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Topic: Neuropeptide Y


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In the News (Sat 19 Dec 09)

  
  NPY - Neuropeptide Y precursor
The influence of neuropeptide Y and norepinephrine on ovulation in the rat ovary.
Involvement of neuropeptide Y and Y1 receptor in antinociception in nucleus raphe magnus of rats.
Norepinephrine release and neuropeptide Y in medulla oblongata of spontaneously hypertensive rats.
www.ihop-net.org /UniPub/iHOP/gi/90628.html   (4261 words)

  
 NPY5R - Neuropeptide Y receptor type 5
Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus.
Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor?
Genotype analysis of the neuropeptide Y (NPY) Y1 and NPY Y5 receptor genes in gonadotropin-releasing hormone-dependent precocious gonadarche.
www.ihop-net.org /UniPub/iHOP/gg/90663.html   (2813 words)

  
 Diabetes: Functional interactions between melanin-concent... @ HighBeam Research   (Site not responding. Last check: 2007-10-26)
Neuropeptide glycine glutamic acid (NGE) and neuropeptide glutamic acid isoleucine amide (NEI) were synthesized in the protein core facility (Joslin Diabetes Center, Boston, MA) using an automated peptide synthesizer, were similarly dissolved in sterile artificial CSF, and were kept frozen until use.
Experimental animals were injected with the respective neuropeptide solution in a volume of 5 [micro]l over 1 min at the beginning of the dark period, returned to their cages, and subsequently left undisturbed.
Finally, it should be noted that we have not examined the effects of other neuropeptides that have been implicated in the regulation of food intake, such as galanin and CRH (36), in the context of our study, even though it is likely that important interactions exist between other neuropeptides and the peptides we studied.
www.highbeam.com /library/doc0.asp?DOCID=1G1:21245946&refid=ip_encyclopedia_hf   (3410 words)

  
 publications.htm
Neuropeptide role of both neuropeptide Y and peptide YY in vertebrates suggested by abundant expression of both mRNAs in a cyclostome brain.
Evolution of the neuropeptide Y receptor family: Gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig.
A neuropeptide Y receptor Y1-like gene from an agnathan, the European river lamprey: a pontential ancestral gene.
www.bmc.uu.se /~danl/publications.html   (4704 words)

  
 A potent neuropeptide Y antagonist, 1229U91, suppressed spontaneous food intake in Zucker fatty rats -- Ishihara et al. ...
Neuropeptide Y (NPY), and endogenous presynaptic modulator of adrenergic neurotransmission in the rat vas deferens: structural and functional studies.
Hypothalamic neuropeptide Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats.
Synthesis of receptor antagonists of neuropeptide Y. Proc.
ajpregu.physiology.org /cgi/content/full/274/5/R1500   (2359 words)

  
 Neuropeptide Y and Y1-receptor agonists increase blood flow through arteriovenous anastomoses in rat tail -- Heath 85 ...
Neuropeptide Y is a vasoconstrictor and adrenergic modulator in hamster microcirculation by acting on neuropeptide Y1 and Y2 receptors.
Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues.
Neuropeptide Y co-exists with vasoactive intestinal polypeptide and actylcholine in parasympathetic cerebrovascular nerves originating in the sphenopalatine, otic, and internal carotid ganglia of the rat.
jap.physiology.org /cgi/content/full/85/1/301   (4364 words)

  
 Neuropeptide Y Family and NPY Receptor Antibodies,
During maturation, the signal and carboxyterminal peptides are cleaved and a common carboxyterminal tyrosine in the mature peptide (36aa) is amidated.
Neuropeptide Y family of peptides signal through a family of G protein-coupled receptors present in the brain and sympathetic neurons.
It is the receptor for Neuropeptide Y and Peptide YY.
www.4adi.com /flr/npyflr.html   (541 words)

  
 Autoreceptor-induced inhibition of neuropeptide Y release from PC-12 cells is mediated by Y2 receptors -- Chen et al. ...
Neuropeptide Y enhances luteinizing hormone-releasing hormone-induced LH release and elevation in cytosolic Ca in rat anterior pituitary cells: evidence for involvement of extracellular Ca influx through voltage-sensitive channels.
Neuropeptide Y inhibits the nicotine-mediated release of catecholamines from bovine adrenal chromaffin cells.
Co-release of neuropeptide Y and noradrenaline from pig spleen in vivo: importance of subcellular storage, nerve impulse frequency and pattern, feedback regulation, and resupply by axonal transport.
ajpheart.physiology.org /cgi/content/full/273/4/H1737   (3691 words)

  
 Y5 Receptors Mediate Neuropeptide Y Actions at Excitatory Synapses in Area CA3 of the Mouse Hippocampus -- Guo et al. ...
Presynaptic inhibition by neuropeptide Y in rat hippocampal slice in vitro is mediated by a Y2 receptor.
Dumont Y, Jacques D, Bouchard P, and Quirion R. Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4, and Y5 receptors in rodents, guinea pig, and primates brains.
Marksteiner J, Ortler M, Bellmann R, and Sperk G. Neuropeptide Y biosynthesis is markedly induced in mossy fibers during temporal lobe epilepsy of the rat.
jn.physiology.org /cgi/content/full/87/1/558   (4815 words)

  
 Neuropeptide Y - Wikipedia, the free encyclopedia
Neuropeptide Y (NPY) is a 36 amino acid peptide neurotransmitter found in the brain and autonomic nervous system.
Neuropeptide Y (NPY) is a 36–amino acid peptide made by neurons throughout the brain and by other secretory cells of the body.
NPY has been associated with a number of physiologic processes in the brain, including the regulation of energy balance, memory and learning, and epilepsy.
en.wikipedia.org /wiki/Neuropeptide_Y   (280 words)

  
 Neuropeptide Y   (Site not responding. Last check: 2007-10-26)
Neuropeptide Y (NPY) is the most abundant neuropeptide in the brain.
The tenative conclusion from these experiments is that leptin's effect on body weight is mediated in part by its effect on NYP expression, but that other systems have overlapping control over food intake and energy expenditure.
Erickson JC, Clegg KE, Palmiter RD: Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381:415, 1996.
arbl.cvmbs.colostate.edu /hbooks/pathphys/endocrine/bodyweight/npy.html   (285 words)

  
 Zinc Deficiency Increases Hypothalamic Neuropeptide Y and Neuropeptide Y mRNA Levels and Does Not Block Neuropeptide ...   (Site not responding. Last check: 2007-10-26)
Neuropeptide Y concentration (ng/mg protein) in the hypothalamic paraventricular nucleus (PVN) of zinc adequate (Zn+) and
Neuropeptide Y concentration in the hypothalamic paraventricular nucleus of zinc-adequate (Zn+), pair-fed (PF) and zinc deficient
Y gene expression induced by zinc deficiency in the rat.
www.nutrition.org /cgi/content/full/128/7/1218   (4729 words)

  
 Neuropeptide Y and body weight
Neuropeptide Y (NPY) is a 36 amino acid protein which acts as a transmitter in the nervous system.
Certain data indicate that neuropeptide Y is also involved in the regulation of feeding behavior including food intake and carbohydrate preference as well as metabolic and lipogenic rates.
The mRNA of preproneuropeptide Y is increased in the in the hypothalamus of genetically obese Zucker rats.
www.bioscience.org /news/scientis/obesity2.htm   (530 words)

  
 Y on Encyclopedia.com   (Site not responding. Last check: 2007-10-26)
In English y mainly represents the semivowel occurring in words such as yet; the same semivowel is the second member of the diphthongs ā, ē, ī, and oi.
The modern ignorant use of y in ye for the (as in “Ye Olde Shoppe”) is based on a misreading of an old sign for th.
In chemistry Y is the symbol for the element yttrium.
www.encyclopedia.com /html/Y/Y.asp   (629 words)

  
 Neuropeptide Y enhances permeability across a rat aortic endothelial cell monolayer -- Nan et al. 286 (3): 1027 -- AJP ...
Neuropeptide Y in the sheep fetus: effects of acute hypoxemia and dexamethasone during late gestation.
Neuropeptide Y acts at an atypical receptor to evoke cardiovascular depression and to inhibit glutamate responsiveness in the brainstem.
Hirabayashi A, Nishiwaki K, Shimada Y, and Ishikawa N. Role of neuropeptide Y and its receptor subtypes in neurogenic pulmonary edema.
ajpheart.physiology.org /cgi/content/full/286/3/H1027   (4306 words)

  
 Cloning and Functional Expression of a cDNA Encoding a Human Type 2 Neuropeptide Y Receptor -- Rose et al. 270 (39): ...
Neuropeptide Y (NPY) is a 36-amino acid polypeptide that is widely distributed in the central nervous system and periphery.
Neuropeptide Y is a peptide hormone with diverse and important physiological effects in the central nervous system and periphery that are mediated through multiple receptor subtypes.
The abbreviations used are: NPY, neuropeptide Y; Y1-Y3, NPY receptors, subtype 1-3; CHO, Chinese hamster ovary; MCP-1, monocytic chemotactic protein-1; kb, kilobase pair(s); BSA, bovine serum albumin; PYY, peptide YY.
www.jbc.org /cgi/content/full/270/39/22661   (4739 words)

  
 Neuropeptide Y and Corticotropin-Releasing Hormone Concentrations within Specific Hypothalamic Regions of Lean but Not ...   (Site not responding. Last check: 2007-10-26)
Neuropeptide Y (NPY) concentrations in specific hypothalamic regions of fed, food-deprived, or refed ob/ob and lean mice.
Beck B., Burlet A., Bazin R., Nicolas J-P., Burlet C. Elevated neuropeptide Y in the arcuate nucleus of young obese Zucker rats may contribute to the development of their overeating.
Beck B., Burlet A., Nicolas J-P., Burlet C. Unexpected regulation of hypothalamic neuropeptide Y by food deprivation and refeeding in the Zucker rat.
www.nutrition.org /cgi/content/full/128/12/2520   (4349 words)

  
 Cloned neuropeptide Y (NPY) Y1 and pancreatic polypeptide Y4 receptors expressed in Chinese hamster ovary cells show ...   (Site not responding. Last check: 2007-10-26)
neuropeptide Y receptor agonist, human/rat neuropeptide Y. The
Parker, S.L., Parker, M.S. and Crowley, W.R. (1998) Characterization of Y1, Y2 and Y5 subtypes of neuropeptide Y (NPY) receptor in rabbit kidney.
Parker, M.S., Berglund, M.M., Lundell, I. and Parker, S.L. (2001) Blockade of pancreatic polypeptide-sensitive neuropeptide Y (NPY) receptors by agonist peptides is prevented by modulators of sodium transport.
content.febsjournal.org /cgi/content/full/268/4/877   (5375 words)

  
 Neuropeptide Y regulated by c-fos in murine dentate gyrus - Neuroscience : Epilepsy.com
Neuropeptide Y regulated by c-fos in murine dentate gyrus - Neuroscience : Epilepsy.com
NewsRxGenomicsGenetics via NewsEdge Corporation : 2004 JUL 30 - (NewsRx.com & NewsRx.net) -- Neuropeptide Y is regulated by c-fos in the murine dentate gyrus, which may help explain the neuroprotective effects of c-fos.
Wu and colleagues published their study in Neuroscience Letters (c-fos regulates neuropeptide Y expression in mouse dentate gyrus.
www.epilepsy.com /newsfeed/pr_1091107800.html   (350 words)

  
 XVI. International Union of Pharmacology Recommendations for the Nomenclature of Neuropeptide Y, Peptide YY, and ...
Grundemar L, Wahlestedt C and Reis DJ (1991) Neuropeptide Y acts at an atypical receptor to evoke cardiovascular depression and to inhibit glutamate responsiveness in the brainstem.
Hirabayashi A, Nishiwaki K, Shimada Y and Ishikawa N (1996) Role of neuropeptide Y and its receptor subtypes in neurogenic pulmonary edema.
Hu Y, Bloomquist BT, Cornfield LJ, Decarr LB, Flores-Riveros JR, Friedman L, Jiang P, Lewis-Higgins L, Sadlowski Y, Schaefer J, Velazquez N and McCaleb ML (1996) Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
pharmrev.aspetjournals.org /cgi/content/full/50/1/143   (5577 words)

  
 Region-Specific Neuropeptide Y Overflows at Rest and During Sympathetic Activation in Humans -- Morris et al. 29 (1): ...
Morris M, Kapoor V, Chalmers J. Plasma neuropeptide Y concentration is increased after haemorrhage in conscious rats: relative contributions of sympathetic nerves and adrenal medulla.
Neuropeptide Y is released together with noradrenaline from the human heart during exercise and hypoxia.
Plasma catecholamines and neuropeptide Y as indices of sympathetic nerve activity in normotensive and stroke-prone hypertensive rats.
hyper.ahajournals.org /cgi/content/full/29/1/137   (5035 words)

  
 Enhancement of Antimicrobial Activity of Neuropeptide Y by N-Terminal Truncation -- Shimizu et al. 42 (10): 2745 -- ...   (Site not responding. Last check: 2007-10-26)
Neuropeptide Y (NPY) is an amidated peptide of 36 amino acids and is known to regulate physiological functions, such as food
Colmers, and C. Wahlestedt (ed.), The biology of neuropeptide Y and related peptides.
Signal epitopes in the three-dimensional structure of neuropeptide Y. Ann.
aac.asm.org /cgi/content/full/42/10/2745   (1177 words)

  
 Central Cardiovascular Action of Neuropeptide Y in Conscious Rabbits -- Matsumura et al. 36 (6): 1040 -- Hypertension
Y and leptin on cardiovascular and sympathetic responses in
Y participates in the regulations of the sympathetic nerve
Y is modulated, at least in part, by central leptin in conscious
hyper.ahajournals.org /cgi/content/abstract/36/6/1040   (479 words)

  
 Diabetes Self-Management - Neuropeptide Y
All of these messages are sent via chemical messengers, and neuropeptide Y is one of these chemical messengers.
What chemical messenger would stimulate the PVN to produce neuropeptide Y? Probably the chemical by-products created when carbohydrates are burned as fuel.
Food depletion, caused by dieting or an overnight fast, and exercise also increase cortisol levels, which then increase neuropeptide Y levels, and ultimately bring on a craving for carbohydrate.
www.diabetes-self-mgmt.com /article.cfm?aid=385&sid=6&sk=5WZ5   (393 words)

  
 Activation of Central Neuropeptide Y Y1 Receptors Potently Stimulates Food Intake in Male Rhesus Monkeys -- Larsen et ...
1993 Increased neuropeptide Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse.
1997 Neuropeptide Y induced feeding in the rat is mediated by a novel receptor.
Neuropeptide Y: A hypothalamic brake restraining the onset of puberty in primates
jcem.endojournals.org /cgi/content/full/84/10/3781   (7518 words)

  
 Neuropeptide Y examined, regulation and modulation in epilepsy defined : Epilepsy.com
Neuropeptide Y examined, regulation and modulation in epilepsy defined : Epilepsy.com
Neuropeptide Y examined, regulation and modulation in epilepsy defined
Silva and colleagues published their study in the Journal of Neurochemistry (Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats.
www.epilepsy.com /newsfeed/pr_1116336609.html   (383 words)

  
 A Possible Role of Neuropeptide Y as a Mediator of Undernutrition to the Hypothalamic Gonadotropin-Releasing Hormone ...
A Possible Role of Neuropeptide Y as a Mediator of Undernutrition to the Hypothalamic Gonadotropin-Releasing Hormone Pulse Generator in Goats -- Ichimaru et al.
Raposinho PD, Broqua P, Pierroz DD, Hayward A, Dumont Y, Quirion R, Junien J-L, Aubert ML 1999 Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype.
Porter DW, Naylor AM, McNeilly AS, Lincoln DW 1993 Endocrine actions of central neuropeptide Y in the ewe: activation of the hypothalamo-pituitary-adrenal axis by exogenous neuropeptide Y and role of endogenous neuropeptide Y in the secretion of luteinizing hormone during the oestrous cycle.
endo.endojournals.org /cgi/content/full/142/6/2489   (5996 words)

  
 Neuropeptide Y Suppresses Epileptiform Activity in Rat Hippocampus In Vitro -- Klapstein and Colmers 78 (3): 1651 -- ...
Neuropeptide Y Suppresses Epileptiform Activity in Rat Hippocampus In Vitro -- Klapstein and Colmers 78 (3): 1651 -- Journal of Neurophysiology
Neuropeptide Y suppresses epileptiform activity in rat hippocampus in
Mechanisms of Neuropeptide Y, Peptide YY, and Pancreatic Polypeptide Inhibition of Identified Green Fluorescent Protein-Expressing GABA Neurons in the Hypothalamic Neuroendocrine Arcuate Nucleus
jn.physiology.org /cgi/content/abstract/78/3/1651   (960 words)

  
 New Scientist Breaking News - Molecular secret of Special Forces toughness
The elite soldiers produced more of a molecule called neuropeptide Y in their blood than regular soldiers.
"The Special Forces types had a greater capacity for mobilising neuropeptide Y than ordinary soldiers, and they were also able to sustain it for longer periods," he told a session on PTSD at the American Association for the Advancement of Science's annual conference in Denver, Colorado.
Furthermore, neuropeptide Y in Special Forces personnel returned to normal levels within 24 hours, whereas it dipped below normal in the others.
www.newscientist.com /article.ns?id=dn3402   (443 words)

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