, the glia depolarizes.
		Paroxysmal excitation in the neuron is accompanied by a sustained negative potential shift in the extracellular field potential.
		Neuronal capacitance follows the overall evolution of the seizure, whereas the glial capacitance first decreases, before assuming a delayed time course.
	jn.physiology.org /cgi/content/full/82/5/2731 (7504 words)

	Chapter 9 text
		That the interstitial development of fibrous tissue is also observed very frequently in the skin, and, with much less frequency, in the viscera, the appearances presented by this tissue being suggestive of an irritative or inflammatory process.
		That in experiments made upon animals, particularly on monkeys, symptoms resembling in a very close and remarkable way those of myxedema have followed complete removal of the thyroid gland, performed under antiseptic precautions, and with, as far as could be ascertained, no injury to the adjacent nerves or to the trachea.
		Interstitial edema and an increase in fibrous tissue are present.
	www.thyroidmanager.org /Chapter9/9-text.htm (5292 words)

	PATHOLOGY part1
		An example of this is poliovirus, which affects the motor neurones of the anterior horn in the spinal cord, causing paralysis.
		Microglial nodules, lymphocytes, and macrophages infiltrate the lesions.
		Prions (pronounced pree-ons, an acronym for proteinaceous infectious particles) are abnormal isoforms of a neuronal membrane glycoprotein.
	members.fortunecity.com /danilhammoudimd/neuro1/id20.htm (5833 words)

	Neuronal polarity in CNS development -- Solecki et al. 20 (19): 2639 -- Genes and Development
		The leading process of the migrating neuron (blue) and the dendrites of the post-migratory granule cell (blue) express markers in common that distinguish them from the granule cell axon (green).
		During glial-guided of migration of CNS neurons in the developing mammalian brain, the centrosome controls the polarity and direction of cell movement.
		Gleeson, J.G. and Walsh, C.A. Neuronal migration disorders: From genetic diseases to developmental mechanisms.
	www.genesdev.org /cgi/content/full/20/19/2639 (5459 words)

	Clinicopathological Conference (CPC's)
		Rheumatoid lung disease, with pleuritis, interstitial lymphocytic infiltrate, arterial hypertension, and venous sclerosis.
		Diffuse lymphoid hyperplasia of lungs, peribronchiolar (follicular bronchiolitis) and interstitial (lymphocytic interstitial pneumonitis);
		Desquamative interstitial pneumonitis, with central bronchiectasis, peribronchiolar fibrosis, and subpleural cysts.
	www.mgh.harvard.edu /pathrecords/cpc_archive92_95.htm (3482 words)

	Neuronal Migration Defects in the Dreher (Lmx1a) Mutant Mouse: Role of Disorders of the Glial Limiting Membrane -- ...
		Neuronal Migration Defects in the Dreher (Lmx1a) Mutant Mouse: Role of Disorders of the Glial Limiting Membrane -- Costa et al.
		Neuronal Migration Defects in the Dreher (Lmx1a) Mutant Mouse: Role of Disorders of the Glial Limiting Membrane
		Pinto-Lord MC, Evrard P, Caviness VS Jr (1982) Obstructed neuronal migration along radial glial fibers in the neocortex of the reeler mouse: a Golgi-EM analysis.
	cercor.oxfordjournals.org /cgi/content/full/11/6/498 (5389 words)

	Microdysgenesis in temporal lobe epilepsy: A quantitative and immunohistochemical study of white matter neurones -- ... (Site not responding. Last check: )
		Preservation of calretinin-immunoreactive neurones in the hippocampus of epilepsy patients with Ammon's horn sclerosis.
		An increase of hippocampal calretinin-immunoreactive neurons correlates with early febrile seizures in temporal lobe epilepsy.
		Interstitial cells of the adult neocortical white matter are the remnant of the early generated subplate neuron population.
	brain.oxfordjournals.org /cgi/content/full/124/11/2299 (4914 words)

	Achalasia
		In the normal cardia, myenteric ganglia, intramuscular nerve fibers, and interstitial cells of Cajal were numerous, whereas myenteric fibrosis and lymphocyte infiltrates were absent.
		Neuronal NO synthase was absent in 7 of 10 and decreased in 3 of 10, whereas interstitial cells of Cajal appeared normal in 7 of 10 and decreased in 3 of 10.
		Achalasia is a motility disorder of the esophagus characterized by the loss of inhibitory neurons in the distal esophagus.
	www.thedoctorsdoctor.com /diseases/achalasia.htm (6594 words)

	TheFetus.net - Bilateral striatal necrosis -Alessandro Giuffrida, MD, Saveria Cantone, MD., Fabiola Galvani, MD, ...
		Others have suggested that glutamate excitotoxicity mediated by glutamate receptors 1, 2/3, and 4 and excessive dopaminergic excitatory activity may play important roles in hypoxic-ischemic basal ganglia necrosis but that neuronal nitric oxide synthase does not contribute to that condition[24].
		Initial computed tomography scans can show mild atrophy of the caudate nuclei or basal ganglia, and the neuropathologic examination can reveal diffuse neuronal loss with some patchy preservation and marked astrogliosis in the striatum and globus pallidus.
		Neuronal death in newborn striatum after hypoxia-ischemia is necrosis and evolves with oxidative stress.
	www.thefetus.net /page.php?id=90 (1263 words)

	World J Gastroenterol
		These neuronal changes, which were reported when the patient was 5 years old, may be considered the result of adaptive phenomena to a long-standing mechanical stimulus, such as obstruction limiting bowel propulsion.
		Further, enteric neuronal changes, ICC (the pace-maker cells of the gut, which act in concert with neurons in governing gut motility) have been found to be reduced in experimental mechanical sub-occlusion of the small bowel as indicated by a decrease in c-Kit immunoreactivity and loss of functions attributed to ICC
		Intestinal neuronal density in childhood: a baseline for the objective assessment of hypo- and
	www.wjgnet.com /1007-9327/12/5229.asp (2825 words)

	USCAP 2002 Annual Meeting
		There is also a report of multiple familial GANT associated with intestinal neuronal dysplasia.
		Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors.
		A case for interstitial cells as pacemakers and mediators of neurotransmission in the gastrointestinal tract.
	www.uscap.org /site~/91st/case11-12.htm (5356 words)

	AANS.org \| Education and Meetings \| AANS Scientific Journals \| Neurosurgical Focus
		Moreover, as similarly reported by others,[52] an association between an area of focal cortical dysplasia and a dysembryoplastic lesion or a ganglioglioma was observed in several of our cases.
		Specific morphological neuronal alterations have been observed in patients with brain tumors that are potentially epileptogenic.[5,13,34,57] It is of particular interest that in four of our cases, seizures recurred at the time of tumor relapse, which suggests a direct relationship between the lesion and the epileptogenic activity of the surrounding brain.
		A long-standing partial seizure disorder could be equally related to a low-grade brain tumor as well as to a focal cortical dysplasia or a dysembryoplastic lesion, all of which presented a similar clinical picture.
	www.aans.org /education/journal/neurosurgical/feb99/6-2-3.asp (6446 words)

	NHLBI Rare Diseases Report, 2001
		Asbestosis, an occupational lung disease, is the interstitial pneumonitis and fibrosis caused by exposure to asbestos fibers.
		Identification of the neuronal pathways producing respiratory rhythm and pattern are prerequisite for a full understanding of a variety of respiratory sleep disorders such as CCHS.
		Because of their ability to generate neurons and glia, stem cells are promising candidates for the development of cellular and genetic therapies for neurological disorders, including neuroregulatory problems in heart, lung, and blood diseases, and sleep disorders.
	www.nhlbi.nih.gov /resources/docs/raredisrpt01.htm (13636 words)

	Classical Lissencephaly Syndromes
		The cytoarchitecture is strikingly abnormal, consisting of four primitive layers including an outer marginal layer, a superficial cellular layer which corresponds to the true cortex, a variable cell sparse layer, and a deep cellular layer comprised of heterotopic neurons which extends more than half the width of the mantle.
		The different structural rearrangements which have been observed include both interstitial and apparently terminal de novo deletions, recombinant chromosomes derived from pericentric inversions, unbalanced derivatives of balanced reciprocal translocations, and rings.
		In contrast, chromosome analysis in over 100 children with ILS or XLIS has been normal except for two children with apparently balanced translocations which are hypothesized to disrupt one of the two known lissencephaly loci in Xq22.3-q23 or 17p13.3 {Dobyns, 1992}{Chong, in press}.
	www.lissencephaly.org /medical/info/classlis.htm (4752 words)

	Table of Contents
		Low-grade tumors, dysplastic lesions, focal neuronal migration disorders, vascular malformations, and secondary scar lesions are all important causative factors in children with partial seizure disorders.
		Whether the severity and the type of the seizures are predictive of the cause of the epileptogenic lesion is still under debate, as well as whether separate study of the epileptogenic activity caused by these pathological entities would be appropriate.
		Specific morphological neuronal alterations have been observed in patients with brain tumors that are potentially epileptogenic.
	www.thejns-net.org /jns/arti_right_test.htm (6812 words)

	Colon-nontumor
		Inflammatory bowel disease: general, Crohn’s, Crohn’s-carcinoma, indeterminate colitis, ulcerative colitis, dysplasia, UC-carcinoma, ulcerative proctitis, diffuse giant inflammatory polyposis
		May be due to loss of interstitial cells of Cajal in small and large bowel (
		Eur J Pediatr Surg 2004;14:384); (2) hyperganglionosis of submucous plexus, giant ganglia and rectal biopsies show either ectopic ganglia, increased acetylcholinesterase activity in lamina propria or increased acetylcholinesterase in nerve fibers around submucosal blood vessels (
	www.pathologyoutlines.com /colon.html (3020 words)

	II. Disorders of enteric neuronal development: insights from transgenic mice -- Gershon 277 (2): 262 -- AJP - ... (Site not responding. Last check: )
		The sacral crest contributes neurons and glia to the post-umbilical gut: spatiotemporal analysis of the development of the enteric nervous system.
		Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: expression of GFRa in vitro and in vivo.
		Regionally defective colonization of the terminal bowel by the precursors of enteric neurons in lethal spotted mutant mice.
	ajpgi.physiology.org /cgi/content/full/277/2/G262 (3689 words)

	taurine-epilepsy.html>
		ABSTRACT: Excitatory amino acids are increasingly implicated in the pathogenesis of neuronal injury induced by a variety of CNS insults, such as ischemia, trauma, hypoglycemia, and epilepsy.
		Several amino acids were measured in cerebrospinal fluid and in microdialysis samples from the interstitial fluid of the frontal cortex in a rabbit model of pneumococcal meningitis.
		Among the amino acids with known excitatory or inhibitory function, interstitial fluid concentrations of glutamate were significantly elevated (by 470%).
	www.indiana.edu /~pietsch/taurine-epilepsy.html (5035 words)

	Structure and Function of Kv4-Family Transient Potassium Channels -- Birnbaum et al. 84 (3): 803 -- Physiological ...
		Neuron was held at –80 mV and stepped to 0 mV.
		neurons is completely blocked by the MEK inhibitor UO126 (228).
		Kv4.2 in supraoptic neurons is concentrated in postsynaptic
	physrev.physiology.org /cgi/content/full/84/3/803 (8011 words)

	Metallothionein Isoform 3 as a Potential Biomarker for Human Bladder Cancer (Site not responding. Last check: )
		The dysplasia included 18 observations from sections with malignancy that had adjacent areas histologically defined as being dysplastic using standard diagnostic criteria.
		The finding that the neuronal expression of MT-3 is associated with the regulation of cell growth allows us to hypothesize that the overexpression of MT-3 in human bladder cancer might also influence the regulation of urothelial cell proliferation.
		The expression of heat shock protein 60 is reduced in the bladder of patients with interstitial cystitis.
	www.ehponline.org /realfiles/members/2000/108p413-418sens/sens-full.html (5810 words)

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