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Topic: Neurospora

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	Neurospora crassa - Wikipedia, the free encyclopedia
		Neurospora crassa is a type of red bread mold of the phylum Ascomycota.
		Neurospora was used by Edward Tatum and George Wells Beadle in their experiments for which they won the Nobel Prize in Physiology or Medicine.
		Froehlich, AC, Noh, B and Vierstra, RD, Loros J and Dunlap JC (December 2005), "Genetic and molecular analysis of Phytochromes from the filamentous fungus Neurospora crassa", Eukaryot Cell, vol.
	en.wikipedia.org /wiki/Neurospora_crassa (437 words)

	Useful Neurospora References (Site not responding. Last check: 2007-10-15)
		Lessons from the genome sequence of Neurospora crassa: Tracing the path from genomic blueprint to multicellular organism.
		Davis, R. Compartmental and regulatory mechanisms in the arginine pathways of Neurospora crassa and Saccharomyces cerevisiae.
		Neurospora from natural populations: Toward the population biology of a haploid eukaryote.
	www.stanford.edu /group/neurospora/UsefulRefs.html (794 words)

	WICGR Press Releases -Scientists Publish Draft Sequence and Analysis of Neurospora crassa
		Neurospora has close fungal relatives that cause animal disease such as athlete's foot and valley fever, or plant diseases that decimate staple crops such as rice, corn, and soy.
		Among the findings in the Neurospora analysis is that the genome encodes about 10,000 protein-coding genes, far less than the estimated 30,000 that humans have, but comparable to that of the fruitfly.
		Neurospora is the flagship of fungal genome sequencing efforts, and the first filamentous fungus to be sequenced.
	www.broad.mit.edu /media/2003/pr_03_neurospora.html (970 words)

	The Neurospora - Fungal Genome Initiative: White Paper
		Research on Neurospora is at the cutting edge of many fields of fungal genetics, development, and filamentous fungal cell biology - heterothallism, sexual development, temporal regulation, cytoplasmic movement, signal transduction, meiotic drive, transvection, and the role of methylation in gene expression, to name a few.
		Although Neurospora is nonpathogenic, it is phylogenetically very closely allied with and genetically similar to several important plant pathogens including Cochliobolus (Southern corn leaf blight, which resulted in crop losses in excess of $1.5 billion in 1970 alone), Fusarium, and Magnaporthe grisea (the rice blast fungus).
		Neurospora is now being used for industrial manufacture on a small scale (Neugenesis Inc.) and it is closely related to several industrially important organisms such as Trichoderma reesii.
	biology.unm.edu /biology/ngp/WhitePaper.html (2532 words)

	References - Neurospora - HORT640 - Metabolic Plant Physiology - Department of Horticulture and Landscape Architecture ...
		Calderon J, Martinez LM, Mora J 1990 Isolation and characterization of a Neurospora crassa mutant altered in the alpha polypeptide of glutamine synthetase.
		Heck IS, Ninnemann H 1995 Molybdenum cofactor biosynthesis in Neurospora crassa: biochemical characterization of pleiotropic molybdoenzyme mutants nit-7, nit-8, nit-9A, B and C. Photochem.
		MacPhee KG, Nelson RE, Schuster SM 1983 Neurospora crassa mutants deficient in asparagine synthetase.
	www.hort.purdue.edu /rhodcv/hort640c/referen/neuros.htm (4981 words)

	The Neurospora Genome Project: Home Page
		A German consortion coordinated by Dr. Ulrich Schulte (at the Institute of Biochemistry, Heinrich-Heine-University, D-40225 Duesseldorf) is sequencing two chromosomes (linkage groups II and V); this project is supported by the Deutsche Forschungsgesellschaft (DFG).
		The primary role of the NGPC is to facilitate communication between the Neurospora community and established sequencing groups that might efficiently complete the genome sequencing.
		The initial members of the NGPC are: Mary Anne Nelson (chair), Kathy Borkovich, Jay Dunlap, Matthew Sachs, Ulrich Schulte and Eric Selker.
	biology.unm.edu /biology/ngp/home.html (690 words)

	Fungal Genomic Cosmid and cDNA Sequencing
		Fungal (Aspergillus nidulans, Aspergillus parasiticus and Neurospora crassa) Cosmid and cDNA Sequencing
		Fungal (Aspergillus nidulans, Aspergillus flavus and Neurospora crassa) cDNA Sequencing
		The Neurospora crassa perathecia cDNAs are being sequenced by Doris Kupfer, Hua Zhu, and Sara Downard in collaboration with Mary Ann Nelson's group at University of New Mexico.
	www.genome.ou.edu /fungal.html (964 words)

	NEUROSPORA IN TEACHING
		Lacy, A. Neurospora in the freshman biology course.
		Neurospora (wild type) will grow on a medium containing inorganic salts, a carbon source such as sucrose, and one of the B vitamins, biotin.
		Neurospora powder: Neurospora powder can be produced by harvesting mycelia grown in liquid medium (for a period of 14-18 hours) and then lyophilizing in a freeze dryer.
	www.fgsc.net /teaching/teach1.htm (15354 words)

	Neurosporagenome Project Overview (Site not responding. Last check: 2007-10-15)
		Most Neurospora genes have no homologs in yeasts and nearly 40% have no strong homologs in any organism to date, suggesting that examination of the functions of these genes will both novel and informative.
		Neurospora is an important model for basic research in eukaryotes, and fungi allied to Neurospora include significant animal and plant pathogens and industrial strains yielding antibiotics, chemicals, enzymes, and pharmaceuticals.
		This effort will provide a baseline analysis of gene expression under a variety of growth conditions, and later begin to analyze the global effects of loss of novel genes in strains created by Project #1; these data will be made available through the web via structures created in Project #2.
	www.dartmouth.edu /~neurosporagenome/proj_overview.html (363 words)

	The Neurospora Sporulation Rhythm (Site not responding. Last check: 2007-10-15)
		Neurospora crassa has a sexual and an asexual life cycle.
		Neurospora does not respond to red light and work that should be performed under dark conditions can be done under a red safety light (right picture above).
		If you don't have it (or are unsure about it), go to www.apple.com to download the latest version of the free player.
	www.ux.uis.no /~ruoff/Neurospora_Rhythm.html (641 words)

	Structure of the Chromosome VII Centromere Region in Neurospora crassa: Degenerate Transposons and Simple Repeats -- ... (Site not responding. Last check: 2007-10-15)
		The chromosomes of the filamentous fungus Neurospora crassa
		Schematic diagram illustrating the structure of the centromere of LG VII and the region that was subcloned and sequenced.
		Preliminary observations of the chromosomes of Neurospora crassa.
	mcb.asm.org /cgi/content/full/18/9/5465 (7394 words)

	UC Riverside scientists contribute to study that unveils genome sequence of bread mold
		Neurospora, commonly known as the orange bread mold, was first described during an infestation of French bakeries in 1843.
		Neurospora sexual spores are well-known for their ability to germinate after a forest fire; the resulting colony then utilizes the burnt plant matter as a food source.
		The Neurospora sequence is the first for a filamentous fungus and only the third fungal genome sequence that has been determined.
	www.eurekalert.org /pub_releases/2003-04/uoc--urs043003.php (892 words)

	What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence -- Mannhaupt et al. 31 (7): ... (Site not responding. Last check: 2007-10-15)
		Radford,A. and Parish,J.H. (1997) The genome and genes of Neurospora crassa.
		Cambareri,E.B., Jensen,B.C., Schabacht,E. and Selker,E.U. (1989) Repeat-induced G-C to A-T mutations in Neurospora.
		Kupper,U., Niedermann,D.M., Travaglini,G. and Lerch,K. (1989) Isolation and characterization of the tyrosinase gene from Neurospora crassa.
	nar.oxfordjournals.org /cgi/content/full/31/7/1944 (6358 words)

	Regulation of the Neurospora circadian clock by casein kinase II -- Yang et al. 16 (8): 994 -- Genes and Development (Site not responding. Last check: 2007-10-15)
		Neurospora is not essential for the survival of Neurospora.
		In conclusion, we have identified Neurospora CKII as a kinase that phosphorylates FRQ.
		Bell-Pedersen, D., Dunlap, J.C., and Loros, J.J. The Neurospora circadian clock-controlled gene, ccg-2, is allelic to eas and encodes a fungal hydrophobin required for formation of the conidial rodlet layer.
	www.genesdev.org /cgi/content/full/16/8/994 (8053 words)

	MIPS Neurospora crassa database
		The entire genome sequence of Neurospora crassa is determined in a collaboration with the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, USA.
		The sequencing project of Neurospora crassa chromosome II and V as well as the manual annotation of the complete genome during and after finishing the sequencing process was supported by the Deutsche Forschungsgemeinschaft (DFG).
		In the course of the project the analysis and annotation of the data by PEDANT was accompanied by elaborate manual annotation.
	mips.gsf.de /projects/fungi/neurospora.html (940 words)

	Structural and regulatory genes of nitrate reduction (Neurospora) - Nitrate uptake and reduction - HORT640 - Metabolic ...
		Ammonium repression of NR in blue-green algae and Neurospora is no longer evident in cells without an active glutamine synthetase (GS).
		Lee HM, Flores E, Forchhammer K, Herrero A, Tandeau De Marsac N 2000 Phosphorylation of the signal transducer PII protein and an additional effector are required for the PII-mediated regulation of nitrate and nitrite uptake in the cyanobacterium Synechococcus sp.
		Lee HM, Flores E, Herrero A, Houmard J, Tandeau de Marsac N 1998 A role for the signal transduction protein PII in the control of nitrate/nitrite uptake in a cyanobacterium.
	www.hort.purdue.edu /rhodcv/hort640c/nuptake/nu00008.htm (1005 words)

	Neurospora crassa
		Neurospora crassa is an ascomycete, the red bread mold.
		Mitosis of the haploid nuclei of the active, growing fungus generates the conidia.
		Then individual irradiated spores were allowed to germinate on a "complete" medium; that is, one enriched with various vitamins and amino acids.
	home.comcast.net /~john.kimball1/BiologyPages/N/Neurospora.html (579 words)

	Role of Unc104/KIF1-related Motor Proteins in Mitochondrial Transport in Neurospora crassa -- Fuchs and Westermann 16 ... (Site not responding. Last check: 2007-10-15)
		Mitochondria were isolated from a Neurospora strain expressing mtGFP and preincubated in the absence or presence of the indicated antibodies.
		The genome sequence of the filamentous fungus Neurospora crassa.
		Steinberg, G., and Schliwa, M. Organelle movements in the wild type and wall-less fz;sg;os-1 mutants of Neurospora crassa are mediated by cytoplasmic microtubules.
	www.molbiolcell.org /cgi/content/full/16/1/153 (5041 words)

	Neurospora wc-1 and wc-2: Transcription, Photoresponses, and the Origins of Circadian Rhythmicity -- Crosthwaite et al. ... (Site not responding. Last check: 2007-10-15)
		Neurospora wc-1 and wc-2: Transcription, Photoresponses, and the Origins of Circadian Rhythmicity -- Crosthwaite et al.
		Phosphorylation of the Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences the period length of the circadian clock.
		Circadian rhythms in Neurospora crassa: Lipid deficiencies restore robust rhythmicity to null frequency and white-collar mutants.
	www.sciencemag.org /cgi/content/abstract/276/5313/763 (1797 words)

	Whitehead Institute - Grant to Sequence Neurospora
		In fact, it was with Neurospora that scientists first demonstrated the concept that one gene makes one corresponding protein.
		It is the most intensively investigated member of the filamentous fungi, a group of organisms that are more complex than yeasts, and that are of profound significance to human health and welfare.
		Another important outcome of Neurospora sequencing will be its contribution to the growing field of comparative genomics.
	www.wi.mit.edu /news/archives/2000/el_0926.html (610 words)

	CEPCEB - Center for Plant Cell Biology at UC Riverside
		The filamentous fungus Neurospora crassa was the organism used by Beadle and Tatum to prove the one-gene one-polypeptide hypothesis more than 60 years ago.
		Neurospora possesses three sporulation pathways, a circadian rhythm, numerous blue-light responses and differentiates male and female reproductive structures, making it an ideal organism for studies of molecular genetics, cell biology and development.
		We have demonstrated that G proteins are critical for proliferative growth and differentiation in filamentous fungi, controlling growth rate, asexual sporulation, female fertility and stress tolerance.
	www.cepceb.ucr.edu /members/borkovich.htm (1670 words)

	The antifungal effect of sphinganine: differential sensitivity in Neurospora and Candida induced by media composition ...
		The antifungal effect of sphinganine: differential sensitivity in Neurospora and Candida induced by media composition and hyphal morphology.
		In both the nonpathogenic mold, Neurospora crassa, and the dimorphic pathogen, Candida albicans, sensitivity of the fungi to Sph varies dramatically with respect to the availability of certain nutrients.
		These data support the contention that the antifungal effect of Sph is not due to a mere detergent-like disruption of cells, and that Sph may be interacting with discrete cellular targets which may be variably expressed.
	gateway.nlm.nih.gov /robot_pages/MeetingAbstracts/102226597.html (474 words)

	Genetic and Molecular Analysis of Phytochromes from the Filamentous Fungus Neurospora crassa -- Froehlich et al. 4 ... (Site not responding. Last check: 2007-10-15)
		Reversion of Pfr to Pr was monitored by the increase in absorbance at 693 nm.
		Photoregulation of the albino-3 gene in Neurospora crassa.
		The nop-1 gene of Neurospora crassa encodes a seven transmembrane helix retinal-binding protein homologous to archaeal rhodopsins.
	ec.asm.org /cgi/content/full/4/12/2140 (8997 words)

	Neurospora Initiative
		For instance in the best described system, Neurospora crassa, greater than 50% of the protein coding regions sequenced in an ongoing pilot project do not correspond to genes found in yeast; they are novel.
		The field of biochemical genetics was invented using Neurospora; there is over 50 years of research in connecting genes with biochemical function.
		Reflecting the presence of a large and vibrant research community, the largest devoted to a fungus except for yeast, nearly twice as many research papers are published annually on Neurospora than on any other filamentous fungus; within the past 30 years nearly 5000 papers have been published on Neurospora.
	gene.genetics.uga.edu /white_papers/ncrassa.html (2574 words)

	The Membrane Topology of the Carboxyl-terminal Third of the Neurospora Plasma Membrane H[IMAGE]-ATPase -- Lin and ... (Site not responding. Last check: 2007-10-15)
		S]methionine in the Neurospora in vitro system, fractionation of the products on an alkaline sucrose step gradient, digestion of products by proteinase K and by N-glycosidase F, immunoprecipitation of products, and preparation of samples for SDS-polyacrylamide gel electrophoresis were as described (Lin and Addison, 1994; 1995).
		This demonstrates that the fusion proteins had assumed the orientation of a type II bitopic integral membrane protein in the microsomes (Singer, 1990) with carboxyl-terminal residues on the exoplasmic (trans) side and the amino-terminal residues on the cytoplasmic (cis) side of the microsomes (see Fig.
		The major assumption for the basis of the experiments described herein is that transmembrane segments in fusion proteins mimic their behavior in the native protein.
	www.jbc.org /cgi/content/full/270/12/6942 (5316 words)

	Mass flow and pressure-driven hyphal extension in Neurospora crassa -- Lew 151 (8): 2685 -- Microbiology (Site not responding. Last check: 2007-10-15)
		The Neurospora crassa wild-type strain 74-OR23-1A (FGSC 987)
		Schumacher, M. M., Enderlin, C. and Selitrennikoff, C. The osmotic-1 locus of Neurospora crassa encodes a putative histidine kinase similar to osmosensors of bacteria and yeast.
		Virag, A. and Griffiths, A. A mutation in the Neurospora crassa actin gene results in multiple defects in tip growth and branching.
	mic.sgmjournals.org /cgi/content/full/151/8/2685 (3169 words)

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